Interleukin-13 Genetic Variants, Household Carpet Use and Childhood Asthma

10.1371/journal.pone.0051970PLoS ONE81

Genome-wide association study for Atopy and Allergic Rhinitis in a Singapore Chinese population

10.1371/journal.pone.0019719PLoS ONE65

Differential Metabolite Profiles during Fruit Development in High-Yielding Oil Palm Mesocarp

10.1371/journal.pone.0061344PLoS ONE84

QCD Glueball Regge Trajectories and the Pomeron

We report a glueball Regge trajectory emerging from diagonalizing a confining Coulomb gauge Hamiltonian for constituent gluons. Using a BCS vacuum ansatz and gap equation, the dressed gluons acquire a mass, of order 800 $MeV$, providing the quasiparticle degrees of freedom for a TDA glueball formulation. The TDA eigenstates for two constituent gluons have orbital, $L$, excitations with a characteristic energy of 400 $MeV$ revealing a clear Regge trajectory for $\vec{J} = \vec{L} + \vec{S}$, where $S$ is the total (sum) gluon spin. Significantly, the $S = 2$ glueball spectrum coincides with the Pomeron given by $\alpha_P(t)=1.08+0.25 t$. Finally, we also ascertain that lattice data supports our result, yielding an average intercept of 1.1 in good agreement with the Pomeron.Comment: 10 pages, 4 ps figure

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy

Undiagnosed Phenylketonuria Can Exist Everywhere: Results From an International Survey

peer reviewedMany countries do not have a newborn screening (NBS) program, and immigrants from such countries are at risk for late diagnosis of phenylketonuria (PKU). In this international survey, 52 of 259 patients (20%) with late diagnosed PKU were immigrants, and 145 of the 259 (55%) were born before NBS or in a location without NBS. © 2021 The Author

Conformational IgE Epitope Mapping of der p 2 and the Evaluations of Two Candidate Hypoallergens for Immunotherapy

10.1038/s41598-018-21792-1Scientific Reports81339

Systematic review of the epidemiology of acne vulgaris

10.1038/s41598-020-62715-3Scientific Reports101575

Utilization of healthcare resources for asthma in Singapore: Demographic features and trends

Asian Pacific Journal of Allergy and Immunology162-357-68APJI