Towards Generalizable Diabetic Retinopathy Grading in Unseen Domains

Diabetic Retinopathy (DR) is a common complication of diabetes and a leading cause of blindness worldwide. Early and accurate grading of its severity is crucial for disease management. Although deep learning has shown great potential for automated DR grading, its real-world deployment is still challenging due to distribution shifts among source and target domains, known as the domain generalization problem. Existing works have mainly attributed the performance degradation to limited domain shifts caused by simple visual discrepancies, which cannot handle complex real-world scenarios. Instead, we present preliminary evidence suggesting the existence of three-fold generalization issues: visual and degradation style shifts, diagnostic pattern diversity, and data imbalance. To tackle these issues, we propose a novel unified framework named Generalizable Diabetic Retinopathy Grading Network (GDRNet). GDRNet consists of three vital components: fundus visual-artifact augmentation (FundusAug), dynamic hybrid-supervised loss (DahLoss), and domain-class-aware re-balancing (DCR). FundusAug generates realistic augmented images via visual transformation and image degradation, while DahLoss jointly leverages pixel-level consistency and image-level semantics to capture the diverse diagnostic patterns and build generalizable feature representations. Moreover, DCR mitigates the data imbalance from a domain-class view and avoids undesired over-emphasis on rare domain-class pairs. Finally, we design a publicly available benchmark for fair evaluations. Extensive comparison experiments against advanced methods and exhaustive ablation studies demonstrate the effectiveness and generalization ability of GDRNet.Comment: Earyly Accepted by MICCAI 2023, the 26th International Conference on Medical Image Computing and Computer Assisted Interventio

Quarkyonic matter and quarkyonic stars in an extended RMF model

By combining RMF models and equivparticle models with density-dependent quark masses, we construct explicitly ``a quark Fermi Sea'' and ``a baryonic Fermi surface'' to model the quarkyonic phase, where baryons with momentums ranging from zero to Fermi momentums are included. The properties of nuclear matter, quark matter, and quarkyonic matter are then investigated in a unified manner, where quarkyonic matter is more stable and energy minimization is still applicable to obtain the microscopic properties of dense matter. Three different covariant density functionals TW99, PKDD, and DD-ME2 are adopted in our work, where TW99 gives satisfactory predictions for the properties of nuclear matter both in neutron stars and heavy-ion collisions and quarkyonic transition is unfavorable. Nevertheless, if PKDD with larger slope of symmetry energy $L$ or DD-ME2 with larger skewness coefficient $J$ are adopted, the corresponding EOSs are too stiff according to both experimental and astrophysical constraints. The situation is improved if quarkyonic transition takes place, where the EOSs become softer and can accommodate various experimental and astrophysical constraints

Label-Efficient Deep Learning in Medical Image Analysis: Challenges and Future Directions

Deep learning has seen rapid growth in recent years and achieved state-of-the-art performance in a wide range of applications. However, training models typically requires expensive and time-consuming collection of large quantities of labeled data. This is particularly true within the scope of medical imaging analysis (MIA), where data are limited and labels are expensive to be acquired. Thus, label-efficient deep learning methods are developed to make comprehensive use of the labeled data as well as the abundance of unlabeled and weak-labeled data. In this survey, we extensively investigated over 300 recent papers to provide a comprehensive overview of recent progress on label-efficient learning strategies in MIA. We first present the background of label-efficient learning and categorize the approaches into different schemes. Next, we examine the current state-of-the-art methods in detail through each scheme. Specifically, we provide an in-depth investigation, covering not only canonical semi-supervised, self-supervised, and multi-instance learning schemes, but also recently emerged active and annotation-efficient learning strategies. Moreover, as a comprehensive contribution to the field, this survey not only elucidates the commonalities and unique features of the surveyed methods but also presents a detailed analysis of the current challenges in the field and suggests potential avenues for future research.Comment: Update Few-shot Method

An enzyme-responsive conjugate improves the delivery of a PI3K inhibitor to prostate cancer

AbstractAn enzyme-responsive peptide drug conjugate was developed for TGX-D1, a promising PI3K inhibitor for prostate cancer therapy. LNCaP-specific KYL peptide was used as the targeting ligand and the prostate specific antigen (PSA) cleavable peptide (SSKYQSL) was used as the enzyme-responsive linker. SSKYQSL is cleaved by recombinant human PSA at 10–250 μg/mL. By contrast, the linker is stable in the serum of prostate cancer patients with high PSA levels (>500 ng/mL), indicating that this linker can survive the systemic circulation in prostate cancer patients but be cleaved in the tumor microenvironment. Cellular uptake of the peptide drug conjugate in prostate cancer cells is improved by about nine times. Biodistribution study reveals significant tumor accumulation of the peptide drug conjugate in nude mice bearing C4–2 tumor xenografts. Meanwhile, distribution of the conjugate in other major tissues is the same as the parent drug, indicating a high specificity of the conjugate to prostate cancers in vivo

Experimental Test of Tracking the King Problem

In quantum theory, the retrodiction problem is not as clear as its classical counterpart because of the uncertainty principle of quantum mechanics. In classical physics, the measurement outcomes of the present state can be used directly for predicting the future events and inferring the past events which is known as retrodiction. However, as a probabilistic theory, quantum-mechanical retrodiction is a nontrivial problem that has been investigated for a long time, of which the Mean King Problem is one of the most extensively studied issues. Here, we present the first experimental test of a variant of the Mean King Problem, which has a more stringent regulation and is termed "Tracking the King". We demonstrate that Alice, by harnessing the shared entanglement and controlled-not gate, can successfully retrodict the choice of King's measurement without knowing any measurement outcome. Our results also provide a counterintuitive quantum communication to deliver information hidden in the choice of measurement.Comment: 16 pages, 5 figures, 2 table

Delving Deeper into Data Scaling in Masked Image Modeling

Understanding whether self-supervised learning methods can scale with unlimited data is crucial for training large-scale models. In this work, we conduct an empirical study on the scaling capability of masked image modeling (MIM) methods (e.g., MAE) for visual recognition. Unlike most previous works that depend on the widely-used ImageNet dataset, which is manually curated and object-centric, we take a step further and propose to investigate this problem in a more practical setting. Specifically, we utilize the web-collected Coyo-700M dataset. We randomly sample varying numbers of training images from the Coyo dataset and construct a series of sub-datasets, containing 0.5M, 1M, 5M, 10M, and 100M images, for pre-training. Our goal is to investigate how the performance changes on downstream tasks when scaling with different sizes of data and models. The study reveals that: 1) MIM can be viewed as an effective method to improve the model capacity when the scale of the training data is relatively small; 2) Strong reconstruction targets can endow the models with increased capacities on downstream tasks; 3) MIM pre-training is data-agnostic under most scenarios, which means that the strategy of sampling pre-training data is non-critical. We hope these observations could provide valuable insights for future research on MIM