279 research outputs found
Some Like It Hot, Some Like It Warm: Phenotyping To Explore Thermotolerance Diversity
Plants have evolved overlapping but distinct cellular responses to different aspects of high temperature stress. These responses include basal thermotolerance, short- and long-term acquired thermotolerance, and thermotolerance to moderately high temperatures. This ‘thermotolerance diversity’ means that multiple phenotypic assays are essential for fully describing the functions of genes involved in heat stress responses. A large number of genes with potential roles in heat stress responses have been identified using genetic screens and genome wide expression studies. We examine the range of phenotypic assays that have been used to characterize thermotolerance phenotypes in both Arabidopsis and crop plants. Three major variables differentiate thermotolerance assays: (1) the heat stress regime used, (2) the developmental stage of the plants being studied, and (3) the actual phenotype which is scored. Consideration of these variables will be essential for deepening our understanding of the molecular genetics of plant thermotolerance
Correcting magnification error in foveal avascular zone area measurements of optical coherence tomography angiography images with estimated axial length
Background
To generate and validate a method to estimate axial length estimated (ALest) from spherical equivalent (SE) and corneal curvature [keratometry (K)], and to determine if this ALest can replace actual axial length (ALact) for correcting transverse magnification error in optical coherence tomography angiography (OCTA) images using the Littmann-Bennett formula.
Methods
Data from 1301 participants of the Raine Study Gen2-20 year follow-up were divided into two datasets to generate (n = 650) and validate (n = 651) a relationship between AL, SE, and K. The developed formula was then applied to a separate dataset of 46 participants with AL, SE, and K measurements and OCTA images to estimate and compare the performance of ALest against ALact in correcting transverse magnification error in OCTA images when measuring the foveal avascular zone area (FAZA).
Results
The formula for ALest yielded the equation: ALest = 2.102K − 0.4125SE + 7.268, R2 = 0.794. There was good agreement between ALest and ALact for both study cohorts. The mean difference [standard deviation (SD)] between FAZA corrected with ALest and ALact was 0.002 (0.015) mm2 with the 95% limits of agreement (LoA) of − 0.027 to 0.031 mm2. In comparison, mean difference (SD) between FAZA uncorrected and corrected with ALact was − 0.005 (0.030) mm2, with 95% LoA of − 0.064 to 0.054 mm2.
Conclusions
ALact is more accurate than ALest and hence should be used preferentially in magnification error correction in the clinical setting. FAZA corrected with ALest is comparable to FAZA corrected with ALact, while FAZA measurements using images corrected with ALest have a greater accuracy than measurements on uncorrected images. Hence, in the absence of ALact, clinicians should use ALest to correct for magnification error as this provides for more accurate measurements of fundus parameters than uncorrected images
Evaluating distribution of foveal avascular zone parameters corrected by lateral magnification and their associations with retinal thickness
Purpose
To examine the distribution of foveal avascular zone (FAZ) parameters, with and without correction for lateral magnification, in a large cohort of healthy young adults.
Design
Cross-sectional, observational cohort study.
Participants
A total of 504 healthy adults, 27 to 30 years of age.
Methods
Participants underwent a comprehensive ophthalmic examination including axial length measurement and OCT angiography (OCTA) imaging of the macula. OCT angiography images of combined superficial and deep retinal vessel plexuses were processed via a custom software to extract foveal avascular zone area (FAZA) and foveal density-300 (FD-300), the vessel density in a 300-μm wide annulus surrounding the FAZ, with and without correction for lateral magnification. Bland–Altman analyses were performed to examine the effect of lateral magnification on FAZA and FD-300, as well as to evaluate the interocular agreement in both parameters. Linear mixed-effects models were used to examine the relationship between retinal thicknesses and OCTA parameters.
Main Outcome Measures
The FAZA and FD-300, corrected for lateral magnification.
