Association between triglyceride levels and cardiovascular disease in patients with acute pancreatitis

<div><p>Conventional wisdom supports prescribing “fibrates before statins”, that is, prioritizing treatment of hypertriglyceridemia (hTG) to prevent pancreatitis ahead of low-density lipoprotein cholesterol to prevent coronary heart disease. The relationship between hTG and acute pancreatitis, however, may not support this approach to clinical management. This study analyzed administrative data from the Veterans Health Administration for evidence of (1) temporal association between assessed triglycerides level and days to acute pancreatitis admission; (2) association between hTG and outcomes in the year after hospitalization for acute pancreatitis; (3) relative rates of prescription of fibrates vs statins in patients with acute pancreatitis; (4) association of prescription of fibrates alone versus fibrates with statins or statins alone with rates of adverse outcomes after hospitalization for acute pancreatitis. Only modest association was found between above-normal or extremely high triglycerides and time until acute pancreatitis. CHD/MI/stroke occurred in 23% in the year following AP, supporting cardiovascular risk management. Fibrates were prescribed less often than statins, defying conventional wisdom, but the high rates of cardiovascular events in the year following AP support a clinical focus on reducing cardiovascular risk factors.</p></div

Mean triglyceride level by months until admission for acute pancreatitis among 20,608 veterans (FY2006-FY2009).

<p>Mean triglyceride level by months until admission for acute pancreatitis among 20,608 veterans (FY2006-FY2009).</p

QTptsd_AnnalsPharm_Supplemental_11022018 – Supplemental material for Psychotropic Pharmacotherapy Associated With QT Prolongation Among Veterans With Posttraumatic Stress Disorder

<p>Supplemental material, QTptsd_AnnalsPharm_Supplemental_11022018 for Psychotropic Pharmacotherapy Associated With QT Prolongation Among Veterans With Posttraumatic Stress Disorder by Eileen M. Stock, John E. Zeber, Catherine J. McNeal, Javier E. Banchs and Laurel A. Copeland in Annals of Pharmacotherapy</p

Characteristics of VA patients admitted with acute pancreatitis FY2006-FY2009 (n = 20,608).

<p>Characteristics of VA patients admitted with acute pancreatitis FY2006-FY2009 (n = 20,608).</p