43 research outputs found
Antigenic variability in Neuraminidase protein of Influenza A/H3N2 vaccine strains (1968 – 2009)
- Publication venue
- Biomedical Informatics
- Publication date
- 01/01/2011
- Field of study
Antigenic drift and shift involving the surface proteins of Influenza virus gave rise to new strains that caused epidemics affecting
millions of people worldwide over the last hundred years. Variations in the membrane proteins like Hemagglutinin (HA) and
Neuraminidase (NA) necessitates new vaccine strains to be updated frequently and poses challenge to effective vaccine design.
Though the HA protein, the primary target of the human immune system, has been well studied, reports on the antigenic
variability in the other membrane protein NA are sparse. In this paper we investigate the molecular basis of antigenic drift in the
NA protein of the Influenza A/H3N2 vaccine strains between 1968 and 2009 and proceed to establish correlation between antigenic
drift and antigen-antibody interactions. Sequence alignments and phylogenetic analyses were carried out and the antigenic
variability was evaluated in terms of antigenic distance. To study the effects of antigenic drift on the protein structures, 3D
structure of NA from various strains were predicted. Also, rigid body docking protocol has been used to study the interactions
between these NA proteins and antibody Mem5, a 1998 antibody
Genetic diversity fuels gene discovery for tobacco and alcohol use
- Author
- Addison Clifton
- Akiyama Masato
- Albert Christine M.
- Aliev Fazil
- Alonso Alvaro
- Arnett Donna K.
- Ashley-Koch Allison E.
- Ashrani Aneel A.
- Barnes Kathleen C.
- Barr R. Graham
- Bartz Traci M.
- Batini Chiara
- Becker Diane M.
- Benjamin Emelia J.
- Bergen Andrew W.
- Bielak Lawrence F.
- Bierut Laura J.
- Bis Joshua C.
- Bjornsdottir Gyda
- Blangero John
- Bleecker Eugene R.
- Boardman Jason D.
- Boerwinkle Eric
- Boomsma Dorret I.
- Boorgula Meher Preethi
- Bowden Donald W.
- Brody Jennifer A.
- Cade Brian E.
- Chasman Daniel I.
- Chavan Sameer
- Chen Fang
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Iona
- Cho Michael H.
- Choquet Hélène
- Cole John W.
- Cornelis Marilyn C.
- Cucca Francesco
- Curran Joanne E.
- David Sean P.
- de Andrade Mariza
- Dick Danielle M.
- Docherty Anna R.
- Duggirala Ravindranath
- Eaton Charles B.
- Ehringer Marissa A.
- Esko Tõnu
- Faul Jessica D.
- Fiorillo Edoardo
- Fornage Myriam
- Freedman Barry I.
- Gabrielsen Maiken E.
- Gagliano Taliun Sarah A.
- Gao Shuang
- Garrett Melanie E.
- Gharib Sina A.
- Gieger Christian
- Gillespie Nathan
- Glahn David C.
- Gordon Scott D.
- Gu Charles C.
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Guo Xiuqing
- Haessler Jeffrey
- Hall Michael E.
- Haller Toomas
- Hancock Dana B.
- Harris Kathleen Mullan
- He Jiang
- Herd Pamela
- Hewitt John K.
- Hickie Ian
- Hidalgo Bertha
- Hokanson John E.
- Hopfer Christian
- Hottenga JoukeJan
- Hou Lifang
- Huang Hongyan
- Hung Yi-Jen
- Hunter David J.
- Hveem Kristian
- Hwang Shih-Jen
- Hwu Chii-Min
- Iacono William
- Irvin Marguerite R.
- Jang Seon-Kyeong
- Jee Yon Ho
- Jiang Bibo
- Jiang Yu
- Johnson Eric O.
- Joo Yoonjung Y.
- Jorgenson Eric
- Justice Anne E.
- Kamatani Yoichiro
- Kaplan Robert C.
- Kaprio Jaakko
- Kardia Sharon L. R.
- Keller Matthew C.
- Kelly Tanika N.
- Khunsriraksakul Chachrit
- Kooperberg Charles
- Korhonen Tellervo
- Kraft Peter
- Krauter Kenneth
- Kuusisto Johanna
- Laakso Markku
- Lasky-Su Jessica
- Lee James J.
- Lee Wen-Jane
- Levy Daniel
- Li Kevin
- Li Liming
- Li Yuqing
- Lin Kuang
- Lind Penelope A.
- Liu Chunyu
- Liu Dajiang J.
- Liu Mengzhen
- Lloyd-Jones Donald M.
- Lutz Sharon M.
- Ma Jiantao
- Manichaikul Ani
- Martin Nicholas G.
- Mathur Ravi
- Matoba Nana
- McArdle Patrick F.
- McGue Matt
- McQueen Matthew B.
- Medland Sarah E.
- Metspalu Andres
- Meyers Deborah A.
- Millwood Iona Y.
- Mitchell Braxton D.
- Mohlke Karen L.
- Moll Matthew
- Montasser May E.
- Morrison Alanna C.
- Mulas Antonella
- Munafò Marcus R.
- Mägi Reedik
- Nielsen Jonas B.
- North Kari E.
- Oelsner Elizabeth C.
- Okada Yukinori
- Orrù Valeria
- Otto Jacqueline M.
- Palmer Nicholette D.
- Palviainen Teemu
- Pandit Anita
- Park S. Lani
- Peters Annette
- Peters Ulrike
- Peyser Patricia A.
- Polderman Tinca J. C.
- Rafaels Nicholas
- Redline Susan
- Reed Robert M.
- Reiner Alex P.
- Rice John P.
- Rich Stephen S.
- Richmond Nicole E.
- Roan Carol
- Rotter Jerome I.
- Rueschman Michael N.
- Runarsdottir Valgerdur
- Saccone Nancy L.
- Saunders Gretchen R. B.
- Schwartz David A.
- Shadyab Aladdin H.
- Shi Jingchunzi
- Shringarpure Suyash S.
- Sicinski Kamil
- Silva Lilian Fernandes
- Skogholt Anne Heidi
- Smith Jennifer A.
- Smith Nicholas L.
- Sotoodehnia Nona
- Stallings Michael C.
- Stefansson Hreinn
- Stefansson Kari
- Stitzel Jerry A.
- Sun Xiao
- Syed Moin
- Tal-Singer Ruth
- Taylor Amy E.
- Taylor Kent D.
- Telen Marilyn J.
- Thai Khanh K.
- Thorgeirsson Thorgeir E.
- Tiwari Hemant
- Turman Constance
- Tyrfingsson Thorarinn
- Vrieze Scott
- Wall Tamara L.
- Walters Robin G.
- Wang Chen
- Wang Xingyan
- Weir David R.
- Weiss Scott T.
- White Wendy B.
- Whitfield John B.
- Wiggins Kerri L.
- Willemsen Gonneke
- Willer Cristen J.
- Winsvold Bendik S.
- Xu Huichun
- Yanek Lisa R.
- Yin Jie
- Young Kendra A.
