38 research outputs found
The benefit of evolving multidisciplinary care in ALS: a diagnostic cohort survival comparison
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND
Care for people with amyotrophic lateral sclerosis (ALS) has altered at King's College Hospital over the last 20 years. The clinic has been a multidisciplinary, specialist, tertiary referral centre since 1995 with a large team with integrated palliative and respiratory care since 2006. We hypothesised that these changes would improve survival.
METHODS
In this retrospective observational study, patients diagnosed with El Escorial definite, probable and possible ALS between 1995-1998 and 2008-2011 were followed up. The primary outcome measure was a chi-square test for the proportion of each cohort surviving. Kaplan-Meier survival analysis and Cox multivariate regression were secondary analyses.
RESULTS
There was low reporting of some interventions. Five hundred and forty-seven people were included. Survival between the cohorts was significantly different (p = 0.022) with a higher proportion surviving during 2008-2011. Survival time was 21.6 (95% CI 19.2-24.0) months in the 2008-2011 cohort compared to 19.2 years (15.6-21.6) in the 1995-1998 cohort (log rank p = 0.018). Four hundred and ninety-three cases were included in the Cox regression. Diagnostic cohort was a significant predictor variable (HR 0.79 (0.64-0.97) p = 0.023).
CONCLUSIONS
These results support the hypothesis that integrated specialist clinics with multidisciplinary input improve survival in ALS
Cosmological parameters from SDSS and WMAP
- Author
- A. de Oliveira-Costa
- A. Gelman
- A. Kogut
- A. Kosowsky
- A. Lewis
- A. Linde
- A. Melchiorri
- A. Refregier
- A. Vilenkin
- A.B. Balakin
- A.C. Taylor
- A.D. Dolgov
- A.D. Linde
- A.E. Lange
- A.J.S. Hamilton
- A.R. Liddle
- A.R. Liddle
- A.T. Lee
- Adrian Pope
- Albert Stebbins
- Alexander S. Szalay
- Andreas Berlind
- Andrew Connolly
- B. Kyae
- B. Novosyadlyj
- B.M.S. Hansen
- Bhuvnesh Jain
- Brian C. Lee
- Brian Yanny
- Bruce Gillespie
- C. Stoughton
- C.H. Lineweaver
- C.H. Lineweaver
- C.L. Bennett
- C.L. Kuo
- C.R. Contaldi
- Christopher Stoughton
- Constance Rockosi
- D. Bacon
- D. Wands
- D.G. York
- D.H. Lyth
- D.J. Eisenstein
- D.J. Eisenstein
- D.J. Eisenstein
- D.N. Spergel
- D.W. Hogg
- Daniel E. Vanden Berk
- Daniel J. Eisenstein
- David H. Weinberg
- David Johnston
- David Schlegel
- David W. Hogg
- Don Q. Lamb
- Donald G. York
- Donald P. Schneider
- Douglas Finkbeiner
- Douglas L. Tucker
- E. Pierpaoli
- E. Pierpaoli
- Fiona Hoyle
- Francisco J. Castander
- G. Efstathiou
- G. Efstathiou
- G. Efstathiou
- G. Hinshaw
- Gillian R. Knapp
- Greg Hennessy
- H. Hoestra
- H. Sandvik
- H.V. Peiris
- Havard Sandvik
- Huan Lin
- I. Zehavi
- Idit Zehavi
- Istvan Csabai
- István Szapudi
- J. Brinkmann
- J. Weller
- J.A. Smith
- J.E. Gunn
- J.E. Lidsey
- J.E. Ruhl
- J.L. Sievers
- J.L. Tonry
- J.N. Bahcall
- J.P. Ostriker
- J.R. Bond
- J.R. Bond
- J.R. Pier
- James Annis
- James E. Gunn
- Jeffrey A. Munn
- Jeffrey R. Pier
- Jeremiah P. Ostriker
- John Peoples
- Jon Loveday
- Joshua A. Frieman
- K. Abazajian
- K.N. Abazajian
- K.N. Abazajian
- K.N. Abazajian
- Kevork Abazajian
- L. Hui
- L. Knox
- L. Page
- L. van Waerbeke
- L. Verde
- L. Verde
- Lam Hui
- Liam O’Connell
- M. Chu
- M. Colless
- M. Fukugita
- M. Jarvis
- M. Kaplinghat
- M. Kaplinghat
- M. Tegmark
- M. Tegmark
- M. Tegmark
- M. Tegmark
- M. Tegmark
- M. White
- M. Zaldarriaga
- M.A. Strauss
- M.L. Brown
- M.R. Blanton
- M.S. Smith
- Mamoru Doi
- Masataka Fukugita
- Max Tegmark
- Michael A. Strauss
- Michael R. Blanton
- Michael Richmond
- Michael S. Vogeley
- N. Christensen
- N. Metropolis
- N.A. Bahcall
- N.A. Bahcall
- N.W. Halverson
- Neta A. Bahcall
- O Zahn
- O. Elgaroy
- O. Lahav
- P. Crotty
- P. Di Bari
- P. Di Bari
- P. Fischer
- P. Fosalba
- P. Schuecker
- P.N. Walker
- P.T.P. Viana
- Peter Kunszt
- R. Trotta
- R.E. Smith
- R.H. Cyburt
- R.R. Caldwell
- R.R. Caldwell
- Ravi K. Sheth
- Reiko Nakajima
- Robert C. Nichol
- Robert H. Lupton
- Roman Scoccimarro
- Ryan Scranton
- S. Borgani
- S. Bridle
- S. Burles
- S. DeDeo
- S. Dodelson
- S. Hannestad
- S.L. Bridle
- S.M. Carroll
- S.S. McGaugh
- S.W. Allen
- S.W. Allen
- Scott Burles
- Scott Dodelson
- Stephen Kent
- T. Barreiro
- T. Budavari
- T. Hamana
- T.H. Reiprich
- T.J. Pearson
- Tamás Budavari
- Timothy A. McKay
- U. Seljak
- U. Seljak
- U. Seljak
- Uroš Seljak
- W. Hu
- W. Hu
- W. Hu
- W.J. Percival
- W.K. Hastings
- W.L. Freedman
- X. Wang
- X. Wang
- Xiaomin Wang
- Y. Song-S
- Y. Wang
- Y.Y. Wong
- Yongzhong Xu
