27 research outputs found
The Life and Times of Joseph Beuys
- Author
- Armster Sven
- Bewley James
- Caulfield Dawn Marie
- Fabian Roy
- Feder Andrew
- Gizycki Marcin
- Godena Ellen
- King Scott
- Koto Maki
- Lee Ting-Ting
- Lewis Margaret
- Mallozzi Luciana
- McLarney Megan
- Pellicano Christine
- Roe Yvonne
- Saam Matthew
- Smith Leah
- Snyder Mark
- Strandberg Julie
- Taborska Agnieszka
- Warner Catherine
- Whong Shirly
- Wolf Lucinda
- Wolfe Lucinda
- Publication venue
- DigitalCommons@RISD
- Publication date
- 24/02/1994
- Field of study
Program for the seventh annual RISD Cabaret held in the Waterman Building. Graphic design: Mark Snyder; program editor: Margaret Lewis; program photography: Marcin Gizycki.https://digitalcommons.risd.edu/liberalarts_cabaret_programs/1006/thumbnail.jp
The Big Yes and the Little No
- Author
- Abide Adele
- Borchherdt Miriam
- Campbell David L.
- Caulfield Dawn Marie
- Chung Mimi
- Fiss Daniela
- Gonzalez Hector
- Hamazaki Akiko
- Hill Elsie T.
- Jobe Steven L.
- Kreiger Sarah R.
- Lowery Christopher F.
- Mallozzi Luciana L.
- Phillips Paul
- Ramos Ervin
- Sheehan Katherine
- Sterbenz Vanessa
- Taborska Agnieszka
- Tennis Bruce Jason
- Vainius Antanas
- Winter Andrea
- Wollaeger Julie
- Yacobi Ofra
- Yeh Priscilla
- Publication venue
- DigitalCommons@RISD
- Publication date
- 03/03/1993
- Field of study
Program for the sixth annual RISD Cabaret held in the cellar at the top of the Waterman Building. Design and layout by Nonie Close.https://digitalcommons.risd.edu/liberalarts_cabaret_programs/1005/thumbnail.jp
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
- de Geus Eco J C
- Deary Ian J
- Dedoussis George
- Dedoussis George V
- Dedoussis George V Z
- Deelen Joris
- Deelman Ewa
- Dehghan Abbas
- Delgado Graciela
- Deloukas Panagiotis
- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
- Demirkan Ayşe
- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
- Deshmukh Harshal A
- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
- Duncan Emma L
- Dupuis Josee
- Dupuis Josée
- Durbin Richard
- Durda Peter
- Döring Angela
- Dörr Marcus
- Eastell Richard
- Easton Douglas F
- Ebrahim Shah
- Econs Michael J
- Edkins Sarah
- Egan Josephine
- Ehret Georg
- Eiriksdottir Gudny
- Eisman John A
- Eklund Niina
- El Mokhtari NourEddine
- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Endlich Karlhans
- Epstein Stephen E
- Erbel Raimund
- Erdmann Jeanette
- Erdos Michael R
- Eriksson Joel
- Eriksson Johan
- Eriksson Niclas
- Eriksson Per
- Ernst Florian
- Esko Tonu
- Esko Tõnu
- Esko Tönu
- Estrada Karol
- Eury Elodie
- Evangelou Evangelos
- Evans Alun
- Evans David M
- Eyheramendy Susana
- Eyjolfsson Gudmundur Ingi
- Fagerholm Emma
- Falhammar Henrik
- Fall Tove
- Farrall Martin
- Fauser Bart C J M
- Fava Cristiano
- Feenstra Bjarke
- Fehrmann Rudolf
- Feitosa Mary
- Feranil Alan B
- Ferrannini Ele
- Ferrario Marco M
- Ferreira Teresa
- Ferreli Liana
- Ferrières Jean
- Ferrucci Luigi
- Fischer Krista
- Florez Jose C
- Folkersen Lasse
- Folsom Aaron R
- Fontanillas Pierre
- Ford Ian
- Fornage Myriam
- Foroud Tatiana
- Forouhi Nita G
- Forrester Terrence
- Forsblom Carol
- Foster Meredith C
- Fowke Jay
- Fowkes F Gerald R
- Fowkes Gerard R
- Fox Caroline S
- Fox Ervin R
- Franceschini Nora
- Franco Oscar H
- Franco-Cereceda Anders
- Franke Andre
- Franke Lude
- Franks Paul W
- Frants Rune
- Fraser Ross M
- Frayling Timothy M
- Freedman Barry I
- Freimer Nelson B
- Freitag Daniel F
- Friedrich Nele
- Froguel Philippe
- Frost Morten
- Fuchsberger Christian
- Galan Pilar
- Ganesh Santhi K
- Ganna Andrea
- Gansevoort Ron T
- Gao Xiaoyi
- Garcia Melissa
- Garcia-Giralt Natàlia
- Garnaas Maija
- Gasparini Paolo
- Gauguier Dominique
- Gaunt Tom R
- Gautvik Kaare M
- Geller Frank
- Gharavi Ali G
- Giedraitis Vilmantas
- Gieger Christian
- Gierman Hinco J
- Gigante Bruna
- Gill Geoffrey V
- Giroux Sylvie
- Giulianini Franco
- Glass Daniel
- Glazer Nicole
- Glazer Nicole L
- Glenn Kim
- Glorioso Nicola
- Go Alan S
- Go Min Jin
- Godson Catherine
- Goel Anuj
- Goessling Wolfram
- Golay Alain
- Goldstein Benjamin A
- Goltzman David
- Gong Jian
- González-Macías Jesús
- Goodall Alison H
- Goodarzi Mark O
- Goodloe Robert
- Gordin Daniel
- Gordon Scott D
- Gorski Mathias
- Grabe Hans-Jörgen
- Graff Misa
- Grallert Harald
- Grammer Tanja B
- Gravito Martha L
- Greenwood Celia M T
- Grewal Jagvir
- Grimsby Jonna
- Grobbee Diederick E
- Groop Leif
- Groop Per-Henrik
- Gross Myron
- Groves Christopher J
- Grundberg Elin
- Grässler Jürgen
- Gräßler Jürgen
- Gu Harvest F
- Gu Tianwei
- Guarrera Simonetta
- Gudbjartsson Daniel F
- Gudnason Villi
- Gudnason Vilmundur
- Guiducci Candace
- Guo Qun
- Guo Xiuqing
- Gurdasani Deepti
- Gustafsson Stefan
- Gyllensten Ulf
- Gyllensten Ulf B
- Hadjadj Samy
- Hadley David
- Haessler Jeff
- Hager Jörg
- Haiman Christopher
- Haines Jonathan
- Hall Alistair S
- Hall Per
- Hallan Stein
- Haller Toomas
- Hallmans Goran
- Hallmans Göran
- Hamsten Anders
- Han Bok-Ghee
- Hankinson Susan E
- Hanson Robert L
- Hardy Rebecca
- Haritunians Talin
- Harjutsalo Valma
- Harris Tamara
- Hartikainen Anna-Liisa
- Hartman Catharina A
- Hass Merli
- Hassanali Neelam
- Hassinen Maija
- Hastie Nicholas D
- Hastie Nick
- Hattersley Andrew T
- Haun Margot
- Havulinna Aki S
- Hayward Caroline
- Hazen Stanley L
- He Bing
- He Chunyan
- Heard-Costa Nancy L
- Heath Andrew C
- Heath Simon
- Heckbert Susan R
- Hedblad Bo
- Hedman Åsa K
- Heid Iris M
- Heikkilä Kauko
- Heikkilä Outi
- Heiss Gerardo
- Heliövaara Markku
- Helmer Catherine
- Helmer Quinta
- Henders Anjali K
- Henderson Brian
- Hengstenberg Christian
- Henneman Peter
- Hercberg Serge
- Herder Christian
- Hernandez Dena
- Hernandez Dena G
- Herrera Lizbeth
- Herzig Karl-Heinz
- Hicks Andrew A
- Hietala Kustaa
- Higashio Julia
- Hillege Hans L
- Hilton Gina
- Hindorff Lucia
- Hingorani Aroon
- Hirschhorn Joel N
- Hivert Marie-France
- Ho Weang K
- Hocking Lynne J
- Hoffmann Wolfgang
- Hofman Albert
- Holliday Elizabeth G
- Holm Hilma
- Holmen Oddgeir
- Homuth Georg
- Hopewell Jemma C
- Horikoshi Momoko
- Hosseini Mohsen
- Hottenga Jouke-Jan
- Hovingh G Kees
- Howard Philip
- Hsiung Chao Agnes
- Hsu Yi-Hsiang
- Hu Frank B
- Huang Huateng
- Huang Jinyan
- Hui Jennie
- Humphries Steve E
- Hundertmark Claudia
- Hung Yi-Jen
- Hunt Sarah E
- Hunt Steven C
- Hunter David J
- Husted Lise Bjerre
- Hveem Kristian
- Hwang Shih-Jen
- Hyppönen Elina
- Igl Wilmar
- Ikram M Arfan
- Illig Thomas
- Imboden Medea
- Ingelsson Erik
- Ingle Catherine
- Ingvarsson Thorvaldur
- Ioannidis John P A
- Iribarren Carlos
