100 research outputs found
Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle
- Author
- A Achilli
- A Achilli
- A Esteve-Codina
- A Gotherstrom
- A Seguin-Orlando
- A Vaysse
- A Winter
- AE Minoche
- AJ Amaral
- Alison Murphy
- Amanda J. Lohan
- Andrew T. Chamberlain
- AV Zimin
- B Grisart
- B Grisart
- BP Lewis
- Brendan J. Loftus
- C Gamba
- C Glaser
- Ceiridwen J. Edwards
- CG Elsik
- Charles Spillane
- CJ Edwards
- CJ Edwards
- CJ Edwards
- CJ Rubin
- CJ Stevens
- CM Leu
- CS Troy
- D Reich
- Daniel G. Bradley
- David A. Magee
- David E. MacHugh
- DE MacHugh
- DG Bradley
- DM Larkin
- DP Toews
- E Palkopoulou
- E Svensson
- EJ McTavish
- EY Durand
- H Jonsson
- H Jonsson
- H Li
- H Zhang
- HD Daetwyler
- J Clutton-Brock
- J Diamond
- J Kantanen
- J Lenstra
- J Schibler
- JA Guerra-Assuncao
- JD Vigne
- JE Decker
- JK Pickrell
- JK Pritchard
- JS Pedersen
- K Prufer
- KA Moutou
- Kévin Rue-Albrecht
- L Orlando
- L Perez-Pardal
- LK Matukumalli
- M Gautier
- M Hofreiter
- M Li
- M Meyer
- M Raghavan
- M Rasmussen
- M Schubert
- MA DePristo
- MA Greagg
- MA Groenen
- Mark T. Donoghue
- Martin Braud
- Matthew D. Teasdale
- MJ Montague
- N Murakami
- N Patterson
- NA Rosenberg
- O Smith
- Paul A. McGettigan
- R Bollongino
- R Chen
- RA Gibbs
- RE Green
- RE Green
- RH Meadow
- RR Hudson
- RT Loftus
- S Bonfiglio
- S Bonfiglio
- S Bonfiglio
- S Guindon
- S Koks
- S Paabo
- S Qanbari
- S Sawyer
- Shuaishuai Tai
- Stephen D E Park
- Steven Schroeder
- Tad S. Sonstegard
- TH Lee
- W McLaren
- Y Benjamini
- Yuan Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Background
Domestication of the now-extinct wild aurochs, Bos primigenius, gave rise to the two major domestic extant cattle taxa, B. taurus and B. indicus. While previous genetic studies have shed some light on the evolutionary relationships between European aurochs and modern cattle, important questions remain unanswered, including the phylogenetic status of aurochs, whether gene flow from aurochs into early domestic populations occurred, and which genomic regions were subject to selection processes during and after domestication. Here, we address these questions using whole-genome sequencing data generated from an approximately 6,750-year-old British aurochs bone and genome sequence data from 81 additional cattle plus genome-wide single nucleotide polymorphism data from a diverse panel of 1,225 modern animals.
Results
Phylogenomic analyses place the aurochs as a distinct outgroup to the domestic B. taurus lineage, supporting the predominant Near Eastern origin of European cattle. Conversely, traditional British and Irish breeds share more genetic variants with this aurochs specimen than other European populations, supporting localized gene flow from aurochs into the ancestors of modern British and Irish cattle, perhaps through purposeful restocking by early herders in Britain. Finally, the functions of genes showing evidence for positive selection in B. taurus are enriched for neurobiology, growth, metabolism and immunobiology, suggesting that these biological processes have been important in the domestication of cattle.
Conclusions
This work provides important new information regarding the origins and functional evolution of modern cattle, revealing that the interface between early European domestic populations and wild aurochs was significantly more complex than previously thought
Genomic analyses in african populations identify novel risk loci for cleft palate
- Author
- Abate Firke
- Abdur-Rahman Lukman O.
- Adamson Olatunbosun O.
- Adekunle Adegbayi A.
- Adeyemo Adebowale A.
- Adeyemo Wasiu L.
- Agbenorku Pius
- Amendt Brad A.