- Young Kristin L.
- Yu Bing
- Zhao Wei
- Zhou Wei
- Zuccolo Luisa
- Zöllner Sebastian
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury(1-4). These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries(5). Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction.Peer reviewe
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdollahi Hamed
- Abdullah Tala
- Abecasis Goncalo R.
- Abedalthagafi Malak
- Abul-Husn Noura S.
- Acquilini Donatella
- Adams Emma L.
- Adamsara Alireza
- Adeleye Olumide
- Adra Darin
- Afilalo Jonathan
- Afilalo Marc
- Afrasiabi Zaman
- Agüero Daiana
- Ahmadi Saeideh
- Aksentijevich Alexandra
- Al Harthi Fawz
- Al Mutairi Amal
- Al-Afghani Hani
- Al-Awdah Laila
- Alaamery Manal
- Alahmadey Ziab Z.
- Alaverdian Diana
- Alavere Helene
- Albader Anoud
- Albaiceta Guillermo M.
- Albakri Jehad K.
- AlBardis Hadeel
- Albeladi Maha
- Albesher Nour
- Albrich Werner
- AlDhawi Nouf
- Aleagha Afshar Etemadi
- Alghamdi Bader
- Alghamdi Jahad
- Ali Altaf
- Aliannejad Rasoul
- Aljawini Nora
- AlJohani Sameera
- Alkwai Sarah
- Allos Raili
- AlMalik Abdulaziz
- Almalki Faisal
- Almohammed Iman
- Almutairi Mansour
- Alotaibi Sara
- Alowayn Albandary M.
- Alqahtani Saleh
- Alqubaishi Fatimah
- Alrashed May
- Alshareef Abdulraheem
- Alsolm Ebtehal
- Alswailm Moneera
- AlZahrani Deema
- Amirsavadkouhi Ali
- Amitrano Sara
- Andolfo Immacolata
- Andretta Francesca
- Andreucci Elena
- Andrews Shea J.
- Andrews Shea J.
- Andrews Shea J.
- Anedda Federico
- Anemoli Valentina
- Anne Feng Yen-Chen
- Annis Aubrey
- Antinori Andrea
- Antoni Melania Degli
- Aprile von Hohenstaufen Kathrin
- Arabi Yaseen M.
- Armstrong Jacob
- Arning Nicolas
- Arranz Maria J.
- Arribas Elisa
- Arthur Timothy D.
- Artuso Rosangela
- Arumugam Prabhu
- Ascolillo Steven
- Atkinson Elizabeth G.
- Aucella Filippo
- Auld Daniel
- Azarzar Samira
- Åsvold Bjørn Olav
- Bachetti Tiziana
- Balaconis Mary K.
- Baldassarri Margherita
- Ball Catherine A.
- Baltzell Asher Haug
- Band Gavin
- Bandini Maria
- Baraka Dona
- Baras Aris
- Baratti Stefano
- Barbieri Chiara
- Bargagli Elena
- Barhoush Eman
- Barnes Kathleen C.
- Baroni Silvia
- Bartels Meike
- Bassetti Matteo
- Batini Chiara
- Baya Nikolas
- Beck Andrew
- Beckmann Noam D.
- Bedini Josep L.
- Bee Catherine E.
- Beguin Yves
- Belbin Gillian M.
- Belhaj Yasmine
- Beligni Giada
- Belisle Alexandre
- Belli Mary Ann
- Below Jennifer
- Benetti Elisa
- Bennett David
- Bergantini Laura
- Bergomi Paola
- Berkowitz Nathan
- Bernardo David
- Bibert Stéphanie
- Biscarini Filippo
- Blay Natalia
- Bochud Pierre-Yves
- Boillat Noémie
- Bottà Giordano
- Bouab Meriem
- Boughton Andrew P.
- Bradford Yuki
- Branka Vulesevic Nardin Rezk
- Brassard Nathalie
- Brenner Bluma
- Britvan Bari
- Brumpton Ben M.
- Bruno Raffaele
- Bruttini Mirella
- Bryant Sam
- Bryant Sam
- Buring Julie E.
- Busani Stefano
- Bussotti Maurizio
- Butler-Laporte Guillaume
- Butler-Laporte Guillaume
- Butterworth Adam S.
- Buxbaum Joseph D.
- Cal-Sabater Paloma de la
- Caldarelli Gian Piero
- Callier Shawneequa
- Cameli Paolo
- Campbell Archie
- Campbell Archie
- Canaccini Anna
- Cantarini Luca
- Cantor Michael N.
- Capasso Mario
- Capitani Katia
- Cappelli Silvia
- Carella Massimo
- Carey Dave J.
- Carreras Anna
- Carriero Miriam Lucia
- Castaño-Vinyals Gemma
- Castelli Francesco
- Castori Marco
- Catena Emanuele
- Caulfield Mark J.
- Cárcel-Márquez Jara
- Ceri Stefano
- Chamnanphon Monpat
- Chan Georgia
- Chang Xiao
- Chang Xiao
- Chariyavilaskul Pajaree
- Charney Alexander W.
- Chasman Daniel I.
- Chassé Michaël
- Chaudhary Kumardeep
- Chavan Sameer
- Chen Hung-Hsin
- Cheng Nathan
- Chetruengchai Wanna
- Chittoor Geetha
- Cho Judy H.
- Cho Kelly
- Choi Sam
- Churchhouse Claire
- Chwialkowska Karolina
- Claassen Sabine
- Claringbould Annique
- Coignet Marie
- Coiro Gabriella
- Collins Brett L.
- Colobrán Roger
- Colombo Riccardo
- Conticini Edoardo
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Corridi Marta
- Cortés Beatriz
- Cossarizza Andrea
- Coto Eliecer
- Coviello Domenico A.
- CRiPSI null
- Croci Leonardo
- Croci Susanna
- Crook Derrick W.
- Crooks Kristy
- Crotti Lia
- Cullell Natalia
- Cusick Caroline
- Daga Sergio
- Dalmau David
- Daly Mark
- Danesh John
- Darcis Gilles
- Daya Michelle
- de Cid Rafael
- de Felipe Mimbrera Alicia
- de geus Eco (E. J. C. )
- De Vivo Oreste
- DeDiego Marta L.
- Deelen Patrick
- Dei Simona
- Della Monica Matteo
- Desanctis Elena
- Di Angelantonio Emanuele
- Di Biagio Antonio
- Di Domenico Paolo
- Di Pietro Massimo
- Di Sarno Laura
- Dietl Beatriz
- Do Ron
- Dobaño Carlota
- Doddato Gabriella
- Domingo Carlos
- Domínguez-Mayoral Anna
- Donati Alice
- Donner Kati
- Durand Madeleine
- D’Alessandro Miriana
- D’Antonio Matteo
- D’Antonio-Chronowska Agnieszka
- D’Arminio Monforte Antonella
- D’Mellow Kenton
- Earle Sarah G.
- Eid Mohammed A.
- El-Jawhari Jehan J.