- Isaacs Aaron
- Isakova Tamara
- Islam Muhammad
- Ittermann Till
- Iwai Naoharu
- Jackson Anne U
- Jackson Rebecca
- Jacobs Gunnar
- Jafar Tazeen H
- James Alan L
- Jameson Karen A
- Jang Yangsoo
- Janipalli Charles S
- Jansen Hanneke
- Janssens A Cecile J W
- Jarvelin Marjo-Riitta
- Jeff Janina
- Jenny Nancy
- Johannsdottir Hrefna
- Johansen Berit
- Johansson Ingegerd
- Johansson Åsa
- Johnson Andrew
- Johnson Louise
- Johnson Paul C D
- Johnson Toby
- Jones Graeme
- Jones Michelle R
- Jousilahti Pekka
- Ju Sung Yun
- Jukema J Wouter
- Jula Antti
- Juliusdottir Thorhildur
- Justice Anne E
- Järvelin Marjo-Riitta
- Jöckel Karl-Heinz
- Kaakinen Marika
- Kahali Bratati
- Kalafati Ioanna-Panagiota
- Kaleebu Pontiano
- Kammerer Candace M
- Kanaya Alka
- Kang Hyun M
- Kang Hyun Min
- Kangas Antti J
- Kanoni Stavroula
- Kao Linda
- Kao W H L
- Kao Wen Hong Linda
- Kaplan Robert C
- Kaprio Jaakko
- Kaptoge Stephen K
- Kapur Karen A
- Karasik David
- Kardia Sharon L
- Karjalainen Juha
- Karlsson Magnus
- Karpe Fredrik
- Kastelein John J P
- Kathiresan Sekar
- Katsareli Efi
- Kedenko Lyudmyla
- Kee Frank
- Keildson Sarah
- Keinanen-Kiukaanniemi Sirkka M
- Keller Benjamin J
- Kemp John P
- Kennedy Stephen H
- Kessler Thorsten
- Kestenbaum Bryan
- Kesäniemi Antero
- Ketkar Shamika
- Kettunen Johannes
- Keyzer Jules
- Khaw Kay-Tee
- Khusainova Rita
- Khusnutdinova Elza
- Kiel Douglas P
- Kiess Wieland
- Kilpeläinen Tuomas O
- Kim Eric
- Kim Ghi Su
- Kim Hyo-Soo
- Kim Hyung-Lae
- Kim Stuart K
- Kinnunen Leena
- Kinra Sanjay
- Kiryluk Krzysztof
- Kita Yoshikuni
- Kivimaki Mika
- Kizer Jorge R
- Klaric Irena Martinovic
- Kleber Marcus E
- Klopp Norman
- Kloppenburg Margreet
- Knowles David
- Knowles Joshua W
- Kocarnik Jonathan
- Koenig Wolfgang
- Koh Jung-Min
- Kolcic Ivana
- Koller Daniel L
- Kollerits Barbara
- Kollia Panagoula
- Kolonel Laurence
- Kolovou Genovefa
- Komulainen Pirjo
- Kong Augustine
- Kooner Ishminder K
- Kooner Jaspal
- Kooperberg Charles
- Koromila Theodora
- Koudstaal Peter J
- Kovacs Peter
- Kraft Peter
- Kraja Aldi T
- Kramer Holly
- Kratzer Wolfgang
- Krauss Ronald M
- Krestyaninova Maria
- Kretzler Matthias
- Kristiansson Kati
- Kroemer Heyo K
- Kronenberg Florian
- Kruk Marcin
- Krämer Bernhard K
- Kuh Diana
- Kulkarni Smita R
- Kuller Lew
- Kumar M J Kranthi
- Kumari Meena
- Kung Annie Wai Chee
- Kutalik Zoltan
- Kutalik Zoltán
- Kuulasmaa Kari
- Kuusisto Johanna
- Kuznetsova Tatiana
- Kwan Tony
- Kytö Janne
- Kyvik Kirsten O
- Kähönen Mika
- König Inke R
- Körner Antje
- Köttgen Anna
- Laakso Markku
- Laaksonen Marika
- Laaksonen Reijo
- Laan Maris
- LaCroix Andrea
- Lacroix Andrea Z
- Ladenvall Claes
- Ladouceur Martin
- Lagou Vasiliki
- Lahermo Päivi
- Lahti Jari
- Lai Sandra
- Laisk Triin
- Laitinen Jaana
- Lajer Maria
- Lakatta Edward G
- Lakka Timo A
- Lambert Ann
- Lamina Claudia
- Langdahl Bente Lomholt
- Langefeld Carl D
- Langenberg Claudia
- Langford Cordelia
- Larson Martin
- Larson Martin G
- Lathrop Mark
- Lauc Lovorka Barac
- Launer Lenore
- Laven Joop S E
- Lawlor Debbie A
- Lawrence Robert W
- Le Marchand Loic
- Le Marchand Loïc
- Leak Tennille S
- Leander Karin
- Lecoeur Cecile
- Lee Ji-Young
- Lee Jong-Young
- Lee Nanette R
- Lee Sang Hong
- Lee Seung Hun
- Lefebvre Pierre
- Lehtimäki Terho
- Lehto Markku
- Leo Paul J
- Leslie William D
- Leung Ping C
- Levy Daniel
- Lewis Joshua R
- Li Guo
- Li Man
- Li Rui
- Li Shengxu
- Li Xiaohui
- Li Yali
- Liang Liming
- Lichtner Peter
- Lifton Richard P
- Lim Unhee
- Lin Danyu
- Lin Peng
- Lin Shih-Yi
- Lin Yi
- Lind Lars
- Lindgren Cecilia M
- Lindström Jaana
- Lips Paul
- Liu Ching-Ti
- Liu Jianjun
- Liu Yongmei
- Ljunggren Östen
- Lobbens Stéphane
- Locke Adam E
- Lohman Kurt
- Lohman Kurt K
- Lokki Marja-Liisa
- Longstreth W T
- Loo Britt-Marie
- Loos Ruth J F
- Lopez Lorna M
- Lorenc Roman S
- Lorentzon Mattias
- Louwers Yvonne V
- Lowe Christopher E
- Lu Xiaoning
- Luan Jian'an
- Luben Robert
- Lucas Gavin
- Ludwig Barbara
- Lumley Thomas
- Lundmark Anders
- Lundmark Per
- Lunetta Kathryn L
- Lyssenko Valeriya
- Lyytikainen Leo-Pekka
- Lyytikäinen Leo-Pekka
- Ma Baoshan
- MacCluer Jean
- Macgregor Stuart
- Mach François
- Maerz Winfried
- Maestroni Anna
- Maestroni Silvia
- Magnusson Patrik K E
- Mahajan Anubha
- Malinowski Jennifer
- Mangino Massimo
- Mani K Radha
- Manning Alisa K
- Manolio Teri
- Maouche Seraya
- Marc Janja
- Marette André
- Marmot Michael G
- Marongiu Mara
- Marre Michel
- Martin Finian
- Martin Nicholas G
- Marullo Letizia
- Masciullo Corrado
- Masi Laura
- Mateo Leach Irene
- Matise Tara
- Mattace-Raso Francesco U S
- Matullo Giuseppe
- Maxwell Alexander P
- McArdle Patick F
- McArdle Patrick F
- McArdle Wendy L
- McCarthy Mark I
- McCloskey Eugene
- McKay Gareth J
- McKenzie Colin A
- McKnight Amy J
- McKnight Amy Jayne
- McKnight Barbara
- McPherson Ruth
- Medina-Gomez Carolina
- Medina-Gómez Carolina
- Medland Sarah E
- Meduri Eshwar
- Meigs James B
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Melbye Mads
- Mellström Dan
- Melzer David
- Mencej-Bedrac Simona
- Meneton Pierre
- Menni Cristina
- Merger Sigrun
- Meschia James F
- Metspalu Andres
- Metzger Marie
- Meulenbelt Ingrid
- Mihai Ioana
- Mihailov Evelin
- Miki Tetsuro
- Milaneschi Yuri
- Milani Lili
- Miljkovic Iva
- Mills Rebecca
- Min Josine L
- Minelli Cosetta
- Minster Ryan L
- Mirel Daniel B
- Missmer Stacey A
- Mitchell Braxton D
- Mitchell Paul
- Mitchell Sabrina L
- Moayyeri Alireza
- Moffatt Miriam F
- Mohlke Karen L
- Moilanen Leena
- Monda Keri L
- Monroe Kristine
- Montasser May E
- Montgomery Grant W
- Montgomery Stephen B
- Mooijaart Simon P
- Mooser Vincent
- Mora Samia
- Morken Mario A
- Morris Andrew D
- Morris Andrew P
- Morris Richard W
- Morrison Alanna C
- Mosley Thomas H
- Mota Eugen
- Mota Maria
- Mulas Antonella
- Munroe Patricia
- Murabito Joanne M
- Murdock Deborah
- Murgia Federico
- Murray Anna
- Murray Jeffrey C
- Murray Sarah S
- Musani Solomon
- Musk Arthur W
- Mychaleckyj Josyf C
- Mägi Reedik
- Mäkinen Ville-Petteri
- Männistö Satu
- März Winfried
- Möhlenkamp Stefan
- Möllsten Anna
- Mühleisen Thomas W
- Müller Gabriele
- Müller Gabrielle
- Müller-Nurasyid Martina
- Nagaraja Ramaiah
- Najjar Samer
- Nalls Michael A
- Nandakumar Kannabiran
- Narisu Narisu
- Nato Andrew
- Nauck Matthias
- Navarro Pau
- Navis Gerjan
- Nelis Mari
- Nelson Robert G
- Ness Andrew R
- Nestle Frank O
- Newman Anne B
- Newton-Cheh Christopher
- Nguyen Khanh-Dung Hoang
- Nguyen Tuan V
- Nica Alexandra C
- Nicholson Geoffrey C
- Nicholson George
- Nieminen Markku S
- Nieminen Tuomo V M
