Happy faces and other rewards:Different perspectives on a bias away from positive and toward negative information as an underlying mechanism of depression

People generally show strong responses to positive or rewarding experiences, for example, winning a prize or seeing someone smile. However, not all people respond the same to positive information; some people show weaker responses to positive information and stronger responses to negative information. These people show a so-called low positive bias. In 7 different studies, I investigated low positive bias in adolescence as an underlying mechanism of depression with different instruments and from different perspectives, combining longitudinal data collected every 2-3 years with more fine-grained momentary assessments collected three times per day, data from laboratory tasks and salivary biomarkers. I studied whether a low bias toward positive information in adolescence predicted later onset of depression and also investigated the daily life implications of a low positive bias. From a treatment perspective, I studied whether tailored lifestyle advice and an extreme free-fall experience (tandem skydive) could be effective in increasing pleasure and implicit positive bias in young adults suffering from loss of pleasure. One of the main findings reported in my dissertation is that low positive bias during early and mid-adolescence predicted onset of depression later in life and may mark vulnerability for depression. In daily life, young adults with a high positive bias sustained their positive emotions and experiences more strongly over time than those with a low happy bias. I further found evidence that tailored lifestyle advice increased self-reported daily pleasure, but no evidence that this intervention also increased positive bias

Reward Responsiveness, Optimism, and Social and Mental Functioning in Children Aged 6-7:Protocol of a Cross-Sectional Pilot Study

Background: There is evidence that reward responsiveness and optimism are associated with mental and social functioning in adolescence and adulthood, but it is unknown if this is also the case for young children. Part of the reason for this gap in the literature is that the instruments that are used to assess reward responsiveness and optimism in adolescents and adults are usually not suitable for young children. Objective: Two behavioral tasks to assess reward learning, a questionnaire on reward responsiveness, and a questionnaire on optimism/pessimism will be tested on their feasibility and reliability in children aged 6-7. Depending on their feasibility and reliability, these instruments will also be used to investigate if reward responsiveness and optimism are associated with mental and social functioning in young children. Methods: For this cross-sectional pilot study, we adapted a number of tasks and questionnaires to the needs of 6-7-year-old children, by simplification of items, oral rather than written assessment, and reducing the number of conditions and items. We will approach teachers and, with their help, aim to include 70 children aged 6-7 to assess the feasibility and reliability of the tasks and questionnaires. Feasibility measures that will be reported are the proportion of children completing the task/questionnaire, the proportion of children that were able to explain the instructions in their own words to the researcher, and the proportion of children that correctly answered the control questions. The reliability of the scales will be assessed by computing Cronbach α and item-total score correlations and the reliability of the tasks by correlations between different consecutive blocks of trials. Ethics approval was obtained from the Ethics Committee of the Department of Pedagogy and Educational Sciences. Results: Data collection was originally planned in March and April 2020, but has been postponed due to Corona virus regulations. We expect to collect the data in the first half of 2021. The findings will be disseminated in preprints and peer-reviewed publications. Conclusions: The development of feasible and reliable instruments for assessing reward responsiveness and optimism in young children is expected to benefit future research on underlying mechanisms of mental and social functioning in young children. If the instruments assessed in this study are usable with young children, it would be particularly interesting to include them in cohort studies because this would enable investigating not only concurrent associations, but also prospective associations between reward responsiveness and optimism early in life and mental and social functioning later in life. If, as we hypothesize, reward responsiveness and optimism are not only associated with (prospective) mental and social functioning in adults and adolescents but also in young children, this could provide a way of identifying vulnerable children already at an early stage

Intergenerational Transmission of Peer Aggression

It is plausible that peer aggression—like general forms of aggression—is transmitted from one generation to the next. As such, parental behavior in childhood and adolescence may be associated with offspring aggressive behavior against peers. This study used 1970 British Cohort Study data to test intergenerational transmission of peer aggression. The baseline sample consisted of 13,135 participants. At the first assessment that was used in this study, participants were on average 4.95 years old (SD = 0.79; 48.20% female). At the last assessment, participants were on average 33.88 years old (SD = 0.36; 52.1% female). Models were computed for early and middle childhood, and adolescence. Significant associations between parents’ and offspring peer aggression were found in most models – especially when correlating aggression in similar developmental periods for parents and children. Other transmission mechanisms such as genetic transmission may be relevant and should be taken into account in future studies