- El-Lawaty Walaa M.
- El-shanshory Mohamed R.
- El-Sherbiny Yasser M.
- Elhadidy Tamer A.
- Elnagdy Marwa H.
- Eltoukhy Madonna M.
- Emiliozzi Arianna
- Emma Duncan
- Erard Véronique
- Esko Tõnu
- Fabbiani Massimiliano
- Falcone Marco
- Fallerini Chiara
- Farré Xavier
- Fava Francesca
- Fawns-Ritchie Chloe
- Fawns-Ritchie Chloe
- Fawzy Mohammad S.
- Felemban Walaa A.
- Feri Marco
- Fernandez-Cadenas Israel
- Ferreira Manuel A. R.
- Ferri Claudio
- FHoGID null
- Finer Sarah
- FinnGen null
- Finucane Hilary
- Fiorentino Giuseppe
- Fiz-López Aida
- Forgetta Vincenzo
- Forgetta Vincenzo
- Fowler Tom
- Francesco Bianchi Antonio Perrella
- Franchi Federico
- Francisci Daniela
- Franco Giulianini
- Frazer Kelly A.
- Frediani Bruno
- Free Robert C.
- Frippiat Frederic
- Frithiof Robert
- Frullanti Elisa
- Furini Simone
- Gabbi Chiara
- Gabrieli Arianna
- Gaddis Michael
- Galván-Femenía Iván
- Ganna Andrea
- Ganna Andrea
- Garcia-Aymerich Judith
- García-Clemente Marta
- García-Madrona Sebastian
- Gass Matthew C.
- Gatti Francesca
- Gaziano J. Michael
- Genes &
- Georges Michel
- Gettler Kyle
- Ghosh Biswarup
- Giannattasio Ferdinando
- Gignoux Christopher R.
- Giliberti Annarita
- Giorli Alessia
- Giot Jean-Baptiste
- Girardis Massimo
- Girshick Ahna
- Glessner Joseph R.
- Glessner Joseph T.
- Gofflot Stéphanie
- Goldstein Jacqueline I.
- Gomez Juan
- González-Villa Esther
- Gori Marco
- Grassi Davide
- Green Robert C.
- Griffiths Christopher J.
- Grip Jonathan
- Guarnaccia Alessandra
- Guerrini Susanna
- Guidelli Luca
- Guindo-Martinez Marta
- Guiot Julien
- Guntz Julien
- Gupta Rahul
- Guturu Harendra
- Guyatt Anna L.
- Guzman Charlotte
- Hakonarson Hakon
- Hakonarson Hakon
- Halawani Roaa T.
- Harerimana Nadia
- Harris Jennifer R.
- Hasanato Rana
- Hayward Caroline
- Hayward Caroline
- Health Research Team null
- Hegazy Mohamed A. F.
- Helgeland Øyvind
- Henry Danielle
- Hensen Kati
- Hiester Liam L.
- Hirankarn Nattiya
- Ho Yuk-Lam
- Hoggart Clive
- Hollox Edward J.
- Hong Eurie L.
- Horowitz Julie E.
- Hosseini Abdolmajid
- Hottenga Jouke Jan
- Huang Qin Qin
- Huckins Laura M.
- Huffman Jennifer E.
- Hultström Michael
- Hunt Karen A.
- Huynen Pascale
- Hveem Kristian
- Iglesias Lara Lloret
- Ikram M. Arfan
- Iolascon Achille
- Itan Yuval
- Jacques Jessica
- Jantarabenjakul Watsamon
- Jiménez-Xarrié Elena
- John Catherine
- Jordan Daniel M.
- Josyula Navya Shilpa
- Jung Junghyun
- Justice Anne E.
- Kallaste Anne
- Kamdar Dhryata
- Kanai Masahiro
- Kanai Masahiro
- Kanai Masahiro
- Karczewski Konrad J.
- Karjalainen Juha
- Karlson Elizabeth W.
- Karp Avromie
- Kaufmann Daniel E.
- Kaunisto Mari
- Keller Katherine
- Kenny Eimear E.
- Kerr Shona M.
- Khafaga Walid T.
- Khattab Amin K.
- Kimchi Nofar
- King Daniel
- Kisand Kai
- Kivinen Katja
- Knight Spencer
- Koelling Nils
- Kogevinas Manolis
- Koskelainen Sami
- Kosmicki Jack A.
- Kousathanas Athanasios
- Kristiansson Kati
- La Rovere Maria Teresa
- Laane Edward
- Labkowsky Alexander
- Laisk Triin
- Lambermont Bernard
- Lanting Pauline
- Lathrop G. Mark
- Lauren Petty E.
- Laurent Laetitia
- Läll Kristi
- Leader Joseph B.
- Lee Paul H.
- Lee Yunsung
- LeFaive Jonathon
- Lena Fabio
- Lepage Pierre
- Lepamets Maarja
- Levy Tess
- Léonard Philippe
- Li Binglan
- Li Kevin W.
- Li Rui
- Liao Rachel G.
- Lin Shang-Kuan
- Lipcsey Miklos
- Lista Mirjam
- Llucià-Carol Laia
- Lo Rizzo Caterina
- Loos Ruth J. F.
- Lopera Esteban
- Lorubbio Maria
- Lozano Francisco
- Lu Wenhan
- Lucas Anastasia
- Luchi Sauro
- Ludovisi Serena
- Maggiolo Franco
- Magnus Per
- Mahmoud Ebrahim S.
- Malaise Olivier
- Mamlouk Noor
- Mancarella Sandro
- Mandalà Marco
- Mangino Massimo
- Mangul Serghei
- Manson JoAnn E.
- Mantovani Stefania
- Marcantonio Simona
- Marciano Carmen
- Mari Francesca
- Maricic Tomislav
- Marike Boezen Lude Franke
- Martin Alicia R.
- Martin Hilary C.
- Martinelli Enrico
- Martí-Fàbregas Joan
- Martín-Nalda Andrea
- Martínez Alba Parra
- Masjuan Jaime
- Mason Dan
- Massadeh Salam
- Masucci Luca
- Matsui Hiroko
- Mazzei Maria Antonietta
- Márquez Leonardo
- Mägi Reedik
- McCormick Joseph B.
- McCurdy Shannon
- Medina-Gomez Carolina
- Meigs James B.
- Meloni Ilaria
- Menatti Elisabetta
- Mencarelli Maria Antonietta
- Menéndez-Valladares Paloma
- Mercader Josep
- Mercader Josep Maria
- Merla Giuseppe
- Metsalu Kristjan
- Metspalu Andres
- Meuris Christelle
- Milani Lili
- Miraglia Federica Gaia
- Mirshahi Tooraj
- Misset Benoit
- Moahmed Hanteera S.
- Mohamed Attia A. S.
- Mohseni Moghaddam Seyed Behrooz
- Mondelli Mario Umberto
- Montagnani Francesca
- Mooser Vincent
- Moreno Victor
- Morris Marcela
- Morrison David R.