- Nikopensius Tiit
- Nikus Kjell
- Nilsson Peter
- Nisbet James
- Njølstad Inger
- Nogues Xavier
- Nolte Ilja M
- North Kari E
- Northstone Kate
- Nsubuga Rebecca N
- Ntzani Evangelia E
- Nuotio Marja-Liisa
- Nyberg Fredrik
- Nyholt Dale R
- Nöthlings Ute
- O'Connell Jeffrey R
- O'Donnell Chris
- O'Rahilly Stephen
- O'Reilly Paul
- O'Reilly Paul F
- O'Seaghdha Conall M
- Obermayer-Pietsch Barbara
- Oei Ling
- Oetjens Matthew
- Ogihara Toshio
- Ohkubo Takayoshi
- Ohlsson Claes
- Okamura Tomonori
- Oksa Heikki
- Olafsson Isleifur
- Oldehinkel Albertine J
- Olden Matthias
- Olmos José M
- Olsson Christian
- Ong Ken K
- Ong Rick Twee-Hee
- Ongen Halit
- Onland-Moret N Charlotte
- Oostra Ben A
- Ordovas Jose M
- Org Elin
- Ormel Johan
- Orru Marco
- Ouwehand Willem H
- Painter Jodie N
- Palmas Walter
- Palmen Jutta
- Palmer Cameron
- Palmer Colin
- Palmer Lyle J
- Palmer Nicholette D
- Palotie Aarno
- Palsson Stefan Th
- Panduru Nicolae Mircea
- Pankow James
- Papamarkou Theodore
- Parish Sarah
- Park Jeong E
- Park Lani
- Parker Alex N
- Parkkonen Maija
- Parsa Afshin
- Parts Leopold
- Parving Hans-Henrik
- Paré Guillaume
- Pasko Dorota
- Pastinen Tomi
- Patel Millan S
- Paterson Andrew D
- Patsy Bruce
- Pattaro Cristian
- Paulweber Bernhard
- Peacock Munro
- Pechlivanis Sonali
- Peden John F
- Pedersen Nancy L
- Peeters Petra H M
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- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
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- A Roynon-Reed
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- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
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- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
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- B Digby
- B Faulkner
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- B Gumbrill
- B Gurung
- B Hadebe
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- Chloe Donohue
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- Danilo Tacconi
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- Debby Bogaert
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- Domenico A Coviello
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- E Fisher
- E Gendall
- E Goff
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- E Gordon
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- E Knights
- E Lee
- E London
- E Maccacari
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- E Meadows
- E Moncur
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- E Peasgood
- E Perkins
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- E Salciute
- E Smith
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- E Stoddard
- E Stones
- E Thomas
- E Tilney
- E Timlick
- E Treus Gude
- E Virgilio
- E Watson
- E Wilby
- Edoardo Conticini
- Egle Saviciute
- Elena Bargagli
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- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Emma C Thomson
- Emmanuelle Marques
- Enrico Martinelli
- Esther Duncan
- Esther Merlini
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- F Anderson
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- F Williams
- Fabio Lena
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- Federico Anedda
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- Ferdinando Giannattasio
- Filip Taneski
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- Francesca Andretta
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- Giuseppe Merla
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- Hanning Mal
- Harrison David
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- Hayward Caroline
- Helen Szoor-McElhinney
- Hinds Charles
- Ho Antonia
- Horby Peter
- I Ali Mohamed Ali
- I Balagosa
- I Birkinshaw
- I Burn
- I Chadbourn
- I D Clement
- I Edmond
- I Frost
- I Hass
- I Hussain
- I Lancoma-Malcolm
- I Leadbitter
- I Nagra
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- Openshaw Peter J M
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- Porteous David J
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- S Srikaran
- S Stone
- S Swann
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- S Turney
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- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- Seán Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
- T Coventry
- T Duncan
- T Felton
- T Geary
- T Hazleton
- T Joefield
- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
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- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
- Author
- Aaron Folsom
- Aaron Isaacs
- Abbas Dehghan
- Adebowale Adeyemo
- Adrienne Tin
- Afshin Parsa
- Aida Karina Dieffenbach
- Alan B. Weder
- Alan B. Zonderman
- Alan F. Wright
- Alan Go
- Alan R. Shuldiner
- Alanna C. Morrison
- Albert Hofman
- Albert V. Smith
- Albert W. Dreisbach
- Alena Stancakova
- Alex N. Parker
- Alexander Teumer
- Alexandre F. R. Stewart
- Alistair Hall
- Amy J. Swift
- Anders Hamsten
- Andre Franke
- Andre G. Uitterlinden
- Andreas Meinitzer
- Andreas Tomaschitz
- Andreas Ziegler
- Andres Metspalu
- Andrew A. Hicks
- Andrew D. Johnson
- Andrew Plump
- Andrew Singleton
- Andrew Taylor
- Andrew Wong
- Angela Doering
- Angelo Scuteri
- Anika Grosshennig
- Anja Medack
- Anke Tonjes
- Anna F. Dominiczak
- Anna Köttgen
- Anna Maria Corsi
- Anna-Liisa Hartikainen
- Anne U. Jackson
- Annette Peters
- Annika Rosengren
- Anthony J. Balmforth
- Antonietta Robino
- Antonio Lupo
- Anuj Goel
- Aravinda Chakravarti
- Arne Schillert
- Arnika K. Wagner
- Aroon D. Hingorani
- Asif Rasheed
- Atsushi Takahashi
- Aude Saint-Pierre
- Audrey Y. Chu
- Augustine Kong
- Augusto D. Pichard
- Ayo Doumatey
- Ayse Demirkan
- Bamidele Tayo
- Barbara Kollerits
- Barbara Ludwig
- Barry I. Freedman
- Belen Ponte
- Ben A. Oostra
- Benedicte Stengel
- Benjamin F. Voight
- Benjamin J. Wright
- Bernhard K. Krämer
- Bernhard O. Böhm
- Bernhard Paulweber
- Bernhard R. Winkelmann
- Bo Hedblad
- Bok-Ghee Han
- Braxton D. Mitchell
- Brenda W. Penninx
- Brendan M. Buckley
- Bruce M. Psaty
- Bruno H. Stricker
- Candace Guiducci
- Carl D. Langefeld
- Carl G. P. Platou
- Carlos Iribarren
- Carmen A. Peralta
- Carole Proust
- Caroline Hayward
- Caroline S. Fox
- Carsten A. Böger
- Catherine Helmer
- Charles N. Rotimi
- Charles S. Janipalli
- Chien-Hsiun Chen
- Chittaranjan S. Yajnik
- Christa Meisinger
- Christian Fuchsberger
- Christian Gieger
- Christian Hengstenberg
- Christian M. Shaffer
- Christian Müller
- Christina Loley
- Christina Willenborg