- Željko Ivezić
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 15/01/2004
- Field of study
We measure cosmological parameters using the three-dimensional power spectrum
P(k) from over 200,000 galaxies in the Sloan Digital Sky Survey (SDSS) in
combination with WMAP and other data. Our results are consistent with a
``vanilla'' flat adiabatic Lambda-CDM model without tilt (n=1), running tilt,
tensor modes or massive neutrinos. Adding SDSS information more than halves the
WMAP-only error bars on some parameters, tightening 1 sigma constraints on the
Hubble parameter from h~0.74+0.18-0.07 to h~0.70+0.04-0.03, on the matter
density from Omega_m~0.25+/-0.10 to Omega_m~0.30+/-0.04 (1 sigma) and on
neutrino masses from <11 eV to <0.6 eV (95%). SDSS helps even more when
dropping prior assumptions about curvature, neutrinos, tensor modes and the
equation of state. Our results are in substantial agreement with the joint
analysis of WMAP and the 2dF Galaxy Redshift Survey, which is an impressive
consistency check with independent redshift survey data and analysis
techniques. In this paper, we place particular emphasis on clarifying the
physical origin of the constraints, i.e., what we do and do not know when using
different data sets and prior assumptions. For instance, dropping the
assumption that space is perfectly flat, the WMAP-only constraint on the
measured age of the Universe tightens from t0~16.3+2.3-1.8 Gyr to
t0~14.1+1.0-0.9 Gyr by adding SDSS and SN Ia data. Including tensors, running
tilt, neutrino mass and equation of state in the list of free parameters, many
constraints are still quite weak, but future cosmological measurements from
SDSS and other sources should allow these to be substantially tightened.Comment: Minor revisions to match accepted PRD version. SDSS data and ppt
figures available at http://www.hep.upenn.edu/~max/sdsspars.htm
Vigorous lateral export of the meltwater outflow from beneath an Antarctic ice shelf
- Author
- A Fabregat Tomàs
- A Jenkins
- A Jenkins
- A Shepherd
- Adrian Jenkins
- AG Pauling
- AL Stewart
- Alberto C. Naveira Garabato
- Alexander Forryan
- AM Thurnherr
- B Loose
- BJ Hoskins
- CD Rye
- D Carroll
- DL Rudnick
- FS Paolo
- G Richardson
- GJ Shutts
- HD Pritchard
- I Joughin
- I Kim
- J Feldmann
- J Marshall
- Karen J. Heywood
- KR Arrigo
- KR Arrigo
- KW Nicholls
- L Herráiz-Borreguero
- L Padman
- Liam Brannigan
- LN Thomas
- Louise C. Biddle
- M Thoma
- MA Depoorter
- NC Swart
- NS Oakey
- P Dutrieux
- P St-Laurent
- Pierre Dutrieux
- R Bintanja
- R Hohmann
- R Pawlowicz
- R Robertson
- R Robertson
- S Schmidtko
- Satoshi Kimura
- SG Purkey
- T Cowton
- TR Osborn
- TWN Haine
- V Daru
- Y Nakayama
- Y Xu
- Yvonne L. Firing
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 27/01/2017
- Field of study
The instability and accelerated melting of the Antarctic Ice Sheet are among the foremost elements of contemporary global climate change1, 2. The increased freshwater output from Antarctica is important in determining sea level rise1, the fate of Antarctic sea ice and its effect on the Earth’s albedo4, 5, ongoing changes in global deep-ocean ventilation6, and the evolution of Southern Ocean ecosystems and carbon cycling7, 8. A key uncertainty in assessing and predicting the impacts of Antarctic Ice Sheet melting concerns the vertical distribution of the exported meltwater. This is usually represented by climate-scale models3–5, 9 as a near-surface freshwater input to the ocean, yet measurements around Antarctica reveal the meltwater to be concentrated at deeper levels10, 11, 12, 13, 14. Here we use observations of the turbulent properties of the meltwater outflows from beneath a rapidly melting Antarctic ice shelf to identify the mechanism responsible for the depth of the meltwater. We show that the initial ascent of the meltwater outflow from the ice shelf cavity triggers a centrifugal overturning instability that grows by extracting kinetic energy from the lateral shear of the background oceanic flow. The instability promotes vigorous lateral export, rapid dilution by turbulent mixing, and finally settling of meltwater at depth. We use an idealized ocean circulation model to show that this mechanism is relevant to a broad spectrum of Antarctic ice shelves. Our findings demonstrate that the mechanism producing meltwater at depth is a dynamically robust feature of Antarctic melting that should be incorporated into climate-scale models
Innovative methods of community engagement: towards a low carbon climate resilient future
- Author
- Boyle Evan
- Brereton Pat
- Byrne Edmond P.
