Sex Differences in Internalizing and Externalizing Behaviors in Children with Autism Spectrum Disorder

This study used a retrospective practice-based research method to compare levels of internalizing and externalizing behaviors of a clinically-ascertained sample of young children with autism spectrum disorder (ASD; n=90). As measured by the Child Behavior Checklist (CBCL), internalizing and externalizing behaviors were compared to normative behavior, and between boys and girls with ASD. Findings suggest that in a clinical sample, children with ASD are more likely than typically developing children to have internalizing and/or externalizing problems. No significant sex differences were found for Internalizing Problems, Externalizing Problems, or Total Problems scores on either the parent or teacher versions of the CBCL. These findings may help clinicians better understand how children with ASD are affected by co-morbid psychiatric disorders, and could help to inform diagnosis and intervention

The Heart Wants What It Wants: Effects of Desirability and Body Part Salience on Distance Perceptions (DeWitt)

Previous research has shown that the desirability of an object influences perceived distance from the object, such that desirable objects are perceived as closer than objects that are not desirable (Balcetis & Dunning, 2010). It has also been suggested that metaphors reflect how our knowledge is represented; so, for example, making the head or heart more salient produces characteristics commonly associated with those body parts (i.e., emotionality for the heart and rationality for the head) (Fetterman & Robinson, 2013). The current study examined the effects of head or heart salience and desirability on distance perception. We hypothesized that since common idioms relate the heart to desirability, salience of the heart would cause desirable objects to be perceived as closer than would salience of the head, but there would be no such difference between the head and heart conditions when the object was neutral. To test this hypothesis, participants had their attention drawn to either their head or their heart by placing their index finger there while throwing a beanbag towards a desirable or a neutral object. In Experiment 2, a verbal distance estimate was also included. We predicted that there would be a significant interaction between desirability of object and hand placement. Specifically, we expected that there would be no effect of hand placement when the object was neutral but that heart-pointers would perceive a desirable object as closer than the head-pointers. Results from both experiments failed to support our hypothesis

A comprehensive evaluation of alignment algorithms in the context of RNA-seq.

Transcriptome sequencing (RNA-Seq) overcomes limitations of previously used RNA quantification methods and provides one experimental framework for both high-throughput characterization and quantification of transcripts at the nucleotide level. The first step and a major challenge in the analysis of such experiments is the mapping of sequencing reads to a transcriptomic origin including the identification of splicing events. In recent years, a large number of such mapping algorithms have been developed, all of which have in common that they require algorithms for aligning a vast number of reads to genomic or transcriptomic sequences. Although the FM-index based aligner Bowtie has become a de facto standard within mapping pipelines, a much larger number of possible alignment algorithms have been developed also including other variants of FM-index based aligners. Accordingly, developers and users of RNA-seq mapping pipelines have the choice among a large number of available alignment algorithms. To provide guidance in the choice of alignment algorithms for these purposes, we evaluated the performance of 14 widely used alignment programs from three different algorithmic classes: algorithms using either hashing of the reference transcriptome, hashing of reads, or a compressed FM-index representation of the genome. Here, special emphasis was placed on both precision and recall and the performance for different read lengths and numbers of mismatches and indels in a read. Our results clearly showed the significant reduction in memory footprint and runtime provided by FM-index based aligners at a precision and recall comparable to the best hash table based aligners. Furthermore, the recently developed Bowtie 2 alignment algorithm shows a remarkable tolerance to both sequencing errors and indels, thus, essentially making hash-based aligners obsolete

Accretion Discs Trapped Near Corotation

We show that discs accreting onto the magnetosphere of a rotating star can end up in a 'trapped' state, in which the inner edge of the disc stays near the corotation radius, even at low and varying accretion rates. The accretion in these trapped states can be steady or cyclic; we explore these states over wide range of parameter space. We find two distinct regions of instability, one related to the buildup and release of mass in the disk outside corotation, the other to mass storage within the transition region near corotation. With a set of calculations over long time scales we show how trapped states evolve from both nonaccreting and fully accreting initial conditions, and also calculate the effects of cyclic accretion on the spin evolution of the star. Observations of cycles such as found here would provide important clues on the physics of magnetospheric accretion. Recent observations of cyclic and other unusual variability in T Tauri stars (EXors) and X-ray binaries are discussed in this context.Comment: 14 pages, 10 figures, accepted to MNRA

Episodic Accretion on to Strongly Magnetic Stars

Some accreting neutron stars and young stars show unexplained episodic flares in the form of quasi-periodic oscillations or recurrent outbursts. In a series of two papers we present new work on an instability that can lead to episodic outbursts when the accretion disc is truncated by the star's strong magnetic field close to the corotation radius (where the Keplerian frequency matches the star's rotational frequency). In this paper we outline the physics of the instability and use a simple parameterization of the disc-field interaction to explore the instability numerically, which we show can lead to repeated bursts of accretion as well as steady-state solutions, as first suggested by Sunyaev and Shakura. The cycle time of these bursts increases with decreasing accretion rate. These solutions show that the usually assumed `propeller' state, in which mass is ejected from the system, does not need to occur even at very low accretion rates.Comment: 13 pages, 8 figures, accepted to MNRAS, minor corrections following referee repor

Rapid evolution of morphology and adaptive life history in the invasive California wild radish (Raphanus sativus) and the implications for management.

Understanding the evolution and demography of invasive populations may be key for successful management. In this study, we test whether or not populations of the non-native, hybrid-derived California wild radish have regionally adapted to divergent climates over their 150-year history in California and determine if population demographic dynamics might warrant different region-specific strategies for control. Using a reciprocal transplant approach, we found evidence for genetically based differences both between and among northern, coastal and southern, inland populations of wild radish. Individual fitness was analyzed using a relatively new statistical method called 'aster modeling' which integrates temporally sequential fitness measurements. In their respective home environments, fitness differences strongly favored southern populations and only slightly favored northern populations. Demographic rates of transition and sensitivities also differed between regions of origin, suggesting that the most effective approach for reducing overall population growth rate would be to target different life-history stages in each region

Leadership of Integrated Health and Social Care Services

This research explores the lived experience of those individuals charged with leading the integration of health and social care services in Scotland. The research was primarily qualitative in nature – comprising of a qualitative survey of front-line managers of integrated health and social care services from a single partnership area. The survey explored the management and leadership tasks and activities expected of those leading health and social care teams. The research uncovers a sense that these new leadership positions are both overwhelming in the scope of tasks required and lack clarity in how these tasks should be undertaken. This highlights a need for coordinated support and training for staff who are charged with leading integrated health and social care teams. Three key recommendations have been drawn from the findings of this research: more support should be provided to managers working within these complex integrated systems; a joint training programme should be developed for managers across both partnering organisations and finally relevant policies and procedures should be compiled into one reference resource for managers of integrated services

On the global warping of a thin self-gravitating near Keplerian gaseous disk with application to the disk in NGC 4258

On the global warping of a thin self-gravitating near Keplerian gaseous disk with application to the disk in NGC 4258Comment: 36 pages (including 4 figures), Latex, to appear in Ap