- Christoph Bickel
- Christoph Sinning
- Christopher J. O’Donnell
- Christopher Newton-Cheh
- Christopher P. Nelson
- Christopher W. Knouff
- Cinzia Sala
- Claire Perret
- Colin A. McKenzie
- Cornelia M. van Duijn
- Cristian Pattaro
- Cristiano Fava
- Cuno S. P. M. Uiterwaal
- D. G. Vinay
- Dabeeru C. Rao
- Daehee Kang
- Dag S. Thelle
- Dan E. Arking
- Daniel Ackermann
- Daniel I. Chasman
- Daniel J. Rader
- Daniel Levy
- Daniel Shriner
- Daniel Taliun
- Daniela Ruggiero
- Daniela Toniolo
- Daniele Cusi
- Danish Saleheen
- Darina Czamara
- David Altshuler
- David Couper
- David Ellinghaus
- David Hadley
- David P. Strachan
- David S. Siscovick
- Dawn M. Waterworth
- Debbie A. Lawlor
- Dena Hernandez
- Devin Absher
- Diana Kuh
- Diana Zelenika
- Diederick E. Grobbee
- Dongfeng Gu
- Donna K. Arnett
- Dorairajan Prabhakaran
- Douglas Ruderfer
- E-Shyong Tai
- Edward G. Lakatta
- Elena Rochtchina
- Elin Org
- Elizabeth G. Holliday
- Elizabeth J. Atkinson
- Emelia Benjamin
- Eran Halperin
- Eric Boerwinkle
- Eric J. G. Sijbrands
- Erik Ingelsson
- Erika Salvi
- Erkki Vartiainen
- Ervin R. Fox
- Erwin P. Bottinger
- Eva Albrecht
- Eva Brand
- Ewa Zukowska-Szczechowska
- F. Gerald R. Fowkes
- Fadi J. Charchar
- Federico Murgia
- Feng Zhang
- Fernando Rivadeneira
- Florian Ernst
- Florian Kronenberg
- Francesco U. S. Mattace-Raso
- Francis S. Collins
- Francois Cambien
- Frank B. Hu
- Fredrik Nyberg
- Fulvio Ricceri
- Fumihiko Takeuchi
- Fuu-Jen Tsai
- Gang Shi
- Gary C. Curhan
- Gary F. Mitchell
- Gavin Lucas
- Georg Homuth
- George A. Wells
- George B. Ehret
- George Davey Smith
- Gerjan J. Navis
- Germaine C. Verwoert
- Gian-Andri Thun
- Gina Hilton
- Giorgio Pistis
- Giovanni Gambaro
- Giovanni Malerba
- Giriraj R. Chandak
- Giuseppe Matullo
- Goncalo R. Abecasis
- Grant W. Montgomery
- Guangju Zhai
- Gudmar Thorleifsson
- Gudmundur Thorgeirsson
- Gudny Eiriksdottir
- Gudrun Veldre
- Gunnar Jacobs
- Guo Li
- H-Erich Wichmann
- Haidong Zhu
- Hakon H. Hakonarson
- Halit Ongen
- Hans J. Rupprecht
- Hao Mei
- Harald Dobnig
- Harald Grallert
- Harold Snieder
- Harry Campbell
- Heather M. Stringham
- Helena Schmidt
- Henri Wallaschofski
- Henry Völzke
- Heribert Schunkert
- Hermann Brenner
- Heyo K. Kroemer
- Hilma Holm
- Hirotsugu Ueshima
- Holly Kramer
- Honghuang Lin
- Hua Tang
- Hubert Scharnagl
- Hugh Watkins
- Hyung-Lae Kim
- I. Mateo Leach
- Ian Ford
- Ian H. de Boer
- Ian N. M. Day
- Ida Yii-Der Chen
- Idris Guessous
- Iftikhar Kullo
- Igor Rudan
- Ilja M. Nolte
- Ines Barroso
- Inga Prokopenko
- Ingrid Borecki
- Inke R. König
- Ioanna Tzoulaki
- Iris M. Heid
- Ivana Kolcic
- Ivana Persico
- J. H. Young
- J. Wouter Jukema
- Jaakko Tuomilehto
- Jaana Laitinen
- Jaap W. Deckers
- Jackie A. Cooper
- Jacqueline C. M. Witteman
- Jacques S. Beckmann
- James E. Hixson
- James F. Meschia
- James F. Wilson
- James Scott
- James T. Willerson
- Jan A. Staessen
- Jan Stritzke
- Janine F. Felix
- Janja Nahrstedt
- Janos Terzic
- Jasmin Divers
- Jaspal S. Kooner
- Jayashri Aragam
- Jean-Charles Lambert
- Jean-Michel Gaspoz
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- Jeanette M. Stafford
- Jeffrey R. Gulcher
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- Jemma C. Hopewell
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- Jennifer L. Bragg-Gresham
- Jer-Yuarn Wu
- Jerome I. Rotter
- Jessica D. Faul
- Jiang He
- Jianjun Liu
- Jian’an Luan
- Jie Jin Wang
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- Jingzhong Ding
- Joanne Murabito
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- Joe Devaney
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- John F. Peden
- John M. Connell
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- Jong-Young Lee
- Jorma Viikari
- Josef Coresh
- Joseph M. Lindsay
- Joshua C. Bis
- Joshua C. Denny
- Joshua Knowles
- Juan P. Casas
- Judith A Hoffman Bolton
- Juha Karjalainen
- Jutta Palmen
- Jyotika K. Fernandes
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- Kari Stefansson
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- Kazuhiko Yamamoto
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- Kerri L. Wiggins
- Khanh-Dung Hoang Nguyen
- Kiran Musunuru
- Klaus Stark
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- Li Chen
- Li-Ching Chang
- Liming Qu
- Linda S. Adair
- Loic Yengo
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- Louise V. Wain
- Lowell Satler
- Lude Franke
- Luigi Ferrucci
- Lyle J. Palmer
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- Rainer Rettig
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- Thomas Quertermous
- Thor Aspelund
- Thorsten Reffelmann
- Tien-Yin Wong
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- Timothy M. Frayling
- Tin Aung
- Toby Johnson
- Tom R. Gaunt
- Tomohiro Katsuya
- Tomonori Okamura
- Tonu Esko
- Toshihiro Tanaka
- Toshiko Tanaka
- Toshio Ogihara
- Tunde Salako
- Tune H. Pers
- Ulf Gyllensten
- Unnur Thorsteinsdottir
- Uwe Völker
- Valur Emilsson
- Vasyl Pihur
- Veikko Salomaa
- Veronique Vitart
- Vikal Tripathy
- Ville Aalto
- Vilmundur Gudnason
- Vincent Chouraki
- Vincent Mooser
- Viviane Nicaud
- Vladan Mijatovic
- W. H. Linda Kao
- Walter Palmas
- Wayne D. Rosamond
- Wei-Min Chen
- Weihua Zhang
- Wendy L. McArdle
- Wiek H. van Gilst
- Wilfried Renner
- Will T. Longstreth
- William Matthai
- Wilmar Igl
- Winfried März
- Wolfgang Koenig
- Wolfgang Lieb
- Wolfram Goessling
- Xiaofeng Zhu
- Xiaoling Wang
- Xiuqing Guo
- Xueling Sim
- Yali Li
- Yan V. Sun
- Yanbin Dong
- Yasuharu Tabara
- Yen-Pei C. Chang
- Yi-An Ko
- Yik-Ying Teo
- Ying A. Wang
- Ying Wu
- Yingchang Lu
- Yong Li
- Yongmei Liu
- Yoon Shin Cho
- Yoshikuni Kita
- Young Jin Kim
- Yuan-Tsong Chen
- Yukinori Okada
- Yuri Milaneschi
- Yurii Aulchenko
- Yusuke Nakamura
- Yvonne T. van der Schouw
- Zouhair Aherrahrou
- Åsa Johansson
- Publication venue
- Springer Nature America, Inc
- Publication date
- 27/10/2015
- Field of study
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways
stairs and fire
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adair Antony
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Arora Sanjay
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Banzuzi Kukka
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Barth Christian
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
- Bauer Gerry
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baur Ulrich
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Bedjidian Marc
- Beernaert Kelly
- Behrenhoff Wolf
- Behrens Ulf
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W.