- Carr Liam
- Carroll James
- Doyle Ruth
- Dunphy Niall
- Emerson Harriet
- Fahy Frances
- Farrell Eugene
- Glynn James
- Greene Mary
- Hugel Stephan
- Lennon Breffni
- McGookin Connor
- Morrissey John
- Mullally Gerard
- O'Dwyer Barry
- Revez Alexandra
- Rogan Fionn
- Schuitema Geertje
- Smith Sonja
- Torney Diarmuid
- Watson Clare
- Publication venue
- 'International Energy and Environmental Research Institute'
- Publication date
- 29/01/2021
- Field of study
The proceedings of the Innovative Methods of Community Engagement: Toward a Low Carbon, Climate Resilient Future workshop have been developed by the Imagining2050 team in UCC and the Secretariat to the National Dialogue on Climate Action (NDCA). The NDCA also funded the workshop running costs. The proceedings offer a set of recommendations and insights into leveraging different community engagement approaches and methodologies in the area of climate action. They draw from interdisciplinary knowledge and experiences of researchers for identifying, mobilizing and mediating communities. The work presented below derives from a workshop held in the Environmental Research Institute in UCC on the 17th January 2019. These proceedings are complementary to an earlier workshop also funded by the NDCA and run by MaREI in UCC, titled ‘How do we Engage Communities in Climate Action? – Practical Learnings from the Coal Face’. The earlier workshop looked more closely at community development groups and other non-statutory organizations doing work in the area of climate change
Vigorous lateral export of the meltwater outflow from beneath an Antarctic ice shelf
- Author
- A Fabregat Tomàs
- A Jenkins
- A Jenkins
- A Shepherd
- Adrian Jenkins
- AG Pauling
- AL Stewart
- Alberto C. Naveira Garabato
- Alexander Forryan
- AM Thurnherr
- B Loose
- BJ Hoskins
- CD Rye
- D Carroll
- DL Rudnick
- FS Paolo
- G Richardson
- GJ Shutts
- HD Pritchard
- I Joughin
- I Kim
- J Feldmann
- J Marshall
- Karen J. Heywood
- KR Arrigo
- KR Arrigo
- KW Nicholls
- L Herráiz-Borreguero
- L Padman
- Liam Brannigan
- LN Thomas
- Louise C. Biddle
- M Thoma
- MA Depoorter
- NC Swart
- NS Oakey
- P Dutrieux
- P St-Laurent
- Pierre Dutrieux
- R Bintanja
- R Hohmann
- R Pawlowicz
- R Robertson
- R Robertson
- S Schmidtko
- Satoshi Kimura
- SG Purkey
- T Cowton
- TR Osborn
- TWN Haine
- V Daru
- Y Nakayama
- Y Xu
- Yvonne L. Firing
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Harvesting Memory, Preserving Home: A Cookbook of the Painted Turtle Farm/Cosechando Memoria, Preservando el Hogar: Un Libro de Cocina de la Granja de la Tortuga Pintada
- Author
- Aguilar Ricardo
- Aguilera Gonzalez Juliet
- Bacilio Aldair
- Barreiro Ashley G.
- Bochenek Anna H.
- Carroll Liam P.
- Clemens Isabella
- Combs Harrison
- Davis Theodore J.
- Geddes Ana L.
- Goldman Gussie W.
- Graham John R.
- Groff Emma Groff
- Hedgepeth Emma
- Krumsiek James P.
- Marigliano Amy N.
- McCluff Jarek D.
- Michael Kaley M.
- O\u27Shea Molly A.
- Panero Tessa G.
- Paulin Taylor I.
- Rodriguez Janet
- Rousseau Elizabeth A.
- Rutter Hope R.
- Sachenik Daniel B.
- Schmidt William M.
- Sydney Lajuan A., Jr.
- Tasnim Nishat
- Velez Jayleen N.
- Wilcox Daegan H.
- Wirth Cole H.
- Wu Yihan
- Publication venue
- The Cupola: Scholarship at Gettysburg College
- Publication date
- 01/10/2018
- Field of study
About this Project
In the fall of 2018, 14 of the families and 32 students from two first-year seminars, Crossing Borders: Immigration, Identity, and Development and Immigrant Stories, worked together to create this cookbook. Families submitted their favorite dishes and then invited students to their homes to demonstrate the preparation. As they cooked and ate together, students recorded the steps to make the recipe and listened as connections between food, memory, family, migration, traditions, and religion emerged.
Harvesting Memory, Preserving Home: A Cookbook of the Painted Turtle Farm is the product of this undertaking. In it, we offer the collection of recipes as well as a short story from each family, bring meaning to the food we eat, the places life brings us, and the memories we share.
Sobre este Projecto
En el otoño de 2018, 12 de las familias y 32 estudiantes de dos clases, Cruzando Fronteras: Immigración, Identidad, y Desarrollo y Las Historias Immigrantes trabajaron juntos para cear este libro de cocina. Las familias escogieron platos con una importancia o una memoria especial para preparar en sus casas con los estudiantes. Durante el proceso de concinar y comer juntos, los estudiantes anotaron los pasos para preparar la receta. Ellos escucharon las conexiones entre la comida, la memoria, la familia, la migración, las tradiciones, y la religión.
Cosechando Memoria, Preservando el Hogar: Un Libro de Cocina de la Granja de la Tortuga Pintada es el fruto de este proyecto. Ofrecemos la collección de recetas además de una historia breve de cada familia, para dar significado a los alimentos que comemos, los lugares donde la vida nos trae, y las memorias que nos compartimos
BHPR research: qualitative1. Complex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis
- Author
- Abernethy Veronica
- Abignano Giuseppina
- Abraham David
- Abraham David
- Abraham David J.
- Abraham Sonya
- Adams Jo
- Adams Jo
- Adshead Rebecca
- Ahmad Yasmeen A.
- Ahmed Tazeen J.
- Ainley Louise
- Al-Allaf Wahab
- Alber Catherine Fouad
- Alhusain Awal Z.
