Effecs of cyclosporine on bronchial anastomotic healing in canine lung allograf t

Wound healing at bronchial anastomosis of the lung allograft in canine was compared between allografts prescribed with cyclosporine and/or azathioprine and autografts in terms of recanalization of bronchial artery, breaking strength and histologic findings. 1) Restoration of interrupted bronchial artery completed at the 14 day following transplantation in autografts and allografts with cyclosporine, although it has been retarded until day 21 when azathioparine was given. 2) Satisfactory breaking strength at anastomosis was equally measured in autografts and allografts with cyclosporine. In allografts with azathioprine, weakened breaking strength was noticed on day 14 with significant difference (p<0.05). 3) From the standpoint of histologic finding, cyclosporine is of benefit to eliminate inflammatory response and to promote collagen production which was essential to good wound healing

Granulocyte Colony-Stimulating Factor Alleviates Bacterial-Induced Neuronal Apoptotic Damage in the Neonatal Rat Brain through Epigenetic Histone Modification

Bacterial meningitis during the perinatal period may cause long-term neurological deficits. The study investigated whether bacterial lipopolysaccharide (LPS) derived from E. coli. led to neuronal apoptosis with an impaired performance of long-term cognitive function involving the activation of histone modification in the TNF-α gene promoter. Further, we looked into the therapeutic efficacy of granulocyte colony-stimulating factor (G-CSF) in a neonatal brain suffering from perinatal bacterial meningitis. We applied the following research techniques: neurobehavioral tasks, confocal laser microscopy, chromatin immunoprecipitation, and Western blotting. At postnatal day 10, the animals were subjected to LPS and/or G-CSF. The target brain tissues were then collected at P17. Some animals (P45) were studied using neurobehavioral tasks. The LPS-injected group revealed significantly increased expression of NF-κB phosphorylation and trimethylated H3K4 in the TNFA gene promoter locus. Furthermore, the caspase-3, neuronal apoptosis expression, and an impaired performance in cognitive functions were also found in our study. Such deleterious outcomes described above were markedly alleviated by G-CSF therapy. This study suggests that selective therapeutic action sites of G-CSF through epigenetic regulation in the TNFA gene promoter locus may exert a potentially beneficial role for the neonatal brain suffering from perinatal bacterial-induced meningitis

Primary malignant tumors of the small intestine

From 1967 through 1987, 43 of primary malignant tumors of the small intestine were experienced at the First Department of Surgery, Nagasaki University Hospital and affiliated hospital, and clinically analysed. 1) Carcinoma, leiomyosarcoma and malignant lymphoma occupied one third in number. The preferable location of carcinomas and malignant lymphomas was lower part of the small bowel although that of leiomyosarcoma was upper part. 2) Diagnosis was mainly made by means of laparotomy which was carried out by clinical signs of obstruction or peritonitis. poor prognosis attributed to extension of a disease to nodes and liver. An early and accurate diagnosis of small bowel tumors is necessary for improving the survival rate

Open data from the first and second observing runs of Advanced LIGO and Advanced Virgo

Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and second observing runs. The main data products are gravitational-wave strain time series sampled at 16384 Hz. The datasets that include this strain measurement can be freely accessed through the Gravitational Wave Open Science Center at http://gw-openscience.org, together with data-quality information essential for the analysis of LIGO and Virgo data, documentation, tutorials, and supporting software