- Anand Deepti
- Aregbesola Babatunde S
- Arthur Fareed Kow Nanse
- Audu Rosemary
- Auslander Allyn
- Ayelomi Oluwanifemi I.
- Bello Saidu A.
- Braimah Ramat O.
- Brindopke Frederick
- Busch Tamara D.
- Butali Azeez
- Caggana Michele
- Cornell Robert A.
- Demissie Yohannes
- Derebew Miliard
- Desai Shaan
- Donkor Peter
- Eliason Steve
- Elufowoju Abosede A.
- Erinoso Akinwunmi O.
- Eshete Mekonen A.
- Gowans Lord J. J.
- Hailu Abiye
- Hailu Taiye
- Huan Liu
- Jain Deepti
- James Olutayo
- Kay Denise M.
- Lachke Salil A.
- Laurie Cathy C.
- Laurie Cecelia A.
- Li Mary
- Lo Cynthia
- Magee Kathleen S.
- Magee William P.
- Marazita Mary L.
- Mills James L.
- Mohammed Muiawa
- Mossey Peter A.
- Murray Jeffrey C.
- Nelson Sarah
- Obiri-Yeboah Solomon
- Oginni Fadekemi O.
- Ogunlewe Olugbenga M.
- Oladega Afisu A.
- Oladele Ayodeji O.
- Oladugba Abimibola V.
- Olaitan Peter B.
- Onwuamah Chika
- Oseni Ganiyu O.
- Oti Alexander Acheampong
- Owais Arwa
- Park James
- Plange-Rhule Gyikua
- Rhodes Jennifer
- Romero-Bustillous Miguel
- Romitti Paul A.
- Rotimi Charles N.
- Saadi Irfaan
- Sanchez-Lara Pedro A.
- Shiang Rita
- Twumasi Peter
- Yu Wenjie
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 19/11/2018
- Field of study
The contribution of X-linked coding variation to severe developmental disorders
- Author
- Abbs S
- Akawi N
- Armstrong R
- Azam T
- Baple E
- Baptista J
- Berg J
- Bodek S
- Borras S
- Bradley L
- Bradley T
- Brewer C
- Castle B
- Clark C
- Cleary E
- Cole T
- Comerford J
- Cooper N
- Cooper-Charles L
- Cox H
- Dabir T
- Davidson R
- Dean J
- Donaldson A
- Donnelly D
- Dunn C
- Eberhardt RY
- Gallone G
- Gardner EJ
- Goudie D
- Green A
- Hills A
- Holden S
- Humphreys M
- Islam L
- Jackson A
- Jarvis J
- Kaplanis J
- Keelagher R
- Kivuva E
- Lam W
- Lampe A
- Lim D
- Low K
- Lynch S
- Magee A
- Martin HC
- Mavrak E
- McConnell V
- McKee S
- McLean J
- McMullan D
- McNerlan S
- McQuaid S
- McRae J
- McWilliam C
- Miedzybrodzka Z
- Moore D
- Morrison PJ
- Morton J
- Mullaney B
- Naik S
- Neville MDC
- Newbury-Ecob R
- Niemi MEK
- Norman AM
- Ong KR
- Osio D
- Owens M
- O’Driscoll M
- Park SM
- Paterson J
- Porteous M
- Ragge N
- Rankin J
- Raymond L
- Rea G
- Reavey E
- Reid E
- Roberts E
- Ross A
- Samocha KE
- Sandford R
- Scurr I
- Shaw-Smith C
- Sifrim A
- Simonic I
- Smithson S
- Stewart F
- Tavares ALT
- Tennant S
- Tischkowitz M
- Tooley M
- Turner C
- Turnpenny P
- Turton S
- Tysoe C
- Vogt J
- Williams D
- Woods G
- Publication venue
- Publication date
- 01/12/2021
- Field of study
Over 130 X-linked genes have been robustly associated with developmental disorders, and X-linked causes have been hypothesised to underlie the higher developmental disorder rates in males. Here, we evaluate the burden of X-linked coding variation in 11,044 developmental disorder patients, and find a similar rate of X-linked causes in males and females (6.0% and 6.9%, respectively), indicating that such variants do not account for the 1.4-fold male bias. We develop an improved strategy to detect X-linked developmental disorders and identify 23 significant genes, all of which were previously known, consistent with our inference that the vast majority of the X-linked burden is in known developmental disorder-associated genes. Importantly, we estimate that, in male probands, only 13% of inherited rare missense variants in known developmental disorder-associated genes are likely to be pathogenic. Our results demonstrate that statistical analysis of large datasets can refine our understanding of modes of inheritance for individual X-linked disorders
Supplement: "Localization and broadband follow-up of the gravitational-wave transient GW150914" (2016, ApJL, 826, L13)
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- Abbott B. P.