- Ali Fizzah
- Allen Roger
- Alston Claire
- Alton Peter
- Anderson Marina
- Appleton Louise H.
- Ariyo Mercy
- Aronson Diane
- Arthanari S.
- Atteno Mariangela
- Backhouse Michael R.
- Backhouse Michael R.
- Bacon Paul A.
- Bacon Pauline
- Baker Sarah
- Baker Sharon
- Baker Sharon
- Balarajah Sharmili
- Ball Elisabeth
- Baqai Charlotte
- Bari Farhan
- Barton Anne
- Benson Claire
- Berry Jacqueline
- Bertolino Arthur
- Betteridge Zoe
- Beutler Anna
- Beutler Anna
- Beynon Huw
- Bhaduri Mahua
- Birt Linda
- Black Carol M.
- Bombardieri Michele
- Boton-Maggs Ben
- Bourke Brian E.
- Bouças Sofia Barbosa
- Braun Jürgen
- Breslin Anne
- Briggs N.
- Brophy Richard
- Brophy Sinead
- Brown Diane
- Browne Hannah K.
- Bruce Ian
- Bruce Ian
- Brunner Hermine
- Buch Maya H.
- Buckley Christopher
- Bunn Chris
- Bunn Diane
- Burns James
- Cadman Susan
- Campbell Sophie
- Carroll Douglas
- Carroll Douglas
- Castiglione Fabiana
- Cavet Guy
- Chaitow Jeffrey
- Chamberlain Victoria A.
- Chan Marian
- Chard Michael
- Charles Peter
- Charleton Rebecca C.
- Charlton-Menys Valentine
- Chattopadhyay Chandrabhusan
- Chattopadhyay Chandrabhusan
- Chevance Aurelie
- Chighizola Cecilia
- Chowdhary Bhavani
- Choy Ernest
- Choy Ernest H.
- Ciurtin Coziana
- Ciurtin Coziana
- Clayton Ann M.
- Clemence Mark
- Clewes Adrian
- Coghlan Gerry
- Coghlan Gerry
- Cohen Carla J.
- Collins David
- Conaghan Philip
- Conaghan Philip
- Conaghan Philip
- Connor John
- Cook Haley
- Cooksey Roxanne
- Cooney Jennifer K.
- Coop Hazel
- Cope Andrew
- Cornell Patricia
- Cornell Tricia
- Costa Luisa
- Crooks Daniel
- Cuomo Giovanna
- Dabu Bogdan
- Dabu Mihaela
- Dahmen Georg
- Dale Rebecca M.
- Dario Di Minno M. N.
- Davies Helen
- Davies Rebecca
- Davies Ursula
- Dawson Julie
- De Benedetti Fabrizio
- De Lord Denise
- Del Galdo Francesco
- Dennis Michael S.
- Dennis Sean
- Denton Chris
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Derrett-Smith Emma
- Devlin Clare
- Dey Dzifa
- Di Cicco Maria
- Dimofte Ionela
- Dixon William
- Dobarro David
- Dobarro David
- Done John
- Donnelly Simon P.
- Dougados Maxime
- Douiri Abdel
- Drew Sarah
- Duddy Martin
- Dunkley Lisa
- Dunphy Juliet
- Dures Emma
- Durrington Paul
- Dyke Claire
- Dziedzic Krysia
- Edwards Elizabeth A.
- Ehrenstein Michael
- Ellegard Karen
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Ennis Holly
- Epis Oscar
- Espada Graciela
- Evans Rob
- Eyes Brian
- Farewell Daniel
- Farrar Claire
- Ferguson Anna M.
- Filer Andrew
- Fisher Ben
- Flato Berit
- Fleischmann Roy
- Flurey Caroline A.
- Foglia Francesca
- Fonseca Carmen
- Foo Joanne
- France Brisa
- France Brisa
- Freeman Tanya
- Freeston Jane
- Freeston Jane
- Furlong Anita
- Furlong Anita
- Galloway James
- Gathany Tim
- Gaywood Ian C.
- Genovese Mark C.
- George Malal Joby J.
- Giancola Giorgio
- Giles Ian
- Gill Rachel
- Gladman Dafna
- Gladman Dafna
- Gooberman-Hill Rachael
- Goodacre Lynne
- Goodfellow Rhian
- Gordhan Chandrika
- Gorodkin Rachel
- Grainger Andrew
- Greenhalgh Ann
- Greenwood James
- Greenwood Mandy
- Griffith Sian
- Griffiths Ann E.
- Griffiths Bridget
- Grover Bob
- Gsteiger Sandro
- Gullick Nicola J.
- Gullick Nicola J.
- Hadjinicolaou Andreas V.
- Hadjinicolaou Andreas V.
- Hale Elizabeth
- Hale Elizabeth D.
- Hall Frances C.
- Hall Frances C.
- Hall John
- Halls Serena
- Hamilton Jennifer
- Hamilton Jennifer
- Hammond Alison
- Han Chenglong
- Han Chenglong
- Han Chenglong
- Handler Clive
- Handler Clive
- Hands Rebecca
- Haney Doug
- Hanson Mark
- Haq Inam
- Haq Inam
- Hayes Janita
- Haywood Kirstie L.
- Heckaman Michele
- Heckaman Michele
- Helliwell Philip
- Helliwell Philip
- Hensor Elizabeth
- Hensor Elizabeth
- Herrick Ariane L.
- Herrick Ariane L.
- Hewlett Sarah
- Hewlett Sarah
- Heycock Carol
- Hill Ingrid
- Hill Ingrid
- Hislop Kelly
- Ho Pauline
- Hodgson Richard
- Holmes A.