- Moutschen Michel
- Moutsianas Loukas
- Muiño Elena
- Murphy Shawn N.
- Mussini Cristina
- Naaber Paul
- Naderpour Zeinab
- Nadkarni Girish N.
- Nakanishi Tomoko
- Nakanishi Tomoko
- Neale Benjamin M.
- Nencioni Cesira
- Neofytos Dionysios
- Nguyen Huy
- Nguyen Jennifer P.
- Niavarani Ahmadreza
- Niblo Kristi
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Nilaratanakul Voraphoj
- Nivard Michel (M. G. )
- Nkambul Lindo
- Nkambul Lindokuhle
- Nkambul Lindokuhle
- Nkambule Lindokuhle
- Nkambule Lindokuhle
- North Kari
- Noto Keith
- Nussle Semira Gonseth
- Odhams Christopher A.
- Ognibene Agostino
- Okasha Kamal
- Oliveira Maureen
- Ori Anil P. S.
- O’Connell Anne Marie
- O’Donnell Christopher J.
- O’Reilly Paul
- P-PredictUs null
- Paciosi Francesco
- Paciosi Francesco
- Packer Richard J.
- Palmer Duncan S.
- Palmieri Maria
- Palotie Aarno
- Pancrazzi Alessandro
- Panese Sandro
- Parati Gianfranco
- Parisi Saverio Giuseppe
- Park Danny
- Parravicini Pierpaolo
- Partha Raghavendran
- Pasko Dorota
- Pathak Gita A.
- Pathak Gita A.
- Pavlovic Milos
- Peloso Gina
- Perez Emma F.
- Perez-Tur Jordi
- Perna Rita
- Perola Markus
- Peruggia Michael
- Pessina Gloria
- Pesukova Jaana
- Peterson Pärt
- Petitjean Louis
- Petrocelli Paola
- Phokaew Chureerat
- Piacentini Paolo
- Picchiotti Nicola
- Pigazzini Sara
- Pigazzini Sara
- Pigazzini Sara
- Pigazzini Sara
- Pinoli Pietro
- Pinto Anna Maria
- Pirinen Matti
- Piscopo Carmelo
- Planas Anna M.
- Polikowski Hannah
- Polimanti Renato
- Polymeropoulos Christos
- Polymeropoulos Mihael H.
- Polymeropoulos Vasilios
- Pongpanich Monnat
- Porteous David J.
- Porteous David J.
- Poscente Monica
- Preuss Michael
- Przychodzen Bartlomiej P.
- Putchareon Opass
- Puthanakit Thanyawee
- Puusepp Mairo
- Quinodoz Mathieu
- Quiros-Roldan Eugenia
- Rader Daniel
- Rafaels Nicholas
- Raggi Pamela
- Ragoussis Jiannis
- Rahmouni Souad
- Raimondi Francesco
- Rancan Ilaria
- Rand Kristin
- Ravaglia Sabrina
- RegCOVID null
- Reimann Ene
- Rendon Augusto
- Renieri Alessandra
- Rhead Brooke
- Rhodes Daniel
- Richards J. Brent
- Richards J. Brent
- Richmond Anne
- Richmond Anne
- Rico Veronica
- Ridker Paul M.
- Ringmets Inge
- Ripamonti Diego
- Ripatti Samuli
- Ritchie Marylyn D.
- Riva Agostino
- Rivolta Carlo
- Rizzi Marco
- Roberts Genevieve
- Robles Veronica
- Rogne Tormod
- Rojo Silvia
- Romani Davide
- Rooyackers Olav
- Rossetti Barbara
- Rudkin Justine K.
- Ruiz Luong
- Ruiz-Jaén Francisca
- Ruotsalainen Sanni
- Rusconi Stefano
- Russo Roberta
- Sabrina Ravaglia
- Saeedi Morteza
- Safieh Leen Abu
- Salerni Lorenzo
- Salib Irene
- Samir Amr
- Sanarico Maurizio
- Sanguinetti Maurizio
- Sarma Gopal
- Sarzi-Braga Simona
- Satterstrom F. Kyle
- Sauvage Anne-Sophie
- Sawaji Mona
- Scaggiante Renzo
- Scala Raffaele
- Schadt Eric E.
- Schiaroli Elisabetta
- Schurr Erwin
- Scolletta Sabino
- Scott Richard H.
- Scotton Pier Giorgio
- Sealfon Stuart C.
- Sebastian Zöllner Brooke Wolford
- Sebra Robert P.
- Seed Cotton
- Segala Francesco Vladimiro
- Segura Tomás
- SeroCOVID null
- Serra-Llovich Alex
- Serrano-Heras Gemma
- Sesso Howard D.
- Shahin Doaa
- Sharififard Bahareh
- Shaw Douglas M.
- Shortt Jonathan
- Shotelersuk Vorasuk
- Shrine Nick
- Siano Matteo
- Sloofman Laura G.
- Smieszek Sandra P.
- Smith Albert V.
- Smoller Jordan W.
- Sobh Ali
- Sodsai Pimpayao
- Soler Pere
- Solligard Erik
- Solomonson Matthew
- Solomonson Matthew
- Soranzo Nicole
- Soriano Alex
- Spargi Genni
- Spector Tim D.
- Spencer Chris C. A.
- Spertilli Chiara
- Squeo Gabriella Maria
- Starkopf Joel
- Stella Alessandra
- Stevens Christine
- Stevens Christine
- Stuckey Alex
- Suardi Claudia
- Suchartlikitwong Pintip
- Suh Noémie
- Suliman Bandar A.
- Sumoy Lauro
- Sun Yan V.
- Suttichet Thitima B.
- Tabri Jekaterina
- Tacconi Danilo
- Tadi Hengameh Ansari
- Tamm Anu
- Tanfoni Marco
- Tang Lara
- Tardif Nicolas
- Tavecchia Luisa
- Tenesa Albert
- Thompson Ryan C.
- Thys Marie
- Timmers Paul R. H. J.
- Tiseo Giusy
- Tita Rossella
- Tobin Martin D.
- Tommasi Andrea
- Torky Mohamed S.
- Torrents David
- Torvorapanit Pattama
- Trankiem Amy
- Trembath Richard C.
- Trivedi Bhavi
- Trogstad Lill-Iren S.
- Trotta Tullio
- Tsao Phil
- Tselios Chris
- Tsuo Kristin
- Tumbarello Mario
- Turley Patrick
- Uitterlinden Andre G.
- Underwood Slayton J.
- Vaghi Massimo
- Valente Serafina
- Valentino Floriana
- van Blokland Irene
- van Heel David A.
- Vecchia Marco
- Veerapen Kumar
- Venn Laura D.
- Venturelli Sophie
- Vergori Alessandra
- Verma Anurag
- Verma Shefali S.
- Verzuri Agnese
- Villalonga Joan Montaner
- Vincenti Antonella
- Voide Cathy
- Von Frenckell Christian
- Vonk Judith. M.
- Wain Louise V.
- Walker Susan
- Walters Raymond K.
