The impact of dedollarization in the Angolan Banking sector: Banco de Fomento de Angola case study

It is the scope of this project to analyse how the past and current economic conjuncture in Angola, mainly driven and characterized by the Dedollarization process that is undergoing, has been impacting the Angolan Baking Sector, one of the biggest pillars of the Angolan economic activity. Given the known data constraints, this project only focused on the analysis of the Dedollarization impact in one of Angola’s biggest banks: Banco de Fomento de Angola. The statistical approach consisted on two multi-factor regression models to analyse the impact on two different Key Performance Indicators of the bank: Return on Equity and Regulated Solvency Ratio. Although it was complicated to derive statistical significance for the two models, mainly due to a reduced number of observations and the quality of the model, the results converged to what a financial economics analysis led later on the final part of the project. The final remarks regarding the role of Dedollarization in the Banking sector, with a focus on BFA, are extremely eye-opening. Unlike what was thought à priori, the overall impact on BFA’s results is positive, mainly in the back of the high inflation environment that is being felt in Angola, which increases the spread of the assets’ returns in national currency versus in foreign currency on the bank’s balance sheet

A natureza jurídica da ação do agente infiltrado digital

Não temos dúvidas que nos dias de hoje os meios informáticos são já indissociáveis do quotidiano de cada um. A rapidez e, mais propriamente, a facilidade com que se pode comunicar com familiares, amigos, conhecidos ou não, para qualquer parte do globo, atingiu proporções que ainda há poucos anos eram tidas como inimagináveis. Mas se esta dinâmica tecnológica abriu novas portas ao bem-estar de todos nós, o mundo cibernético não deixou indiferentes os agentes criminosos, potenciando uma nova criminalidade. Com novos tipos de crime ou simplesmente com recurso a um novo meio, caraterizado pela falta de fronteiras e pelo anonimato, estes vêm pôr à prova o acompanhamento por parte dos investigadores. As novas tecnologias não trazem apenas obstáculos à investigação criminal, também permitem potencializar novos meios de obtenção de prova, ou ainda a adaptação de métodos tradicionais. É neste contexto que a figura do agente infiltrado digital emerge. Como tal importa saber como se enquadra no ordenamento português. Os meios ocultos de obtenção de prova são um meio excecional de investigação, mas que conflituem com direitos fundamentais. Perante isto, temos de saber qual o resultado da atividade do agente infiltrado face às provas que o tribunal vier a apreciar.We have no doubt that nowadays computerized means are inseparable from everyone’s daily life. The speed and easiness through which is possible to get in touch with relatives or friends to any part of the globe has just reached proportions which would be unimaginable a few years ago. However, if this technological dynamic opened new doors to the welfare of us all, the cyber world has not left indifferent criminal agents either, fostering a new criminality. With new types of crime or simply the access to a new mean characterized by being borderless and anonym, the digital era has arrived to test both researchers and security systems. New technologies do not only bring obstacles to criminal investigation; they also create or adapt methods for obtaining evidences. It is in this context that the figure of the digital undercover agent emerges and falls within the Portuguese legal order. The hidden means of obtaining evidences are exceptional means of investigation which collides with fundamental rights. In this regard, it is important to know what is the result of the activity of the undercover agent in light of the evidences that the court will take into consideration

Valorizar e divulgar o património geológico do geopark Naturtejo: estratégias para o Parque Icnológico de Penha Garcia

