On the Double Planet System Around HD 83443

The Geneva group has reported two Saturn-mass planets orbiting HD 83443 (K0V) with periods of 2.98 and 29.8 d. The two planets have raised interest in their dynamics because of the possible 10:1 orbital resonance and the strong gravitational interactions. We report precise Doppler measurements of HD 83443 obtained with the Keck/HIRES and the AAT/UCLES spectrometers. These measurements strongly confirm the inner planet with period of 2.985 d, with orbital parameters in very good agreement with those of the Geneva group. However these Doppler measurements show no evidence of the outer planet, at thresholds of 1/4 (3 m/s) of the reported velocity amplitude of 13.8 m/s. Thus, the existence of the outer planet is in question. Indeed, the current Doppler measurements reveal no evidence of any second planet with periods less than a year.Comment: 26 pages incl. 3 tables and 8 figures; uses AASTE

Interaction between oxytocin receptor DNA methylation and genotype is associated with risk of postpartum depression in women without depression in pregnancy

Postpartum depression (PPD) affects up to 19% of women, negatively impacting maternal and infant health. Reductions in plasma oxytocin levels have been associated with PPD and heritability studies have established a genetic contribution. Epigenetic regulation of the oxytocin receptor gene (OXTR) has been demonstrated and we hypothesized that individual epigenetic variability at OXTR may impact the development of PPD and that such variability may be central to predicting risk. This case-control study is nested within the Avon Longitudinal Study of Parents and Children and included 269 cases with PPD and 276 controls matched on age group, parity, and presence or absence of depressive symptoms in pregnancy as assessed by the Edinburgh Postnatal Depression Scale. OXTR DNA methylation (CpG site -934) and genotype (rs53576 and rs2254298) were assayed from DNA extracted from blood collected during pregnancy. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association of elevated symptoms of PPD with genotype, methylation, and their interaction adjusted for psychosocial factors (n=500). There was evidence of an interaction between rs53576 and methylation in the OXTR gene amongst women who did not have depression prenatally but developed PPD (p interaction=0.026, adjusted for covariates, n=257). Those women with GG genotype showed 2.63 greater odds of PPD for every 10% increase in methylation level (95% CI: 1.37, 5.03), whereas methylation was unrelated to PPD amongst A carriers (OR=1.00, 95%CI: 0.58, 1.73). There was no such interaction among women with PPD and prenatal depression. These data indicate that epigenetic variation that decreases expression of OXTR in a susceptible genotype may play a contributory role in the etiology of postpartum depression

A Super-Earth and Two Neptunes Orbiting the Nearby Sun-like Star 61 Virginis

We present precision radial velocity data that reveal a multiple exoplanet system orbiting the bright nearby G5V star 61 Virginis. Our 4.6 years of combined Keck/HIRES and Anglo-Australian Telescope precision radial velocities indicate the hitherto unknown presence of at least three planets orbiting this well-studied star. These planets are all on low-eccentricity orbits with periods of 4.2, 38.0, and 124.0 days, and projected masses (Msin i) of 5.1, 18.2, and 24.0 M_⊕, respectively. Test integrations of systems consistent with the radial velocity data suggest that the configuration is dynamically stable. Depending on the effectiveness of tidal dissipation within the inner planet, the inner two planets may have evolved into an eccentricity fixed-point configuration in which the apsidal lines of all three planets corotate. This conjecture can be tested with additional observations. We present a 16-year time series of photometric observations of 61 Virginis, which comprise 1194 individual measurements, and indicate that it has excellent photometric stability. No significant photometric variations at the periods of the proposed planets have been detected. This new system is the first known example of a G-type Sun-like star hosting a Super-Earth mass planet. It joins HD 75732 (55 Cnc), HD 69830, GJ 581, HD 40307, and GJ 876 in a growing group of exoplanet systems that have multiple planets orbiting with periods less than an Earth-year. The ubiquity of such systems portends that space-based transit-search missions such as Kepler and CoRoT will find many multi-transiting systems

Hairy Black Holes in String Theory

Solutions of bosonic string theory are constructed which correspond to four-dimensional black holes with axionic quantum hair. The basic building blocks are the renormalization group flows of the CP1 model with a theta term and the SU(1,1)/U(1) WZW coset conformal field theory. However the solutions are also found to have negative energy excitations, and are accordingly expected to decay to the vacuum.Comment: 14 pages (References added

Accuracy and Efficiency of Recording Pediatric Early Warning Scores Using an Electronic Physiological Surveillance System Compared With Traditional Paper-Based Documentation