- Wang Jiongming
- Wang Xueyang
- Wanying Zhu
- Warmerdam Robert
- Weiss Scott T.
- Wicks Stephen J.
- Willer Cristen
- Williams Alexander T.
- Wilson Daniel J.
- Wilson James F.
- Wolford Brooke
- Wolford Brooke
- Woolley Ann E.
- Wright John
- Wyllie David H.
- Xue Xiaoqing
- Yadav Ashish
- Yassen Amr M.
- Zanella Isabella
- Zeberg Hugo
- Zguro Kristina
- Zhang Miao
- Zhao Jing Hua
- Zhou Wei
- Zhou Wei
- Zlatopolsky Menachem
- Zucchi Patrizia
- Zyndorf Marissa
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to
genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility
and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component.
Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci
(eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene),
including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform
genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer
SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the
diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbasi Behzad
- Abbasi-Kangevari Mohsen
- Abbasi-Kangevari Zeinab
- Abbastabar Hedayat
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdoli Amir
- Abebe Haimanot
- Abedi Aidin
- Abidi Hassan
- Abolhassani Hassan
- Abu-Gharbieh Eman
- Abubaker Ali Hiwa
- Achappa Basavaprabhu
- Acuna Juan Manuel
- Adedeji Isaac Akinkunmi
- Adegboye Oyelola A
- Adnani Qorinah Estiningtyas Sakilah
- Advani Shailesh M
- Afzal Muhammad Sohail
- Aghaie Meybodi Mohamad
- Ahadinezhad Bahman
- Ahinkorah Bright Opoku
- Ahmad Sajjad
- Ahmadi Sepideh
- Ahmed Rashid Tarik
- Ahmed Salih Yusra
- Ahmed Muktar Beshir
- Aiman Wajeeha
- Akalu Gizachew Taddesse
- Al Hamad Hanadi
- Al-Maweri Sadeq Ali
- Al-Raddadi Rajaa M
- Alahdab Fares
- AlAmodi Abdulhadi A
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Alem Adugnaw Zeleke
- Alem Dejene Tsegaye
- Alemayehu Yosef
- Alhalaiqa Fadwa Naji
- Alhassan Robert Kaba
- Ali Saqib
- Alicandro Gianfranco
- Alipour Vahid
- Aljunid Syed Mohamed
- Alkhayyat Motasem
- Alluri Sunitha
- Almasri Nihad A
- Almustanyir Sami
- Alvarez Elysia M
- Alvis-Guzman Nelson
- Ameyaw Edward Kwabena
- Amini Saeed
- Amu Hubert
- Ancuceanu Robert
- Andrei Catalina Liliana
- Andrei Tudorel
- Ansari Fereshteh
- Ansari-Moghaddam Alireza
- Anvari Davood
- Anyasodor Anayochukwu Edward
- Arab-Zozani Morteza
- Arabloo Jalal
- Argaw Ayele Mamo
- Ariffin Hany
- Arshad Muhammad
- Arulappan Judie
- Aryannejad Armin
- Asemi Zatollah
- Asghari Jafarabadi Mohammad
- Atashzar Mohammad Reza
- Atorkey Prince
- Atreya Alok
- Attia Sameh
- Aujayeb Avinash
- Ausloos Marcel
- Avila-Burgos Leticia
- Awedew Atalel Fentahun
- Ayala Quintanilla Beatriz Paulina
- Ayele Alemu Degu
- Ayen Solomon Shitu
- Azab Mohammed A
- Azadnajafabad Sina
- Azami Hiva
- Azangou-Khyavy Mohammadreza
- Azari Jafari Amirhossein
- Azarian Ghasem
- Azzam Ahmed Y
- Bahadory Saeed
- Bai Jianjun
- Baig Atif Amin
- Baker Jennifer L
- Banach Maciej
- Barone-Adesi Francesco
- Barr Ronald D
- Barra Fabio
- Barrow Amadou
- Basaleem Huda
- Batiha Abdul-Monim Mohammad
- Behzadifar Masoud
- Bekele Niguss Cherie
- Belete Rebuma
- Belgaumi Uzma Iqbal
- Bell Arielle Wilder
- Berhie Alemshet Yirga
- Bhagat Devidas S
- Bhagavathula Akshaya Srikanth
- Bhakta Nickhill
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhaskar Sonu
- Bhattacharyya Krittika
- Bhojaraja Vijayalakshmi S
- Bibi Sadia
- Bijani Ali
- Biondi Antonio
- Birara Setognal
- Bjørge Tone
- Bleyer Archie
- Bolarinwa Obasanjo Afolabi
- Bolla Srinivasa Rao
- Boloor Archith
- Braithwaite Dejana
- Brenner Hermann
- Bulamu Norma B
- Burkart Katrin
- Bustamante-Teixeira Maria Teresa
- Butt Nadeem Shafique
- Butt Zahid A
- Bärnighausen Till Winfried
- C. La Vecchia
- Caetano dos Santos Florentino Luciano
- Cao Chao
- Cao Yin
- Carreras Giulia
- Catalá-López Ferrán
- Cembranel Francieli
- Cerin Ester
- Chakinala Raja Chandra
- Chakraborty Promit Ananyo
- Chattu Vijay Kumar
- Chaturvedi Pankaj
- Chaurasia Akhilanand
- Chavan Prachi P
- Chimed-Ochir Odgerel
- Choi Jee-Young Jasmine
- Christopher Devasahayam J
- Chu Dinh-Toi
- Chung Michael T
- Compton Kelly
- Conde Joao
- Costa Vera Marisa
- D'Amico Emanuele
- Da'ar Omar B
- Dadras Omid
- Dahlawi Saad M A
- Dai Xiaochen
- Damiani Giovanni
- Dandona Lalit
- Dandona Rakhi
- Daneshpajouhnejad Parnaz
- Darwish Amira Hamed
- Daryani Ahmad
- De la Hoz Fernando Pio
- Dean Frances E
- Debela Sisay Abebe
- Demie Takele Gezahegn G
- Demissie Getu Debalkie
- Demissie Zeleke Geto
- Denova-Gutiérrez Edgar
- Derbew Molla Meseret
- Desai Rupak
- Desta Abebaw Alemayehu
- Dhamnetiya Deepak
- Dharmaratne Samath Dhamminda
- Dhimal Mandira Lamichhane
- Dhimal Meghnath
- Dianatinasab Mostafa
- Didehdar Mojtaba
- Diress Mengistie
- Djalalinia Shirin
- Do Huyen Phuc
- Doaei Saeid
- Dorostkar Fariba
- dos Santos Wendel Mombaque
- Drake Thomas M
- Ekholuenetale Michael
- El Sayed Zaki Maysaa
- El Sayed Iman
- El Tantawi Maha
- El-Abid Hassan
- El-Jaafary Shaimaa I
