An Investigation into Power from Pitch-Surge Point-Absorber Wave Energy Converters.

There is a worldwide opportunity for clean renewable power. The results from the UK Government's "Marine Energy Challenge" showed that marine energy has the potential to become competitive with other forms of energy. The key to success in this lies in a low lifetime-cost of power as delivered to the user. Pitch-surge point-absorber WECs have the potential to do this with average annual powers of around 2 MW in North Atlantic conditions from relatively small devices that would be economically competitive with other technologies and would be relatively easy to install and maintain. The paper examines the factors governing the performance of such devices and outlines their underlying theory Preliminary laboratory test results from a 1/100 scale pilot design are presented. It is hoped that more extensive development work will follow these promising early results. Engineering designs for devices based on these findings are outlined

Control systems for WRASPA.

The paper discusses the need for a wave energy converter (WEC) to sense and respond to its environment in order to survive and to produce its maximum useful output. Such systems are described for Wraspa, a WEC being developed at Lancaster University and first reported at ICCEP in 2007. The main control system that continually monitors and optimises the power-take-off is termed ldquoStepwise Controlrdquo and seeks to continually adjust the damping force applied to the collector to suit the wave force that drives it. The complete instrumentation and control system that will be needed is considered briefly, including the above PTO control system; direction sensing and heading control; tide level compensation; condition monitoring and provisions for access and maintenance

Proof of principle : the adaptive geometry of social foragers

Acknowledgments We thank Cape Nature for permission to undertake the study. We thank Dr Matt Grove and two anonymous referees for comments and suggestions that improved the manuscript substantially. This research was funded by grants from the Leakey Foundation, National Science and Engineering Research Council, Canada to S.P.H. and L.B., and by the National Research Foundation, South Africa to S.P.H. His co-authors dedicate this paper to the memory of P.M.R.C. The authors declare no competing interests.Peer reviewedPostprin

Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations

BackgroundThe frequency of vitamin D-associated gene variants appear to reflect changes in long-term ultraviolet B radiation (UVB) environment, indicating interactions exist between the primary determinant of vitamin D status, UVB exposure and genetic disposition. Such interactions could have health implications, where UVB could modulate the impact of vitamin D genetic variants identified as disease risk factors. However, the current understanding of how vitamin D variants differ between populations from disparate UVB environments is limited, with previous work examining a small pool of variants and restricted populations only.MethodsGenotypic data for 46 variants within multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP27A1, CYP24A1, VDR, RXRα and RXRγ) was collated from 60 sample sets (2633 subjects) with European, East Asian and Sub-Saharan African origin via the NCBI 1000 Genomes Browser and ALFRED (Allele Frequency Database), with the aim to examine for patterns in the distribution of vitamin D-associated variants across these geographic areas.ResultsThe frequency of all examined genetic variants differed between populations of European, East Asian and Sub-Saharan African ancestry. Changes in the distribution of variants in CYP2R1, CYP11A1, CYP24A1, RXRα and RXRγ genes between these populations are novel findings which have not been previously reported. The distribution of several variants reflected changes in the UVB environment of the population’s ancestry. However, multiple variants displayed population-specific patterns in frequency that appears not to relate to UVB changes.ConclusionsThe reported population differences in vitamin D-related variants provides insight into the extent by which activity of the vitamin D system can differ between cohorts due to genetic variance, with potential consequences for future dietary recommendations and disease outcomes

3D Simulations of Ion Thruster Accelerator Grid Erosion Accounting for Charge Exchange Ion Space Charge

Accelerator (accel) grid sputtering by ions formed through charge-exchange (CEX) reactions between beam ions and residual neutral gas is a critical life-limiting mechanism for gridded ion thrusters. The three-dimensional ion optics code CEX3D is designed to simulate this grid erosion for a single beamlet, with a particular emphasis on non-axisymmetric features such as the "pits and grooves" erosion commonly observed on the accel grid downstream face in two-grid thrusters. The treatment of CEX ions in the code was recently upgraded with a new particle-in-cell (PIC) module to account for the influence of these ions' space charge on the electrostatic potential downstream of the grids. In order to achieve reasonable computation times while resolving the Debye length near the grids and avoiding gross violations of the Courant-Friedrichs-Lewy (CFL) condition, macroparticle velocities in the PIC calculation are limited through a rescaling procedure that preserves ion trajectories and space charge density. The code accounts for beam divergence, finite momentum transfer in CEX collisions, and radial losses of CEX ions from the beam; these effects are important for determining the CEX ion flux to the accel grid because the calculated potential downstream of the grids can become very flat. The upgraded code has been used to simulate operation of NASA's Evolutionary Xenon Thruster (NEXT) during the 51 kHr Long Duration Test - a selection of results is presented and compared with experimental data

