Association between SRS total T-score and right or left P1m latency for each diagnosis group controlling for K-ABC mental processing scale score.

Association between SRS total T-score and right or left P1m latency for each diagnosis group controlling for K-ABC mental processing scale score.</p

Association between SRS total T-score and leftward lateralization in P1m latency controlling for K-ABC mental processing scale score and signal noise ratio.

Association between SRS total T-score and leftward lateralization in P1m latency controlling for K-ABC mental processing scale score and signal noise ratio.</p

Characteristics of participants.

In previous magnetoencephalography (MEG) studies, children with autism spectrum disorder (ASD) have been shown to respond differently to speech stimuli than typically developing (TD) children. Quantitative evaluation of this difference in responsiveness may support early diagnosis and intervention for ASD. The objective of this research is to investigate the relationship between syllable-induced P1m and social impairment in children with ASD and TD children. We analyzed 49 children with ASD aged 40–92 months and age-matched 26 TD children. We evaluated their social impairment by means of the Social Responsiveness Scale (SRS) and their intelligence ability using the Kaufman Assessment Battery for Children (K-ABC). Multiple regression analysis with SRS score as the dependent variable and syllable-induced P1m latency or intensity and intelligence ability as explanatory variables revealed that SRS score was associated with syllable-induced P1m latency in the left hemisphere only in the TD group and not in the ASD group. A second finding was that increased leftward-lateralization of intensity was correlated with higher SRS scores only in the ASD group. These results provide valuable insights but also highlight the intricate nature of neural mechanisms and their relationship with autistic traits.</div

Association between SRS total T-score and right or left P1m log-intensity controlling for K-ABC mental processing scale score.

Association between SRS total T-score and right or left P1m log-intensity controlling for K-ABC mental processing scale score.</p

Position of the three coils on the heads of the participants.

Position of the three coils on the heads of the participants.</p

Association between SRS-total T-score and leftward lateralization in P1m latency controlling for Mental processing scale score in K-ABC.

Association between SRS-total T-score and leftward lateralization in P1m latency controlling for Mental processing scale score in K-ABC.</p

Association between SRS total T-score and right or left P1m latency controlling for K-ABC mental processing scale score.

Association between SRS total T-score and right or left P1m latency controlling for K-ABC mental processing scale score.</p

S1 Data -

In previous magnetoencephalography (MEG) studies, children with autism spectrum disorder (ASD) have been shown to respond differently to speech stimuli than typically developing (TD) children. Quantitative evaluation of this difference in responsiveness may support early diagnosis and intervention for ASD. The objective of this research is to investigate the relationship between syllable-induced P1m and social impairment in children with ASD and TD children. We analyzed 49 children with ASD aged 40–92 months and age-matched 26 TD children. We evaluated their social impairment by means of the Social Responsiveness Scale (SRS) and their intelligence ability using the Kaufman Assessment Battery for Children (K-ABC). Multiple regression analysis with SRS score as the dependent variable and syllable-induced P1m latency or intensity and intelligence ability as explanatory variables revealed that SRS score was associated with syllable-induced P1m latency in the left hemisphere only in the TD group and not in the ASD group. A second finding was that increased leftward-lateralization of intensity was correlated with higher SRS scores only in the ASD group. These results provide valuable insights but also highlight the intricate nature of neural mechanisms and their relationship with autistic traits.</div

S1 Checklist -

In previous magnetoencephalography (MEG) studies, children with autism spectrum disorder (ASD) have been shown to respond differently to speech stimuli than typically developing (TD) children. Quantitative evaluation of this difference in responsiveness may support early diagnosis and intervention for ASD. The objective of this research is to investigate the relationship between syllable-induced P1m and social impairment in children with ASD and TD children. We analyzed 49 children with ASD aged 40–92 months and age-matched 26 TD children. We evaluated their social impairment by means of the Social Responsiveness Scale (SRS) and their intelligence ability using the Kaufman Assessment Battery for Children (K-ABC). Multiple regression analysis with SRS score as the dependent variable and syllable-induced P1m latency or intensity and intelligence ability as explanatory variables revealed that SRS score was associated with syllable-induced P1m latency in the left hemisphere only in the TD group and not in the ASD group. A second finding was that increased leftward-lateralization of intensity was correlated with higher SRS scores only in the ASD group. These results provide valuable insights but also highlight the intricate nature of neural mechanisms and their relationship with autistic traits.</div

Correlation between the leftward lateralization in log-transformed P1m intensity and coil positions.

Correlation between the leftward lateralization in log-transformed P1m intensity and coil positions.</p