- Abbott R.
- Abbott T. D.
- Abbott T. M. C.
- Abdalla F. B.
- Abe F.
- Abernathy M. R.
- Acernese F.
- Ackermann M.
- Ackley K.
- Adame J. A.
- Adams C.
- Adams T.
- Addesso P.
- Adhikari R. X.
- Adya V. B.
- Affeldt C.
- Agathos M.
- Agatsuma K.
- Aggarwal N.
- Aguiar O. D.
- Aiello L.
- Ain A.
- Ajello M.
- Ajith P.
- Albert A.
- Algerian National Observatory Algerian Collaboration
- Allam S.
- Allen B.
- Allen W. H.
- Allison J.
- Allocca A.
- Altin P. A.
- AMATI LORENZO
- Anderson B.
- Anderson J. P.
- Anderson S. B.
- Anderson W. G.
- Annis J.
- ANTONELLI Lucio Angelo
- Aptekar R. L.
- Arai K.
- Araya M. C.
- Arceneaux C. C.
- Areeda J. S.
- Armstrong R.
- Arnaud N.
- Arun K. G.
- Ascenzi S.
- ASCENZI STEFANO
- Ashton G.
- Ast M.
- Aston S. M.
- Astone P.
- Atwood W. B.
- Aufmuth P.
- Aulbert C.
- Australian Square Kilometer Array Pathfinder (ASKAP Collaboration)
- Axelsson M.
- Babak S.
- Bacon P.
- Bader M. K. M.
- Bai J.
- Baiardi L. C.
- Baker P. T.
- Balanutsa P.
- Baldaccini F.
- Baldini L.
- Ballardin G.
- Ballmer S. W.
- Baltay C.
- Banerji M.
- Bannister K.
- Barayoga J. C.
- Barbiellini G.
- Barclay S. E.
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- Barker D.
- Barlow T.
- Barone F.
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- Barsotti L.
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- Bartlett J.
- Bartos I.
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- Basti A.
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- Baune C.
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- BAZZANO ANGELA
- Behnke B.
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- Bhagwat S.
- Bhalerao V.
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- Billingsley G.
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- Blackburn J. K.
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- BOOTES Collaboration
- Bork R.
- Boschi V.
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- Bottacini E.
- BOTTICELLA MARIA TERESA
- Bouffanais Y.
- Bozzi A.
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- Braginsky V. B.
- Branchesi M.
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- Brinkmann M.
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- BROCATO Enzo
- Brockill P.
- Broderick J. W.
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- C2PU Collaboration
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- CAMPANA Sergio
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- Capozzi D.
- CAPPELLARO Enrico
- Caragiulo M.
- CARAVEO PATRIZIA
- Carbognani F.
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- CASENTINI CLAUDIO
- CASENTINI CLAUDIO
- Castander F. J.
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- Coughlin M. W.
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- Coulon J. -P.
- Countryman S. T.
- Courvoisier T. J. -L.
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- COVINO Stefano
- Cowan E. E.
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- Cumming A.
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- D'AMMANDO FILIPPO
- D'Andrea C. B.
- D'Antonio S.
- D'AVANZO Paolo
- D'Elia V.
- da Costa L. N.
- Dal Canton T.
- Danilishin S. L.
- Danzmann K.
- Dark Energy Camera GW-EM Collaboration
- Dark Energy Survey Collaboration
- Darman N. S.
- Darnley M. J.
- Dattilo V.
- Dave I.
- Daveloza H. P.
- Davier M.
- Davies G. S.
- Daw E. J.
- Day R.
- De Laurentis M.
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- De Rosa R.
- de Ugarte Postigo A.