“A nossa história e a da Terra são inseparáveis; a sua origem e a sua história são nossas; o seu futuro será o nosso futuro”. Para concretizar o 4º princípio da Declaração Internacional sobre os Direitos da Memória da Terra (1991), é premente conservar e gerir os locais chave que testemunham a História do nosso Planeta, isto é, os geossítios, que no seu conjunto constituem o Património Geológico. Para que estes locais possam ser protegidos, devem ser alvo de uma estratégia de geoconservação. Ao valorizar e divulgar esse tipo de património, integrante do Património Natural contribui-se para sua salvaguarda, dado que se aproxima o público das geociências, permitindo a sua conscientização para a necessidade da procura de equilíbrio na relação Homem-Natureza. Por outro lado pode contribuir-se para o desenvolvimento económico local sustentável através do geoturismo e dos geoparques. No âmbito da presente dissertação planeámos, desenvolvemos e implementámos estratégias de valorização e divulgação do Património Geológico do Geopark Naturtejo (integrado nas Redes Europeia e Global de Geoparques da Unesco, desde Setembro de 2006), especialmente o do Parque Icnológico de Penha Garcia. Estas estratégias eram diferenciadas consoante se destinavam ao público em geral, ao público escolar ou ao público mais especializado. Das estratégias de valorização e de divulgação desenvolvidas e implementadas destacamos três: os Programas Educativos do Geopark Naturtejo, nomeadamente “A Escola vai ao Geopark” e o “O Geopark vai à Escola” e respectivo Booklet de divulgação; o Concurso destinado a jovens dos Geoparques Europeus, designado “Conhece o teu Geopark” e os materiais inerentes produzidos, e por fim, o documento de apoio para Guias da Rota dos Fósseis de Penha Garcia, “Perguntas e respostas sobre a Rota dos Fósseis – Geologia”, recurso educativo que pretendemos que seja integrado em Acções de Formação futuras. Cremos que esta dissertação seja um contributo para o desenvolvimento sustentável do território Naturtejo, mormente do concelho raiano que nos viu nascer, Idanha-a-Nova, onde se localiza o Parque Icnológico de Penha Garcia.“Our history and the history of the Earth cannot be separated. Its origins are our origins, its history is our history and its future will be our future.” In order to substantiate the 4th principle of the International Declaration about the Rights of the Memory of the Earth (1991), it’s urgent to preserve and manage the key sites which have witnessed our Planet’s history, i.e, the geosites which constitute the Geological Heritage on its whole. To be protected these sites must be the target of a geoconservation strategy. By valuing and promoting this heritage, a part from the Natural Heritage, we contribute for its preservation and the general public reaches geosciences, therefore allowing its awareness and the need to search for the balance in the Man-Nature’s relationship. On the other hand we may also contribute for the local sustainable economic development through geotourism and geoparks. In the extent of this master thesis we have planned, developed and implemented strategies to value and promote Naturtejo Geopark’s Geological Heritage (a member of both the European and the UNESCO Global Geoparks Networks since September 2006), especially the one from the Ichnological Park of Penha Garcia. These strategies were differentiated according to its target: the general public, the students or a more specialized public. From the interpretation and valuing strategies already developed and carried on we point out three: the Educational Programs of the Naturtejo Geopark, namely “School goes to Geopark” and “Geopark goes to School” and its promoting Booklet; the Competition “Meet your Geopark” addressed to young people from the European Geoparks along with the inherent resources and, finally, the supporting document for the Guides of the Fossils Trail of Penha Garcia entitled “Questions and answers on the Fossils Trail – Geology”, an educational resource which we intend to be part of future workshops. We believe this master thesis can be a contribution for the sustainable development of the Naturtejo’s territory and mainly of the border municipality where we were born – Idanha-a- Nova – the location of the Ichnological Park of Penha Garcia

