Circumnuclear Gas in Seyfert 1 Galaxies: Morphology, Kinematics, and Direct Measurement of Black Hole Masses

(Abridged) The two-dimensional distribution and kinematics of the molecular, ionized, and highly ionized gas in the nuclear regions of Seyfert 1 galaxies have been measured using high spatial resolution (~0''.09) near-infrared spectroscopy from NIRSPEC with adaptive optics on the Keck telescope. Molecular hydrogen, H2, is detected in all nine Seyfert 1 galaxies and, in the majority of galaxies, has a spatially resolved flux distribution. In contrast, the narrow component of the BrG emission has a distribution consistent with that of the K-band continuum. In general, the kinematics of H2 are consistent with thin disk rotation, with a velocity gradient of over 100 km/s measured across the central 0''.5 in three galaxies, and across the central 1''.5 in two galaxies. The kinematics of BrG are in agreement with the H2 rotation, except in all four cases the central 0''.5 is either blue- or redshifted by more than 75 km/s. The highly ionized gas, measured with the [Ca VIII] and [Si VII] coronal lines, is spatially and kinematically consistent with BrG in the central 0''.5. Dynamical models have been fitted to the two-dimensional H2 kinematics, taking into account the stellar mass distribution, the emission line flux distribution, and the point spread function. For NGC 3227 the modeling indicates a black hole mass of Mbh = 2.0{+1.0/-0.4} x 10^7 Msun, and for NGC 4151 Mbh = 3.0{+0.75/-2.2} x 10^7 Msun. In NGC 7469 the best fit model gives Mbh < 5.0 x 10^7 Msun. In all three galaxies, modeling suggests a near face-on disk inclination angle, which is consistent with the unification theory of active galaxies. The direct black hole mass estimates verify that masses determined from the technique of reverberation mapping are accurate to within a factor of three with no additional systematic errors.Comment: 43 pages, including 47 figures; Accepted for publication in ApJ. All 2-D maps (in high resolution) are available at http://www.astro.ucla.edu/~ehicks . Minor changes to the text and updated reverberation mapped black hole mass estimates; the conclusions are unchange

A Complete Catalog of Swift GRB Spectra and Durations: Demise of a Physical Origin for Pre-Swift High-Energy Correlations

We calculate durations and spectral paramaters for 218 Swift bursts detected by the BAT instrument between and including GRBs 041220 and 070509, including 77 events with measured redshifts. Incorporating prior knowledge into the spectral fits, we are able to measure the characteristic $\nu F_{\nu}$ spectral peak energy $E_{\rm pk,obs}$ and the isotropic equivalent energy $E_{\rm iso}$ (1--$10^4$ keV) for all events. This complete and rather extensive catalog, analyzed with a unified methodology, allows us to address the persistence and origin of high-energy correlations suggested in pre-Swift observations. We find that the $E_{\rm pk,obs}$-$E_{\rm iso}$ correlation is present in the Swift sample; however, the best-fit powerlaw relation is inconsistent with the best-fit pre-Swift relation at >5 sigma significance. Moreover, it has a factor >~ 2 larger intrinsic scatter, after accounting for large errors on $E_{\rm pk,obs}$. A large fraction of the Swift events are hard and subluminous relative to (and inconsistent with) the pre-Swift relation, in agreement with indications from BATSE GRBs without redshift. Moreover, we determine an experimental threshold for the BAT detector and show how the $E_{\rm pk,obs}$--$E_{\rm iso}$ correlation arises artificially due to partial correlation with the threshold. We show that pre-Swift correlations found by Amati et al.(2002), Yonetoku et al. (2004), Firmani et al.(2006) (and independently by others) are likely unrelated to the physical properties of GRBs and are likely useless for tests of cosmology. Also, an explanation of these correlations in terms of a detector threshold provides a natural and quantitative explanation for why short-duration GRBs and events at low redshift tend to be outliers to the correlations.Comment: 25 pages, 9 figures, 2 tables, Accepted to Ap

An X-ray absorption analysis of the high-velocity system in NGC 1275

We present an X-ray absorption analysis of the high-velocity system (HVS) in NGC 1275 using results from a deep 200 ks Chandra observation. We are able to describe the morphology of the HVS in more detail than ever before. We present an HST image for comparison, and note close correspondence between the deepest X-ray absorption and the optical absorption. A column density map of the HVS shows an average column density NH of 1x10^21 cm^-2 with a range from ~5x10^20 to 5x10^21 cm^-2. From the NH map we calculate a total mass for the absorbing gas in the HVS of (1.32+-0.05)x10^9 solar masses at solar abundance. 75 per cent of the absorbing mass is contained in the four regions of deepest absorption. We examine temperature maps produced by spectral fitting and find no direct evidence for shocked gas in the HVS. Using deprojection methods and the depth of the observed absorption, we are able to put a lower limit on the distance of the HVS from the nucleus of 57 kpc, showing that the HVS is quite separate from the body of NGC 1275.Comment: 6 pages, 5 colour figures, accepted by MNRA

Seasonal analysis of submicron aerosol in Old Delhi using high-resolution aerosol mass spectrometry: chemical characterisation, source apportionment and new marker identification

