Peripheral ameloblastoma: use of cytokeratin 19 and Ber-EP4 to distinguish it from basal cell carcinoma

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Bringing the Embedded Systems Industry Towards Open Source: the SHARE project experience

International audienceOpen source software adoption in the embedded systems domain is gaining growing interest within the european industrial and academic communities due to the significant benefits it brings in terms of flexibility and cost reduction.Nonetheless, scepticism about open source as a viable option to support critical business functions still holds, since its decentralized and distributed development model makes quality evaluation and assessment hard to achieve. This paper reports the SHARE project experience, aimed at facilitating and promoting the use of open source software in the embedded systems industry. Performed activities, proposed methodology and achieved results are presented, along with lessons learned to exploit for enabling further initiatives in the next future

Use of beneficial bacteria Azospirillum brasilense Sp245 on grapevine rootstocks grafted with 'Sangiovese'

Azospirillum brasilense Sp245, a well-known PGPR (plant growth-promoting rhizobacteria), was examined in order to evaluate the effects on nursery propagation. In addition the aim was to test the ability of the inoculated bacterium to improve the rooting parameters of some rootstocks that do not easily root through conventional techniques. Nine rootstocks were tested in a conventional nursery, while two rootstocks were tested in organic nursery: V. berlandieri × V. riparia 420A, 161-49, 157-11, SO4; V. berlandieri × V. rupestris 140Ru, 775P, 1103P; V. riparia × V. rupestris 101-14, 3309C. The quality of the root system was improved in terms of the number of roots, root architecture and the total biomass of vines produced in the organic nursery, while in the conventional nursery the results depended on the rootstock. The results suggest that further study is needed for a better comprehension of the mode of action and to establish how PGPR could be used for the sustainable production of grapevine plants

The Role of Field Data for Analyzing the Dependability of Short Range Wireless Technologies

Abstract. The migration from mobile to ubiquitous Internet is at hand, due to the intense growth of short range wireless technologies. Users accessing the Internet through wireless devices are increasing, if compared to "wired" ones, and they expect the same dependability level they already experience on wired networks, that is high quality "always on" wireless networks. But how can we analyze the dependability level of a wireless network? Direct analysis of failures from the field of application is an effective practice to understand the actual dependability behavior of an operational system. However, despite its wide use over the last four decades on a large variety of systems, field data analysis has rarely been applied to wireless networks. Through the experience gained from extensive failure analysis of Bluetooth networks, the article shows how field failure data can play a key role to fill the gap on understanding the dependability behavior of wireless networks

Design of a cybernetic hand for perception and action

Strong motivation for developing new prosthetic hand devices is provided by the fact that low functionality and controllability—in addition to poor cosmetic appearance—are the most important reasons why amputees do not regularly use their prosthetic hands. This paper presents the design of the CyberHand, a cybernetic anthropomorphic hand intended to provide amputees with functional hand replacement. Its design was bio-inspired in terms of its modular architecture, its physical appearance, kinematics, sensorization, and actuation, and its multilevel control system. Its underactuated mechanisms allow separate control of each digit as well as thumb–finger opposition and, accordingly, can generate a multitude of grasps. Its sensory system was designed to provide proprioceptive information as well as to emulate fundamental functional properties of human tactile mechanoreceptors of specific importance for grasp-and-hold tasks. The CyberHand control system presumes just a few efferent and afferent channels and was divided in two main layers: a high-level control that interprets the user’s intention (grasp selection and required force level) and can provide pertinent sensory feedback and a low-level control responsible for actuating specific grasps and applying the desired total force by taking advantage of the intelligent mechanics. The grasps made available by the high-level controller include those fundamental for activities of daily living: cylindrical, spherical, tridigital (tripod), and lateral grasps. The modular and flexible design of the CyberHand makes it suitable for incremental development of sensorization, interfacing, and control strategies and, as such, it will be a useful tool not only for clinical research but also for addressing neuroscientific hypotheses regarding sensorimotor control

Assessing Mn as an antioxidant agent in bioactive glasses by quantification of catalase and superoxide dismutase enzymatic mimetic activities