A doença rara na família e na escola : a perspetiva parental

Este trabalho aborda as implicações da Doença Rara na vida familiar e escolar das crianças/jovens, sob o ponto de vista parental. Pretendemos divulgar a temática das Doenças Raras, concretamente no meio escolar, considerando que o conhecimento propicia melhores práticas educativas. Interessou-nos conhecer as necessidades familiares, bem como o impacto positivo e negativo da Doença Rara na família. Uma vez que os sistemas da família e da escola partilham a educação da criança/jovem, procuramos também conhecer as perceções parentais acerca dos serviços educativos. Para tal, elaborámos um questionário com contributos de outros já existentes, nacionais e estrangeiros (Genetic Syndrome Stressors Scale, Positive Contributions Scale, Questionário sobre as Necessidades Familiares e Parents’ Perceptions of Educational Services for Children with a Chronic Illness) e dirigimo-lo a pais de crianças/jovens com Doença Rara e Necessidades Educativas Especiais (n=55), pertencentes à Associação Raríssimas. Os resultados revelam que a amostra apresenta elevados índices de stress parental por ter a seu cargo um filho com Doença Rara, devido a fatores intrínsecos e extrínsecos à criança, com claros indicadores relacionados com a raridade da patologia. No entanto, independentemente do stress percebido, estes pais identificam contribuições positivas, encarando o filho como uma mais-valia na vida pessoal e familiar. Verificámos ainda que as necessidades de informação e as financeiras são as mais sentidas pelas famílias e que as preocupações relativamente à escolaridade dos filhos se relacionam sobretudo com o bem-estar emocional e social destes na escola. Na generalidade, os pais consideram que o serviço educativo prestado é satisfatório e que a relação pais-professores se pauta pela parceria e partilha. No entanto, não se sentem muito seguros de que a escola responda adequadamente às necessidades médicas do filho. Apesar das limitações, este estudo poderá servir de mote a futuras abordagens que visem o conhecimento e a divulgação da problemática das Doenças Raras.This paper approaches the issue of the implications of Rare Disease for family and school life of children/young people from the parental point of view. We aim to disclose the subject of Rare Diseases, particularly in the school environment, considering that knowledge provides better educational practices. We intended to identify the family needs as well as the positive and negative impact of rare disease in the family. As family and school share the upbringing of the child/young person, we also intend to study the parental perceptions of their child’s educational services. To do so, we have designed a questionnaire with inputs from others already existing, both national and from other countries (Genetic Syndrome Stressors Scale, Positive Contributions Scale, Questionnaire on Family Needs and Parents' Perceptions of Educational Services for Children with Chronic Illness) and we administered it to parents of children/young people with Rare Diseases and Special Educational Needs (n = 55), belonging to Associação Raríssimas. Results reveal that parents who take care of a child with a Rare Disease show high levels of parental stress, due to factors intrinsic and extrinsic to the child, with clear indicators related to the rarity of the condition. However, regardless the perceived stress, these parents identify positive contributions, seeing their child as a plus in their personal and family life. We also found that the needs of information and the financial needs and are ones most felt by families and that their concerns about their children’s education mainly regard their emotional and social wellbeing in school. Overall, parents feel that the educational service provided is satisfactory and that the parent-teacher relationship is characterized by cooperation and sharing. However, parents do not feel very confident about the school properly responding to the medical needs of the child. Despite the limitations, this study could serve as a starting point for future approaches aiming the knowledge and the disclosure and the issue of Rare Diseases

Bioengineering bacterial encapsulin nanocompartments as targeted drug delivery system

The development of Drug Delivery Systems (DDS) has led to increasingly efficient therapies for the treatment and detection of various diseases. DDS use a range of nanoscale delivery platforms produced from polymeric of inorganic materials, such as micelles, and metal and polymeric nanoparticles, but their variant chemical composition make alterations to their size, shape, or structures inherently complex. Genetically encoded protein nanocages are highly promising DDS candidates because of their modular composition, ease of recombinant production in a range of hosts, control over assembly and loading of cargo molecules and biodegradability. One example of naturally occurring nanocompartments are encapsulins, recently discovered bacterial organelles that have been shown to be reprogrammable as nanobioreactors and vaccine candidates. Here we report the design and application of a targeted DDS platform based on the Thermotoga maritima encapsulin reprogrammed to display an antibody mimic protein called Designed Ankyrin repeat protein (DARPin) on the outer surface and to encapsulate a cytotoxic payload. The DARPin9.29 chosen in this study specifically binds to human epidermal growth factor receptor 2 (HER2) on breast cancer cells, as demonstrated in an in vitro cell culture model. The encapsulin-based DDS is assembled in one step in vivo by co-expressing the encapsulin-DARPin9.29 fusion protein with an engineered flavin-binding protein mini-singlet oxygen generator (MiniSOG), from a single plasmid in Escherichia coli. Purified encapsulin-DARPin_miniSOG nanocompartments bind specifically to HER2 positive breast cancer cells and trigger apoptosis, indicating that the system is functional and specific. The DDS is modular and has the potential to form the basis of a multi-receptor targeted system by utilising the DARPin screening libraries, allowing use of new DARPins of known specificities, and through the proven flexibility of the encapsulin cargo loading mechanism, allowing selection of cargo proteins of choice

Effects of immunosuppressive drugs on COVID-19 severity in patients with autoimmune hepatitis