We present the first real-time composition of submicron particulate matter (PM1) in Old Delhi using high-resolution aerosol mass spectrometry (HR-AMS). Old Delhi is one of the most polluted locations in the world, and PM1 concentrations reached ∼ 750 µg m−3 during the most polluted period, the post-monsoon period, where PM1 increased by 188 % over the pre-monsoon period. Sulfate contributes the largest inorganic PM1 mass fraction during the pre-monsoon (24 %) and monsoon (24 %) periods, with nitrate contributing most during the post-monsoon period (8 %). The organics dominate the mass fraction (54 %–68 %) throughout the three periods, and, using positive matrix factorisation (PMF) to perform source apportionment analysis of organic mass, two burning-related factors were found to contribute the most (35 %) to the post-monsoon increase. The first PMF factor, semi-volatility biomass burning organic aerosol (SVBBOA), shows a high correlation with Earth observation fire counts in surrounding states, which links its origin to crop residue burning. The second is a solid fuel OA (SFOA) factor with links to local open burning due to its high composition of polyaromatic hydrocarbons (PAHs) and novel AMS-measured marker species for polychlorinated dibenzodioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). Two traffic factors were resolved: one hydrocarbon-like OA (HOA) factor and another nitrogen-rich HOA (NHOA) factor. The N compounds within NHOA were mainly nitrile species which have not previously been identified within AMS measurements. Their PAH composition suggests that NHOA is linked to diesel and HOA to compressed natural gas and petrol. These factors combined make the largest relative contribution to primary PM1 mass during the pre-monsoon and monsoon periods while contributing the second highest in the post-monsoon period. A cooking OA (COA) factor shows strong links to the secondary factor, semi-volatility oxygenated OA (SVOOA). Correlations with co-located volatile organic compound (VOC) measurements and AMS-measured organic nitrogen oxides (OrgNO) suggest SVOOA is formed from aged COA. It is also found that a significant increase in chloride concentrations (522 %) from pre-monsoon to post-monsoon correlates well with SVBBOA and SFOA, suggesting that crop residue burning and open waste burning are responsible. A reduction in traffic emissions would effectively reduce concentrations across most of the year. In order to reduce the post-monsoon peak, sources such as funeral pyres, solid waste burning and crop residue burning should be considered when developing new air quality policy

Measuring brain atrophy with a generalized formulation of the boundary shift integral

AbstractBrain atrophy measured using structural magnetic resonance imaging (MRI) has been widely used as an imaging biomarker for disease diagnosis and tracking of pathologic progression in neurodegenerative diseases. In this work, we present a generalized and extended formulation of the boundary shift integral (gBSI) using probabilistic segmentations to estimate anatomic changes between 2 time points. This method adaptively estimates a non-binary exclusive OR region of interest from probabilistic brain segmentations of the baseline and repeat scans to better localize and capture the brain atrophy. We evaluate the proposed method by comparing the sample size requirements for a hypothetical clinical trial of Alzheimer's disease to that needed for the current implementation of BSI as well as a fuzzy implementation of BSI. The gBSI method results in a modest but reduced sample size, providing increased sensitivity to disease changes through the use of the probabilistic exclusive OR region

APOE ε4 is associated with disproportionate progressive hippocampal atrophy in AD.

OBJECTIVES: To investigate whether APOE ε4 carriers have higher hippocampal atrophy rates than non-carriers in Alzheimer's disease (AD), mild cognitive impairment (MCI) and controls, and if so, whether higher hippocampal atrophy rates are still observed after adjusting for concurrent whole-brain atrophy rates. METHODS: MRI scans from all available visits in ADNI (148 AD, 307 MCI, 167 controls) were used. MCI subjects were divided into "progressors" (MCI-P) if diagnosed with AD within 36 months or "stable" (MCI-S) if a diagnosis of MCI was maintained. A joint multi-level mixed-effect linear regression model was used to analyse the effect of ε4 carrier-status on hippocampal and whole-brain atrophy rates, adjusting for age, gender, MMSE and brain-to-intracranial volume ratio. The difference in hippocampal rates between ε4 carriers and non-carriers after adjustment for concurrent whole-brain atrophy rate was then calculated. RESULTS: Mean adjusted hippocampal atrophy rates in ε4 carriers were significantly higher in AD, MCI-P and MCI-S (p≤0.011, all tests) compared with ε4 non-carriers. After adjustment for whole-brain atrophy rate, the difference in mean adjusted hippocampal atrophy rate between ε4 carriers and non-carriers was reduced but remained statistically significant in AD and MCI-P. CONCLUSIONS: These results suggest that the APOE ε4 allele drives atrophy to the medial-temporal lobe region in AD