Polygenic risk for aggressive behavior from late childhood through early adulthood

Twin studies suggest a substantial role for genes in explaining individual differences in aggressive behavior across development. It is unclear, however, how directly measured genetic risk is associated with aggressive behavior at different moments across adolescence and how genes might distinguish developmental trajectories of aggressive behavior. Here, a polygenic risk score derived from the EAGLE-Consortium genome-wide association study of aggressive behavior in children was tested as predictor of latent growth classes derived from those measures in an adolescent population (n = 2229, of which n = 1246 with genetic information) and a high-risk sample (n = 543, of which n = 335 with genetic information). In the population sample, the polygenic risk score explained variation in parent-reported aggressive behavior at all ages and distinguished between stable low aggressive behavior and moderate and high-decreasing trajectories based on parent-report. In contrast, the polygenic risk score was not associated with self- and teacher-reported aggressive behavior, and no associations were found in the high-risk sample. This pattern of results suggests that methodological choices made in genome-wide association studies impact the predictive strength of polygenic risk scores, not just with respect to power but likely also in terms of generalizability and specificity.</p

Childhood and Adolescent Bullying Perpetration and Later Substance Use:A Meta-analysis

CONTEXT: Previous meta-analyses substantially contributed to our understanding of increased drug use risk in bullies but only included research up to 2014 and did not report on other types of substances. OBJECTIVE: To review and meta-analyze existing evidence regarding the prospective association between peer bullying perpetration in childhood and adolescence and later substance use. DATA SOURCES: Electronic databases were searched on March 14, 2019. STUDY SELECTION: We selected peer-reviewed articles and dissertations in English reporting original empirical studies on associations between bullying perpetration in childhood or adolescence and later use of drugs, alcohol, or tobacco. Records were assessed for eligibility independently by 2 authors. DATA EXTRACTION: Data extraction and quality assessment was performed by one author and checked by another author. RESULTS: In total, 215 effects were included from 28 publications, reporting on 22 samples, comprising 28 477 participants. Bullying perpetration was associated positively with all types of substance use (drugs, alcohol, tobacco, and general). The results for combined bullying-victimization were more mixed, with generally weaker effects. LIMITATIONS: Effects were based on a large variability in operationalizations and measures of bullying and substance use, impeding the interpretation of the pooled effect sizes. Although bullying appears to be a risk factor for substance use, no inferences can be made about so-called causal risk factors that can provide the basis for preventive interventions. CONCLUSIONS: There is evidence that adolescents and particularly children who bully their peers have a higher risk of substance use later in life than their nonbullying peers

Alpha-amylase reactivity and recovery patterns in anhedonic young adults performing a tandem skydive

Background Anhedonia (loss of pleasure) is characterized by low responsiveness to rewards and, by virtue of being one of the two core symptoms of depression, by altered responses to stress. We investigated the effect of an acute stress experience (i.e., a tandem skydive) that was expected to elicit both intense fear and intense euphoria in a sample of anhedonic young adults. Objective (1) To examine individual differences in alpha-amylase reactivity to and recovery from a tandem skydive in anhedonic young adults; (2) to investigate whether trait depressive and anxiety problems, trait positive affect (PA), i.e., level of pleasure and reward responsiveness, and state anxiety, PA and self-esteem prior to the skydive were associated with alpha-amylase reactivity and recovery patterns; (3) to investigate whether alpha-amylase reactivity and recovery patterns were associated with pre-to post-jump changes in state anxiety, PA, and self-esteem. Method Participants were 61 individuals with persistent anhedonia (Mage = 21.38, 78.7% female), who filled out a baseline questionnaire at the start of the study, and momentary questionnaires (3 times per day) before and after the tandem skydive. Alpha-amylase was measured at four time points by means of salivettes (2 before and 2 after the skydive). Results Alpha-amylase reactivity and recovery patterns were highly similar across individuals, although mean levels varied greatly. No associations were found between any of the trait and state measures and reactivity and recovery. Only state self-esteem was affected by the reactivity and recovery patterns, in that individuals who showed high reactivity and low recovery experienced decreases in self-esteem after the skydive. Conclusions Alpha-amylase patterns following a tandem skydive in anhedonic individuals are highly similar to patterns previously found in healthy individuals. Although replication is warranted, our findings tentatively suggest that a strong stress response that cannot be downregulated well predicts a decrease in self-esteem