- Bellan Paolo
- Bellan Riccardo
- Bellinger James Nugent
- Belotelov Ivan
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Bergholz Matthias
- Beri Suman Bala
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- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
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- Berryhill Jeffrey
- Bertl Willi
- Berzano Umberto
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- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Beuselinck Raymond
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
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- Bornheim Adolf
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- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Bostock Francis
- Botta Cristina
- Boudoul Gaelle
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- Boumediene Djamel
- Bourilkov Dimitri
- Boutemeur Madjid
- Boutle Sarah
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G.
- Breedon Richard
- Breto Guillermo
- Breuker Horst
- Brew Christopher
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Broutin Clementine
- Brown Robert M.
- Brownson Eric
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- Chao Yuan
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan Serguei
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- Chen He-Sheng
- Chen Jie
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- Chen Kuan-Hsin
- Chen Mingshui
- Chen Yi
- Chen Zhiling
- Cherepanov Vladimir
- Chertok Maxwell
- Chetluru Vasundhara
- Cheung Harry
- Chhibra Simranjit Singh
- Chierici Roberto
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Cho Yongjin
- Choi Minkyoo
- Choi Suyong
- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C.
- Choudhury Rajani Kant
- Choudhury Somnath
- Christiansen Tim
- Chuang Shan-Huei
- Chung Jin Hyuk
- Chung Yeon Sei
- Chwalek Thorsten
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Cirino Guy
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R.
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- Cline David
- CMS Collaboration
- Coarasa Perez Jose Antonio
- Cockerill David J. A.
- Codispoti Giuseppe
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- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Conetti Sergio
- Contardo Didier
- Conte Eric
- Contreras-Campana Christian
- Contreras-Campana Emmanuel
- Conway John
- Conway Rylan
- Cooper Seth
- Cooper William
- Cornelis Tom
- Correa Martins Junior Marcos
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costantini Silvia
- Coughlan John A.
- Cousins Robert
- Covarelli Roberto
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremaldi Lucien Marcus
- Cripps Nicholas
- Cuevas Javier
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- Cussans David
- Custódio Analu
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- Cutts David
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- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Enterria David
- D'Hondt Jorgen
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- Daci Nadir
- Dahmes Bryan
- Dahms Torsten
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- Damgov Jordan
- Dammann Dirk
- Danielson Thomas
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Daubie Evelyne
- Dauncey Paul
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- Davids Martina
- Davies Gavin
- De Almeida Dias Flavia
- de Barbaro Pawel
- De Benedetti Abraham
- De Boer Wim
- De Cosa Annapaola
- De Favereau De Jeneret Jerome
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F.
- De Visscher Simon
- De Wolf Eddi A.
- Deisher Amanda
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delgado Peris Antonio
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- Dell'Orso Roberto
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- Demaria Natale
- Demina Regina
- Demortier Luc
- Denegri Daniel
- Deniz Muhammed
- Depasse Pierre
- Dermenev Alexander
- Dero Vincent
- Dhingra Nitish
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- Di Guida Salvatore
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- Di Matteo Leonardo
- Diamond Brendan
- Diemoz Marcella
- Dierlamm Alexander
- Dietz Charles
- Dietz-Laursonn Erik
- Diez Pardos Carmen
- Dimitrov Anton
- Dinardo Mauro Emanuele
- Dirkes Guido
- Dissertori Günther
- Dittmar Michael
- Djordjevic Milos
- Dobrzynski Ludwik
- Dobson Marc
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- Pieta Holger
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- Wang Zheng
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- Wardrope David
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- Wood Jeffrey Scott
- Wood John
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- Wrochna Grzegorz
- Wu Weimin
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- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xie Si
- Xu Ming
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- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yildirim Eda
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zotto Pierluigi
- Zou Wei
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Recommended from our members
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
- Author
- Abecasis Goncalo
- Alam Dewan S
- Alfred Tamuno
- Allison Matthew
- Amouyel Philippe
- Arzumanyan Zorayr
- Auer Paul L
- Balkau Beverley
- Bastarache Lisa
- Bergmann Sven
- Bielak Lawrence F
- Blüher Matthias
- Boehnke Michael
- Boeing Heiner
- Boerwinkle Eric
- Borecki Ingrid B
- Bork-Jensen Jette
- Bottinger Erwin P
- Bowden Donald W
- Brandslund Ivan
- Broer Linda
- Burt Amber A
- Butterworth Adam
- Böger Carsten A
- Caulfield Mark J
- Cesana Giancarlo
- Chambers John C
- Chasman Daniel I
- CHD Exome+ Consortium
- Chen Yii-Der Ida
- Chowdhury Rajiv
- Christensen Cramer
- Chu Audrey Y
- Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium
- Collins Francis S
- Cook James P
- Cox Amanda J
- Crosslin David S
- Cupples L Adrienne
- Danesh John
- de Bakker Paul IW
- Dedoussis George
- Deloukas Panos
- Demerath Ellen W
- Dennis Joe
- Denny Josh C
- Denus Simon de
- Di Angelantonio Emanuele
- Drenos Fotios
- Dubé Marie-Pierre
- Dunning Alison
- Dörr Marcus
- Easton Douglas
- Elliott Paul
- EPIC-CVD Consortium
- Esko Tõnu
- Evangelou Evangelos
- Ewing Ailith
- ExomeBP Consortium
- Farmaki Aliki-Eleni
- Feitosa Mary F
- Feng Shuang
- Ferrannini Ele
- Ferrieres Jean
- Fine Rebecca S
- Florez Jose C
- Fornage Myriam
- Fox Caroline S
- Franks Paul W
- Frayling Timothy M
- Friedrich Nele
- Gan Wei
- Gandin Ilaria
- Gasparini Paolo
- Giedraitis Vilmantas
- Giri Ayush
- Girotto Giorgia
- Global Lipids Genetic Consortium
- Gorski Mathias
- GoT2D Genes Consortium
- Graff Mariaelisa
- Grallert Harald
- Grarup Niels
- Grove Megan L
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeff
- Hansen Torben
- Hattersley Andrew T
- Hayward Caroline
- Heard-Costa Nancy L
- Heid Iris M
- Highland Heather M
- Hirschhorn Joel N
- Holmen Oddgeir L
- Hovingh G Kees
- Howson Joanna
- Hu Yao
- Hung Yi-Jen
- Hveem Kristian
- Ikram M Arfan
- Ingelsson Erik
- InterAct
- Jackson Anne U
- Jarvik Gail P
- Jia Yucheng
- Jousilahti Pekka
- Justesen Johanne M
- Justice Anne E
- Jørgensen Torben
- Kahali Bratati
- Karaderi Tugce
- Karaleftheri Maria
- Kardia Sharon LR