A meta-analytic review of stand-alone interventions to improve body image

Objective Numerous stand-alone interventions to improve body image have been developed. The present review used meta-analysis to estimate the effectiveness of such interventions, and to identify the specific change techniques that lead to improvement in body image. Methods The inclusion criteria were that (a) the intervention was stand-alone (i.e., solely focused on improving body image), (b) a control group was used, (c) participants were randomly assigned to conditions, and (d) at least one pretest and one posttest measure of body image was taken. Effect sizes were meta-analysed and moderator analyses were conducted. A taxonomy of 48 change techniques used in interventions targeted at body image was developed; all interventions were coded using this taxonomy. Results The literature search identified 62 tests of interventions (N = 3,846). Interventions produced a small-to-medium improvement in body image (d+ = 0.38), a small-to-medium reduction in beauty ideal internalisation (d+ = -0.37), and a large reduction in social comparison tendencies (d+ = -0.72). However, the effect size for body image was inflated by bias both within and across studies, and was reliable but of small magnitude once corrections for bias were applied. Effect sizes for the other outcomes were no longer reliable once corrections for bias were applied. Several features of the sample, intervention, and methodology moderated intervention effects. Twelve change techniques were associated with improvements in body image, and three techniques were contra-indicated. Conclusions The findings show that interventions engender only small improvements in body image, and underline the need for large-scale, high-quality trials in this area. The review identifies effective techniques that could be deployed in future interventions

Stroke recovery in rats after 24h-delayed intramuscular neurotrophin-3 infusion

Objective Neurotrophin‐3 (NT3) plays a key role in the development and function of locomotor circuits including descending serotonergic and corticospinal tract axons and afferents from muscle and skin. We have previously shown that gene therapy delivery of human NT3 into affected forelimb muscles improves sensorimotor recovery after stroke in adult and elderly rats. Here, to move toward the clinic, we tested the hypothesis that intramuscular infusion of NT3 protein could improve sensorimotor recovery after stroke. Methods Rats received unilateral ischemic stroke in sensorimotor cortex. To simulate a clinically feasible time to treatment, 24 hours later rats were randomized to receive NT3 or vehicle by infusion into affected triceps brachii for 4 weeks using implanted catheters and minipumps. Results Radiolabeled NT3 crossed from the bloodstream into the brain and spinal cord in rodents with or without strokes. NT3 increased the accuracy of forelimb placement during walking on a horizontal ladder and increased use of the affected arm for lateral support during rearing. NT3 also reversed sensory impairment of the affected wrist. Functional magnetic resonance imaging during stimulation of the affected wrist showed spontaneous recovery of peri‐infarct blood oxygenation level–dependent signal that NT3 did not further enhance. Rather, NT3 induced neuroplasticity of the spared corticospinal and serotonergic pathways. Interpretation Our results show that delayed, peripheral infusion of NT3 can improve sensorimotor function after ischemic stroke. Phase I and II clinical trials of NT3 (for constipation and neuropathy) have shown that peripheral high doses are safe and well tolerated, which paves the way for NT3 as a therapy for stroke

Volumetric laser endomicroscopy and its application to Barrett\u27s esophagus: results from a 1,000 patient registry.

Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan was performed. The objective of this registry was to determine usage patterns of VLE in clinical practice and to estimate quantitative and qualitative performance metrics as they are applied to Barrett\u27s esophagus (BE) management. All procedures utilized the NvisionVLE Imaging System (NinePoint Medical, Bedford, MA) which was used by investigators to identify the tissue types present, along with focal areas of concern. Following the VLE procedure, investigators were asked to answer six key questions regarding how VLE impacted each case. Statistical analyses including neoplasia diagnostic yield improvement using VLE was performed. One thousand patients were enrolled across 18 US trial sites from August 2014 through April 2016. In patients with previously diagnosed or suspected BE (894/1000), investigators used VLE and identified areas of concern not seen on white light endoscopy (WLE) in 59% of the procedures. VLE imaging also guided tissue acquisition and treatment in 71% and 54% of procedures, respectively. VLE as an adjunct modality improved the neoplasia diagnostic yield by 55% beyond the standard of care practice. In patients with no prior history of therapy, and without visual findings from other technologies, VLE-guided tissue acquisition increased neoplasia detection over random biopsies by 700%. Registry investigators reported that VLE improved the BE management process when used as an adjunct tissue acquisition and treatment guidance tool. The ability of VLE to image large segments of the esophagus with microscopic cross-sectional detail may provide additional benefits including higher yield biopsies and more efficient tissue acquisition. Clinicaltrials.gov NCT02215291

Changing Bodies: Experiences of Women Who Have Undergone a Surgically Induced Menopause.

We aimed to explore the lived experiences of women who had a surgical menopause as a result of undergoing a hysterectomy with Bilateral Salpingo-Oopherectomy (BSO). We adopted a qualitative interview design using Interpretative Phenomenological Analysis (IPA), and recruited 7 women aged 47 to 59. We conducted synchronous online semistructured interviews using the MSN (Microsoft Network) Messenger program. In the findings, we examine the prominent and underresearched theme of body image change. We discuss the women's journey from a deep internal bodily change, the meaning of this changing body image, through to the thoughts and behaviors involved with self-presentation concerns and coping with body image changes. A woman's perceived attractiveness and appearance investment are important factors to consider regarding adaptation to change over this transition. The findings might have implications for interventions designed to enhance mental well-being and increase health behaviors in women experiencing gynecological illness and/or menopause