Results
The mean (standard deviation [SD]) of laterally corrected FAZA and FD-300 was 0.22 mm2 (0.10 mm2) and 51.9% (3.2%), respectively. Relative to uncorrected data, 55.6% of corrected FAZA showed a relative change > 5%, whereas all FD-300 changes were within 5%. There was good interocular symmetry (mean right eye–left eye difference, 95% limits of agreement [LoA]) in both FAZA (0.006 mm2, -0.05 mm2, to 0.07 mm2) and FD-300 (-0.05%, -5.39%, to 5.30%). There were significant negative associations between central retinal thickness and FAZA (β = -0.0029), as well as between central retinal thickness and FD-300 (β = -0.044), with the relationships driven by inner, not outer, retina.
Conclusions
We reported lateral magnification adjusted normative values for FAZA and FD-300 in a large cohort of young, healthy eyes. Clinicians should strongly consider accounting for lateral magnification when evaluating FAZA. Good interocular agreement in FAZA and FD-300 suggests the contralateral eye can be used as control data
Puzzles in physics
I discuss some puzzles observed in exclusive meson decays, concentrating
on the large difference between the direct CP asymmetries in the and modes, the large
branching ratio, and the large deviation of the mixing-induced CP asymmetries
in the penguins from those in the trees.Comment: 6 pages, 1 figure, talk presented at the 9th Workshop on High Energy
Physics Phenomenology, Bhubaneswar, Orissa, India, Jan. 3-14, 2006; reference
adde
Inflation and nonequilibrium renormalization group
We study de spectrum of primordial fluctuations and the scale dependence of
the inflaton spectral index due to self-interactions of the field. We compute
the spectrum of fluctuations by applying nonequilibrium renormalization group
techniques.Comment: 6 pages, 1 figure, submitted to J. Phys.
Nonperturbative bound on high multiplicity cross sections in phi^4_3 from lattice simulation
We have looked for evidence of large cross sections at large multiplicities
in weakly coupled scalar field theory in three dimensions. We use spectral
function sum rules to derive bounds on total cross sections where the sum can
be expresed in terms of a quantity which can be measured by Monte Carlo
simulation in Euclidean space. We find that high multiplicity cross sections
remain small for energies and multiplicities for which large effects had been
suggested.Comment: 23 pages, revtex, seven eps figures revised version: typos corrected,
some rewriting of discusion, same resul
Characterization of the Kinetic, Regulatory, and Structural Properties of ADP-Glucose Pyrophosphorylase from Chlamydomonas reinhardtii
Soft end-point and mass corrections to the eta' g*g* vertex function
Power-suppressed corrections arising from end-point integration regions to
the space-like vertex function of the massive eta'-meson virtual gluon
transition eta' - g*g* are computed. Calculations are performed within the
standard hard-scattering approach (HSA) and the running coupling method
supplemented by the infrared renormalon calculus. Contributions to the vertex
function from the quark and gluon contents of the eta' -meson are taken into
account and the Borel resummed expressions for F_{eta' g*g*}(Q2,\omega ,\eta),
as well as for F_{eta' g g*}}(Q^{2},\omega =\pm 1,\eta) and F_{eta'
g*g*}(Q^{2},\omega =0,\eta) are obtained. It is demonstrated that the
power-suppressed corrections \sim (\Lambda ^{2}/Q^{2})^{n}, in the explored
range of the total gluon virtuality 1 <Q2 < 25 GeV2, considerably enhance the
vertex function relative to the results found in the framework of the standard
HSA with a fixed coupling. Modifications generated by the eta ' -meson mass
effects are discussed
Performance metrics and auditing framework using application kernels for high‐performance computer systems
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97468/1/cpe2871.pd
Okubo-Zweig-Iizuka-rule violation and B\to \eta^{(\prime)}K branching ratios
We show that few-percent Okubo-Zweig-Iizuka-rule violating effects in the
quark-flavor basis for the - mixing can enhance the chiral scale
associated with the meson few times. This enhancement is sufficient
for accommodating the dramatically different data of the
and branching ratios. We comment on other proposals for resolving
this problem, including flavor-singlet contributions, axial U(1) anomaly, and
nonperturbative charming penguins. Discrimination of the above proposals by
means of the and
data is suggested.Comment: 7 pages, 2 figures, discussion on B\to\eta^{(\prime)}K* added, more
references adde
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