A Model of Precipitation Rates in Kentucky, 1965-1996

Hourly precipitation data from thirty cooperative stations in Kentucky from 1965 to 1996 were used to determine the diurnal distribution of precipitation rates. Descriptive summaries for the diurnal distribution for each climate division in Kentucky and for Kentucky as a whole were calculated. In each case, the trends were similar. Precipitation rates increased into the afternoon and then decreased until sunrise. A stochastic model was developed to estimate mean seasonal precipitation rates in Kentucky by using regional and localized parameters. More than half of the variation (r2 = 0.57) in precipitation rates can be explained by the following variables: 1) Distance away from the moisture source, the Gulf of Mexico; 2) Roughness of topography; 3) Degree of urbanization. Precipitation rates decrease in a northeasterly direction across Kentucky as air moves farther away from the Gulf of Mexico along its path of migration. The maritime tropical air mass migrating out of the Gulf of Mexico loses its water vapor over its path of migration. As a result, less water vapor is available for precipitation processes in areas farther away. As a precipitation event moves over rougher terrain and more urbanized areas, precipitation rates decrease as well. A rougher terrain absorbs more solar radiation because it has more surface area. An urbanized area absorbs more solar radiation because of the urban structures (e.g., buildings, asphalt, roofs). As a result, both will radiate more heat causing the air to be buoyant at the surface to either enhance convection or increase vertical air motions. Increased vertical air motions will cause an increase in air resistance acting upon precipitation falling, thereby, causing a decrease in the amount falling to the surface per hour

Evaluation of an Alternate Method for Determining Yield Strength Offset Values for Selective Laser Sintered Polymeric Materials

Due to the unique characteristics of Additively Manufactured (AM) polymeric materials, typical mechanical strength characterization methods such as those commonly used for traditionally-processed polymers or composite materials can produce results that do not accurately represent material capabilities. In order to characterize mechanical properties of these materials, new test and analysis methods are required. As part of the National Aeronautics and Space Administration (NASA) Advanced Composites Project (ACP), Boeing has evaluated true yield testing as an alternative or complimentary test to 0.2% offset yield testing for determining appropriate yield strength values of polymer materials. Previous testing has shown high strain, low modulus polymer materials such as selective laser sintered (SLS) Nylon 11 at elevated temperatures produce large variations in yield strength. The true yield test method was successful in finding the applied strain level when yield commences and appears to offer an increase in data robustness

Examining Form and Function of Dendritic Spines

The majority of fast excitatory synaptic transmission in the central nervous system takes place at protrusions along dendrites called spines. Dendritic spines are highly heterogeneous, both morphologically and functionally. Not surprisingly, there has been much speculation and debate on the relationship between spine structure and function. The advent of multi-photon laser-scanning microscopy has greatly improved our ability to investigate the dynamic interplay between spine form and function. Regulated structural changes occur at spines undergoing plasticity, offering a mechanism to account for the well-described correlation between spine size and synapse strength. In turn, spine structure can influence the degree of biochemical and perhaps electrical compartmentalization at individual synapses. Here, we review the relationship between dendritic spine morphology, features of spine compartmentalization and synaptic plasticity. We highlight emerging molecular mechanisms that link structural and functional changes in spines during plasticity, and also consider circumstances that underscore some divergence from a tight structure-function coupling. Because of the intricate influence of spine structure on biochemical and electrical signalling, activity-dependent changes in spine morphology alone may thus contribute to the metaplastic potential of synapses. This possibility asserts a role for structural dynamics in neuronal information storage and aligns well with current computational models

Growing Season Air mass Equivalent Temperature (T\u3csub\u3eE\u3c/sub\u3e) in the East Central USA

Equivalent temperature (TE), which incorporates both dry (surface air temperature, T) and moist heat content associated with atmospheric moisture, is a better indicator of overall atmospheric heat content compared to T alone. This paper investigates the impacts of different types of air masses on TE during the growing season (April–September). The study used data from the Kentucky Mesonet for this purpose. The growing season was divided into early (April–May), mid (June–July), and late (August–September). Analysis suggests that TE for moist tropical (MT) air mass was as high as 61 and 81 °C for the early and mid-growing season, respectively. Further analysis suggests that TE for different parts of the growing seasons were statistically significantly different from each other. In addition, TE for different air masses was also statistically significantly different from each other. The difference between TE and T (i.e. TE-T) is smaller under dry atmospheric conditions but larger under moist conditions. For example, in Barren County, the lowest difference (20–10 °C) was 10 °C. It was reported on 18 April 2010, a dry weather day. On the other hand, the highest difference for this site was 48 °C and was reported on 11 August 2010, a humid day