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- Debreczeni G.
- Degallaix J.
- Del Pozzo W.
- DELLA VALLE Massimo
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- DePoy D. L.
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- Dergachev V.
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- Desai S.
- DeSalvo R.
- Desiante R.
- Dhurandhar S.
- Di Fiore L.
- Di Giovanni M.
- Di Lalla N.
- Di Lieto A.
- Di Mauro M.
- DI MAURO Maria Giuseppina
- Di Pace S.
- Di Palma I.
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- Di Virgilio A.
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- ELIAS DE LA ROSA NANCY DEL CARMEN
- Ellman N.
- Engels W.
- Essick R. C.
- Estrada J.
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- Favata M.
- Favuzzi C.
- Fays M.
- Fehrmann H.
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- Fender R. P.
- Feng L.
- Fermi GBM Collaboration
- Fermi LAT Collaboration
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- GETMAN FEDOR
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- GIROLETTI MARCELLO
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- GRADO ANIELLO
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- GRAvitational Wave Inaf TeAm (GRAWITA)
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- Gustafson E. K.
- Gustafson R.
- Gutierrez G.
- Guziy S.
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- Hammond G.
- Haney M.
- Hanke M. M.
- Hanks J.
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- Iannicola G.
- Idrisy A.
- Indermuehle B.
- Indik N.
- Ingram D. R.
- Inserra C.
- Inta R.
- INTEGRAL Collaboration
- Intermediate Palomar Transient Factory (iPTF Collaboration)
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- Publication date
- 01/01/2016
- Field of study
This Supplement provides supporting material for Abbott et al. (2016a). We briefly summarize past electromagnetic (EM) follow-up efforts as well as the organization and policy of the current EM follow-up program. We compare the four probability sky maps produced for the gravitational-wave transient GW150914, and provide additional details of the EM follow-up observations that were performed in the different bands
Localization and broadband follow-up of the gravitational-wave transient GW150914
- Author
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- Abbott R
- Abbott TD
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- Abe F
- Abernathy MR
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- Publication venue
- Astrophysical Journal Letters
- Publication date
- 01/01/2016
- Field of study
A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams
Global economic burden of unmet surgical need for appendicitis
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- Publication venue
- Oxford University Press
- Publication date
- 01/01/2022
- Field of study
Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
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- Aamer A
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- Abd El Hamid N
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- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
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- Abdel-Kader SM
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- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
- Ali H
- Ali S
- Ali SAWEW
- Ali SS
- Ali THA
- Ali W
- Alihonou T
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
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- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
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- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
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- Ashton A
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- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
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- Atiyeh A
- Atkins ET
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- Attard M
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- Aung KP
- Austraite A
- Aviles S
- Avoka A
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- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
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- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
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- Bahar S
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- Bakhaidar M
- Baki BE
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- Bala M
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- Baldacchino M
- Balducci G
- Balila RMH
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- Balmaceda R
- Balmaceda R
- Balmaceda R
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- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
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- Bassem M
- Bassit KA
- Basso SMM
- Basson S
- Batt J
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- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet AH
- Bekhet NM
- Beleno AEM
- Belkouchi A
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- Benevento A
- Benevento A
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- Bennai RM
- Benons N
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- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
- Bisset C
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- Bjorklund I
- Blacker S
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- Blanco-Colino R
- Blencowe N
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- Bliksoen M
- Blower E
- Bluelle R
- Blundell R
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- Boal M
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- Boddy A
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- Bondin J
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- Bondurri A
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- Bonnard A
- Bonney W
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- Borda-Luque G
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- Borin E
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- Bortolasi L
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- Botes S
- Bottini C
- Botto N
- Bouali O
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- Bradulskis S
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- Bratu MR
- Bratu R-M
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- Bray LD
- Breaud J
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat SD
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- Brogden T
- Brown D
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- Brown J
- Browning DRL
- Brunoni B
- Bsisu I
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- Bugaev N
- Bugeja R
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- Burger S
- Burmistrovas A
- Burns H
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- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
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- Camilleri-Brennan J
- Camilleri-Brennan JF
- Camilo Correa J
- Campagnaro T
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- Capito C
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- Carmela Lapitan M
- Carmona JM
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- Carrasco N
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- Cassar K
- Castro Mollo M
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
- Celik S
- Cengiz TB
- Cengiz Y
- Cengiz Y
- Cengiz Y
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- Chabok A
- Chachulski W
- Chai C-A
- Chai FY
- Chambers A
- Chambers A
- Chan E
- Chan L
- Chan T-YK
- Chan XW
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Charles A
- Cheah AEZ
- Chen CY
- Chen KY
- Chen T-L
- Chenn R
- Cheong YJ
- Chetta N
- Cheung YHE
- Chew LS
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
- Chiu S
- Chiu SMY
- Choi J
- Choi P
- Chong BFHK
- Chong CL
- Chong CL
- Chong CL
- Chong CS
- Chong H-Y
- Chong HY
- Choudhry A
- Chow CYN
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung KJ
- Chung S
- Ciccioli E
- Cirocchi R
- Ciubotaru C
- Claire R
- Clarissa A
- Clark DJ
- Clark T
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- Clegg-Lamptey J-N
- Clement KD
- Clements JM
- Clerico G
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Coccolini F
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- Cocorullo G
- Cohen DM
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- Confalonieri G
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- Connor K
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- Contreras Urquizu M
- Contreras Vergara AL
- Contreras E
- Coomber R
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- Corbellini C
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- Corro-Diaz S
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- Costa-Maia J
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- Costas-Chavarri A
- Courboin E
- Court E
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- Cragg J
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- Cullen F
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- Currow C
- Currow C
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- D'Amours S
- D'amours SK
- D'cruz R
- D'Souza MS
- D'Souza R
- Da Silva LA
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- Dablouk M
- Dablouk MO
- Dagoe E
- Dahy A
- Dainius E
- Dakubo J
- Dal Canto M
- Dalli J
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- Dan I
- Danelli P
- Daniels I
- Daniyan M
- Danys D
- Dao W
- Daqeeq A
- Dar M
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- Darweesh M
- Darwish AKZ
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- Datta U
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- De Luca E
- De Marco P
- De Sousa AV
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- Debrah S
- Deckelbaum DL
- Decker E
- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- del Pilar Paucar A
- Delforge X
- Dell A
- Dempster E
- Denakpo M
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar GH
- Dharamshi HA
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu I-B
- Dias S
- Diaz Vico T
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani RMNR
- Dorisme A
- dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake TM
- Drake TM
- Drake TM
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy MM
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eid MM
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- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat MM
- Faraz A
- Fares M
- Farhad M
- Farhan-Alanie MMH
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald JE
- Fitzgerald JE
- Florez Farfan ES
- Foco M
- Fok CYJ
- Fontana T
- Foo CC
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler AJ
- Fozard T
- Fozard T
- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
- Gad A
- Gad MO
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaignard E
- Gaignard E
- Gaizauskas V
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez CP
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan YY
- Gani MA
- Garaycochea O
- Garcia Bernardo C
- Garcia Florez LJ
- Garcia Septiem J
- Garcia Torres CP
- Garcia-Florez L
- Garland A
- Gash K
- Gash K
- Gash K
- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi DG
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
- Germanos S
- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy AA
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim MA
- Ghoneem M
- Ghoneim O
- Giacci L
- Giardino FR
- Giavarini L
- Giglio MC
- Gilbert R
- Gilbert RW
- Giles J
- Gillespie M
- Gimzewska M
- Giraldo RSR
- Giuliani S
- Giuliani S
- Giuriato TF
- Gkiokas G
- Glasbey J
- Glasbey J
- Glasbey JC
- GlobalSurg Collaborative
- Glover TE
- Glover-Addy H
- Glynn M
- Gobin N
- Gobin N
- Goh CC
- Goh CC
- Goh W
- Gohar ME-SAM
- Gokani S
- Goldin E
- Golding D
- Gomaa A
- Gomah M
- Gonzales Montejo MS
- Gonzales Stuva JP
- Gonzalez M
- Goodstein M
- Gosling S
- Gosling SG
- Gouda A
- Gould L
- Gouldthorpe C
- Gouvas N
- Gouws J
- Graffeille V
- Graffieille V
- Gran M
- Grandinetti PP
- Grant A
- Grasset E
- Grasset E
- Grassi V
- Gratton R
- Gravante G
- Gravante G
- Gray D
- Grech N
- Green N
- Grella MG
- Gribauskaite J
- Griffiths E
- Griffiths E
- Griffiths M
- Grima T
- Grisin E
- Grizhja B
- Grobler DC
- Grosos C
- Grossart C
- Gubeli A
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara Torres S
- Guevara R
- Guglielmo V
- Gui D
- Gul E
- Gulbinas A
- Gulcicek OB
- Gulielmi A
- Gultom PA
- Gumar M
- Gunaseelan K
- Gunawan R
- Guner A
- Gunnarsson U
- Guo W
- Gupta A
- Gustafsson U
- Guzman Duenas C
- Gyamfi FE
- Gyanchandani N
- Gyedu A
- Habeeb MA
- Habeeb O
- Habeebullah A
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- Samaraweera DI
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- Tennakoon A
- Teo SY
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- Tew YY
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- Ubhi HK
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- Ukwenya Y
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
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- Urniezius Z
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- Wold TB
- Wolf B
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- Yeung ENW
- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
- Yuksek MA
- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
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- Zakir M
- Zalabia MF
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
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- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
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- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Institutions, Entrepreneurship and Channels to Sustained Economic Growth
- Author
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- _____
- A Bernard
- A Dixit
- A Lindbeck
- A Shleifer
- Alexander Gerschenkron
- Anne Krueger
- B ____
- Barry Weingast
- Brock Magee
- C Cobb
- Charles Jones
- Dani Rodrik
- Daron Acemoglu
- David Landes
- Douglass North
- Eric Jones
- G Grossman
- George Stigler
- Gordon Tullock
- Henry George
- Howard Pack
- Irma Adelman
- J Benhabib
- J Bessant
- Jakob Svensson
- Jean-Baptiste Michau
- Johnson ____
- Joseph Schumpeter
- Karl Shell
- Krugman Brezis
- L E ____
- La Porta
- Lyn Squire
- Mancur Olson
- Moses Abramovitz
- Murphy
- Nathan Rosenberg
- Nicholas Crafts
- Ozler Alesina
- P Aghion
- P Dasgupta
- P H Mo
- Pak-Hung Mo
- Paul Krugman
- Paul Romer
- Pippa Norris
- R ____
- R Hall
- Robert Barro
- Robert Lucas
- Robert Solow
- Romer Mankiw
- S K ____
- S Knack
- Subramanian ____
- Summerhill ____
- Susan Rose-Ackerman
- T ____
- U K ____
- W ____ (with
- W Easterly
- Wilfred Ethier
- William Baumol
- William Mcdougall
- X ____
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Localization and Broadband Follow-up of the Gravitational-wave Transient GW150914
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- Abbott B. P.
- Abbott R.
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- Abdalla F. B.
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- Arceneaux C. C.
- Areeda J. S.
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- Ashton G.
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- Aston S. M.
- Astone P.
- Atwood W. B.
- Aufmuth P.
- Aulbert C.
- Australian Square Kilometer Array Pathfinder (ASKAP) Collaboration
- Axelsson M.
- Babak S.
- Bacon P.
- Bader M. K. M.
- Bai J.
- Baiardi L. C.
- Baker P. T.
- Balanutsa P.
- Baldaccini F.
- Baldini L.
- Ballardin G.
- Ballmer S. W.
- Baltay C.
- Banerji M.
- Bannister K.
- Barayoga J. C.
- Barbiellini G.
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- Barker D.
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- Barthelmy S.
- Bartlett J.
- Bartos I.
- Bassiri R.
- Basti A.
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- Batch J. C.
- Baune C.
- Bavigadda V.
- Bazzan M.
- Bazzano A.
- Behnke B.
- Bejger M.
- Bell A. S.
- Bell C. J.
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- Bellazzini R.
- Bellm E.
- Benacquista M.
- Benoit-Lévy A.
- Berger B. K.
- Berger E.
- Bergman J.
- Bergmann G.
- Bernstein R. A.
- Beroiz M.