- Elbahnasawy Mostafa Ahmed
- Elbarazi Iffat
- Elhabashy Hala Rashad
- Elhadi Muhammed
- Enyew Daniel Berhanie
- Erdomaeva Yana Arturovna
- Erkhembayar Ryenchindorj
- Eshrati Babak
- Eskandarieh Sharareh
- Faisaluddin Mohammed
- Fares Jawad
- Farooque Umar
- Fasanmi Abidemi Omolara
- Fatima Wafa
- Ferreira de Oliveira José Miguel P
- Ferrero Simone
- Ferro Desideri Lorenzo
- Fetensa Getahun
- Filip Irina
- Fischer Florian
- Fisher James L
- Fitzmaurice Christina
- Force Lisa M
- Foroutan Masoud
- Fu Weijia
- Fukumoto Takeshi
- Gaal Peter Andras
- Gad Mohamed M
- Gaewkhiew Piyada
- Gallus Silvano
- Garg Tushar
- Gebremeskel Teferi Gebru
- Gemeda Belete Negese Belete
- Getachew Tamiru
- Ghafourifard Mansour
- Ghamari Seyyed-Hadi
- Ghashghaee Ahmad
- Ghassemi Fariba
- Ghith Nermin
- Gholami Ali
- Gholizadeh Navashenaq Jamshid
- Gilani Syed Amir
- Ginindza Themba G
- Gizaw Abraham Tamirat
- Glasbey James C
- Goel Amit
- Golechha Mahaveer
- Goleij Pouya
- Golinelli Davide
- Gopalani Sameer Vali
- Gorini Giuseppe
- Goudarzi Houman
- Goulart Bárbara Niegia Garcia
- Grada Ayman
- Gubari Mohammed Ibrahim Mohialdeen
- Guerra Maximiliano Ribeiro
- Guha Avirup
- Gunasekera D Sanjeeva
- Gupta Bhawna
- Gupta Sapna
- Gupta Veer Bala
- Gupta Vivek Kumar
- Haddadi Rasool
- Hafezi-Nejad Nima
- Hailu Alemayehu
- Haj-Mirzaian Arvin
- Halwani Rabih
- Hamadeh Randah R
- Hambisa Mitiku Teshome
- Hameed Sajid
- Hamidi Samer
- Haque Shafiul
- Hariri Sanam
- Haro Josep Maria
- Harvey James D
- Hasaballah Ahmed I
- Hasan S M Mahmudul
- Hashemi Seyedeh Melika
- Hassan Treska S
- Hassanipour Soheil
- Hay Simon I
- Hayat Khezar
- Hebo Sultan H
- Heidari Golnaz
- Heidari Mohammad
- Henrikson Hannah Jacqueline
- Herrera-Serna Brenda Yuliana
- Herteliu Claudiu
- Heyi Demisu Zenbaba
- Hezam Kamal
- Hole Michael K
- Holla Ramesh
- Horita Nobuyuki
- Hossain Md Mahbub
- Hossain Mohammad Bellal
- Hosseini Mohammad-Salar
- Hosseini Mostafa
- Hosseinzadeh Ali
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Househ Mowafa
- Hsairi Mohamed
- Huang Junjie
- Hussein Nawfal R
- Hwang Bing-Fang
- Ibitoye Segun Emmanuel
- Ilesanmi Olayinka Stephen
- Ilic Irena M
- Ilic Milena D
- Innos Kaire
- Irham Lalu Muhammad
- Islam Rakibul M
- Islam Sheikh Mohammed Shariful
- Ismail Nahlah Elkudssiah
- Isola Gaetano
- Iwagami Masao
- Jacob Louis
- Jadidi-Niaragh Farhad
- Jain Vardhmaan
- Jakovljevic Mihajlo
- Janghorban Roksana
- Javadi Mamaghani Amirreza
- Jayaram Shubha
- Jayawardena Ranil
- Jazayeri Seyed Behzad
- Jebai Rime
- Jha Ravi Prakash
- John-Akinola Yetunde O
- Joo Tamas
- Joseph Nitin
- Joukar Farahnaz
- Jürisson Mikk
- Kaambwa Billingsley
- Kabir Ali
- Kalankesh Leila R
- Kaliyadan Feroze
- Kamal Zul
- Kamath Ashwin
- Kandel Himal
- Kar Sitanshu Sekhar
- Karaye Ibraheem M
- Karimi Amirali
- Kassa Bekalu Getnet
- Kauppila Joonas H
- Keegan Theresa H M
- Kemp Bohan Phillip M
- Kengne Andre Pascal
- Kerbo Amene Abebe
- Ketterl Tyler G
- Keykhaei Mohammad
- Khader Yousef Saleh
- Khajuria Himanshu
- Khalili Nastaran
- Khalili Neda
- Khan Ejaz Ahmad
- Khan Gulfaraz
- Khan Maseer
- Khan Md Nuruzzaman
- Khan Moien AB
- Khanali Javad
- Khayamzadeh Maryam
- Khosravizadeh Omid
- Khubchandani Jagdish
- Khundkar Roba
- Kim Min Seo
- Kim Yun Jin
- Kisa Adnan
- Kisa Sezer
- Kissimova-Skarbek Katarzyna
- Kocarnik Jonathan M
- Kolahi Ali-Asghar
- Kopec Jacek A
- Koteeswaran Rajasekaran
- Koulmane Laxminarayana Sindhura Lakshmi
- Koyanagi Ai
- Kugbey Nuworza
- Kumar G Anil
- Kumar Nithin
- Kutluk Tezer
- Kwarteng Alexander
- Lan Qing
- Landires Iván
- Lasrado Savita
- Lauriola Paolo
- Ledda Caterina
- Lee Sang-woong
- Lee Wei-Chen
- Lee Yeong Yeh
- Lee Yo Han
- Leigh James
- Leong Elvynna
- Li Bingyu
- Li Jiarui
- Li Ming-Chieh
- Lim Stephen S
- Liu Xuefeng
- Lobo Stany W
- Loureiro Joana A
- Lu Dan
- Lugo Alessandra
- Lunevicius Raimundas
- Magdy Abd El Razek Hassan
- Magdy Abd El Razek Muhammed
- Mahmoudi Morteza
- Majeed Azeem
- Makki Alaa
- Male Shilpa
- Malekpour Mohammad-Reza
- Malekzadeh Reza
- Malik Ahmad Azam
- Malogolowkin Marcio Henrique
- Mamun Mohammed A
- Manafi Navid
- Mansour-Ghanaei Fariborz
- Mansouri Borhan
- Mansournia Mohammad Ali
- Martini Santi
- Masoumi Seyedeh Zahra
- Matei Clara N
- Mathur Manu Raj
- Mathur Prashant
- McAlinden Colm
- Mehrotra Ravi
- Mendoza Walter
- Menezes Ritesh G
- Mentis Alexios-Fotios A
- Meretoja Tuomo J
- Mersha Amanual Getnet
- Mesregah Mohamed Kamal
- Mestrovic Tomislav
- Miao Jonasson Junmei
- Miazgowski Bartosz
- Michalek Irmina Maria
- Miller Ted R
- Mingude Alemu Basazin
- Mirmoeeni Seyyedmohammadsadeq
- Mirzaei Hamed
- Misra Sanjeev
- Mithra Prasanna
- Mohammad Karzan Abdulmuhsin
- Mohammadi Mokhtar
- Mohammadi Seyyede Momeneh
- Mohammadian-Hafshejani Abdollah
- Mohammadpourhodki Reza
- Mohammed Arif
- Mohammed Shafiu
- Mohammed Teroj Abdulrahman
- Moka Nagabhishek
- Mokdad Ali H
- Molokhia Mariam
- Momtazmanesh Sara
- Monasta Lorenzo