- Horneff Gerd
- Howell Kevin
- Hoyles Rachel
- Hsia Elizabeth
- Hueber Wolfgang
- Hughes Gwenan
- Hughes Lyndsay
- Hughes Rod
- Humby Fran
- Hurley Mike
- Hyrich Kimme
- Hyrich Kimme
- Ibrahim Fowzia
- Iervolino Salvatore
- Ioannou John
- Irvine Elizabeth
- Isaacs Anthony
- Isaacs David
- Isaacs John
- Ishorari Jasmine
- Jack James
- Jenkins Jessica
- Jenkins Suzanne
- Jinks Clare
- Jinks Clare
- Jobanputra Paresh
- John Holly
- Jones Jeremy
- Jones Jeremy G.
- Jones Tadeusz
- Jordan Kelsey
- Jordan Kelvin P.
- Juneja Parmjit
- Kamath Sanjeet
- Karaderi Tugce
- Karaderi Tugce
- Kavanaugh Arthur
- Kavanaugh Arthur
- Keenan Anne-Maree
- Keenan Anne-Maree
- Keidel Sarah
- Keller Majella
- Kelly Clive
- Kelly Clive
- Kelly Stephen
- Kenwright Andrew
- Keystone Edward
- Khan Korsa
- Khan Korsa
- Khan Korsa
- Kiely Patrick D.
- Kiely Patrick D.
- Kingsley Gabrielle H.
- Kingsley Gabrielle H.
- Kirkham Bruce
- Kirkham Bruce W.
- Kirwan John
- Kitas George
- Kitas George D.
- Kitas George D.
- Kitas George D.
- Kraus Alexandra
- Krueger Gerald
- Landewé Robert
- Law Rebecca-Jane
- Law Rebecca-Jane
- Lawson Tom
- Lazarus Mark
- Leandro Maria
- Leask Andrew
- Lemmey Andrew
- Lempp Heidi
- Leone Francesca
- Leung Alexander
- Lille Kate
- Liu Shangxi
- Lloyd Mark
- Lloyd Mark
- Lofrano Mariana
- Lottay Neena
- Lovell Daniel
- Low Audrey
- Lunt Mark
- Lunt Mark
- Lynch Michael
- Ma Margaret H.
- Mack Michael
- Mackay Kirsten
- Maddison Peter
- Maddison Peter
- Maddison Peter J.
- Makadsi Raad
- Malaviya Anshuman P.
- Malaviya Anshuman P.
- Malik Saadia
- Malik Saadia
- Manning Joanne
- Markland David
- Martin James C.
- Martin Keith
- Martini Alberto
- McArthur Margaret
- McHugh Neil
- McHugh Neil
- McInnes Iain
- McInnes Iain
- McInnes Iain
- McKeeman Helen
- McKenna Frank
- McLaughlin Maeve
- McLoughlin YokeMei
- McNeilly Natasha E.
- Mease Philip
- Mease Philip
- Mease Philip
- Mercer Louise
- Mewar Devesh
- Mirjafari Hoda
- Moffat Claire
- Moinzadeh Pia
- Moinzadeh Pia
- Moore Jonathan P.
- Moore Owen
- Moore Tonia
- Morris Marianne
- Morris Vanessa
- Mudivarthy Surekha
- Muir Lindsay
- Munns Catherine
- Nandagudi Anupama
- Neville Cai
- Neville Cai
- Ng Nora
- Ngcozana Tanaka
- Nguyen Dianne
- Nightingale Peter
- Nihtyanova Svetlana
- Nisar M.
- Nisar Muhammad K.
- Nisar Muhammad K.
- Nordenskiold Ulla
- O'Connor Philip J.
- Ong Bie Nio
- Ong Voon
- Ong Voon
- Ong Voon
- Owen Pat
- Packham Jon
- Pande Ira
- Panthakalam Sathianathan
- Pardeo Manuela
- Parker Louise
- Parker S.
- Partlett Rosamund
- Patel Dipti
- Patterson Chris
- Pauling John
- Pauling John D.
- Pavey Chee
- Pease Colin T.
- Pease Emily E.
- Pellegrini Vincent
- Peluso Rosario
- Penn Henry
- Petford Sharon
- Pitzalis Costantino
- Pointon Jennifer J.
- Pointon Jennifer J.
- Pollard Louise C.
- Pollock Jon
- Pradère Marie-Josèphe
- Price Elizabeth
- Price Shyra
- Puntis Daniel
- Quest Enid
- Quinlan Tim M.
- Rahmeh Fouz
- Rajak Rizwan
- Rajak Rizwan
- Ramanujan Saroja
- Rankin Elizabeth
- Raut-Roy Dominique
- Redmond Anthony
- Redmond Anthony
- Reynolds John A.
- Rhodes Carol
- Rhys-Dillon Ceril
- Rhys-Dillon Ceril
- Richards Pam
- Richards Selwyn
- Richardson Ann
- Robinson Sandra M.
- Rodziewicz Mia
- Rose Katy
- Rosenberg William M.
- Rubbert-Roth Andrea
- Ruddlesden Michael
- Ruddlesden Michael
- Ruperto Nicola
- Russell Bridget
- Ryan Sarah
- Ryan Sarah
- Ryan Sarah
- Rynne Martin
- Sandhu Amrita
- Sandhu Virinderjit
- Sandoo Aamer
- Sandoo Aamer
- Sanyal Kaushik
- Saravanan Vadivelu
- Scali Juan
- Scarpa Raffaele
- Schneider Rayfel
- Schreiber Benjamin E.
- Schreiber Benjamin E.
- Schulze-Koops Hendrik
- Scott David
- Scott David L.
- Scott David L.
- Scott David L.
- Scott David L.
