Neuroprotection in glaucoma using Gouqizi (Wolfberry)

Aging is an important risk factor for various neurodegenerative diseases such as glaucoma and Alzheimer's disease (AD). Glaucoma is a common eye disease that may lead to irreversible blindness. Recent studies suggest that development of anti-aging drugs from Chinese medicinal herbs may be one of the possible interventions. The fruits of Lycium barbarum (or commonly known as Gou Qi Zi, or wolfberry), has been used for thousands of years in China and is believed to be effective as an anti-aging agent as well as nourishment of eyes, livers and kidneys. We have shown that aqueous extract of wolfberry provides neuroprotection to the eyes against degeneration in an experimental model of glaucoma.published_or_final_versio

Molecular mechanism of neuroprotection in glaucoma using gouqizi (wolfberry)

published_or_final_version首都醫科大學眼科學院2009年學術年會, 北京, 2009年10月9日-10月11日. In 首都醫科大學眼科學院2009年學術年會會議指南, 2009, p. 1

New positive small vacuum region gravitational energy expressions

We construct an infinite number of new holonomic quasi-local gravitational energy-momentum density pseudotensors with good limits asymptotically and in small regions, both materially and in vacuum. For small vacuum regions they are all a positive multiple of the Bel-Robinson tensor and consequently have positive energy.Comment: 4 page

Reducing calcium-mediated endoplasmic reticulum stress could attenuate beta-amyloid peptide neurotoxicity

published_or_final_versio

Lycium barbarum (wolfberry) polysaccharide facilitates ejaculatory behaviour in male rats

Poster Session AOBJECTIVE: Lycium barbarum (wolfberry) is a traditional Chinese medicine, which has been considered to have therapeutic effect on male infertility. However, there is a lack of studies support the claims. We thus investigated the effect of Lycium barbarum polysaccharide (LBP), a major component of wolfberry, on male rat copulatory behavior. METHOD: Sprague-Dawley rats were divided into two groups (n=8 for each group). The first group received oral feeding of LBP at dosage of 1mg/kg daily. The control group received vehicle (0.01M phosphate-buffered saline, served as control) feeding daily for 21 days. Copulatory tests were conducted at 7, 14 and 21 days after initiation of treatment. RESULTS: Compared to control animals, animals fed with 1mg/kg LBP showed improved copulatory behavior in terms of: 1. Higher copulatory efficiency (i.e. higher frequency to show intromission rather than mounting during the test), 2. higher ejaculation frequency and 3. Shorter ejaculation latency. The differences were found at all time points (Analyzed with two-tailed student’s t-test, p<0.05). There is no significant difference found between the two groups in terms of mount/intromission latency, which indicates no difference in time required for initiation of sexual activity. Additionally, no difference in mount frequency and intromission frequency was found. CONCLUSION: The present study provides scientific evidence for the traditional use of Lycium barbarum on male sexual behavior. The result provides basis for further study of wolfberry on sexual functioning and its use as an alternative treatment in reproductive medicine.postprintThe 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society (ANS/AuPS 2010), Sydney, Australia, 31 January-3 February 2010. In Abstract Book of ANS/AuPS, 2010, p. 177, abstract no. POS-TUE-19

Irrational vs. rational charge and statistics in two-dimensional quantum systems

We show that quasiparticle excitations with irrational charge and irrational exchange statistics exist in tight-biding systems described, in the continuum approximation, by the Dirac equation in (2+1)-dimensional space and time. These excitations can be deconfined at zero temperature, but when they are, the charge re-rationalizes to the value 1/2 and the exchange statistics to that of "quartons" (half-semions).Comment: 4 pages, 2 figure

Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons

Glutamate excitotoxicity is involved in many neurodegenerative diseases including Alzheimer's disease (AD). Attenuation of glutamate toxicity is one of the therapeutic strategies for AD. Wolfberry (Lycium barbarum) is a common ingredient in oriental cuisines. A number of studies suggest that wolfberry has anti-aging properties. In recent years, there is a trend of using dried Wolfberry as food supplement and health product in UK and North America. Previously, we have demonstrated that a fraction of polysaccharide from Wolfberry (LBA) provided remarkable neuroprotective effects against beta-amyloid peptide-induced cytotoxicity in primary cultures of rat cortical neurons. To investigate whether LBA can protect neurons from other pathological factors such as glutamate found in Alzheimer brain, we examined whether it can prevent neurotoxicity elicited by glutamate in primary cultured neurons. The glutamate-induced cell death as detected by lactate dehydrogenase assay and caspase-3-like activity assay was significantly reduced by LBA at concentrations ranging from 10 to 500 μg/ml. Protective effects of LBA were comparable to memantine, a non-competitive NMDA receptor antagonist. LBA provided neuroprotection even 1 h after exposure to glutamate. In addition to glutamate, LBA attenuated N-methyl-d-aspartate (NMDA)-induced neuronal damage. To further explore whether LBA might function as antioxidant, we used hydrogen peroxide (H2O2) as oxidative stress inducer in this study. LBA could not attenuate the toxicity of H2O2. Furthermore, LBA did not attenuate glutamate-induced oxidation by using NBT assay. Western blot analysis indicated that glutamate-induced phosphorylation of c-jun N-terminal kinase (JNK) was reduced by treatment with LBA. Taken together, LBA exerted significant neuroprotective effects on cultured cortical neurons exposed to glutamate. © 2009 Springer Science+Business Media, LLC.postprin

Evaluating Firm-Level Expected-Return Proxies

We develop and implement a rigorous analytical framework for empirically evaluating the relative performance of firm-level expected-return proxies (ERPs). We show that superior proxies should closely track true expected returns both cross-sectionally and over time (that is, the proxies should exhibit lower measurement-error variances). We then compare five classes of ERPs nominated in recent studies to demonstrate how researchers can easily implement our two-dimensional evaluative framework. Our empirical analyses document a tradeoff between time-series and cross-sectional ERP performance, indicating the optimal choice of proxy may vary across research settings. Our results illustrate how researchers can use our framework to critically evaluate and compare a growing body of ERPs