- Karpe Fredrik
- Kee Frank
- Kitajima Hidetoshi
- Komulainen Pirjo
- Kooner Jaspal S
- Kovacs Peter
- Krämer Bernhard K
- Kutalik Zoltán
- Kuulasmaa Kari
- Kuusisto Johanna
- Laakso Markku
- Lakka Timo A
- Lamparter David
- Lange Leslie A
- Langenberg Claudia
- Larson Eric B
- Lee Nanette R
- Lee Wen-Jane
- Lehtimäki Terho
- Lempradl Adelheid
- Lettre Guillaume
- Lewis Cora E
- Li Huaixing
- Li Jin
- Li-Gao Ruifang
- Lin Li-An
- Lin Xu
- Lind Lars
- Lindgren Cecilia M
- Lindström Jaana
- Linneberg Allan
- Liu Ching-Ti
- Liu Dajiang J
- Lo Ken Sin
- Locke Adam E
- Loos Ruth JF
- Lu Yingchang
- Luan Jian'an
- Lyytikäinen Leo-Pekka
- MacGregor Stuart
- MAGIC Investigators
- Mahajan Anubha
- Manning Alisa K
- Marenne Gaëlle
- Marouli Eirini
- Marten Jonathan
- Masca Nicholas GD
- McCarthy Mark I
- Medina-Gomez Carolina
- Meidtner Karina
- Mihailov Evelin
- Mohlke Karen L
- Moilanen Leena
- Moitry Marie
- Mook-Kanamori Dennis O
- Morgan Anna
- Morris Andrew P
- Mudgal Poorva
- Munroe Patricia B
- Mutsert Renée de
- Mägi Reedik
- Männistö Satu
- Müller-Nurasyid Martina
- Narisu Narisu
- Nelson Christopher P
- Neville Matt
- Ng Maggie CY
- North Kari E
- Ntalla Ioanna
- O'Connell Jeffrey R
- Owen Katharine R
- Pedersen Oluf
- Peloso Gina M
- Pennell Craig E
- Perola Markus
- Perry James A
- Perry John
- Pers Tune H
- Polasek Ozren
- Pospisilik J Andrew
- Raitakari Olli T
- Rasheed Asif
- Raulerson Chelsea K
- Rauramaa Rainer
- Reilly Dermot F
- Reiner Alex P
- ReproGen Consortium
- Ridker Paul M
- Rivadeneira Fernando
- Rivas Manuel A
- Robertson Neil R
- Robino Antonietta
- Rotter Jerome I
- Rudan Igor
- Ruth Katherine S
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J
- Schreiner Pamela J
- Schulze Matthias B
- Schurmann Claudia
- Scott Robert A
- Segura-Lepe Marcelo
- Sim Xueling
- Sivapalaratnam Suthesh
- Slater Andrew J
- Small Kerrin S
- Smith Blair H
- Smith Jennifer A
- Southam Lorraine
- Spector Timothy D
- Speliotes Elizabeth K
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stirrups Kathleen
- Strauch Konstantin
- Stringham Heather M
- Stumvoll Michael
- Sun Liang
- Surendran Praveen
- Swart Karin MA
- T2D-Genes Consortium
- Tardif Jean-Claude
- Taylor Kent D
- Teumer Alexander
- Thompson Deborah
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Thuesen Betina H
- Torres Mina
- Tsafantakis Emmanouil
- Tuomilehto Jaakko
- Turcot Valérie
- Tönjes Anke
- Uitterlinden André G
- Uusitupa Matti
- van Duijn Cornelia M
- Vanhala Mauno
- Varma Rohit
- Vedantam Sailaja
- Vermeulen Sita H
- Vestergaard Henrik
- Vitart Veronique
- Vogt Thomas F
- Vuckovic Dragana
- Wagenknecht Lynne E
- Walker Mark
- Wallentin Lars
- Wang Carol A
- Wang Feijie
- Wang Shuai
- Wareham Nicholas
- Warren Helen R
- Waterworth Dawn M
- Wessel Jennifer
- White Harvey D
- Willems Sara M
- Willer Cristen J
- Wilson James G
- Winkler Thomas W
- Wood Andrew R
- Wu Ying
- Yaghootkar Hanieh
- Yao Jie
- Yerges-Armstrong Laura M
- Young Kristin L
- Young Robin
- Zeggini Eleftheria
- Zhan Xiaowei
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng He
- Zhou Wei
- Zillikens M Carola
- Publication venue
- Nat Genet
- Publication date
- 01/03/2019
- Field of study
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF <5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants
Search for narrow resonances using the dijet mass spectrum in pp collisions at s√=8 TeV
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Alimena Juliette
- Almeida Nuno
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Asin Ivan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Auffray Etiennette
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- Smirnov Vitaly
- Smith Geoffrey
- Smith James
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- Smith Wesley H
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- Tonelli Manganote Edmilson José
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- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Yücel Mete
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zarubin Anatoli
- Zeinali Maryam
- Zeise Manuel
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zielinski Marek
- Zito Giuseppe
- Zotto Pierluigi
- Zou Wei
- Zsigmond Anna Julia
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2013
- Field of study
Results are presented of a search for the production of new particles decaying to pairs of partons (quarks, antiquarks, or gluons), in the dijet mass spectrum in proton-proton collisions at s√=8 TeV. The data sample corresponds to an integrated luminosity of 4.0 fb−1, collected with the CMS detector at the LHC in 2012. No significant evidence for narrow resonance production is observed. Upper limits are set at the 95% confidence level on the production cross section of hypothetical new particles decaying to quark-quark, quark-gluon, or gluon-gluon final states. These limits are then translated into lower limits on the masses of new resonances in specific scenarios of physics beyond the standard model. The limits reach up to 4.8 TeV, depending on the model, and extend previous exclusions from similar searches performed at lower collision energies. For the first time mass limits are set for the Randall–Sundrum graviton model in the dijet channel
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body fat distribution
- Author
- Abecasis Goncalo
- Abecasis Goncalo
- Abecasis Goncalo
- Alam Dewan S.
- Alfred Tamuno
- Allison Matthew
- Amouyel Philippe
- Arzumanyanm Zorayr
- Auer Paul L.
- Balkau Beverley
- Bastarache Lisa
- Bergmann Sven
- Bielak Lawrence F.
- Blueher Matthias
- Boeger Carsten A.
- Boehnke Michael
- Boehnke Michael
- Boehnke Michael
- Boehnke Michael
- Boeing Heiner
- Boerwinkle Eric
- Boerwinkle Eric
- Borecki Ingrid B.
- Borecki Ingrid B.
- Bork-Jensen Jette
- Bottinger Erwin P.
- Bowden Donald W.
- Bowden Donald W.
- Brandslund Ivan
- Broer Linda
- Burt Amber A.
- Butterworth Adam S.
- Caulfield Mark J.
- Caulfield Markj
- Cesana Giancarlo
- Chambers John C.
- Chambers John C.
- Chambers John C.
- Chasman Daniel, I
- Chen Yii-Der Ida
- Chowdhury Rajiv
- Christensen Cramer
- Chu Audreyy
- Collins Francis S.
- Collins Francis S.
- Cook James P.
- Cook James P.
- Cox Amanda J.
- Crosslin David S.
- Cupples L. Adrienne
- Cupples L. Adrienne
- Danesh John
- Danesh John
- Danesh John
- de Bakker Paul I. W.
- De Bakker Paul Iw
- de Denus Simon
- de Mutsert Renee
- Dedoussis George
- Deloukas Panos
- Demerath Ellen W.
- Dennis Joe G.
- Denny Josh C.
- Di Angelantonio Emanuele
- Doerr Marcus
- Drenos Fotios
- Dube Marie-Pierre
- Dunning Alison M.
- Easton Douglas F.
- Elliott Paul
- Elliott Paul
- Esko Tnu
- Esko Tonu
- Evangelou Evangelos
- Evangelou Evangelos
- Ewing Ailith
- Farmaki Aliki-Eleni
- Farmaki Aliki-Eleni
- Feitosa Mary F.
- Feng Shuang
- Ferrannini Ele
- Ferrieres Jean
- Fine Rebecca S.
- Florez Jose C.
- Florez Jose C.
- Florez Jose C.
- Fornage Myriam
- Fornage Myriam
- Fox Caroline S.
- Franks Paul W.
- Franks Paul W.
- Frayling Timothy M.
- Frayling Timothy M.
- Frayling Timothy M.
- Friedrich Nele
- Gan Wei
- Gandin Ilaria
- Gasparini Paolo
- Giedraitis Vilmantas
- Giri Ayush
- Girotto Giorgia
- Gorski Mathias
- Graff Mariaelisa
- Graff Mariaelisa
- Grallert Harald
- Grarup Niels
- Grove Megan L.
- Groves Megan L.