Blije gezichten en andere beloningen:aandacht voor positieve informatie als beschermend mechanisme tegen depressie

Dit artikel is een bewerkte versie van de Nederlandse samenvatting van het proefschrift “Happy faces and other rewards. Different perspectives on a bias away from positive and toward negative information as an underlying mechanism of depression” van Charlotte Vrijen [1]; Promotores: Albertine J. Oldehinkel, Catharina A. Hartman en Peter de Jonge. Doorgaans laten mensen sterke reacties zien op positieve informatie, maar sommige mensen reageren hier minder sterk op; zij hebben een zogenaamde lage positieve bias. In dit proefschrift werd het verband tussen lage positieve bias en depressie onderzocht. We onderzochten of een lage positieve bias tijdens de adolescentie een voorspeller was van latere depressie en wat de implicaties van een lage positieve bias waren in het dagelijks leven. Met een interventiestudie onderzochten we of op de persoon toegesneden leefstijladvies en een vrije-val-ervaring voor meer plezier en een positievere bias konden zorgen bij jongvolwassenen die last hadden van verlies van plezier. Een belangrijke uitkomst van ons onderzoek is dat een lage positieve bias gedurende de adolescentie een latere depressie voorspelde en daarmee mogelijk een indicator is van vatbaarheid voor depressie. In het dagelijks leven hielden jongeren met een hoge positieve bias het goede gevoel dat ze van positieve ervaringen kregen langer vast dan jongeren met een lage bias. Dit zou kunnen verklaren waarom jongeren met een lage positieve bias meer kans hebben om depressief te worden. In de interventiestudie werden aanwijzingen gevonden dat op de persoon toegesneden leefstijladvies resulteerde in een toename in plezier, maar niet in een positievere bias

Gene-Environment Interplay in the Development of Overweight

PURPOSE: Overweight in youth is influenced by genes and environment. Gene-environment interaction (G×E) has been demonstrated in twin studies and recent developments in genetics allow for studying G×E using individual genetic predispositions for overweight. We examine genetic influence on trajectories of overweight during adolescence and early adulthood and determine whether genetic predisposition is attenuated by higher socioeconomic status and having physically active parents.METHODS: Latent class growth models of overweight were fitted using data from the TRacking Adolescents' Individual Lives Survey (n = 2720). A polygenic score for body mass index (BMI) was derived using summary statistics from a genome-wide association study of adult BMI (N = ∼700,000) and tested as predictor of developmental pathways of overweight. Multinomial logistic regression models were used to examine effects of interactions of genetic predisposition with socioeconomic status and parental physical activity (n = 1675).RESULTS: A three-class model of developmental pathways of overweight fitted the data best ("non-overweight", "adolescent-onset overweight", and "persistent overweight"). The polygenic score for BMI and socioeconomic status distinguished the persistent overweight and adolescent-onset overweight trajectories from the non-overweight trajectory. Only genetic predisposition differentiated the adolescent-onset from the persistent overweight trajectory. There was no evidence for G×E.DISCUSSION: Higher genetic predisposition increased the risk of developing overweight during adolescence and young adulthood and was associated with an earlier age at onset. We did not find that genetic predisposition was offset by higher socioeconomic status or having physically active parents. Instead, lower socioeconomic status and higher genetic predisposition acted as additive risk factors for developing overweight.</p