Turning noise into signal: learning from the scatter in the Hubble diagram

The supernova (SN) Hubble diagram residual contains valuable information on both the present matter power spectrum and its growth history. In this paper we show that this information can be retrieved with precision by combining both peculiar velocity and weak-lensing analysis on the data. To wit, peculiar velocity induces correlations on the nearby SN while lensing induces a non-Gaussian dispersion in faraway objects. We show that both effects have almost orthogonal degeneracies and discuss how they can be extracted simultaneously from the data. We analyze the JLA supernova catalog in a 14-dimensional parameter space, assuming a flexible growth-rate index $\gamma$. We arrive at the following marginalized constraints: $\sigma_8 = 0.65^{+0.23}_{-0.37}$ and $\gamma = 1.38^{+1.7}_{-0.65}$. Assuming instead GR as the correct gravitation theory (and thus $\gamma \equiv 0.55$), the constraints in $\sigma_8$ tighten further: $\sigma_8 = 0.40^{+0.21}_{-0.23}$. We show that these constraints complement well the ones obtained from other datasets and that they could improve substantially with more SNe.Comment: v2: Real data results corrected; forecast for future data added; discussion extended. v3: Improved discussion; matches published version. 8 figs 15 page

Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells

Recent studies in cystic fibrosis (CF) transmembrane regulator (CFTR) mutations and function have shed light on its involvement in disease progression. The extent of cell and tissue distribution of CFTR facilitates systemic dysfunction of ion transport in patients carrying a mutation in CFTR, however, its incidences as cofounding risk factor to develop other diseases is not well studied. In this review we differentiate the dysfunctions driven by CFTR mutations in cell of the immune system and their role in CF progression and examine the types of medical treatments available to patients up to date.Fil: Grumelli, Sandra. Universidad Católica de Córdoba; ArgentinaFil: Islan, German Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentin

Marginalized narratives

This issue of CITAR (Journal of Arts Science and Technology) is especially devoted to what we designated as Marginalized Narratives. It is a special issue that collects studies published upon the 5th Colloquium on Narrative, Medium and Cognition, held at the University of Algarve in November 2018, and which was focused on that topic. In line with what the colloquium proposed, the works now published share a broad understanding of the concept of narrative.info:eu-repo/semantics/publishedVersio

El rol de los problemas en la elaboración de contenidos escolares de geografía. Reflexiones desde la reforma educativa en Argentina