- Sebba Anthony
- Sen Debajit
- Sengupta Raj
- Sengupta Raj
- Shah Preeti
- Shattles Warren
- Shipley Mike
- Shiwen Xu
- Shiwen Xu
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- Sieper Joachim
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- Smith H.
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- Smith Jacqueline
- Smith Jacqueline P.
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- Symmons Deborah
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- Taylor Peter
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- Thom Jeanette M.
- Thom Jeanette M.
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- Toms Tracey E.
- Trehane Anne
- Treharne Gareth J.
- Turner Michael
- Turner-Cobb Julie
- Tyson Sarah
- Vail Andy
- Valentini Gabriele
- van der Heijde Desiree
- van der Heijde Désirée
- Van Vollenhoven Ronald
- van Zanten Jet J. Veldhuijzen
- Verstappen Suzanne M.
- Vinall Karen A.
- Wajed Julekha
- Wakefield Richard J.
- Walker David
- Wallis Dinny
- Wardle Phil
- Warrell Clare
- Warrell Clare E.
- Waterfield Jackie
- Watson Kath
- Watson Liam
- Westlake Sarah L.
- Westlake Sarah L.
- White Catherine
- White Derrick
- Wig Surabhi
- Wilby M. J.
- Wilkinson Kate
- Williams Ann
- Williamson Lyn
- Wilson Jo
- Wilson Oonagh
- Wincup Chris
- Winfield Rachel A.
- Wing Charlotte
- Winter Richard
- Wollenhaupt Jürgen
- Wong Henna
- Woo Patricia
- Wordsworth Bryan P.
- Wordsworth Bryan P.
- Wren Damian
- Wright Gary
- Xu Weichun
- Yau Wing Hoi
- Youll Matthew J.
- Young Adam
- Young Adam
- Zayat Ahmed S.
- Zilberstein Moshe
- Zouita Louisa
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: Foot surgery is common in patients with RA but research into surgical outcomes is limited and conceptually flawed as current outcome measures lack face validity: to date no one has asked patients what is important to them. This study aimed to determine which factors are important to patients when evaluating the success of foot surgery in RA Methods: Semi structured interviews of RA patients who had undergone foot surgery were conducted and transcribed verbatim. Thematic analysis of interviews was conducted to explore issues that were important to patients. Results: 11 RA patients (9 ♂, mean age 59, dis dur = 22yrs, mean of 3 yrs post op) with mixed experiences of foot surgery were interviewed. Patients interpreted outcome in respect to a multitude of factors, frequently positive change in one aspect contrasted with negative opinions about another. Overall, four major themes emerged. Function: Functional ability & participation in valued activities were very important to patients. Walking ability was a key concern but patients interpreted levels of activity in light of other aspects of their disease, reflecting on change in functional ability more than overall level. Positive feelings of improved mobility were often moderated by negative self perception ("I mean, I still walk like a waddling duck”). Appearance: Appearance was important to almost all patients but perhaps the most complex theme of all. Physical appearance, foot shape, and footwear were closely interlinked, yet patients saw these as distinct separate concepts. Patients need to legitimize these feelings was clear and they frequently entered into a defensive repertoire ("it's not cosmetic surgery; it's something that's more important than that, you know?”). Clinician opinion: Surgeons' post operative evaluation of the procedure was very influential. The impact of this appraisal continued to affect patients' lasting impression irrespective of how the outcome compared to their initial goals ("when he'd done it ... he said that hasn't worked as good as he'd wanted to ... but the pain has gone”). Pain: Whilst pain was important to almost all patients, it appeared to be less important than the other themes. Pain was predominately raised when it influenced other themes, such as function; many still felt the need to legitimize their foot pain in order for health professionals to take it seriously ("in the end I went to my GP because it had happened a few times and I went to an orthopaedic surgeon who was quite dismissive of it, it was like what are you complaining about”). Conclusions: Patients interpret the outcome of foot surgery using a multitude of interrelated factors, particularly functional ability, appearance and surgeons' appraisal of the procedure. While pain was often noted, this appeared less important than other factors in the overall outcome of the surgery. Future research into foot surgery should incorporate the complexity of how patients determine their outcome Disclosure statement: All authors have declared no conflicts of interes
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
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- Abdellah Zahra
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- Howe Kevin
- Howell Gareth
- Howell Latoya Lynette
- Howells Sally Lucinda
- Hsu Fan
- Hu George
- Hu Jie
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- Huang Fang
- Huang Guyang
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- Huang Wei
- Huang Wei
- Huang Wei
- Huang Zhengping
- Hubbard Timothy
- Huber James W.
- Huckle Elizabeth
- Hue Heather
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- Hughes Jennifer
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- Hulme Bill
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- Hunt Paul
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- Hunter Rov, II
- Hupman Matt
- Huynh Sandy
- Hyde David
- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
- Ingram Drew
- Inoue Shuuji
- Isak Amber
- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
- Isozaki Emi
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- Ito Fumiaki
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- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
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- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
- Jacintho Mark
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- Jackson Terri
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- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
- Jeffery Kim
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- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
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- Jiang Lu
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- Jimenez Alberto
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- Jones Myrna D.
- Jones Steven
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- Kettleborough Ross
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- Khan Umer F.
- Khan Ziad Mohid
- Khine Susu
- Khurama Divya
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- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
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- Lamar Betty
- Lambart Christine
- Lamble Ralph
- Lamerdin Jane E.
- Lander Eric S.
- Landers Tom
- Langford Cordelia
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- Lao Victoria
- Lapidus Alla
- Larke Ben
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- Leger Jean Pierre
- Lehman Karl
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- Lei Meng
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- Lesar Kendra
- Levan Jaclyn M.