Background: We investigated associations between baseline use of immunosuppressive drugs and severity of Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis (AIH). Patients and methods: Data of AIH patients with laboratory confirmed COVID-19 were retrospectively collected from 15 countries. The outcomes of AIH patients who were on immunosuppression at the time of COVID-19 were compared to patients who were not on AIH medication. The clinical courses of COVID-19 were classified as (i)-no hospitalization, (ii)-hospitalization without oxygen supplementation, (iii)-hospitalization with oxygen supplementation by nasal cannula or mask, (iv)-intensive care unit (ICU) admission with non-invasive mechanical ventilation, (v)-ICU admission with invasive mechanical ventilation or (vi)-death and analysed using ordinal logistic regression. Results: We included 254 AIH patients (79.5%, female) with a median age of 50 (range, 17-85) years. At the onset of COVID-19, 234 patients (92.1%) were on treatment with glucocorticoids (n = 156), thiopurines (n = 151), mycophenolate mofetil (n = 22) or tacrolimus (n = 16), alone or in combinations. Overall, 94 (37%) patients were hospitalized and 18 (7.1%) patients died. Use of systemic glucocorticoids (adjusted odds ratio [aOR] 4.73, 95% CI 1.12-25.89) and thiopurines (aOR 4.78, 95% CI 1.33-23.50) for AIH was associated with worse COVID-19 severity, after adjusting for age-sex, comorbidities and presence of cirrhosis. Baseline treatment with mycophenolate mofetil (aOR 3.56, 95% CI 0.76-20.56) and tacrolimus (aOR 4.09, 95% CI 0.69-27.00) were also associated with more severe COVID-19 courses in a smaller subset of treated patients. Conclusion: Baseline treatment with systemic glucocorticoids or thiopurines prior to the onset of COVID-19 was significantly associated with COVID-19 severity in patients with AIH.Fil: Efe, Cumali. Harran University Hospita; TurquíaFil: Lammert, Craig. University School of Medicine Indianapolis; Estados UnidosFil: Taşçılar, Koray. Universitat Erlangen-Nuremberg; AlemaniaFil: Dhanasekaran, Renumathy. University of Stanford; Estados UnidosFil: Ebik, Berat. Gazi Yasargil Education And Research Hospital; TurquíaFil: Higuera de la Tijera, Fatima. Hospital General de México; MéxicoFil: Calışkan, Ali R.. No especifíca;Fil: Peralta, Mirta. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Gerussi, Alessio. Università degli Studi di Milano; ItaliaFil: Massoumi, Hatef. No especifíca;Fil: Catana, Andreea M.. Harvard Medical School; Estados UnidosFil: Purnak, Tugrul. University of Texas; Estados UnidosFil: Rigamonti, Cristina. Università del Piemonte Orientale ; ItaliaFil: Aldana, Andres J. G.. Fundacion Santa Fe de Bogota; ColombiaFil: Khakoo, Nidah. Miami University; Estados UnidosFil: Nazal, Leyla. Clinica Las Condes; ChileFil: Frager, Shalom. Montefiore Medical Center; Estados UnidosFil: Demir, Nurhan. Haseki Training And Research Hospital; TurquíaFil: Irak, Kader. Kanuni Sultan Suleyman Training And Research Hospital; TurquíaFil: Melekoğlu Ellik, Zeynep. Ankara University Medical Faculty; TurquíaFil: Kacmaz, Hüseyin. Adıyaman University; TurquíaFil: Balaban, Yasemin. Hacettepe University; TurquíaFil: Atay, Kadri. No especifíca;Fil: Eren, Fatih. No especifíca;Fil: Alvares da-Silva, Mario R.. Universidade Federal do Rio Grande do Sul; BrasilFil: Cristoferi, Laura. Università degli Studi di Milano; ItaliaFil: Urzua, Álvaro. Universidad de Chile; ChileFil: Eşkazan, Tuğçe. Cerrahpaşa School of Medicine; TurquíaFil: Magro, Bianca. No especifíca;Fil: Snijders, Romee. No especifíca;Fil: Barutçu, Sezgin. No especifíca;Fil: Lytvyak, Ellina. University of Alberta; CanadáFil: Zazueta, Godolfino M.. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Demirezer Bolat, Aylin. Ankara City Hospital; TurquíaFil: Aydın, Mesut. Van Yuzuncu Yil University; TurquíaFil: Amorós Martín, Alexandra Noemí. No especifíca;Fil: De Martin, Eleonora. No especifíca;Fil: Ekin, Nazım. No especifíca;Fil: Yıldırım, Sümeyra. No especifíca;Fil: Yavuz, Ahmet. No especifíca;Fil: Bıyık, Murat. Necmettin Erbakan University; TurquíaFil: Narro, Graciela C.. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Bıyık, Murat. Uludag University; TurquíaFil: Kıyıcı, Murat. No especifíca;Fil: Kahramanoğlu Aksoy, Evrim. No especifíca;Fil: Vincent, Maria. No especifíca;Fil: Carr, Rotonya M.. University of Pennsylvania; Estados UnidosFil: Günşar, Fulya. No especifíca;Fil: Reyes, Eira C.. Hepatology Unit. Hospital Militar Central de México; MéxicoFil: Harputluoğlu, Murat. Inönü University School of Medicine; TurquíaFil: Aloman, Costica. Rush University Medical Center; Estados UnidosFil: Gatselis, Nikolaos K.. University Hospital Of Larissa; GreciaFil: Üstündağ, Yücel. No especifíca;Fil: Brahm, Javier. Clinica Las Condes; ChileFil: Vargas, Nataly C. E.. Hospital Nacional Almanzor Aguinaga Asenjo; PerúFil: Güzelbulut, Fatih. No especifíca;Fil: Garcia, Sandro R.. Hospital Iv Víctor Lazarte Echegaray; PerúFil: Aguirre, Jonathan. Hospital Angeles del Pedregal; MéxicoFil: Anders, Margarita. Hospital Alemán; ArgentinaFil: Ratusnu, Natalia. Hospital Regional de Ushuaia; ArgentinaFil: Hatemi, Ibrahim. No especifíca;Fil: Mendizabal, Manuel. Universidad Austral; ArgentinaFil: Floreani, Annarosa. Università di Padova; ItaliaFil: Fagiuoli, Stefano. No especifíca;Fil: Silva, Marcelo. Universidad Austral; ArgentinaFil: Idilman, Ramazan. No especifíca;Fil: Satapathy, Sanjaya K.. No especifíca;Fil: Silveira, Marina. University of Yale. School of Medicine; Estados UnidosFil: Drenth, Joost P. H.. No especifíca;Fil: Dalekos, George N.. No especifíca;Fil: N.Assis, David. University of Yale. School of Medicine; Estados UnidosFil: Björnsson, Einar. No especifíca;Fil: Boyer, James L.. University of Yale. School of Medicine; Estados UnidosFil: Yoshida, Eric M.. University of British Columbia; CanadáFil: Invernizzi, Pietro. Università degli Studi di Milano; ItaliaFil: Levy, Cynthia. University of Miami; Estados UnidosFil: Montano Loza, Aldo J.. University of Alberta; CanadáFil: Schiano, Thomas D.. No especifíca;Fil: Ridruejo, Ezequiel. Universidad Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Wahlin, Staffan. No especifíca

