Il biglietto. Su alcuni aspetti del significato del denaro – La carta e la moneta, La promessa e la verità - nel Faust di Goethe

Focusing on the paper-money episode in the first Act of Part II, the following analysis will briefly consider the conflicting relation between seeming (Schein) and essential being (Sein), between fiction and truth, as it is represented in Goethe’s Faust. It will then focus more elaborately on Goethe’s late thinking from which transpires a painful awareness of an epochal turning point far removed from the premises, on which the worldview of the Goethezeit was based.Focusing on the paper-money episode in the first Act of Part II, the following analysis will briefly consider the conflicting relation between seeming (Schein) and essential being (Sein), between fiction and truth, as it is represented in Goethe’s Faust. It will then focus more elaborately on Goethe’s late thinking from which transpires a painful awareness of an epochal turning point far removed from the premises, on which the worldview of the Goethezeit was based

Il principio dissonante. Su un paradigma romantico e le sue variazioni nella lirica di Georg Trakl

La poetica dell’Espressionismo viene osservata dapprima alla luce di un suo confronto con temi e motivi ripresi da autori dell’epoca classico-romantica, con riferimento soprattutto a Hölderlin e a Novalis.L’argomento della dissonanza viene considerato in questa prospettiva nell’ambito della metrica (la harte Fügung di Hölderlin) e nell’ambito della riflessione poetologica.Si prende poi in considerazione la poesia di Georg Trakl alla luce del suo rapporto con l’eredità classico-romantica e con l’arte moderna.Infine si fa riferimento all’incontro di Anton Webern (op. 13/4 e op. 14) con la poesia di Trakl, concentrandosi su alcuni argomenti dei testi trakliani nella loro trasposizione musicale.The Dissonant Principle. On a Romantic Paradigm and its Variations in Georg Trakl's PoetryThe poetics of expressionism is first observed in the light of a comparison with themes and motifs taken from authors of the classical-romantic era, with reference above all to Hölderlin and Novalis.The argument of dissonance is considered in this perspective in the context of metre (Hölderlin's harte Fügung) and in the context of poetological reflection.We then consider the poetry of Georg Trakl in light of his relationship with the classic-romantic legacy and with modern art.Finally we refer to the meeting of Anton Webern (op. 13/4 and op. 14) with Trakl's poetry, focusing on some topics of the Traklian texts in their musical transposition

Disease status, reasons for discontinuation and adverse events in 1038 Italian children with juvenile idiopathic arthritis treated with etanercept

Background: Data from routine clinical practice are needed to further define the efficacy and safety of biologic medications in children with juvenile idiopathic arthritis (JIA). The aim of this analysis was to investigate the disease status, reasons for discontinuation and adverse events in Italian JIA patients treated with etanercept (ETN). Methods: In 2013, all centers of the Italian Pediatric Rheumatology Study Group were asked to make a census of patients given ETN after January 2000. Patients were classified in three groups: group 1 = patients still taking ETN; group 2 = patients discontinued from ETN for any reasons; group 3 = patients lost to follow-up while receiving ETN. All three groups received a retrospective assessment; patients in group 1 also underwent a cross-sectional assessment. Results: 1038 patients were enrolled by 23 centers: 422 (40.7%) were in group 1, 462 (44.5%) in group 2, and 154 (14.8%) in group 3. Median duration of ETN therapy was 2.5 years. At cross-sectional assessment, 41.8% to 48.6% of patients in group 1 met formal criteria for inactive disease, whereas 52.4% of patients in group 2 and 55.8% of patients in group 3 were judged in clinical remission by their caring physician at last visit. A relatively greater proportion of patients with systemic arthritis were discontinued or lost to follow-up. Parent evaluations at cross-sectional visit in group 1 showed that 52.4% of patients had normal physical function, very few had impairment in quality of life, 51.2% had no pain, 76% had no morning stiffness, and 82.7% of parents were satisfied with their child's illness outcome. Clinically significant adverse events were reported for 27.8% of patients and ETN was discontinued for side effects in 9.5%. The most common adverse events were new onset or recurrent uveitis (10.2%), infections (6.6%), injection site reactions (4.4%), and neuropsychiatric (3.1%), gastrointestinal (2.4%), and hematological disorders (2.1%). Ten patients developed an inflammatory bowel disease and 2 had a malignancy. One patient died of a fulminant streptococcal sepsis. Conclusions: Around half of the patients achieved complete disease quiescence under treatment with ETN. The medication was overall well tolerated, as only one quarter of patients experienced clinically significant adverse events and less than 10% had treatment discontinued for toxicity

Aspetti della corporeità nel Wilhelm Meister di Goethe: dalle esequie di Mignon ai membra disiecta dei Wanderjahre

Nell’ambito di una più ampia e generale crisi della conoscenza, che appare come la caratteristica fondamentale del tardo Settecento europeo, emerge l’attenzione che i più grandi narratori dell’epoca dedicano alla rappresentazione del corpo umano, nella quale sembrano raccogliersi soprattutto gli esiti degli studi antropologici settecenteschi e della discussione sulla separazione cartesiana di spirito e corpo, osservati ora come premessa di una palese crisi culturale e come condizione di un pa..