- Moni Mohammad Ali
- Moradi Ghobad
- Moradi Yousef
- Moradzadeh Maliheh
- Moradzadeh Rahmatollah
- Moraga Paula
- Morrison Shane Douglas
- Mostafavi Ebrahim
- Mousavi Khaneghah Amin
- Mpundu-Kaambwa Christine
- Mubarik Sumaira
- Murray Christopher J L
- Mwanri Lillian
- Nabhan Ashraf F
- Nagaraju Shankar Prasad
- Nagata Chie
- Naghavi Mohsen
- Naimzada Mukhammad David
- Naldi Luigi
- Nangia Vinay
- Naqvi Atta Abbas
- Narasimha Swamy Sreenivas
- Narayana Aparna Ichalangod
- Nayak Biswa Prakash
- Nayak Vinod C
- Nazari Javad
- Nduaguba Sabina Onyinye
- Negoi Ionut
- Negru Serban Mircea
- Nejadghaderi Seyed Aria
- Nepal Samata
- Neupane Kandel Sandhya
- Nggada Haruna Asura
- Nguyen Cuong Tat
- Nnaji Chukwudi A
- Nosrati Hamed
- Nouraei Hasti
- Nowroozi Ali
- Nuñez-Samudio Virginia
- Nwatah Vincent Ebuka
- Nzoputam Chimezie Igwegbe
- Oancea Bogdan
- Odukoya Oluwakemi Ololade
- Oguntade Ayodipupo Sikiru
- Oh In-Hwan
- Olagunju Andrew T
- Olagunju Tinuke O
- Olakunde Babayemi Oluwaseun
- Oluwasanu Mojisola Morenike
- Omar Bali Ahmed
- Omar Emad
- Ong Sokking
- Onwujekwe Obinna E
- Ortega-Altamirano Doris V
- Otstavnov Nikita
- Otstavnov Stanislav S
- Oumer Bilcha
- Owolabi Mayowa O
- P A Mahesh
- Padron-Monedero Alicia
- Padubidri Jagadish Rao
- Pakshir Keyvan
- Pana Adrian
- Pandey Anamika
- Pardhan Shahina
- Pashazadeh Kan Fatemeh
- Pasovic Maja
- Patel Jenil R
- Pati Siddhartha
- Pattanshetty Sanjay M
- Paudel Uttam
- Pennini Alyssa
- Pereira Renato B
- Peres Mario F P
- Perianayagam Arokiasamy
- Postma Maarten J
- Pourjafar Hadi
- Pourshams Akram
- Prashant Akila
- Pulakunta Thejodhar
- Qadir Mirza Muhammad Fahd Fahd
- Rabiee Mohammad
- Rabiee Navid
- Radfar Amir
- Radhakrishnan Raghu Anekal
- Radhakrishnan Venkatraman
- Rafiee Ata
- Rafiei Alireza
- Rafiei Sima
- Rahim Fakher
- Rahimzadeh Shadi
- Rahman Mosiur
- Rahman Muhammad Aziz
- Rahmani Amir Masoud
- Rajesh Aashish
- Ramezani-Doroh Vajiheh
- Ranabhat Kamal
- Ranasinghe Priyanga
- Rao Chythra R
- Rao Sowmya J
- Rashedi Sina
- Rashidi Mahsa
- Rashidi Mohammad-Mahdi
- Rath Goura Kishor
- Rawaf David Laith
- Rawaf Salman
- Rawal Lal
- Rawassizadeh Reza
- Razeghinia Mohammad Sadegh
- Regasa Misganu Teshoma
- Renzaho Andre M N
- Rezaei Maryam
- Rezaei Negar
- Rezaei Nima
- Rezaeian Mohsen
- Rezapour Aziz
- Rezazadeh-Khadem Sahba
- Riad Abanoub
- Ries Lynn Ann Gloeckler
- Rios Lopez Ligia Estefania
- Rodriguez Jefferson Antonio Buendia
- Rodriguez-Galindo Carlos
- Ronfani Luca
- Roshandel Gholamreza
- Rwegerera Godfrey M
- Saber-Ayad Maha Mohamed
- Sabour Siamak
- Saddik Basema
- Sadeghi Erfan
- Sadeghian Saeid
- Saeed Umar
- Sagoyan Garik Barisovich
- Sahebkar Amirhossein
- Saif-Ur-Rahman KM
- Sajadi S Mohammad
- Salahi Sarvenaz
- Salehi Sana
- Salem Marwa Rashad
- Salimzadeh Hamideh
- Samy Abdallah M
- Sanabria Juan
- Sanmarchi Francesco
- Sarveazad Arash
- Sathian Brijesh
- Sawhney Monika
- Sawyer Susan M
- Saylan Mete
- Schneider Ione Jayce Ceola
- Seidu Abdul-Aziz
- Sendo Endalew Gemechu
- Sepanlou Sadaf G
- Seylani Allen
- Seyoum Kenbon
- Sha Feng
- Shafaat Omid
- Shaikh Masood Ali
- Shamsoddin Erfan
- Shannawaz Mohammed
- Sharma Rajesh
- Sheikhbahaei Sara
- Shetty Adithi
- Shetty B Suresh Kumar
- Shetty Pavanchand H
- Shin Jae Il
- Shirkoohi Reza
- Shivakumar K M
- Shobeiri Parnian
- Siabani Soraya
- Sibhat Migbar Mekonnen
- Siddappa Malleshappa Sudeep K
- Sidemo Negussie Boti
- Silva Julian Guilherme
- Silva Diego Augusto Santos
- Singh Achintya Dinesh
- Singh Jasvinder A
- Singh Jitendra Kumar
- Singh Surjit
- Sinke Abiy H
- Sintayehu Yitagesu
- Skryabin Valentin Yurievich
- Skryabina Anna Aleksandrovna
- Smith Lee
- Sofi-Mahmudi Ahmad
- Soltani-Zangbar Mohammad Sadegh
- Song Suhang
- Spurlock Emma Elizabeth
- Steiropoulos Paschalis
- Straif Kurt
- Subedi Ranjeeta
- Sufiyan Mu'awiyyah Babale
- Suliankatchi Abdulkader Rizwan
- Sultan Iyad
- Sultana Saima
- Szerencsés Viktória
- Szócska Miklós
- Tabaeian Seidamir Pasha
- Tabary Mohammadreza
- Tabarés-Seisdedos Rafael
- Tabuchi Takahiro
- Tadbiri Hooman
- Taheri Majid
- Taherkhani Amir
- Takahashi Ken
- Tampa Mircea
- Tan Ker-Kan
- Tat Vivian Y
- Tavakoli Ahmad
- Tbakhi Abdelghani
- Tehrani-Banihashemi Arash
- Temsah Mohamad-Hani
- Tesfay Fisaha Haile
- Tesfaye Bekele
- Thakur Jarnail Singh
- Thapar Rekha
- Thavamani Aravind
- Thiyagarajan Arulmani
- Thomas Nihal
- Tobe-Gai Ruoyan
- Togtmol Munkhsaikhan
- Tohidast Seyed Abolfazl
- Tohidinik Hamid Reza
- Tolani Musliu Adetola
- Tollosa Daniel Nigusse
- Touvier Mathilde
- Tovani-Palone Marcos Roberto
- Traini Eugenio
- Tran Bach Xuan
- Tran Mai Thi Ngoc
- Tripathy Jaya Prasad
- Tusa Biruk Shalmeno
- Ukke Gebresilasea Gendisha
- Ullah Irfan
- Ullah Saif
- Umapathi Krishna Kishore
- Unnikrishnan Bhaskaran
- Upadhyay Era
- Ushula Tolassa Wakayo
- Vacante Marco
- Valadan Tahbaz Sahel
- Vargas Martina T
- Varthya Shoban Babu
- Veroux Massimiliano
- Villeneuve Paul J
- Violante Francesco S
- Vlassov Vasily
- Vu Giang Thu
