Introduction to The Chinese and the Iron Road

Excerpt from The Chinese and the Iron Road: Building the Transcontinental Railroad, edited by Gordon H. Chang and Shelley Fisher Fishkin, with Hilton Obenzinger and Roland Hs

Rapidity Correlations and ΔG\Delta G from Prompt Photon plus Jet Production in Polarized pppp Collisions

A study of prompt photon plus associated jet production is performed at next-to-leading order (O($\alpha\alpha_s^2$)) in QCD at $\sqrt{S}=200-500$ GeV, appropriate for the RHIC polarized $\vec{p}\vec{p}$ collider experiment. Momentum correlations between the jet and photon are examined and the utility of the process as a method for constraining the size and shape of the polarized gluon density of the proton $\Delta G$ is examined.Comment: 22 pages, 12 figure

Spin Dependence of Massive Lepton Pair Production in Proton-Proton Collisions

We calculate the transverse momentum distribution for the production of massive lepton-pairs in longitudinally polarized proton-proton reactions at collider energies within the context of perturbative quantum chromodynamics. For values of the transverse momentum Q_T greater than roughly half the pair mass Q, Q_T > Q/2, we show that the differential cross section is dominated by subprocesses initiated by incident gluons, provided that the polarized gluon density is not too small. Massive lepton-pair differential cross sections should be a good source of independent constraints on the polarized gluon density, free from the experimental and theoretical complications of photon isolation that beset studies of prompt photon production. We provide predictions for the spin-averaged and spin-dependent differential cross sections as a function of Q_T at energies relevant for the Relativistic Heavy Ion Collider (RHIC) at Brookhaven, and we compare these with predictions for real prompt photon production.Comment: 34 pages, RevTeX including 17 figures in .ps file

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.

Estrogen receptor (ER)-negative cancers have a poor prognosis, and few targeted therapies are available for their treatment. Our previous analyses have identified potential kinase targets critical for the growth of ER-negative, progesterone receptor (PR)-negative and HER2-negative, or "triple-negative" breast cancer (TNBC). Because phosphatases regulate the function of kinase signaling pathways, in this study, we investigated whether phosphatases are also differentially expressed in ER-negative compared to those in ER-positive breast cancers. We compared RNA expression in 98 human breast cancers (56 ER-positive and 42 ER-negative) to identify phosphatases differentially expressed in ER-negative compared to those in ER-positive breast cancers. We then examined the effects of one selected phosphatase, dual specificity phosphatase 4 (DUSP4), on proliferation, cell growth, migration and invasion, and on signaling pathways using protein microarray analyses of 172 proteins, including phosphoproteins. We identified 48 phosphatase genes are significantly differentially expressed in ER-negative compared to those in ER-positive breast tumors. We discovered that 31 phosphatases were more highly expressed, while 11 were underexpressed specifically in ER-negative breast cancers. The DUSP4 gene is underexpressed in ER-negative breast cancer and is deleted in approximately 50 % of breast cancers. Induced DUSP4 expression suppresses both in vitro and in vivo growths of breast cancer cells. Our studies show that induced DUSP4 expression blocks the cell cycle at the G1/S checkpoint; inhibits ERK1/2, p38, JNK1, RB, and NFkB p65 phosphorylation; and inhibits invasiveness of TNBC cells. These results suggest that that DUSP4 is a critical regulator of the growth and invasion of triple-negative breast cancer cells

Theory of an optical dipole trap for cold atoms

The theory of an atom dipole trap composed of a focused, far red-detuned, trapping laser beam, and a pair of red-detuned, counterpropagating, cooling beams is developed for the simplest realistic multilevel dipole interaction scheme based on a model of a (3+5)-level atom. The description of atomic motion in the trap is based on the quantum kinetic equations for the atomic density matrix and the reduced quasiclassical kinetic equation for atomic distribution function. It is shown that when the detuning of the trapping field is much larger than the detuning of the cooling field, and with low saturation, the one-photon absorption (emission) processes responsible for the trapping potential can be well separated from the two-photon processes responsible for sub-Doppler cooling atoms in the trap. Two conditions are derived that are necessary and sufficient for stable atomic trapping. The conditions show that stable atomic trapping in the optical dipole trap can be achieved when the trapping field has no effect on the two-photon cooling process and when the cooling field does not change the structure of the trapping potential but changes only the numerical value of the trapping potential well. It is concluded that the separation of the trapping and cooling processes in a pure optical dipole trap allows one to cool trapped atoms down to a minimum temperature close to the recoil temperature, keeping simultaneously a deep potential well

Scalable continuous evolution for the generation of diverse enzyme variants encompassing promiscuous activities

Enzyme orthologs sharing identical primary functions can have different promiscuous activities. While it is possible to mine this natural diversity to obtain useful biocatalysts, generating comparably rich ortholog diversity is difficult, as it is the product of deep evolutionary processes occurring in a multitude of separate species and populations. Here, we take a first step in recapitulating the depth and scale of natural ortholog evolution on laboratory timescales. Using a continuous directed evolution platform called OrthoRep, we rapidly evolve the Thermotoga maritima tryptophan synthase β-subunit (TmTrpB) through multi-mutation pathways in many independent replicates, selecting only on TmTrpB’s primary activity of synthesizing L-tryptophan from indole and L-serine. We find that the resulting sequence-diverse TmTrpB variants span a range of substrate profiles useful in industrial biocatalysis and suggest that the depth and scale of evolution that OrthoRep affords will be generally valuable in enzyme engineering and the evolution of biomolecular functions

Two New Gravitationally Lensed Double Quasars from the Sloan Digital Sky Survey

We report the discoveries of the two-image gravitationally lensed quasars, SDSS J0746+4403 and SDSS J1406+6126, selected from the Sloan Digital Sky Survey (SDSS). SDSS J0746+4403, which will be included in our lens sample for statistics and cosmology, has a source redshift of z_s=2.00, an estimated lens redshift of z_l~0.3, and an image separation of 1.08". SDSS J1406+6126 has a source redshift of z_s=2.13, a spectroscopically measured lens redshift of z_l=0.27, and an image separation of 1.98". We find that the two quasar images of SDSS J1406+6126 have different intervening MgII absorption strengths, which are suggestive of large variations of absorbers on kpc scales. The positions and fluxes of both the lensed quasar systems are easily reproduced by simple mass models with reasonable parameter values. These objects bring to 18 the number of lensed quasars that have been discovered from the SDSS data.Comment: 25 pages, 6 figures, The Astronomical Journal accepte

From d-wave to s-wave pairing in the iron-pnictide superconductor (Ba,K)Fe2As2

The nature of the pairing state in iron-based superconductors is the subject of much debate. Here we argue that in one material, the stoichiometric iron pnictide KFe2As2, there is overwhelming evidence for a d-wave pairing state, characterized by symmetry-imposed vertical line nodes in the superconducting gap. This evidence is reviewed, with a focus on thermal conductivity and the strong impact of impurity scattering on the critical temperature Tc. We then compare KFe2As2 to Ba0.6K0.4Fe2As2, obtained by Ba substitution, where the pairing symmetry is s-wave and the Tc is ten times higher. The transition from d-wave to s-wave within the same crystal structure provides a rare opportunity to investigate the connection between band structure and pairing mechanism. We also compare KFe2As2 to the nodal iron-based superconductor LaFePO, for which the pairing symmetry is probably not d-wave, but more likely s-wave with accidental line nodes

Spin Fluctuation and Persistent Current in a Mesoscopic Ring Coupled to a Quantum Dot

We investigate the persistent current influenced by the spin fluctuations in a mesoscopic ring weakly coupled to a quantum dot. It is shown that the Kondo effect gives rise to some unusual features of the persistent current in the limit where the charge transfer between two subsystems is suppressed. Various aspects of the crossover from a delocalized to a localized dot limit are discussed in relation with the effect of the coherent response of the Kondo cloud to the Aharonov-Bohm flux.Comment: 4 pages, 2 figure