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeff
- Hansen Torben
- Hattersley Andrew T.
- Hattersley Andrew T.
- Hayward Caroline
- Hayward Caroline
- Heard-Costa Nancy L.
- Heard-Costa Nancy L.
- Heid Iris M.
- Highland Heather M.
- Highland Heather M.
- Highland Heather M.
- Hirschhorn Joel N.
- Holmen Oddgeir L.
- Hovingh G. Kees
- Howson Joanna M. M.
- Hu Yao
- Hung Yi-Jen
- Hveem Kristian
- Hveem Kristian
- Ikram M. Arfan
- Ikram M. Arfan
- Ingelsson Erik
- Ingelsson Erik
- Jackson Anne U.
- Jackson Anne U.
- James A.
- Jarvik Gail P.
- Jia Yucheng
- Jorgensen Torben
- Jousilahti Pekka
- Justesen Johanne M.
- Justice Anne E.
- Justice Anne E.
- Kahali Bratati
- Karaderi Tugce
- Karaleftheri Maria
- Kardia Sharon L. R.
- Karpe Fredrik
- Karpe Fredrik
- Kee Frank
- Kitajima Hidetoshi
- Komulainen Pirjo
- Kooner Jaspal S.
- Kooner Jaspal S.
- Kooner Jaspal S.
- Kovacs Peter
- Kraemer Bernhard K.
- Kutalik Zoltan
- Kuulasmaa Kari
- Kuusisto Johanna
- La Nge Leslie A.
- Laakso Markku
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- Langenberg Claudia
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- Lehtimaeki Terho
- Lempradl Adelheid
- Lettre Guillaume
- Lewis Cora E.
- Li Huaixing
- Li Jin
- Lin Li-An
- Lin Xu
- Lind Lars
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- Lindstroem Jaana
- Linneberg Allan
- Liu Ching-Ti
- Liu Ching-Ti
- Liu Dajiang J.
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- Lu Yingchang
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- Luan Jianan
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- MacGregor Stuart
- Magi Reedik
- Mahajan Anubha
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- Manning Alisa K.
- Mannisto Satu
- Marenne Gaelle
- Marouli Eirini
- Marten Jonathan
- Marten Jonathan
- Masca Nicholas G. D.
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- McCarthy Mark, I
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- McCarthy Mark, I
- Medina-Gomez Carolina
- Meidtner Karina
- Mihailov Evelin
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- Ntalla Ioanna
- O'Connell Jeffrey R.
- Owen Katharine R.
- Pedersen Oluf
- Peloso Gina M.
- Pennell Craig E.
- Perola Markus
- Perry John R. B.
- Pers Tune H.
- Polasek Ozren
- Polasek Ozren
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- Raitakari Olli T.
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- Robino Antonietta
- Rotter Jerome, I
- Rudan Igor
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- RuifangLi-Gao
- Ruth Katherine S.
- Saleheen Danish
- Salomaa Veikko
- Salomaa Veikko
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- Schulze Matthias B.
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- Scott Robert A.
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- Sim Xueling
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- Sim Xueling
- Sivapalaratnam Suthesh
- Slater Andrew J.
- Small Kerrin S.
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- Smith Blair H.
- Smith Jennifer A.
- Southam Lorraine
- Spector Timothy D.
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- Spector Timothy D.
- Speliotes Elizabeth K.
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stirrups Kathleen E.
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- Strauch Konstantin
- Stringham Heather M.
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- Stumvoll Michael
- Sun Liang
- Surendran Praveen
- Surendran Praveen
- Surendran Praveen
- Swart Karin M. A.
- Tardif Jean-Claude
- Taylor Kent D.
- Teumer Alexander
- Thompson Deborah J.
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Thuesen Betina H.
- Toenjes Anke
- Torres Mina
- Tsafantakis Emmanouil
- Tuomilehto Jaakko
- Tuomilehto Jaakko
- Tuomilehto Jaakko
- Turcot Valerie
- Uitterlinden Andr G.
- Uitterlinden Andre G.
- Uusitupa Matti
- van Duijn Cornelia M.
- Vanhala Mauno
- Varma Rohit
- Vedantam Sailaja
- Verges-Armstrong Laura M.
- Vermeulen Sita H.
- Vestergaard Henrik
- Vitart Veronique
- Vogt Thomas F.
- Vuckovic Dragana
- Wagenknecht Lynne E.
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- Wallentin Lars
- Wang Carol A.
- Wang Feijie
- Wang Shuai
- Wareham N. Icholas J.
- Wareham Nicholas J.
- Warren Helen R.
- Warren Helen R.
- Waterworth Dawn M.
- Wessel Jennifer
- White Harvey D.
- Willems Sara M.
- Willems Sara M.
- Willems Sara M.
- Willer Cristen J.
- Willer Cristen J.
- Willer Cristen J.
- Wilson James G.
- Wilson James G.
- Wilson James G.
- Winkler Thomas W.
- Wood Andrew R.
- Wu Ying
- Yaghootkar Hanieh
- Yaghootkar Hanieh
- Yao Jie
- Young Kristin L.
- Young Kristin L.
- Young Robin
- Young Robin
- Young Robin
- Zeggini Eleftheria
- Zeggini Eleftheria
- Zeggini Eleftheria
- Zhan Xiaowei
- Zhang Weihua
- Zhang Weihua
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng He
- Zhou Wei
- Zillikens M. Carola
- Zillikens M. Carola
- Publication venue
- Publication date
- 17/12/2018
- Field of study
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF <5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants
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HNRNPC haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder
- Author
- Acosta Maria T.
- Adams David R.
- Admard Jakob
- Afzali Ben
- Allworth Aimee
- Alvarez Raquel L.
- Alvey Justin
- Ambrose J.C.
- Andrews Ashley
- Arumugam P.
- Ashley Euan A.
- Bacino Carlos A.
- Bademci Guney
- Bain Jennifer
- Balasubramanian Meena
- Balasubramanyam Ashok
- Baldridge Dustin
- Bale Jim
- Bamshad Michael
- Banka Siddharth
- Barbouth Deborah
- Bayrak-Toydemir Pinar
- Beck Anita
- Beggs Alan H.
- Behrens Edward
- Bejerano Gill
- Bellen Hugo J.
- Benke Paul J.
- Bennet Jimmy
- Bernstein Jonathan A.
- Berry Gerard T.
- Bertrand Miriam
- Bevers R.
- Bican Anna
- Bivona Stephanie
- Bleda M.
- Blesson Alyssa E.
- Blue Elizabeth
- Boardman-Pretty F.
- Bohnsack John
- Bonner Devon
- Botto Lorenzo
- Bouman Arjan
- Boustred C.R.
- Briere Lauren C.
- Briere Lauren C.
- Brittain H.
- Brown Gabrielle
- Brown M.A.
- Burke Elizabeth A.
- Burrage Lindsay C.
- Butte Manish J.
- Byers Peter
- Byrd William E.
- Carey John
- Carrasquillo Olveen
- Cassini Thomas
- Caulfield M.J.
- Chan G.C.
- Chang Ta Chen
- Chanprasert Sirisak
- Chao Hsiao-Tuan
- Chinn Ivan
- Clark Gary D.
- Clayton-Smith Jill
- Coakley Terra R.
- Cobban Laurel A.
- Cogan Joy D.
- Coggins Matthew
- Cole F. Sessions
- Colley Heather A.
- Cope Heidi
- Corona Rosario
- Craigen William J.
- Crouse Andrew B.
- Cunningham Michael
- D'Souza Precilla
- Dai Hongzheng
- Dasari Surendra
- Davis Joie
- Dayal Jyoti G.
- Delgado Margaret
- Dell'Angelica Esteban C.
- Dipple Katrina
- Doherty Daniel
- Dorrani Naghmeh
- Doss Argenia L.
- Douine Emilie D.
- Earl Dawn
- Eckstein David J.
- Elgersma Minetta
- Elgersma Ype
- Ellingford Jamie M.
- Emrick Lisa T.
- Eng Christine M.
- Falk Marni
- Fieg Elizabeth L.
- Fisher Paul G.
- Fogel Brent L.
- Forghani Irman
- Fu Jiayu
- Gahl William A.
- Genomics England Research Consortium
- Giess A.
- Gillentine Madelyn A.
- Glass Ian
- Goddard Page C.