- Waheed Yasir
- Wang Ning
- Ward Paul
- Weldesenbet Adisu Birhanu
- Wen Yi Feng
- Westerman Ronny
- Winkler Andrea Sylvia
- Wubishet Befikadu Legesse
- Xu Rixing
- Xu Suowen
- Yahyazadeh Jabbari Seyed Hossein
- Yang Lin
- Yaya Sanni
- Yazdi-Feyzabadi Vahid
- Yazie Taklo Simeneh
- Yehualashet Sisay Shewasinad
- Yeshaneh Alex
- Yeshaw Yigizie
- Yirdaw Birhanu Wubale
- Yonemoto Naohiro
- Younis Mustafa Z
- Yousefi Zabihollah
- Yu Chuanhua
- Yunusa Ismaeel
- Zadnik Vesna
- Zahir Mazyar
- Zahirian Moghadam Telma
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zare Fariba
- Zastrozhin Mikhail Sergeevich
- Zastrozhina Anasthasia
- Zhang Jianrong
- Zhang Zhi-Jiang
- Ziapour Arash
- Zoladl Mohammad
- Šekerija Mario
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe
Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015
- Author
- Abajobir Amanuel Alemu
- Abate Kalkidan Hassen
- Abbas Kaja M
- Abd-Allah Foad
- Abdulle Abdishakur M
- Abera Semaw Ferede
- Abu-Raddad Laith J
- Abu-Rmeileh Niveen M E
- Abubakar Ibrahim
- Abyu Gebre Yitayih
- Adebiyi Akindele Olupelumi
- Adedeji Isaac Akinkunmi
- Adelekan Ademola Lukman
- Adofo Koranteng
- Adou Arsène Kouablan
- Ajala Oluremi N
- Akinyemiju Tomi F
- Akseer Nadia
- Al-Aly Ziyad
- Al-Raddadi Salem
- Alam Khurshid
- Alam Noore K M
- Alasfoor Deena
- Aldhahri Saleh Fahed S
- Aldridge Robert William
- Alegretti Miguel Angel
- Aleman Alicia V
- Alemu Zewdie Aderaw
- Alfonso-Cristancho Rafael
- Ali Raghib
- Alkerwi Ala'a
- Alla François
- Alsharif Ubai
- Alvarez Elena
- Alvis-Guzman Nelson
- Amare Azmeraw T
- Amberbir Alemayehu
- Amegah Adeladza Kofi
- Ammar Walid
- Amrock Stephen Marc
- Antonio Carl Abelardo T
- Anwari Palwasha
- Artaman Al
- Asayesh Hamid
- Asghar Rana Jawad
- Assadi Reza
- Atique Suleman
- Atkins Lydia S
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- Awasthi Ashish
- Bacha Umar
- Badawi Alaa
- Barac Aleksandra
- Basu Arindam
- Bayou Tigist Assefa
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- Bazargan-Hejazi Shahrzad
- Beardsley Justin
- Bedi Neeraj
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- Beyene Addisu Shunu
- Bhatia Eesh
- Bhutta Zulfiqar A
- Biadgilign Sibhatu
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- Chang Hsing-Yi
- Chang Jung-chen
- Chavan Laxmikant
- Chen Wanqing
- Chiang Peggy Pei-Chia
- Chibalabala Mirriam
- Chisumpa Vesper Hichilombwe
- Choi Jee-Young Jasmine
- Christopher Devasahayam Jesudas
- Ciobanu Liliana G
- Coates Matthew M
- Cooper Cyrus
- Cárdenas Rosario
- Dahiru Tukur
- Damtew Solomon Abrha
- Dandona Lalit
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- Ronfani Luca
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- Yu Shicheng
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
A first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdollahi Hamed
- Abdullah Tala
- Abecasis Goncalo R.
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- Abul-Husn Noura S.
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- Adra Darin
- Afilalo Jonathan
- Afilalo Marc
- Afrasiabi Zaman
- Agüero Daiana
- Ahmadi Saeideh
- Akhtar Shaheen
- Aksentijevich Alexandra
- Al-Afghani Hani
- Al-Awdah Laila
- Alaamery Manal
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- Alaverdian Diana
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- Alghamdi Bader
- Alghamdi Jahad
- Ali Altaf
- Aliannejad Rasoul
- Aljawini Nora
- AlJohani Sameera
- Alkwai Sarah
- Allos Raili
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- Hirankarn Nattiya
- Ho Yuk-Lam
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- Ikram M. Arfan
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- Kallaste Anne
- Kamdar Dhryata
- Kamdar Dhryata
- Kampouri E. E.
- Kanai Masahiro
- Kanai Masahiro
- Karczewski Konrad J.
- Karjalainen Juha
- Karlson Elizabeth W.
- Karp Avromie
- Kaufmann Daniel E.
- Kaunisto Mari
- Keller Katherine
- Kenny Eimear E.
- Kerchberger V. Eric
- Kerr Shona M.
- Khafaga Walid T.
- Khan Ahsan
- Khan Amara
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- Kimchi Nofar
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- Kivinen Katja
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- Knapp C.
- Knight Spencer
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- Kogevinas Manolis
- Koskelainen Sami
- Kosmicki Jack A.
- Kousathanas Athanasios
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- Labkowsky Alexander
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- Laurent Laetitia
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- Mercader Josep Maria
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- Mirshahi Tooraj
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- Moahmed Hanteera S.
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- Suchartlikitwong Pintip
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- Publication date
- 01/01/2022
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