371 research outputs found
Several Treatments on Nonconforming Element Failed in the Strict Patch Test
For nonconforming finite elements, it has been proved that the models whose convergence is controlled only by the weak form of patch tests will exhibit much better performance in complicated stress states than those which can pass the strict patch tests. However, just because the former cannot provide the exact solutions for the patch tests of constant stress states with a very coarse mesh (strict patch test), their usability is doubted by many researchers. In this paper, the non-conforming plane 4-node membrane element AGQ6-I, which was formulated by the quadrilateral area coordinate method and cannot pass the strict patch tests, was modified by three different techniques, including the special numerical integration scheme, the constant stress multiplier method, and the orthogonal condition of energy. Three resulting new elements, denoted by AGQ6M-I, AGQ6M-II, and AGQ6M, can pass the strict patch test. And among them, element AGQ6M is the best one. The original model AGQ6-I and the new model AGQ6M can be treated as the replacements of the well-known models Q6 and QM6, respectively
A tunable plasmonic refractive index sensor with nanoring-strip graphene arrays
In this paper, a tunable plasmonic refractive index sensor with
nanoring-strip graphene arrays is numerically investigated by the finite
difference time domain (FDTD) method. The simulation results exhibit that by
changing the sensing medium refractive index nmed of the structure, the sensing
range of the system is large. By changing the doping level ng, we noticed that
the transmission characteristics can be adjusted flexibly. The resonance
wavelength remains entirely the same and the transmission dip enhancement over
a big range of incidence angles [0,45] for both TM and TE polarizations, which
indicates that the resonance of the graphene nanoring-strip arrays is
insensitive to angle polarization. The above results are undoubtedly a new way
to realize various tunable plasmon devices, and may have a great application
prospect in biosensing, detection and imaging
An Improved Trace Driven Instruction Cache Timing Attack on RSA
The previous I-cache timing attacks on RSA which exploit the instruction path of a cipher were mostly proof-of-concept, and it is harder to put them into practice than D-cache timing attacks. We propose a new trace driven timing attack model based on spying on the whole I-cache. An improved analysis algorithm of the exponent using the characteristic of the size of the window is advanced, which could further reduce the search space of the bits of the key than the former and provide an error detection mechanism to detect some erroneous decisions of the operation sequence. We implemented an attack on RSA of OpenSSL under a practical environment, proving that the feasibility and effectiveness of I-Cache timing attack could be improved
CPCM: Contextual Point Cloud Modeling for Weakly-supervised Point Cloud Semantic Segmentation
We study the task of weakly-supervised point cloud semantic segmentation with
sparse annotations (e.g., less than 0.1% points are labeled), aiming to reduce
the expensive cost of dense annotations. Unfortunately, with extremely sparse
annotated points, it is very difficult to extract both contextual and object
information for scene understanding such as semantic segmentation. Motivated by
masked modeling (e.g., MAE) in image and video representation learning, we seek
to endow the power of masked modeling to learn contextual information from
sparsely-annotated points. However, directly applying MAE to 3D point clouds
with sparse annotations may fail to work. First, it is nontrivial to
effectively mask out the informative visual context from 3D point clouds.
Second, how to fully exploit the sparse annotations for context modeling
remains an open question. In this paper, we propose a simple yet effective
Contextual Point Cloud Modeling (CPCM) method that consists of two parts: a
region-wise masking (RegionMask) strategy and a contextual masked training
(CMT) method. Specifically, RegionMask masks the point cloud continuously in
geometric space to construct a meaningful masked prediction task for subsequent
context learning. CMT disentangles the learning of supervised segmentation and
unsupervised masked context prediction for effectively learning the very
limited labeled points and mass unlabeled points, respectively. Extensive
experiments on the widely-tested ScanNet V2 and S3DIS benchmarks demonstrate
the superiority of CPCM over the state-of-the-art.Comment: Accepted by ICCV 202
Using Left and Right Brains Together: Towards Vision and Language Planning
Large Language Models (LLMs) and Large Multi-modality Models (LMMs) have
demonstrated remarkable decision masking capabilities on a variety of tasks.
However, they inherently operate planning within the language space, lacking
the vision and spatial imagination ability. In contrast, humans utilize both
left and right hemispheres of the brain for language and visual planning during
the thinking process. Therefore, we introduce a novel vision-language planning
framework in this work to perform concurrent visual and language planning for
tasks with inputs of any form. Our framework incorporates visual planning to
capture intricate environmental details, while language planning enhances the
logical coherence of the overall system. We evaluate the effectiveness of our
framework across vision-language tasks, vision-only tasks, and language-only
tasks. The results demonstrate the superior performance of our approach,
indicating that the integration of visual and language planning yields better
contextually aware task execution.Comment: 19 pages, 13 figure
A tunable plasmonic refractive index sensor with nanoring-strip graphene arrays
In this paper, a tunable plasmonic refractive index sensor with
nanoring-strip graphene arrays is numerically investigated by the finite
difference time domain (FDTD) method. The simulation results exhibit that by
changing the sensing medium refractive index nmed of the structure, the sensing
range of the system is large. By changing the doping level ng, we noticed that
the transmission characteristics can be adjusted flexibly. The resonance
wavelength remains entirely the same and the transmission dip enhancement over
a big range of incidence angles [0,45] for both TM and TE polarizations, which
indicates that the resonance of the graphene nanoring-strip arrays is
insensitive to angle polarization. The above results are undoubtedly a new way
to realize various tunable plasmon devices, and may have a great application
prospect in biosensing, detection and imaging
Ube2L6 promotes M1 macrophage polarization in HFD-fed obese mice via ISGylation of STAT1 to trigger STAT1 activation
Introduction: In obesity-related type 2 diabetes mellitus (T2DM), M1 macrophages aggravate chronic inflammation and insulin resistance. ISG15-conjugation enzyme E2L6 (Ube2L6) has been demonstrated as a promoter of obesity and insulin resistance. This study investigated the function and mechanism of Ube2L6 in M1 macrophage polarization in obesity.
Methods: Obesity was induced in Ube2L6AKO mice and age-matched Ube2L6flox/flox control mice by high-fat diet (HFD). Stromal vascular cells (SVCs) were isolated from epididymal white adipose tissue of mice. Polarization induction was performed in mouse bone marrow-derived macrophages (BMDMs) by exposure to IFN-γ, lipopolysaccharide (LPS), or IL-4. F4/80 expression was assessed by immunohistochemistry staining. Expression of M1/M2 macrophage markers and target molecules was determined by flow cytometry, RT-qPCR, and Western blotting, respectively. Protein interaction was validated by co-immunoprecipitation (Co-IP) assay. The release of TNF-α and IL-10 was detected by ELISA.
Results: The polarization of pro-inflammatory M1 macrophages together with an increase in macrophage infiltration were observed in HFD-fed mice, which could be restrained by Ube2L6 knockdown. Additionally, Ube2L6 deficiency triggered the repolarization of BMDMs from M1 to M2 phenotypes. Mechanistically, Ube2L6 promoted the expression and activation of signal transducer and activator of transcription 1 (STAT1) through interferon-stimulated gene 15 (ISG15)-mediated ISGlylation, resulting in M1 macrophage polarization.
Conclusion: Ube2L6 exerts as an activator of STAT1 via post-translational modification of STAT1 by ISG15, thereby triggering M1 macrophage polarization in HFD-fed obese mice. Overall, targeting Ube2L6 may represent an effective therapeutic strategy for ameliorating obesity-related T2DM
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