En geografía, cada vez más se invoca la necesidad de organizar los contenidos escolares en torno a problemas, básicamente como una herramienta para otorgar significatividad o relevancia a los contenidos y garantizar, así, su carácter innovador. En Argentina, esto es particularmente evidente a partir de la reforma educativa del año 1994, al menos desde los diseños curriculares y otros materiales conexos de las principales jurisdicciones educativas subnacionales. Ahora bien, ¿qué sentido del término «problema» se está invocando y qué derivaciones presenta?; en términos más propositivos: ¿qué implica la construcción de contenidos escolares de geografía en torno a problemas? En primer lugar, se distinguirán y se analizarán algunos de los principales sentidos del término «problema» presentes en la selección y/o elaboración de contenidos escolares (como referente de un conflicto social, como estrategia didáctica, como organización teórico-conceptual de un tema). En segundo lugar, se indagará en las potencialidades de esa última acepción para la construcción de contenidos escolares y se presentarán algunas herramientas para operacionalizarlos.En geografia, cada vegada més s'invoca la necessitat d'organitzar continguts escolars al voltant de problemes, bàsicament com una eina per atorgar significativitat o relleu als continguts i garantir-ne, així, el caràcter innovador. A l'Argentina, això és particularment evident a partir de la reforma educativa de l'any 1994, almenys des dels dissenys curriculars i altres materials connexos de les principals jurisdiccions educatives subnacionals. Ara bé, quin sentit del terme «problema» s'està invocant i quines derivacions presenta?; en termes més propositius: què implica la construcció de continguts escolars de geografia al voltant de problemes? En primer lloc, es distingiran i s'analitzaran en aquest article alguns dels sentits principals del terme «problema» presents en la selecció i/o l'elaboració de continguts escolars: com a referent d'un conflicte social, com a estratègia didàctica i com a organització teoricoconceptual d'un tema. En segon lloc, s'indagarà en les potencialitats d'aquesta darrera accepció per construir continguts escolars i es presentaran algunes eines per operacionalitzar-los.En Géographie, chaque fois plus on invoque le besoin d'organiser les contenus scolaires autour de problèmes, comme un outil pour remarquer l'importance des contenus et garantir, ainsi, son caractère innovateur. En Argentine ceci est particulièrement évident à partir de la Réforme Éducative de l'année 1994, au moins depuis les créations curriculaires et d'autres matériels connexes des principales juridictions éducatives subnationales. Mais, à quel sens du terme «problème» se raconte et quelles dérivations est-ce qu'il présente?; dans des termes plus prépositifs: qu'est-ce qui implique la construction de contenus scolaires de Géographie autour de problèmes? En premier lieu, cet article distingue et analyse quelques-uns des principales connotations du terme «problème» présents dans la sélection et/ou élaboration de contenus scolaires: comme référent d'un conflit social, comme stratégie didactique, comme organisation théorique-conceptuel d'un sujet. En deuxième lieu, on étudie les potentialités de cette dernière acception en relation à la construction de contenus scolaires et se présentent quelques outils pour l'obtenir.The need to organize school contents around specific problems is increasingly invoked in Geography. Problems are considered a useful tool to give relevance to contents and therefore reassure its innovative character. This is particularly evident in Argentine since the Educational Reform of 1994, at least in what concerns curriculums design and other associated materials of the subnational educative jurisdictions. What's sense is given to the concept «problem» in these texts and which are the consequences of the uses of these meanings? From a more propositive view, what do imply the constructions of schools contents in Geography around problems? First, we will distinguish and analyse some of the main meanings of the concept «problem » that are presented in the selection and/or elaboration of school contents, either as a reference of a social conflict, as a learning strategy or as a theoretical and conceptual organization of a subject. Second, we analyse the potential uses of the third meaning in the construction of school contents and we present some tools that help to make these uses operative

Algunos aspectos socio-culturales, didácticos y matemáticos al abordarla conceptualización de la medida

Mostraremos, desde una mirada socio-cultural, didáctica y matemática, algunos aspectos que intervienen en la conceptualización de la medida y que podrían contribuir a enriquecer la fundamentación de procesos y desarrollo de competencias al abordar la medida en la escuela

Economics of the Firm and Economic Growth. An hybrid theoretical framework of analysis

The characterization of individual firms is an essential step toward the study of the behaviour of industries and other more aggregated units of economics, and so to the analysis of economic growth processes. Hence, the main goal of this study is to achieve a critical discussion around the conceptualisation of the firm and its role in the dynamical process of economic growth. The approach to the main topic starts with the construction of a theoretical matrix of the economics of the firm, opening with the two major traditions of institutionalist thought in economics, and evolving then towards some considerations around the contractual and the evolutionary approaches. Another important theoretical stream that deals with organizations in economic and sociological terms also appears, the population ecology approach. After this overview, it is developed a cross-exam of distinct theoretical perspectives and the identification of possible flaws of the neoclassical theory. This confrontation, which goes throughout many imperative and controversial issues within economics such as the nature of the firm and the cognitive capacities of economic agents, results in a systematisation about the impact of this discussion on economic growth. The conclusions appear as crucial to develop further research aiming the construction of economic growth models based on a microeconomics that is closer to the reality of firms.Firm; Economic Growth; Institutionalism; Evolutionary theory; Contractual Theory; Ecology Population Theory.

