The reasons causing initial medical attention.

<p>The reasons causing initial medical attention.</p

Steps in the analysis pipeline.

<p>Steps in the analysis pipeline.</p

Components of the analysis pipeline.

<p>Components of the analysis pipeline.</p

Screenshots of the P-POD web interface.

<p>(A) A portion of the results page for the <i>DPM1</i> OrthoMCL family is shown superimposed on the search form. Results from OrthoMCL are provided, and a link to the larger Jaccard family (B) is also available. Disease information from OMIM is displayed, as well as any relevant disease or cross-complementation literature.</p

Functional conservation vs. ortholog prediction: comparing experimental results with the OrthoMCL ortholog predictions for disease-related families.

<p>In all but one of these experiments, the yeast gene was mutated and the gene from the other organism was tested for the ability to complement the mutant phenotype. In the one exception, the yeast gene <i>DPM1</i> was expressed in mouse. In the OrthoMCL column, “Yes” indicates that the OrthoMCL algorithm placed the two proteins in the same ortholog family, while “No” indicates it did not. In the Experimental column, “Yes” indicates functional complementation, while “No” indicates none. Thus, when both columns are the same, the OrthoMCL prediction is consistent with the experimental result i.e. in the cases where both are “Yes,” the predicted orthologs are functionally conserved, and when both are “No,” the proteins are not predicted to be orthologs, and they are not functionally conserved.</p

Sources and numbers of sequences analyzed.

<p>Sources and numbers of sequences analyzed.</p

The <i>MET3/MET14</i> families.

<p>(A) <i>MET14</i> Jaccard family, and (B) <i>MET3/MET14</i> OrthoMCL family.</p

Interpretation of tumor size difference and survival difference in symptom-caused detection and non-symptom-caused detection.

<p>Interpretation of tumor size difference and survival difference in symptom-caused detection and non-symptom-caused detection.</p

Demographic characteristics of patients diagnosed through symptoms and for other reasons.

*<p>Age 68 is the median.</p>**<p>Determined by chi-square test.</p>▵<p>Symptoms suggestive of LC.</p

OrthoMCL family of the alpha tubulins.

<p>This OrthoMCL family contains only the alpha tubulins, while the tubulin family generated by the Jaccard family (too large to be shown here) contains the alpha, beta, and gamma tubulins.</p