- Leversha Margaret
- Levine Rosie
- Levy Andrew
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- Lewis Doreen
- Lewis Ernest K.
- Lewis Keith
- Lewis Lakeshia C.
- Lewis Lora R.
- Lewis Tammy
- Leyba Tina
- Li Changfeng
- Li Chenji
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- Li Gang
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- Li Jiayang
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- Li Zhangwan
- Lieuallen Kim
- Lightning Julia
- Lim Meng K.
- Lindblad-Toh Kerstin
- Lindo Ken
- Lindquist K.
- Lindsay Sarah
- Lindstrom Kirsten
- LIne Matthew
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- Liu Boyong
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- Liu Cong
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- Liu Yu
- Liu Zhanwei
- Liyanage Dhammika
- Llewellyn-Silva Crystal
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- Lock Victoria
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- Longden Ian
- Longmire Johnathan L.
- Lopez Frederick
- Lopez John
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- Loraine Howard
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- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
- Loveland Jane
- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
- Lu Tao
- Lu Xiuhua
- Lu Yongxiang
- Lu Yontao T.
- Lu Yue
- Lucas Robert
- Lucas Susan
- Lucier Alice
- Lucier Raymond L.
- Ludeman Thom
- Lui Annie
- Lundgren Lyndsey
- Luo Chunqing
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- Lv Gang
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- Lynch Daniel
- Löhnert Tschong-Hun
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- Machrus Migdad
- Macht Madison
- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
- Maglott Donna
- Maheshwari Manjula
- Mahindartne Mathew
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- Mahnke Ryan
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- Major John
- Malfatti Stephanie
- Malloy Kevin
- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
- Manohar Chitra
- Mapua Patricia
- Marabella Dick
- Mardis Elaine R.
- Mareth David
- Mariano Marisa
- Marinelli Lisa
- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
- Marroquin Christian
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- Martinez Diego
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- Maslen Gareth
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- Matsumoto Shuko
- Matsushita Yoshitaka
- Matthews Charles D.
- Matthews Lucy
- Matthews Nick
- Matthews Paul
- Matthews Sterling D.
- Mauceli Evan
- Maunes Cynthia
- Maupin Rachel
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- McLean James
- McLellan Michael D.
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- McMurray Amanda
- McMurray Des
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- McPherson John
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- Meidi Patrick
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- Meneus Louis
- Meng Shanshan
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- Merritt Christina E.
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- Metzker Michael Lee
- Meyer Rekha
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- Miah Asab
- Michaelis Evelyn
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- Mihalkanin Danielle
- Mihova Tanya
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- Morita Hiroko
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- Mullenger Ian
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- Mundt Mark O.
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- Murakami Katsuhiko
- Murayama Yuji
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- Murphy Matthew B.
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- Nagaraja R.
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- Nelson Kathryn
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- Nesbitt Ryan
- Neunkirch Jennifer
- Newes Christian
- Newman April
- Ng Bee
- Ng Terrance
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- Nguyen Lisa
- Nguyen Minh
- Nguyen Na
- Nguyen Natalie M.
- Nguyen Ngoc Bich
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- Nhan Mike
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- Niblett David
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- Ning Zemin
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- Nivens Amber
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- Norbu Chou Dolma
- Norbu Nyima
- Nordsiek Gabriele
- Norris Sarah Louise
- Novik Karen
- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
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- Oddone Paola
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- Ohno Saho
- Ohta Nao
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- Okoawo Ose
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- Oragunye Njideka
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- Parry-Brown Ginny
- Parson-Quintana Beverly
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- Perez Agapito
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- Pettett Roger
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- Polman Jos
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- Prathalingham Radhika
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- Qiang Boqin
- Qiao Zhenyong
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- Rajagopal Mohan
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- Sarmiento R.
- Sasaki Takashi
- Satpathy Suraj
- Saunders David
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- Saxman Eric
- Scarpelli Claude
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- Scherer Steven Edward
- Schilhabel Markus
- Schlessinger David
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- Siddiqui Roman
- Siepel Adam C.
- Silk Richard
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- Sims Matthew
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- Solovyev Victor
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- Sonaike Titilola
- Song Liping
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- Song Xing-Zhi
- Sonnhammer Erik
- Sonnhammer Erik
- Sorelle Richard P.
- Sotheran Elizabeth
- Sougnez Carrie
- Spainhower Corey
- Sparks Anastasia L.
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- Spraggon Lee
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- Stallings Raymond I.
- Stalvey Malinda
- Stamford Steve
- Stammers Melanie
- Standring Lisa
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- Steffen David
- Stege Justin T.
- Steingruber Helen
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- Stephens-Bolds Shaela
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- Stubbs Matthew
- Stultz Janet
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- Su Xiaohu
- Subramanian Sandhya
- Subramanian Sandhya
- Sudbrak Ralf
- Sugnet Charles W.
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- Zhang Yuzhi
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- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Juliette
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- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
- Ang Daniel
- Ann Taehee
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- Ansari Jawaher
- Ansari Jawaher
- Anscombe Eleanor
- Anyamene Nicola
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- Appleby Rowan
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- Archer Denise
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- Archer Simon
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- Arsanious Nasr
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- Ashworth Sue
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- MacRae Robert M
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- Zarkar Anjali
- Zarkar Anjali M.