Pediatric Early Warning Scores are advocated to assist health professionals to identify early signs of serious illness or deterioration in hospitalized children. Scores are derived from the weighting applied to recorded vital signs and clinical observations reflecting deviation from a predetermined "norm." Higher aggregate scores trigger an escalation in care aimed at preventing critical deterioration. Process errors made while recording these data, including plotting or calculation errors, have the potential to impede the reliability of the score. To test this hypothesis, we conducted a controlled study of documentation using five clinical vignettes. We measured the accuracy of vital sign recording, score calculation, and time taken to complete documentation using a handheld electronic physiological surveillance system, VitalPAC Pediatric, compared with traditional paper-based charts. We explored the user acceptability of both methods using a Web-based survey. Twenty-three staff participated in the controlled study. The electronic physiological surveillance system improved the accuracy of vital sign recording, 98.5% versus 85.6%, P < .02, Pediatric Early Warning Score calculation, 94.6% versus 55.7%, P < .02, and saved time, 68 versus 98 seconds, compared with paper-based documentation, P < .002. Twenty-nine staff completed the Web-based survey. They perceived that the electronic physiological surveillance system offered safety benefits by reducing human error while providing instant visibility of recorded data to the entire clinical team

講演 題詠の翻訳 ―頓阿の歌をめぐって―

Many problems face anyone attempting to translate poetry from one language into another. Some of these specific to the languages in question. When it comes to translating traditional Japanese poetry into English, for instance, the translator nearly always must deal with thorny problems of pronoun reference and the challenges of syntactic compression, to name just two.There are also some more universal problems. One of these is just how far to go in preserving the "otherness" of the text. Obviously, the appeal of reading the poetry of another culture is partly in its otherness, which one therefore wants to preserve as much as possible. But deciding just how to do so is no easy task.I have confronted this problem myself over the past twenty years or so in attempting to introduce the poetry of late medieval Japan to an English speaking audience. My first experiences involved the genre of renga, or linked verse; more recently I have been concentrating on uta, the classical thirty-one syllable form that was the major poetic genre of the Japanese poetic tradition from the time of Kokinshu until 1600 or so. At first I thought that translating uta would be an easier task. The verse form was not as short, there was no bothersome "linking" to deal with, and most importantly, there was no need to deal with the tension between completeness and incompleteness that is the essence of linked verse.Needless to say, I was wrong in my assumptions. For in translating medieval uta I learned quickly that the genre poses its own thorny problems, and that--as common sense should have told me--some of the traits of linked verse as a genre were shared by uta, another fact that I should have expected of genres in the same historical situation. Indeed, I discovered that a certain tension between completeness and incompleteness-- in the form of an almost explicit intertextuality--may be even more conspicuous in late medieval uta than it is in linked verse.One can talk about this tension in various ways. For this presentation, I will attempt to do so through a discussion of the practice of daiei, or composition on pre-established topics. Nearly all of the uta of the late medieval age were in fact composed on such topics. Indeed, so central was the practice that poets of the time seem not to have reflected much on the assumptions behind it. For modem readers, however, the practice seems profoundly unusual, presenting us with a potent revelation of the otherness of the form. But can the significance of daiei be communicated through translation? It will be my task to explore that topic, using some poems of Tonna (1289-1372), a true master of daiei, as points of reference

Aptamer-based multiplexed proteomic technology for biomarker discovery

Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 [mu]L of serum or plasma). Our current assay allows us to measure ~800 proteins with very low limits of detection (1 pM average), 7 logs of overall dynamic range, and 5% average coefficient of variation. This technology is enabled by a new generation of aptamers that contain chemically modified nucleotides, which greatly expand the physicochemical diversity of the large randomized nucleic acid libraries from which the aptamers are selected. Proteins in complex matrices such as plasma are measured with a process that transforms a signature of protein concentrations into a corresponding DNA aptamer concentration signature, which is then quantified with a DNA microarray. In essence, our assay takes advantage of the dual nature of aptamers as both folded binding entities with defined shapes and unique sequences recognizable by specific hybridization probes. To demonstrate the utility of our proteomics biomarker discovery technology, we applied it to a clinical study of chronic kidney disease (CKD). We identified two well known CKD biomarkers as well as an additional 58 potential CKD biomarkers. These results demonstrate the potential utility of our technology to discover unique protein signatures characteristic of various disease states. More generally, we describe a versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations. This unbiased and highly multiplexed search engine will enable the discovery of novel biomarkers in a manner that is unencumbered by our incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine

Diversification and agrarian change under environmental constraints in rural China: Evidence from a poor township of Beijing municipality

Working paper du GATE 2007-11This article illustrates the impact of changes related to market reforms and environmental policies on the economic structure in rural China by providing a comparative analysis of several villages in a poor township in Beijing municipality. Two main concomitant phenomena are affecting agricultural and non-agricultural choices in the studied area. First, the introduction of market mechanisms is encouraging local population to engage in new activities that are closer to local comparative advantages. Second, rural households are facing new constraints in the form of environmental protection measures, which have weakened traditional insurance channels provided by forest resources and cattle stock. Drawing on household-level survey data and interviews with village heads conducted in ten villages of Labagoumen township in December 2003, this article analyzes households decisions in response to market reforms and environmental constraints. We find large disparities both between villages and households in the diversification process and discuss the reasons of observed inertia in the region, most households still heavily relying on corn production

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin