Transancestral mapping and genetic load in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (B50% of these regions have multiple independent associations); these include 24 novel SLE regions (Po5 10 8), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SL

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Testimonio auténtico y verdadero de las cosas notables que passaron en la dichosa muerte del Rey ... don Felipe II que santa gloria aya :

Obra perteneciente al Fondo Antiguo de la Biblioteca de la USA

Testimonio autentico y verdadero de las cosas notables que passaron en la dichosa muerte del Rey nuestro señor Don Phelipe II. Autor ... Ceruera de la Torre...

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Testimonio autentico y verdadero de las cosas notables que passaron en la dichosa muerte del Rey N.S. don Felipe II ... : con muchas adiciones nueuas

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Testimonio autentico y verdadero de las cosas notables que passaron en la dichosa muerte del Rey N.S. don Felipe II ... : con muchas adiciones nueuas ... / autor, su capellan el licenciado Frey don Antonio Ceruera de la Torre, sacristan mayor de la Orden de Calatraua ...

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De Felici Excessu Philippi II. Austriaci Hispaniarum Regis Libri III. Sive de rebus memorabilibus quae in eius morte acciderunt, testimonium Authenticum / Scripsit Hispanice iussu Reverendiss. Archiep. Toletani. Cervera, Turrianus. Capell. Reg. Ord. Calat. Vertit Latine mandato ... Archiducis Maximiliani Theutonici ordinis Principis, Franciscus Guillimannus

DE FELICI EXCESSU PHILIPPI II. AUSTRIACI HISPANIARUM REGIS LIBRI III. SIVE DE REBUS MEMORABILIBUS QUAE IN EIUS MORTE ACCIDERUNT, TESTIMONIUM AUTHENTICUM / SCRIPSIT HISPANICE IUSSU REVERENDISS. ARCHIEP. TOLETANI. CERVERA, TURRIANUS. CAPELL. REG. ORD. CALAT. VERTIT LATINE MANDATO ... ARCHIDUCIS MAXIMILIANI THEUTONICI ORDINIS PRINCIPIS, FRANCISCUS GUILLIMANNUS De Felici Excessu Philippi II. Austriaci Hispaniarum Regis Libri III. Sive de rebus memorabilibus quae in eius morte acciderunt, testimonium Authenticum / Scripsit Hispanice iussu Reverendiss. Archiep. Toletani. Cervera, Turrianus. Capell. Reg. Ord. Calat. Vertit Latine mandato ... Archiducis Maximiliani Theutonici ordinis Principis, Franciscus Guillimannus (1) Titelblatt (1) Praefatio. (3) Ad Lectorem. (11) Librorvm Et Capitvm Svmma. (13) Liber Primvs. (17) Liber Secvndvs. (57) Liber Tertivs. (118) Fotodokumentation (185

Aula de innovación educativa

El artículo forma parte de una sección de la revista dedicada al intercambio de experiencias. - Resumen basado en el de la revista.Propuesta educativa que refleja la doble función que se pretende conferir al teléfono móvil en el contexto educacional: ser un dispositivo portátil y su posibilidad de comunicación inalámbrica para descubrir elementos del paisaje autóctono. Estamos ante una experiencia de aprendizaje cooperativo promovida en un instituto de Burgos que pretende estimular el espíritu investigador del alumno, así como potenciar la adquisición de la competencia social y ciudadana, con valores morales y solidarios, intrínsecos a la faceta cultural del entorno del discente. Se ha desarrollado en el marco de una yincana cultural, en la que el teléfono móvil sirve como medio de comunicación, obtención de información y documentación..CataluñaConsejería de Educación, Formación y Empleo. Servicio de Publicaciones y Estadística; Avda. de la Fama, 15 - 1ª Planta; 30006 Murcia; Tel. +34968279685; Fax +34968279835; [email protected]

Maritime Pine Genomics in Focus

International audienceThe advent of next-generation genome sequencing technologies has allowed approaching the sequencing and analysis of large and complex conifer genomes. Maritime pine (Pinus pinaster Ait.) is an economically and ecologically important conifer species widely distributed in South-West Europe, which shows a significant genetic and adaptive variability. This chapter takes on the task of reviewing the insights into the maritime pine genome sequencing breakthrough and its impact on downstream analysis. Maritime pine genome sequencing and assembly approaches are described along with the impact of related tools. A section of the state-of-the-art research on comparative, functional, structural, and translational genomics aimed at dissecting the genetic basis and the specific regulation of biological processes underlying the expression of traits of interest in maritime pine and other conifers is also described. Perspectives about the impact of these tools as well as additional research approaches are discussed