20 research outputs found
Measurement of the W-boson mass in pp collisions at √s=7 TeV with the ATLAS detector
A measurement of the mass of the W boson is presented based on proton–proton collision data recorded in 2011 at a centre-of-mass energy of 7 TeV with the ATLAS detector at the LHC, and corresponding to 4.6 fb−1 of integrated luminosity. The selected data sample consists of 7.8×106 candidates in the W→μν channel and 5.9×106 candidates in the W→eν channel. The W-boson mass is obtained from template fits to the reconstructed distributions of the charged lepton transverse momentum and of the W boson transverse mass in the electron and muon decay channels, yielding
mW=80370±7 (stat.)±11(exp. syst.)
±14(mod. syst.) MeV
=80370±19MeV,
where the first uncertainty is statistical, the second corresponds to the experimental systematic uncertainty, and the third to the physics-modelling systematic uncertainty. A measurement of the mass difference between the W+ and W−bosons yields mW+−mW−=−29±28 MeV
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population
A conservação do papagaio-da-cara-roxa (Amazona brasiliensis) no estado do Paraná: uma experiência de Educação Ambiental no ensino formal Conservation of the red-tailed-parrot (Amazona brasiliensis) in the northern coast of Paraná State: an Environmental Education experience for formal school
No presente trabalho, avaliou-se a experiência de Educação Ambiental do "Projeto de Conservação do Papagaio-da-Cara-Roxa (Amazona brasiliensis)", no ensinoformal, realizado pela Sociedade de Pesquisa em Vida Selvagem e Educação Ambiental (SPVS), no litoral norte do Estado do Paraná. A experiência teve o intuito de fomentar, tanto no corpo docente quando no corpo discente, a discussão sobre valores e princípios que norteiam as relações homem/natureza, desenvolvendo-se, assim, uma interação mais responsável com o meio ambiente. Foram desenvolvidos módulos-educativos sobre o papagaio-da-cara-roxa e seu ambiente, direcionados a 795 estudantes do ensino fundamental, nos Municípios de Paranaguá e Guaraqueçaba. Para analisar a eficácia das atividades, os estudantes responderam a testes antes e depois do processo educativo que mediram mudanças obtidas com relação ao incremento de conhecimento, postura e valorização do papagaio-da-cara-roxa e de seu ambiente. Os resultados indicaram que a utilização do exemplo de uma espécie, ameaçada de extinção e que ocorre próximo às comunidades envolvidas no processo de conservação, serviu de base para a associação do tema específico para com uma realidade ambiental mais ampla e contextualizada localmente.<br>The utilization of a flag-species in environmental education can be an important strategy to discuss the interrelations between the species, their habitats, and man. The red-tailed-parrot (Amazona brasiliensis), is endemic in the Atlantic Rainforest and is threatened with extinction. This work aims to analyze the environmental education experience of the project "Conservation of the red-tailed-parrot (Amazona brasiliensis)", together with formal teaching, held by the Society for Wildlife Research and Environmental Education (SPVS), in the northern coast of Paraná State. The objective of this work was to promote a teaching method among students and teachers that contextualizes the local environment and its problems. Discussions on the values and principles of man/nature relations were also promoted, developing a more environmentally-responsible interaction. Educative modules on the red-tailed-parrot and its habitat were developed for 795 students from the municipalities of Paranaguá and Guaraqueçaba. In order to analyze the efficiency of the activities, tests, before and after the process, were developed for the students. This analysis enabled a measurement of changes with respect to an increase in knowledge, posture, and valuation of the red-tailed-parrot and its habitat
Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
