Effects of substrate material on marine fouling community composition and ascidian larval settlement

Driven by the rising global population and shoreline development, man-made marine structures are becoming ubiquitous in coastal areas. These alterations may have enormous ecological consequences, as anthropogenic structures provide novel habitat for marine organisms and often host communities that differ from those on natural substrates. These community differences are frequently driven by non-native species, which can be more prevalent on man-made marine structures than on adjacent natural surfaces. Although multiple factors, including light intensity, surface orientation, predation exposure, and habitat type, are known to contribute to these patterns, relatively few studies have directly examined the influence of substrate material on fouling community development and non-native species abundance. I conducted laboratory and field studies examining larval settlement preferences and fouling community composition on commonly occurring natural (granite) and man-made (concrete, high-density polyethylene, and PVC) marine materials. During laboratory trials, I quantified larval substrate preferences of two introduced species of ascidian, Botrylloides violaceus and Ciona intestinalis. In the field, I sought to determine if observed differences in community composition on man-made and natural substrates resulted from differential organism settlement, or variation in post-settlement survival and growth, on different substrate materials. Results indicate that the effects of substrate on fouling community composition are material-specific; assemblages on concrete differed significantly from those on all other surfaces. These differences appear to result from variation in both organism recruitment and survival on different materials. Notably, I found that material classification, as “man-made” or “natural,” was not a reliable predictor of either species composition or non-native species abundance. Larval substrate preferences were also observed in B. violaceus and C. intestinalis during lab trials. However, these laboratory settlement patterns did not match those observed in the field, indicating the importance of real-world studies when seeking to answer more applied ecological questions. The effects of material on both settlement and community development most likely resulted from variation in chemical leaching or surface pH, as roughness did not seem to explain the observed differences among plate types. Information gained through these studies may help us to understand how substrate features can contribute to differences in fouling community composition and species abundance, and may inform decisions regarding material usage in marine construction. These results also highlight the importance of settlement plate material choice in experimental marine biology research, as plate material may influence experimental conclusions

Post-Surgical Resection of T7-10 AV Malformation Mimics Brown-Sequard: A Case Report

The purpose of this case study is to describe the methods of treatment and outcomes for a patient with a thoracic AVM presenting with spinal cord symptoms mimicking Brown-Sequard syndrome, by focusing on the primary impairments and improving functional mobility.https://soar.usa.edu/flsasummer2018/1008/thumbnail.jp

Early recognition of multiple sclerosis using natural language processing of the electronic health record

Background Diagnostic accuracy might be improved by algorithms that searched patients’ clinical notes in the electronic health record (EHR) for signs and symptoms of diseases such as multiple sclerosis (MS). The focus this study was to determine if patients with MS could be identified from their clinical notes prior to the initial recognition by their healthcare providers. Methods An MS-enriched cohort of patients with well-established MS (n = 165) and controls (n = 545), was generated from the adult outpatient clinic. A random sample cohort was generated from randomly selected patients (n = 2289) from the same adult outpatient clinic, some of whom had MS (n = 16). Patients’ notes were extracted from the data warehouse and signs and symptoms mapped to UMLS terms using MedLEE. Approximately 1000 MS-related terms occurred significantly more frequently in MS patients’ notes than controls’. Synonymous terms were manually clustered into 50 buckets and used as classification features. Patients were classified as MS or not using Naïve Bayes classification. Results Classification of patients known to have MS using notes of the MS-enriched cohort entered after the initial ICD9[MS] code yielded an ROC AUC, sensitivity, and specificity of 0.90 [0.87-0.93], 0.75[0.66-0.82], and 0.91 [0.87-0.93], respectively. Similar classification accuracy was achieved using the notes from the random sample cohort. Classification of patients not yet known to have MS using notes of the MS-enriched cohort entered before the initial ICD9[MS] documentation identified 40% [23–59%] as having MS. Manual review of the EHR of 45 patients of the random sample cohort classified as having MS but lacking an ICD9[MS] code identified four who might have unrecognized MS. Conclusions Diagnostic accuracy might be improved by mining patients’ clinical notes for signs and symptoms of specific diseases using NLP. Using this approach, we identified patients with MS early in the course of their disease which could potentially shorten the time to diagnosis. This approach could also be applied to other diseases often missed by primary care providers such as cancer. Whether implementing computerized diagnostic support ultimately shortens the time from earliest symptoms to formal recognition of the disease remains to be seen

Portable Sensory Room for the West Orange County Consortium for Special Education