- Godfrey Rena A.
- Goodloe Dana H.
- Grajewski Alana
- Griffin J.N.
- Haack Tobias B.
- Halley Meghan C.
- Hamblin A.
- Hamid Rizwan
- Hanchard Neal
- Harris-Mostert Emilio D.R.O.
- Hassey Kelly
- Hayes Nichole
- Henderson S.
- High Frances
- Hing Anne
- Hisama Fuki M.
- Holm Ingrid A.
- Hom Jason
- Hoogenboezem Remco M.
- Horike-Pyne Martha
- Huang Alden
- Huang Yan
- Hubbard T.J.P.
- Hutchison Sarah
- Introne Wendy
- Isasi Rosario
- Izumi Kosuke
- Jackson R.
- Jain Mahim
- Jarvik Gail P.
- Jarvik Jeffrey
- Jayadev Suman
- Jean-Marie Orpa
- Jobanputra Vaidehi
- Jones L.J.
- Kaitryn Emerald
- Kasperaviciute D.
- Kayikci M.
- Ketkar Shamika
- Kiley Dana
- Kilich Gonench
- Kobren Shilpa N.
- Kohane Isaac S.
- Kohler Jennefer N.
- Korrick Susan
- Kousathanas A.
- Krakow Deborah
- Krantz Ian
- Krasnewich Donna M.
- Kravets Elijah
- Lahnstein L.
- Lakey A.
- Lalani Seema R.
- Lam Byron
- Lam Christina
- Lanpher Brendan C.
- Lanza Ian R.
- LeBlanc Kimberly
- Lee Brendan H.
- Leigh S.E.A.
- Leong I.U.S.
- Levitt Roy
- Lewis Richard A.
- Liu Pengfei
- Liu Xue Zhong
- Longo Nicola
- Loo Sandra K.
- Lopez F.J.
- Loscalzo Joseph
- Luu Sharon M.
- Maas Richard L.
- Macnamara Ellen F.
- MacRae Calum A.
- Maduro Valerie V.
- Maghiro AudreyStephannie
- Mahoney Rachel
- Maleady-Crowe F.
- Malicdan May Christine
- Mamounas Laura A.
- Manolio Teri A.
- Mao Rong
- Marom Ronit
- Marth Gabor
- Martin Beth A.
- Martin Martin G.
- Martínez-Agosto Julian A.
- Marwaha Shruti
- McCauley Jacob
- McConkie-Rosell Allyn
- McCray Alexa T.
- McEntagart M.
- McGee Elisabeth
- McPheron Molly
- Might Matthew
- Miller Danny
- Minneci F.
- Mirzaa Ghayda
- Mitchell J.
- Morava Eva
- Moretti Paolo
- Morimoto Marie
- Moutsianas L.
- Mueller M.
- Mulvihill John J.
- Murugaesu N.
- Muss Candace L.
- Nakano-Okuno Mariko
- Need A.C.
- Nelson Stanley F.
- Nieves-Rodriguez Shirley
- Niggl Eva
- Novacic Donna
- Odhams C.A.
- Oglesbee Devin
- Orengo James P.
- O‘Donovan P.
- Pace Laura
- Pak Stephen
- Pallais J. Carl
- Papp Jeanette C.
- Park Joohyun
- Parker Neil H.
- Patch C.
- Pereira M.B.
- Perez-Gil D.
- Petcharet Leoyklang
- Phillips John A.
- Posey Jennifer E.
- Potocki Lorraine
- Pullinger J.
- Quinlan Aaron
- Rahim T.
- Raible Sarah E.
- Rao Deepak A.
- Raper Anna
- Raskind Wendy
- Rendon A.
- Renteria Genecee
- Reuter Chloe
- Rives Lynette
- Robertson Amy K.
- Robin Nathaniel H.
- Rodan Lance H.
- Rogers T.
- Rosenfeld Jill A.
- Rosenthal Elizabeth
- Rossignol Francis
- Ruzhnikov Maura
- Sabaii Marla
- Sacco Ralph
- Sampson Jacinda B.
- Saporta Mario
- Savage K.
- Sawant K.
- Schaechter Judy
- Schedl Timothy
- Schoch Kelly
- Scott Daryl A.
- Scott R.H.
- Seto Elaine
- Sharma Prashant
- Shashi Vandana
- Shelkowitz Emily
- Sheppeard Sam
- Shin Jimann
- Siddiq A.
- Sieghart A.
- Silverman Edwin
- Sinsheimer Janet
- Sisco Kathy
- Smith Edward
- Smith Kevin
- Smith S.C.
- Solnica-Krezel Lilianna
- Solomon Ben
- Sosinsky A.
- Spiller Michael
- Spillmann Rebecca
- Starling Susan
- Stergachis Andrew
- Stoler Joan
- Stuckey A.
- Sullivan Jennifer
- Sullivan Kathleen
- Sutton Shirley
- Sweetser David A.
- Sweetser David A.
- Swerdzewski Barbara N.
- Sybert Virginia
- Tabor Holly K.
- Tan Amelia L.
- Tan Queenie K.-G.
- Tanguy M.
- Tarakad Arjun
- Taylor Tavares A.L.
- Tekin Mustafa
- Telischi Fred
- Thiffault Isabelle
- Thomas E.R.A.
- Thompson S.R.
- Thorson Willa
- Tifft Cynthia
- Toro Camilo
- Tran Alyssa A.
- Tucci A.
- Ungar Rachel A.
- Urv Tiina K.
- van Esbroeck Annelot C.M.
- Vanderver Adeline
- Velinder Matt
- Vetrini Francesco
- Viskochil Dave
- Vogel Tiphanie P.
- Wahl Colleen E.
- Walker Melissa
- Wallaard Ilse
- Walley Nicole M.
- Wambach Jennifer
- Wan Jijun
- Wang Lee-kai
- Wangler Michael F.
- Ward Patricia A.
- Wegner Daniel
- Weisz Monika
- Welland M.J.
- Wener Mark
- Wenger Tara
- Westerfield Monte
- Wheeler Matthew T.
- Whitlock Jordan
- Wilke Martina
- Williams E.
- Witkowska K.
- Witt Dennis
- Wolfe Lynne A.
- Wood S.M.
- Woods Emily
- Yamamoto Shinya
- Zarowiecki M.
- Zhang Zhe
- Zhou Dihong
- Zuchner Stephan
- Publication venue
- Elsevier Inc
- Publication date
- 03/08/2023
- Field of study
Heterogeneous nuclear ribonucleoprotein C (HNRNPC) is an essential, ubiquitously abundant protein involved in mRNA processing. Genetic variants in other members of the HNRNP family have been associated with neurodevelopmental disorders. Here, we describe 13 individuals with global developmental delay, intellectual disability, behavioral abnormalities, and subtle facial dysmorphology with heterozygous HNRNPC germline variants. Five of them bear an identical in-frame deletion of nine amino acids in the extreme C terminus. To study the effect of this recurrent variant as well as HNRNPC haploinsufficiency, we used induced pluripotent stem cells (iPSCs) and fibroblasts obtained from affected individuals. While protein localization and oligomerization were unaffected by the recurrent C-terminal deletion variant, total HNRNPC levels were decreased. Previously, reduced HNRNPC levels have been associated with changes in alternative splicing. Therefore, we performed a meta-analysis on published RNA-seq datasets of three different cell lines to identify a ubiquitous HNRNPC-dependent signature of alternative spliced exons. The identified signature was not only confirmed in fibroblasts obtained from an affected individual but also showed a significant enrichment for genes associated with intellectual disability. Hence, we assessed the effect of decreased and increased levels of HNRNPC on neuronal arborization and neuronal migration and found that either condition affects neuronal function. Taken together, our data indicate that HNRNPC haploinsufficiency affects alternative splicing of multiple intellectual disability-associated genes and that the developing brain is sensitive to aberrant levels of HNRNPC. Hence, our data strongly support the inclusion of HNRNPC to the family of HNRNP-related neurodevelopmental disorders.
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We identified genetic variants of HNRNPC in 13 individuals with intellectual disability and global developmental delay. Through a meta-analysis of multiple cell types, we found that loss of HNRNPC affects alternative splicing, in particular of intellectual disability-associated genes. In vivo assays confirmed that neurodevelopment was affected by aberrant HNRNPC levels