Accelerated creep(ing): A 'buy & forget' mentality for Chinese homes

Accelerated creep(ing): A 'buy & forget' mentality for Chinese home

Evaluating the expression of heat shock protein 27 and topoisomerase II α in a retrospective cohort of patients diagnosed with locally advanced breast cancer and treated with neoadjuvant anthracycline-based chemotherapies

BackgroundNeoadjuvant anthracycline-based chemotherapy (NAC) is a major regimen for the treatment of local advanced breast cancer (LABC), while resistance to NAC remains a paramount clinical obstacle. To investigate the role of heat shock protein 27 (Hsp27) and/or topoisomerase IIα (TopoIIα) in LABC patients treated with NAC, we performed this retrospective study.MethodsAssociations of Hsp27 transcripts with clinic-pathological characteristics, survival and drug response were investigated in public databases. Hsp27-related genes were identified, followed by functional enrichment analyses. Besides, two protein-protein interaction networks were built. Then, tumors from 103 patients who were diagnosed with LABC and received NAC were collected, and Hsp27 and TopoIIα were examined by Immunohistochemistry (IHC). Chi-square or Fisher’s exact tests were performed, as well as survival analyses.ResultsEither at the transcriptional level in public databases or at the protein level tested by IHC, a high level of Hsp27 was associated with aggressive tumor characteristics such as lymph node invasion and chemotherapy resistance. Hsp27-related genes mostly involved in the metabolic pathway and the gamete generation biological process. An elevated Hsp27 indicated a poor prognosis in patients with breast cancer (log-rank test P = 0.002 and 0.004 for disease-free survival [DFS] and overall survival [OS], respectively), while it might not be an independent predictor. Of note, tumors with high TopoIIα expression (TopoIIα+) was less likely to express Hsp27 (Hsp27+), in contrast to those with TopoIIα negativity (31.1% vs. 86.2%, P<0.001), and survival analyses revealed that patients with Hsp27+ and TopoIIα- tumors had a significantly lower DFS and OS (log-rank test P < 0.001 and 0.001, respectively), in contrast to the other three groups.ConclusionsHsp27 was associated with aggressive breast cancers and more predictable for the prognosis of LABC patients treated with NAC when concomitantly considering TopoIIα expression

A comparative analysis of a radiation-cooling-plate-coupled adhesion-jet air conditioning system in different positions

Compared with the traditional radiant cooling combined with a displacement ventilation air conditioning system, an air conditioning system of radiant cooling combined with an attached jet can not only effectively prevent dew on the surface of the radiant cooling plate, but also further improve the cooling capacity of the radiant air conditioning system; however, most scholars have installed the radiant cooling plate on the radiant roof and the ground, and there are fewer studies on installing the radiant cooling plate on the two sides of the wall. Based on this, this paper builds an experimental system of radiant air conditioning and conducts experiments on summer working conditions in June–October to experimentally study the indoor thermal and humid environments and thermal comfort under different water supply temperatures when radiant cold panels are installed in single-side-wall, symmetrical-wall, and top-panel positions. The experimental results show that the optimal water supply temperatures of single-side-wall radiation combined with an attached-jet air conditioning system, symmetrical-wall radiation combined with an attached-jet air conditioning system, and roof radiation combined with an attached-jet air conditioning system are 18 °C, 22 °C, and 16 °C, respectively, and at the same time, the temperatures of the human body’s working area under the above water supply temperatures are 26 °C, 26.3 °C, and 26.4 °C, respectively. The average humidities in the working area are 58%, 53%, and 57%, which can meet the requirements of our country’s level II comfort when the indoor heat and humidity environment is stable, the energy consumption amounts of the radiant end are 5.71 kW·h, 3.99 kW·h, and 10.81 kW·h, respectively, and the highest efficiency of cooling and dehumidification is achieved with the symmetric-wall radiation combined with the adherent-jet air conditioning system

Uncertainty-based robust optimal design of cleanroom air-conditioning systems considering life-cycle performance

Strict and simultaneous space temperature and humidity controls are often required in many applications, such as hospitals, laboratories, cleanrooms for pharmaceutical and semiconductor manufacturing. The energy intensity in such applications can be up to 100 times than typical office buildings, mainly due to the improper system design and control. Although some uncertainty-based design methods have been developed for air-conditioning systems, most of the existing systems are designed based on a certain ventilation mode while neglecting the life-cycle performance of the components. This study, therefore, proposes a robust optimal design method for cleanroom air-conditioning systems, considering the uncertainties in design parameters for inputs and operation strategies as well as the life-cycle performance of components. An adaptive full-range decoupled ventilation strategy, which incorporated five operation modes, was adopted in the design optimization. Two maintenance modes were adopted and compared to consider the flexibility of maintenance. The proposed design method has been implemented and validated in the design optimization of an existing air-conditioning system. The results showed that, compared with the conventional design, up to 54% reduction of life-cycle costs and superior satisfaction of services could be achieved by using the proposed method. </jats:p