The antioxidant activity of Mn as additive in a 45S5 type glass system with and without P2O5 was studied by mimicking the activity of catalase (CMA) and superoxide dismutase (SOD) enzymes. Glasses were melted either under oxidizing or reducing atmosphere (N2/H2) to compare the processing influence on the Mn oxidation state. Thermal (DTA) and optical (UV–Vis) characterizations of the glass powders were carried out to obtain further insight into the structural role of Mn. A correlation of in vitro apatite formation between Tris buffer solution and Simulated Body Fluid (SBF) was performed to optimise Mn substitution, where a decrease in apatite formation was observed by increasing Mn content. Despite this, glasses with up to 1.0 mol% MnO did not show any delay in apatite formation and maintained their CMA and SOD activity. The antioxidant effect of Mn can be attributed to the interconversion Mn2+ ↔ Mn3+ occurring on the glass surface through a heterogeneous catalysis. P2O5 plays an important role in the antioxidant effect of the glass, possibly by charge balancing Mn ions and forming more stable units compared to those formed with Ca and Na. The amount of Mn2+ is predominant in the glass network with respect to Mn3+ in all synthetized glasses. Moreover, glass melting in a reducing atmosphere further avoided Mn oxidation

Productivity Enhancement in Directed Energy Deposition: The Oscillating Scanning Strategy Approach

Directed Energy Deposition (DED) is an additive manufacturing process that enables the production of large metal components by melting the feedstock material while being deposited. An improvement of the production speed of this process would further increase its applicability in many industrial fields. The DED building rate is strictly related to the building parameters adopted, in particular to the laser spot diameter, which also affects the build accuracy and the surface quality of the components. The possibility of using a variable laser spot would result in a significant increase in the production rate in bulky zones, while also providing a good surface quality where needed. In the present work, an oscillating scanning strategy was used to create a large apparent laser spot (+ 170% of the nominal value) to produce 316L stainless steel samples via DED. The optimisation of the DED parameters with the oscillating strategy was performed using the single scan tracks (SSTs) approach. The morphologies of the SSTs obtained with different process parameters were assessed and the geometrical features related to the melt pools were analysed in order to select the most suitable X and Z displacements for the production of the cubic samples. The analyses of the cubes revealed that, if the correct overlap among nearby scans is selected, it is possible to obtain dense samples with all the oscillating diameters tested. Finally, comparing the building rate and powder efficiency values confirmed that this method can accelerate the building process and improve its overall performance

Small ruminant lentivirus genotype B and E interaction: Evidences on the role of Roccaverano strain on reducing proviral load of the challenging CAEV strain.

Live attenuated vaccines provide the most consistent protective immunity in experimental models of lentivirus infections. In this study we tested the hypothesis that animals infected with a naturally attenuated small ruminant lentivirus field strain of genotype E may control a challenge infection with a virulent strain of the caprine arthritis encephalitis virus (CAEV-CO). Within genotype E, Roccaverano strain has been described as attenuated since decreased arthritic pathological indexes were recorded in Roccaverano-infected animals compared to animals of the same breed infected with genotype B strains. Moreover, under natural conditions, animals double-infected with genotypes B and E appear less prone to develop SRLV-related disease, leading to a putative protective role of Roccaverano strain. Here we present evidence that goats experimentally infected with the avirulent genotype E SRLV-Roccaverano strain control the proviral load of a pathogenic challenge virus (CAEV-CO strain) more efficiently than naïve animals and appear to limit the spread of histological lesions to the contralateral joints

Endoscopic Tactile Capsule for Non-Polypoid Colorectal Tumour Detection

An endoscopic tactile robotic capsule, embedding miniaturized MEMS force sensors, is presented. The capsule is conceived to provide automatic palpation of non-polypoid colorectal tumours during colonoscopy, since it is characterized by high degree of dysplasia, higher invasiveness and lower detection rates with respect to polyps. A first test was performed employing a silicone phantom that embedded inclusions with variable hardness and curvature. A hardness-based classification was implemented, demonstrating detection robustness to curvature variation. By comparing a set of supervised classification algorithms, a weighted 3-nearest neighbor classifier was selected. A bias force normalization model was introduced in order to make different acquisition sets consistent. Parameters of this model were chosen through a particle swarm optimization method. Additionally, an ex-vivo test was performed to assess the capsule detection performance when magnetically-driven along a colonic tissue. Lumps were identified as voltage peaks with a prominence depending on the total magnetic force applied to the capsule. Accuracy of 94 % in hardness classification was achieved, while a 100 % accuracy is obtained for the lump detection within a tolerance of 5 mm from the central path described by the capsule. In real application scenario, we foresee our device aiding physicians to detect tumorous tissues

are adverse events aes predictive of nivolumab activity data from the italian expanded access program in metastatic renal cell carcinoma mrcc

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