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2024
- Field of study
Background
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
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- Ansari Jawaher
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- Anyamene Nicola
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- Catton Charles
- Catton Charles N
- Caumont Tom
- Cavanagh Kerrie
- Chadwick David
- Chadwick Eliot
- Chahal Rohit
- Chahine Jacqueline
- Chakraborti Prabir
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- Challipalli Amarnath
- Chamberlain Shelley
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- Chetiyawardana Samantha
- Chetiyawardana Samantha
- Chettle Judith
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- Chikkamuniyappa Bindu
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- Chikopela Loveness
- Chilcott Helen
- Chipman Penny
- Chivers Rachael
- Chornopyski Tracy
- Choudhury Ananya
- Choudhury Ananya
- Chowdhury Amitava D
- Christensen Anne Juel
- Christensen Tine
- Christmas Sallyanne
- Chrystal Melanie
- Chu William
- Chui Amadeus
- Chung Christina
- Chung Hans T
- Chung Hans T
- Chung Peter
- Chung Peter W M
- Churn Mark
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- Clarke Jude
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- Clarke Samantha
- Cleary Kristy
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- Clitheroe Pat
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- Cocks Tracie
- Coe Marc
- Coffin Teresa
- Cogley Lyn
- Cole Aiden
- Cole David J
- Cole David J
- Collard Susan
- Colligan Steve
- Collins Gerald
- Collins Gerald
- Collins Lucy
- Commisso Angela
- Conibear John
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- Connor Marie
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- Conroy Ruth
- Conroy Ruth
- Conway Lisa-Jane
- Conway Rachel
- Cook Adrian
- Cook Adrian D
- Cook Audrey
- Cook Audrey
- Cook Wendy
- Cooke Jill
- Cooke Juniebel
- Cooke Peter
- Coomber Kristy
- Coombs Sarah
- Cooper Adele
- Cooper Sophie
- Coppins Helen
- Corbett Thomas B
- Corcoran Sam
- Corderoy Helen
- Cordwell Amanda
- Corkery Danylle
- Corless Rebecca
- Cormack Margaret
- Cornaby Andrew
- Corner Victoria
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- Corwin Charlotte
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- Coubrough Claudia
- Couch Ellie
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- Cowan Chloe
- Cowan Richard
- Cowan Richard
- Cowley Sue
- Cox Adam
- Cox Christine
- Coyle Catherine
- Coyle Catherine
- Crawford Melanie
- Crawford Sister Denise
- Creelman Brianna
- Crellin Perric
- Crellin Perric
- Crook Juanita
- Cross Vanessa
- Cross William R
- Crossley Lin
- Crowe (nee Hughes) Dawn
- Crowley Claire
- Crundwell M
- Cserbane Anita
- Cuffe Donna
- Cumming Kirsty
- Cunningham Amy
- Curtis Samantha
- Curtis Sandra
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- Dabbs Marianne
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- Dalton-Short Ross
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- Davison Alison
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- Dawe David
- Dawson Elizabeth
- Dawson Louise
- Dawson-Athey Linda
- Dayes Ian S
- De Silva-Minor Shiroma
- Dean Lynsey
- Dearnaley David
- Deenihan Emma
- Degendorfer Sarah
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- Doherty A
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- Downs Nichola
- Doyle Kerrie
- Drachenberg Darrel E
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- Dubey Arbind
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- E Choan
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- Falconer Alison
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- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
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- Glaholm John
- Glaholm John
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- Goel Roshni
- Goh Chee
- Goh Chee L
- Golden Sophie
- Goldenberg S Larry
- Goldstein Cindy
- Goldsworthy Simon
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- Griffiths Theresa
- Gruschy Lisa
- Guarino Robyn
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- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Gujral Sandeep
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- Harding Joshua
- Hardman John
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- Hare Jennifer A
- Hargreaves Carolyn
- Hargreaves Jeanette
- Hargreaves Jeanette
- Harinarayanan Sathish
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- Haydock Helen
- Hayes Jill A
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- Healey-Mariano Jennifer
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- Irwin P
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- Jamieson Ceri
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- Jastrzebska Patrycja
- Javle P
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- Jayachandran Resmi
- Jeffcutt Nicole
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- Joshi Manisha
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- Jovic Gordana
- Kaa Bach Birgit
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- Kanaga-Sundaram Subramanian
- Kancherla Kiran
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- Kapur Guarav
- Karim Omer
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- Karunakaran Subashini
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- Kavanagh Roisin
- Kavanagh Roisin
- Kay Anne Marie
- Kazingizi Memory
- Keane Patrick
- Kearney S
- Kedge Liz
- Kehoe Laura
- Keith Sarah
- Keith Sarah
- Kelkar Anand
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- Kelly Alison
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- Kendal Wayne S
- Keng-Koh Pek
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- Keni Manjusha
- Kennedy Julie
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- Kent Christopher
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- Khoury Ghassan
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- Kilmartin John
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- Kiltie Anne
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- King Amy
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- Klapp Kathi
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- Kodavatiganti Ravi
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- Lloyd-Jones Hugh
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- Logue John
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- MacMullin Lisa
- MacRae Robert M
- Macrory Joanne
- MacVicar Jennifer
- MacVicar Karen
- Madeleine Jude
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- Magwaro Sophia
- Magwaro Sophia
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- Mahmood Rana
- Mahmood Rana
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- Mallett Debbie
- Malone Shawn
- Malone Shawn C
- Manetta Caroline
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- Masson Susan
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- McCormack Anne
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- McFarlane Victoria
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- McGlynn Brian
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- Mcintosh Gregor
- McKee Dianne
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- McKinna Fiona
- McKinna Fiona
- McLain-Smith Susan
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- Melcher Lucinda
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- Mikropoulos Christos
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- Morgan Rachel
- Morgan Scott
- Morris Stephen
- Morris Stephen L
- Morris William James
- Morrison Andrew
- Morrison Jennifer
- Morrison MaryBeth
- Morrow Hugh
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- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- Elsevier
- Publication date
- 07/06/2024
- Field of study
Background
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society