A method for machine learning generation of realistic synthetic datasets for validating healthcare applications

Digital health applications can improve quality and effectiveness of healthcare, by offering a number of new tools to users, which are often considered a medical device. Assuring their safe operation requires, amongst others, clinical validation, needing large datasets to test them in realistic clinical scenarios. Access to datasets is challenging, due to patient privacy concerns. Development of synthetic datasets is seen as a potential alternative. The objective of the paper is the development of a method for the generation of realistic synthetic datasets, statistically equivalent to real clinical datasets, and demonstrate that the Generative Adversarial Network (GAN) based approach is fit for purpose. A generative adversarial network was implemented and trained, in a series of six experiments, using numerical and categorical variables, including ICD-9 and laboratory codes, from three clinically relevant datasets. A number of contextual steps provided the success criteria for the synthetic dataset. A synthetic dataset that exhibits very similar statistical characteristics with the real dataset was generated. Pairwise association of variables is very similar. A high degree of Jaccard similarity and a successful K-S test further support this. The proof of concept of generating realistic synthetic datasets was successful, with the approach showing promise for further work

The 3rd Fermi GBM Gamma-Ray Burst Catalog: The First Six Years

Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has triggered and located on average approximately two gamma-ray bursts (GRB) every three days. Here we present the third of a series of catalogs of GRBs detected by GBM, extending the second catalog by two more years, through the middle of July 2014. The resulting list includes 1405 triggers identified as GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300~keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed, and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBM's low-energy NaI(Tl) detectors. Using statistical methods to assess clustering, we find that the hardness and duration of GRBs are better fitted by a two-component model with short-hard and long-soft bursts, than by a model with three components. Furthermore, information is provided on the settings and modifications of the triggering criteria and exceptional operational conditions during years five and six in the mission. This third catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center (HEASARC).Comment: 225 pages, 13 figures and 8 tables. Accepted for publication in Astrophysical Journal Supplement 201

Challenges in producing policy-relevant global scenarios of biodiversity and ecosystem services

Scenario-based modelling is a powerful tool to describe relationships between plausible trajectories of drivers, possible policy interventions, and impacts on biodiversity and ecosystem services. Model inter-comparisons are key in quantifying uncertainties and identifying avenues for model improvement but have been missing among the global biodiversity and ecosystem services modelling communities. The biodiversity and ecosystem services scenario-based inter-model comparison (BES-SIM) aims to fill this gap. We used global land-use and climate projections to simulate possible future impacts on terrestrial biodiversity and ecosystem services using a variety of models and a range of harmonized metrics. The goal of this paper is to reflect on the steps taken in BES-SIM, identify remaining methodological challenges, and suggest pathways for improvement. We identified five major groups of challenges; the need to: 1) better account for the role of nature in future human development storylines; 2) improve the representation of drivers in the scenarios by increasing the resolution (temporal, spatial and thematic) of land-use as key driver of biodiversity change and including additional relevant drivers; 3) explicitly integrate species- and trait-level biodiversity in ecosystem services models; 4) expand the coverage of the multiple dimensions of biodiversity and ecosystem services; and finally, 5) incorporate time-series or one-off historical data in the calibration and validation of biodiversity and ecosystem services models. Addressing these challenges would allow the development of more integrated global projections of biodiversity and ecosystem services, thereby improving their policy relevance in supporting the interlinked international conservation and sustainable development agendas

The Asteroseismic Poltential of TESS: Exoplanet-Host Stars

New insights on stellar evolution and stellar interior physics are being made possible by asteroseismology. Throughout the course of the Kepler mission, asteroseismology has also played an important role in the characterization of exoplanet-host stars and their planetary systems. The upcoming NASA Transiting Exoplanet Survey Satellite (TESS) will be performing a near all-sky survey for planets that transit bright nearby stars. In addition, its excellent photometric precision, combined with its fine time sampling and long intervals of uninterrupted observations, will enable asteroseismology of solar-type and red-giant stars. Here we develop a simple test to estimate the detectability of solar-like oscillations in TESS photometry of any given star. Based on an all-sky stellar and planetary synthetic population, we go on to predict the asteroseismic yield of the TESS mission, placing emphasis on the yield of exoplanet-host stars for which we expect to detect solar-like oscillations. This is done for both the target stars (observed at a 2-minute cadence) and the full-frame-image stars (observed at a 30-minute cadence). A similar exercise is also conducted based on a compilation of known host stars. We predict that TESS will detect solar-like oscillations in a few dozen target hosts (mainly subgiant stars but also in a smaller number of F dwarfs), in up to 200 low-luminosity red-giant hosts, and in over 100 solar-type and red-giant known hosts, thereby leading to a threefold improvement in the asteroseismic yield of exoplanet-host stars when compared to Kepler's.Science and Technology Facilities Council (Great Britain