Modern sandy contourites: conceptual and economic implications

Bottom currents are common sedimentary and oceanographic processes in deep-marine settings that affect continental margins worldwide. Contourites are defined as sediments deposited or substantially reworked by the persistent action of bottom currents. Despite numerous efforts to differentiate between contourites and other deep-water deposits in cores, reliable diagnostic criteria are still lacking. This Thesis presents a multidisciplinary study based on grain size and geochemistry of sedimentary facies —reinforced by micro- and ichnofacies— in the Gulf of Cadiz Contourite Depositional System, in the upper continental slope of the Mozambican margin and the eastern flank of the Corsica Trough. Discrimination criteria are put forth for hemipelagites, silty contourites, sandy contourites, bottom current reworked sands, fine-grained turbidites, hyperpycnites and debrites in sediment cores. The stacked vertical variability of these deposits evidences that the contourite drifts, contourite channels and contourite terraces were influenced by the interrelation of hemipelagic, gravitational and bottom current induced depositional processes. The interrelation of sedimentary processes is tied to intermittency in bottom current velocity, observed at different scales. In the Gulf of Cadiz, the intermittency is a consequence of precession-driven changes related to Mediterranean climate variability, punctuated by millennial-scale variability. In the Corsica contourite depositional system, bioclastic sands would have been transported to the slope during sea level lowstands, probably during isolated episodes of reworking and transport of sediments from the shelf. In contrast, the Mozambique contourite terrace occupies shallower locations and lies directly offshore the Zambezi delta, meaning it was continuously supplied from the adjacent continent and shelf and by along-slope currents, especially during sea level highstands. At bed scale, the variability in ichnodiversity, abundance and distribution of bioturbation is linked to intermittent interactions between bottom currents and sediment supply, hence different environmental conditions for tracemakers. Such intermittency reflects brief changes in hydrodynamic conditions during its deposition: shorter-term (centennial) yet higher accumulation rates, lower bioturbation rates, and flow variability. This new model could therefore provide support for basic sedimentological interpretation and petroleum exploration strategies

"2º Ciclo de seminários em biopatologia"- o sucesso da iniciativa

O II Ciclo de Seminários em Biopatologia, realizado na Universidade Fernando Pessoa, entre os dias 9 de Janeiro e 12 de Março de 2008, teve por objectivo continuar a dar a conhecer as múltiplas vertentes da Investigação Científica desenvolvida em Portugal, nomeadamente em áreas como células estaminais, cancro, doenças infecciosas, entre outras. The 2nd series of Seminars in Biopathology occurred in Universidade Fernando Pessoa, between January 9th and 12th of March, and the objective was to present the multiple approaches of the scientific research in Portugal in areas like stem cells, cancer, infectious disease and others

La experiencia organizacional vivida por la ONG Luz y Vida durante el periodo 2010-2014 en el municipio de Dosquebradas

Esta tesis fue realizada con el fin de reconstruir la experiencia organizacional vivida por la ONG LUZ Y VIDA en el periodo 2010- 2014 permitiendo desarrollar las categorías fundamentales de una ONG, observamos describimos y conocimos mediante el método exploratorio la creación de la ONG, todo el funcionamiento y todas las estrategias implementadas por la fundación para la inclusión de la comunidad en los aspectos socio-económicos del municipio de Dosquebradas, la investigación realizada fue satisfactoria nos permitió encontrar falencias y virtudes de la fundación. Además de encontrar posibles alternativas para el fortalecimiento de esta organización identificamos la falta de apoyo e interés por parte de las entidades gubernamentales, ya que la fundación presta un servicio a la comunidad, esta requiere de apoyos económicos, de formación en diferentes áreas. Realizaron actividades con tres grupos poblacionales que van dirigidas a tres grupos poblacionales como son los niños ,madres cabeza de hogar y adultos mayores, en los cuales se contribuyó a la prevención de la violencia, drogas y delincuencia común, características propias de estos sectores menos favorecidos, con pocas oportunidades laborales, académicas