BackgroundStudies quantifying SARS-CoV-2 have focused on upper respiratory tract or plasma viral RNA with inconsistent association with clinical outcomes. The association between plasma viral antigen levels and clinical outcomes has not been previously studied. Our aim was to investigate the relationship between plasma SARS-CoV-2 nucleocapsid antigen (N-antigen) concentration and both markers of host response and clinical outcomes.MethodsSARS-CoV-2 N-antigen concentrations were measured in the first study plasma sample (D0), collected within 72 h of hospital admission, from 256 subjects admitted between March 2020 and August 2021 in a prospective observational cohort of hospitalized patients with COVID-19. The rank correlations between plasma N-antigen and plasma biomarkers of tissue damage, coagulation, and inflammation were assessed. Multiple ordinal regression was used to test the association between enrollment N-antigen plasma concentration and the primary outcome of clinical deterioration at one week as measured by a modified World Health Organization (WHO) ordinal scale. Multiple logistic regression was used to test the association between enrollment plasma N-antigen concentration and the secondary outcomes of ICU admission, mechanical ventilation at 28 days, and death at 28 days. The prognostic discrimination of an externally derived "high antigen" cutoff of N-antigen ≥ 1000 pg/mL was also tested.ResultsN-antigen on D0 was detectable in 84% of study participants. Plasma N-antigen levels significantly correlated with RAGE (r = 0.61), IL-10 (r = 0.59), and IP-10 (r = 0.59, adjusted p = 0.01 for all correlations). For the primary outcome of clinical status at one week, each 500 pg/mL increase in plasma N-antigen level was associated with an adjusted OR of 1.05 (95% CI 1.03-1.08) for worse WHO ordinal status. D0 plasma N-antigen ≥ 1000 pg/mL was 77% sensitive and 59% specific (AUROC 0.68) with a positive predictive value of 23% and a negative predictive value of 93% for a worse WHO ordinal scale at day 7 compared to baseline. D0 N-antigen concentration was independently associated with ICU admission and 28-day mechanical ventilation, but not with death at 28 days.ConclusionsPlasma N-antigen levels are readily measured and provide important insight into the pathogenesis and prognosis of COVID-19. The measurement of N-antigen levels early in-hospital course may improve risk stratification, especially for identifying patients who are unlikely to progress to severe disease
Military-related risk factors for dementia
Introduction: In recent years, there has been growing discussion to better understand the pathophysiological mechanisms of traumatic brain injury and post-traumatic stress disorder and how they may be linked to an increased risk of neurodegenerative diseases including Alzheimer's disease in veterans. Methods: Building on that discussion, and subsequent to a special issue of Alzheimer's & Dementia published in June 2014, which focused on military risk factors, the Alzheimer's Association convened a continued discussion of the scientific community on December 1, 2016. Results: During this meeting, participants presented and evaluated progress made since 2012 and identified outstanding knowledge gaps regarding factors that may impact veterans' risk for later life dementia. Discussion: The following is a summary of the invited presentations and moderated discussions of both the review of scientific understanding and identification of gaps to inform further investigations.</p
Recommended from our members
Racial/Ethnic Disparities in HIV Preexposure Prophylaxis Among Men Who Have Sex with Men — 23 Urban Areas, 2017
POUR DANSER.... SOUS LE SIGNE DES POISSONS (pour tous ceux nés du 19 février au 20 mars)
Titre uniforme : [Night and day]Titre uniforme : [Smoke gets in your eyes]Titre uniforme : [Saint Louis blues]Titre uniforme : [Somebody loves me]Titre uniforme : [The man I love]Titre uniforme : [The creep]Titre uniforme : [Petite fleur]Comprend : NIGHT AND DAY - fox / Cole PORTER ; Pierre SELLIN et son Orchestre - SAINT-LOUIS BLUES : fox / W.C. HANDY ; Pierre SELLIN et son Orchestre - MI MUSICA ES PARA TI : cha cha cha / A. TOUAR ; Pepe LUIZ et son Orchestre - PACHITO ECHE : cha cha cha / Pachito José ; Pepe LUIZ et son Orchestre - SMOKE GETS IN YOUR EYES : slow / Jerome KERN ; Pierre SELLIN et son Orchestre - THE MAN I LOVE - slow / George GERSHWIN ; Pierre SELLIN et son Orchestre - UN FLECHAZO - boléro / Luiz ARAQUE ; Pepe LUIZ et son Orchestre - HYMN TO THE FISHES - boléro / Pepe LUIZ et Jim CORRY ; Pepe LUIZ et son Orchestre - SOMEBODY LOVES ME - fox / George GERSHWIN ; Pierre SELLIN et son orchestre - THE CREEP - fox / A. BURTON ; Pierre SELLIN et son orchestre - LA BARCA ("Ma barque blanche") - boléro / R. CANTORAL ; Pepe LUIZ et son orchestre - SABOR A MI ("Le goût de toi") - boléro / Alvaro CARRILLO ; Pepe LUIZ et son orchestre - PETITE FLEUR : médium fox / Sidney BECHET ; Pierre SELLIN et son orchestre - UN CERTAIN SOURIRE - médium fox / S. FAIN ; Pierre SELLIN et son orchestre - FILOMENA : cha cha cha / Don DIEGO - Jim CORRY et Pepe LUIZ ; Pepe LUIZ et son orchestre - MELODY IN CHA CHA ("Cancion en cha cha cha") cha cha cha / Andres ECHEVARRIA Arr. Pepe LUIZ ; Pepe LUIZ et son orchestreBnF-Partenariats, Collection sonore - BelieveContient une table des matière