- Berry C. P. L.
- Bersanetti D.
- Bersier D. F.
- Bertin E.
- Bertolini A.
- Betzwieser J.
- Bhagwat S.
- Bhalerao V.
- Bhandare R.
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- Billingsley G.
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- Biwer C.
- Bizouard M. A.
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- Bojtos P.
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- BOOTES Collaboration
- Bork R.
- Boschi V.
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- Bottacini E.
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- Bozzi A.
- Bozzo E.
- Bradaschia C.
- Brady P. R.
- Braginsky V. B.
- Branchesi M.
- Brandt S.
- Brandt T. J.
- Brau J. E.
- Briant T.
- Briggs M. S.
- Brillet A.
- Brinkmann M.
- Brisson V.
- Brocato E.
- Brockill P.
- Broderick J. W.
- Brooks A. F.
- Brout D.
- Brown D. A.
- Brown D. D.
- Brown N. M.
- Bruel P.
- Buchanan C. C.
- Buckley D.
- Buckley-Geer E.
- Budnev N. M.
- Buikema A.
- Bulik T.
- Bulten H. J.
- Buonanno A.
- Burke D. L.
- Burns E.
- Burrows D. N.
- Buskulic D.
- Buson S.
- Bustillo J. C.
- Buy C.
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- 'American Astronomical Society'
- Publication date
- 28/10/2022
- Field of study
A gravitational-wave (GW) transient was identified in data recorded by
the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO)
detectors on 2015 September 14. The event, initially designated G184098
and later given the name GW150914, is described in detail elsewhere. By
prior arrangement, preliminary estimates of the time, significance, and
sky location of the event were shared with 63 teams of observers
covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths
with ground- and space-based facilities. In this Letter we describe the
low-latency analysis of the GW data and present the sky localization of
the first observed compact binary merger. We summarize the follow-up
observations reported by 25 teams via private Gamma-ray Coordinates
Network circulars, giving an overview of the participating facilities,
the GW sky localization coverage, the timeline, and depth of the
observations. As this event turned out to be a binary black hole merger,
there is little expectation of a detectable electromagnetic (EM)
signature. Nevertheless, this first broadband campaign to search for a
counterpart of an Advanced LIGO source represents a milestone and
highlights the broad capabilities of the transient astronomy community
and the observing strategies that have been developed to pursue neutron
star binary merger events. Detailed investigations of the EM data and
results of the EM follow-up campaign are being disseminated in papers by
the individual teams.
</p
General anaesthetic and airway management practice for obstetric surgery in England: a prospective, multi-centre observational study
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- Z Rajput
- Z Saunders
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
There are no current descriptions of general anaesthesia characteristics for obstetric surgery, despite recent changes to patient baseline characteristics and airway management guidelines. This analysis of data from the direct reporting of awareness in maternity patients' (DREAMY) study of accidental awareness during obstetric anaesthesia aimed to describe practice for obstetric general anaesthesia in England and compare with earlier surveys and best-practice recommendations. Consenting patients who received general anaesthesia for obstetric surgery in 72 hospitals from May 2017 to August 2018 were included. Baseline characteristics, airway management, anaesthetic techniques and major complications were collected. Descriptive analysis, binary logistic regression modelling and comparisons with earlier data were conducted. Data were collected from 3117 procedures, including 2554 (81.9%) caesarean deliveries. Thiopental was the induction drug in 1649 (52.9%) patients, compared with propofol in 1419 (45.5%). Suxamethonium was the neuromuscular blocking drug for tracheal intubation in 2631 (86.1%), compared with rocuronium in 367 (11.8%). Difficult tracheal intubation was reported in 1 in 19 (95%CI 1 in 16-22) and failed intubation in 1 in 312 (95%CI 1 in 169-667). Obese patients were over-represented compared with national baselines and associated with difficult, but not failed intubation. There was more evidence of change in practice for induction drugs (increased use of propofol) than neuromuscular blocking drugs (suxamethonium remains the most popular). There was evidence of improvement in practice, with increased monitoring and reversal of neuromuscular blockade (although this remains suboptimal). Despite a high risk of difficult intubation in this population, videolaryngoscopy was rarely used (1.9%)
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