Growing Season Air mass Equivalent Temperature (TE) in the East Central USA

Equivalent temperature (TE), which incorporates both dry (surface air temperature, T) and moist heat content associated with atmospheric moisture, is a better indicator of overall atmospheric heat content compared to T alone. This paper investigates the impacts of different types of air masses on TE during the growing season (April–September). The study used data from the Kentucky Mesonet for this purpose. The growing season was divided into early (April–May), mid (June–July), and late (August–September). Analysis suggests that TE for moist tropical (MT) air mass was as high as 61 and 81 C for the early and mid-growing season, respectively. Further analysis suggests that TE for different parts of the growing seasons were statistically significantly different from each other. In addition, TE for different air masses was also statistically significantly different from each other. The v between TE and T (i.e. TE-T) is smaller under dry atmospheric conditions but larger under moist conditions. For example, in Barren County, the lowest difference (20–10 C) was 10 C. It was reported on 18 April 2010, a dry weather day. On the other hand, the highest difference for this site was 48 C and was reported on 11 August 2010, a humid day

Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials

Background: This study assessed the immunogenicity of pegvaliase (recombinant Anabaena variabilis phenylalanine [Phe] ammonia lyase [PAL] conjugated with polyethylene glycol [PEG]) treatment in adults with phenylketonuria (PKU) and its impact on safety and efficacy. Methods: Immunogenicity was assessed during induction, upward titration, and maintenance dosing regimens in adults with PKU (n = 261). Total antidrug antibodies (ADA), neutralizing antibodies, immunoglobulin (Ig) M and IgG antibodies against PAL and PEG, IgG and IgM circulating immune complex (CIC) levels, complement components 3 and 4 (C3/C4), plasma Phe, and safety were assessed at baseline and throughout the study. Pegvaliase-specific IgE levels were measured in patients after hypersensitivity adverse events (HAE). Findings: All patients developed ADA against PAL, peaking by 6 months and then stabilizing. Most developed transient antibody responses against PEG, peaking by 3 months, then returning to baseline by 9 months. Binding of ADA to pegvaliase led to CIC formation and complement activation, which were highest during early treatment. Blood Phe decreased over time as CIC levels and complement activation declined and pegvaliase dosage increased. HAEs were most frequent during early treatment and declined over time. No patient with acute systemic hypersensitivity events tested positive for pegvaliase-specific IgE near the time of the event. Laboratory evidence was consistent with immune complex-mediated type III hypersensitivity. No evidence of pegvaliase-associated IC-mediated end organ damage was noted. Interpretation: Despite a universal ADA response post-pegvaliase administration, adult patients with PKU achieved substantial and sustained blood Phe reductions with a manageable safety profile. Fund: BioMarin Pharmaceutical Inc. Keywords: Enzyme replacement therapy, Antidrug antibody, Circulating immune complex, Hypersensitivity, Phenylalanin

Public perceptions of, and responses to, desalination in Australia : a report on findings

Desalination as a method of ensuring a rainfall independent source of potable water has become an increasingly favourable option for Australian governments, particularly over the last decade or so. This is especially true for metropolitan areas. The social acceptability of new sources of water, however, impacts on the readiness with which publics accept changed or augmented water supplies. Researchers at Deakin University, Victoria University and Murdoch University, with funding from the National Centre of Excellence in Desalination Australia (NCEDA), have conducted a study of public attitudes to desalination in Australia. This report outlines the results of the 18 month project, which comprises three sections. The cornerstone of the project is a national survey (n=3077), conducted by Datacol Research. The second component of the study consists of focus groups in the vicinity of three existing or developing desalination plants: Wonthaggi (Victoria), Port Stanvac (South Australia), and Kwinana (Western Australia). The third component of the study presented in this report involves interviews with desalination scientists and other technical experts, in relation to their attitudes to communication with lay publics

The utility of modified Butler-Leggett criteria for right ventricular hypertrophy in detection of clinically significant shunt ratio in ostium secundum-type atrial septal defect in adults

Background: This study was performed to test the hypothesis that there exists a correlation between the Butler-Leggett (BL) criterion for right ventricular hypertrophy on the electrocardiogram and the Qp/Qs shunt ratio in adults with ostium secundum atrial septal defects (ASDs). Methods: Demographic, cardiac catheterization, ASD closure, and electrocardiographic data were acquired on 70 patients with secundum ASDs closed percutaneously. Simple linear regression and logistic regression models were created to test the hypothesis. Results: The mean Qp/Qs ratio and BL criterion value were 1.61 +/- 0.46 and 0.11 +/- 0.41, respectively. The BL criterion values correlated with shunt ratios (r(2) = 0.11 and P = .004). A BL criterion value greater than 0 mV predicted a significant shunt ratio (Qp/Qs \u3e or = 1.5) (odds ratio, 4.8; 95% confidence interval, 1.3, 18.1; P = or \u3c.0001) with a sensitivity of 0.68 and specificity of 0.65. Conclusion: Our results indicate that there is limited utility of the BL criterion at detecting right ventricular volume overload, although a BL criterion value greater than 0 mV being used to identify patients with significant intracardiac shunts yielded a sensitivity of 0.68 and specificity of 0.65