This report discusses the development of a Portable Sensory Room to be used at Newland Elementary School in Huntington Beach. Newland Elementary has an exceptional Special Needs program that teaches the children with the most severe cases of autism in its school district. People with autism typically also have sensory processing disorders, which can be extremely disruptive for a child’s development and can make it difficult for a child to be able to concentrate long enough to gain necessary life skills. The idea behind a Sensory Rooms is to create a place to calm the students and to expose them to new stimuli to explore and learn in a calm and non-threatening environment. There are three different Special Needs classrooms that the Portable Sensory Room will be moved between in a single day. The teachers at Newland Elementary also desired a swing element and a pressure applying device. Both of these components are used regularly in Occupational Therapy with children with autism and have been proven to help children develop necessary skills in life. The design of the Portable Sensory Room, which was composed of several brainstorming sessions and decision matrices, lasted several months from Fall 2015 to midway through the Winter 2016 quarter. The final design consists of seven different components - five of the components act as the structure of the room and can easily connect to one another to achieve a uniform enclosure and two are separate from the room structure. All of these components have interactions on their faces that either comfort or challenge the children and all contribute to a calming sea theme throughout. The components are all on locking casters which makes transportation of the assembly easy. The five components of the room structure are: the tactile wall, the bookshelf, the tactile station, the fabric panels, and the LED panels. The tactile wall focuses on helping the children gain fine motor skills by use of tracks that the children can move fish along, a moveable gear set, and a whiteboard. The bookshelf is filled with activities for fine motor skills as well, and provides extra storage for the teachers to arrange according to their desires. The tactile station is a dresser with calming light effects at the top. The drawers can be completely removed and put on the floor, where the children can play with tactile interactions in an enclosed space to avoid a mess. The fabric panels provide tactile sensations using several swatches of fabric that range from calming to challenging. The LED panels have a calming ocean mural and also allow children to observe the notion of cause-and-effect via a control box that changes the light display. The other two components are the swing structure and the pressure applicator, which can either be used in the room or separately from the room depending on the teachers’ preferences. The swing structure was purchased from Amazon and allows for a 360 degree rotation. The pressure applicator was built by the team and is comprised of two horizontal rollers that the child can slide in between. The addition of rubber bands allows the child/teacher to choose how much pressure will be exerted on the child. The build phase of the project lasted from the end of Winter 2016 quarter to the end of Spring 2016 quarter. All of the components were made from lumber and sanded down in order to avoid any sharp edges. Testing was performed to verify that the teachers would not have to exert an enormous effort to move all of the components, as well as to determine the tipping loads for each of the components. The tipping loads were below the desired specification; in order to mitigate this, two adults will be required to move each component. When the room is assembled together, the entire structure is quite stable and does not pose a tipping hazard. The final product will be delivered to Newland Elementary School on June 17th, 2016

Erythristic leopards Panthera pardus in South Africa

Background. Leopards Panthera pardus show genetically determined colour variation. Erythristic (strawberry) morphs, where individuals are paler and black pigment in the coat is replaced by a red-brown colour, are exceptionally rare in the wild. Historically, few records exist, with only five putative records from India known. Objectives. To record the presence of erythristic leopards in our study site (Thabo Thalo Wilderness Reserve, Mpumalanga), and to collate records from across South Africa. Method. A network of camera traps was used to record individual leopards at Thabo Thalo. We also surveyed local experts, searched the popular South African press and used social media to request observations. Results. Two out of 27 individual leopards (7.1%) recorded in our study site over three years were of this colour morph. We obtained records of five other erythristic leopards in the Waterberg and Mpumalanga region, with no reports outside of this population. Conclusions. Erythristic leopards are widely dispersed across north-west South Africa, predominantly in the Lydenburg region. The presence of this rare colour morph may reflect the consequences of population fragmentation

Hereditary predisposition to ovarian cancer, looking beyond BRCA1/BRCA2

AbstractObjectiveGenetic predisposition to ovarian cancer is well documented. With the advent of next generation sequencing, hereditary panel testing provides an efficient method for evaluating multiple genes simultaneously. Therefore, we sought to investigate the contribution of 19 genes identified in the literature as increasing the risk of hereditary breast and ovarian cancer (HBOC) in a BRCA1 and BRCA2 negative population of patients with a personal history of breast and/or ovarian cancer by means of a hereditary cancer panel.MethodsSubjects were referred for multi-gene panel testing between February 2012 and March 2014. Clinical data was ascertained from requisition forms. The incidence of pathogenic mutations (including likely pathogenic), and variant of unknown significance were then calculated for each gene and/or patient cohort.ResultsIn this cohort of 911 subjects, panel testing identified 67 mutations. With 7.4% of subjects harboring a mutation on this multi-gene panel, the diagnostic yield was increased, compared to testing for BRCA1 and BRCA2 mutations alone. In the ovarian cancer probands, the most frequently mutated genes were BRIP1 (n=8; 1.72%) and MSH6 (n=6; 1.29%). In the breast cancer probands, mutations were most commonly observed in CHEK2 (n=9; 2.54%), ATM (n=3; 0.85%), and TP53 (n=3; 0.85%).ConclusionsAlthough further studies are needed to clarify the exact management of patients with a mutation in each gene, this study highlights information that can be captured with panel testing and provides support for incorporation of panel testing into clinical practice

NASA SpaceCube Next-Generation Artificial-Intelligence Computing for STP-H9-SCENIC on ISS

Recently, Artificial Intelligence (AI) and Machine Learning (ML) capabilities have seen an exponential increase in interest from academia and industry that can be a disruptive, transformative development for future missions. Specifically, AI/ML concepts for edge computing can be integrated into future missions for autonomous operation, constellation missions, and onboard data analysis. However, using commercial AI software frameworks onboard spacecraft is challenging because traditional radiation-hardened processors and common spacecraft processors cannot provide the necessary onboard processing capability to effectively deploy complex AI models. Advantageously, embedded AI microchips being developed for the mobile market demonstrate remarkable capability and follow similar size, weight, and power constraints that could be imposed on a space-based system. Unfortunately, many of these devices have not been qualified for use in space. Therefore, Space Test Program - Houston 9 - SpaceCube Edge-Node Intelligent Collaboration (STP-H9-SCENIC) will demonstrate inflight, cutting-edge AI applications on multiple space-based devices for next-generation onboard intelligence. SCENIC will characterize several embedded AI devices in a relevant space environment and will provide NASA and DoD with flight heritage data and lessons learned for developers seeking to enable AI/ML on future missions. Finally, SCENIC also includes new CubeSat form-factor GPS and SDR cards for guidance and navigation