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Background: In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). Findings: Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001). Interpretation: In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Indisciplina, satisfação profissional e bem-estar docente : um estudo com professores de uma Escola Secundária do Médio Tejo

Dissertação de mestrado em Ciências da Educação (Gestão e Administração Escolar) apresentada à Faculdade de Psicologia e Ciências da Educação da Universidade de Coimbra.Considerando que a satisfação profissional dos docentes vem sendo amplamente estudada, uma vez que se presume estar relacionada com a melhoria das performances do professor e dos alunos, e tendo em conta que o bem-estar docente também tem sido alvo de vários estudos, pareceu-nos relevante, e face ao aumento do fenómeno da indisciplina nas Escolas, introduzir aqui este construto e relacioná-lo com os outras dois. Na sua análise procedemos à revisão das conceções elaboradas pelos especialistas, dando primazia às principais teorias explicativas e estudos já existentes. Dividimos o nosso estudo em duas partes distintas e complementares: a primeira parte composta pela fundamentação teórica (no capítulo I abordámos a indisciplina, no capítulo II a satisfação profissional e no capítulo III o bemestar docente) e a segunda parte contemplando a investigação empírica (no capítulo IV explicámos a conceção, desenvolvimento e a metodologia seguidos e no capítulo V, apresentámos os resultados obtidos, a respetiva análise estatística e as conclusões, tendo por base as hipóteses apresentadas). O principal objetivo do nosso estudo foi tentar responder à questão “Será que a (in)satisfação / bem(mal)-estar que os professores hoje em dia vivem e sentem ainda se deve, principalmente, aos fatores apresentados nos estudos anteriores ou a indisciplina crescente que se tem registado em sala de aula e na Escola ganhou relevância nestas dimensões?”. Dos resultados obtidos destacámos a indisciplina crescente que se tem registado em sala de aula e na Escola tem relevância ao nível da dimensão de satisfação profissional, principalmente, no que se refere ao fator 1 (natureza do próprio trabalho) e da satisfação com a vida dos professores, componente cognitiva da dimensão de bem-estar subjetivo. Porém, apesar dos nossos esforços temos consciência das limitações do nosso estudo e esperamos que a sua concretização possa contribuir para a melhoria do Ensino, da Escola e da Educação em geral.Alors que la satisfaction au travail des enseignants a été largement étudiée, car elle est présumée être liée à l'amélioration des professeurs et des étudiants performances, et en tenant compte du bien-être de l'enseignant ent a également été la cible de plusieurs études, il est apparu pertinent, face à l'augmentation du phénomène de l'indiscipline dans les écoles, introduire ce concept et de le relier avec les deux autres. Dans cette analyse, nous avons passé en revue les concepts développés par des experts, en donnant la priorité aux principales théories explicatives et des études existantes. Nous divisons notre étude en deux parties distinctes et complémentaires: la première partie comprend les bases théoriques (dans le chapitre I, nous avons parlé d'indiscipline, dans le chapitre II de la satisfaction au travail et dans le chapitre III de bien-être de l'enseignant) et la deuxième partie couvre la recherche empirique (dans le chapitre IV, nous avons expliqué la conception, le développement et la méthodologie suivie et dans le chapitre V, nous avons présenté les résultats obtenus, l'analyse statistique respectif et des conclusions basées sur les hypothèses formulées). L'objectif principal de notre étude était d'essayer de répondre à la question: “Est-ce la (in)satisfaction/bien-être (malaise) que les professeurs vivent et se sentent, aujourd'hui, c'est encore à cause des facteurs présentés dans les études antérieures, ou la indiscipline croissante dans la classe et l'école, a pris de l'importance sur ces dimensions?”. De nos résultats, nous avons souligné que l'indiscipline croissante, qui a été enregistré dans la salle de classe et à l'école est pertinent pour la satisfaction au travail, en particulier en ce qui concerne le premier facteur (nature du travail lui-même) et la satisfaction de vie des professeurs, composante de la dimension cognitive de bien-être subjectif. Cependant, malgré nos efforts, nous sommes conscients des limites de notre étude et nous espérons que son application peut contribuer à l'amélioration de l'enseignement, l'école et l'éducation en général.Whereas job satisfaction of teachers has been widely studied, since it is presumed to be related to the improvement of teacher’s and students performances, and taking into account the well-being of teaching has also been the target of several studies, it seemed relevant, facing the increasing of the phenomenon of indiscipline in schools, to introduce this construct and relate it with the other two. In this analysis we have reviewed the concepts developed by experts, giving priority to the main explanatory theories and existing studies. We divided our study into two distinct and complementary parts: the first one comprised the theoretical basis (in Chapter I we talked about indiscipline, in Chapter II the job satisfaction and in Chapter III the teacher’s well-being) and the second covered empirical research (in Chapter IV we explained the design, development and the methodology followed and in Chapter V we presented the results obtained, the respective statistical analysis and conclusions, based on the assumptions made). The main objetive of our study was to try to answer the question: "Does the (dis)satisfaction / well-being(unease) that teachers are still living and feeling today it’s still due to the factors presented in previous studies, or the indiscipline, which has been increasing in the classroom and School, has gained prominence on these dimensions? ". From our results we highlighted that the growing indiscipline, which has been registered in the classroom and School, is relevant for job satisfaction, especially regarding the first fator (nature of work itself) and life satisfaction of teachers, cognitive component of the subjetive well-being dimension. However, despite our efforts, we are aware of the limitations of our study and we hope that its implementation will contribute to the improvement of Teaching, School and Education in general