101 research outputs found
BFORE: The B-mode Foreground Experiment
The B-mode Foreground Experiment (BFORE) is a proposed NASA balloon project
designed to make optimal use of the sub-orbital platform by concentrating on
three dust foreground bands (270, 350, and 600 GHz) that complement
ground-based cosmic microwave background (CMB) programs. BFORE will survey ~1/4
of the sky with 1.7 - 3.7 arcminute resolution, enabling precise
characterization of the Galactic dust that now limits constraints on inflation
from CMB B-mode polarization measurements. In addition, BFORE's combination of
frequency coverage, large survey area, and angular resolution enables science
far beyond the critical goal of measuring foregrounds. BFORE will constrain the
velocities of thousands of galaxy clusters, provide a new window on the cosmic
infrared background, and probe magnetic fields in the interstellar medium. We
review the BFORE science case, timeline, and instrument design, which is based
on a compact off-axis telescope coupled to >10,000 superconducting detectors.Comment: 7 pages, 4 figures, conference proceedings published in Journal of
Low Temperature Physic
Simons Observatory: Broadband Metamaterial Anti-Reflection Cuttings for Large Aperture Alumina Optics
We present the design, fabrication, and measured performance of metamaterial
Anti-Reflection Cuttings (ARCs) for large-format alumina filters operating over
more than an octave of bandwidth to be deployed on the Simons Observatory (SO).
The ARC consists of sub-wavelength features diced into the optic's surface
using a custom dicing saw with near-micron accuracy. The designs achieve
percent-level control over reflections at angles of incidence up to 20.
The ARCs were demonstrated on four 42 cm diameter filters covering the 75-170
GHz band and a 50 mm diameter prototype covering the 200-300 GHz band. The
reflection and transmission of these samples were measured using a broadband
coherent source that covers frequencies from 20 GHz to 1.2 THz. These
measurements demonstrate percent-level control over reflectance across the
targeted pass-bands and a rapid reduction in transmission as the wavelength
approaches the length scale of the metamaterial structure where scattering
dominates the optical response. The latter behavior enables the use of the
metamaterial ARC as a scattering filter in this limit.Comment: 9 pages, 8 figures, submitted to Applied Optic
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Discovery of a mammalian splice variant of myostatin that stimulates myogenesis
Myostatin plays a fundamental role in regulating the size of skeletal muscles. To date, only a single myostatin gene and no splice variants have been identified in mammals. Here we describe the splicing of a cryptic intron that removes the coding sequence for the receptor binding moiety of sheep myostatin. The deduced polypeptide sequence of the myostatin splice variant (MSV) contains a 256 amino acid N-terminal domain, which is common to myostatin, and a unique C-terminus of 65 amino acids. Western immunoblotting demonstrated that MSV mRNA is translated into protein, which is present in skeletal muscles. To determine the biological role of MSV, we developed an MSV over-expressing C2C12 myoblast line and showed that it proliferated faster than that of the control line in association with an increased abundance of the CDK2/Cyclin E complex in the nucleus. Recombinant protein made for the novel C-terminus of MSV also stimulated myoblast proliferation and bound to myostatin with high affinity as determined by surface plasmon resonance assay. Therefore, we postulated that MSV functions as a binding protein and antagonist of myostatin. Consistent with our postulate, myostatin protein was
co-immunoprecipitated from skeletal muscle extracts with an MSV-specific antibody. MSV over-expression in C2C12 myoblasts blocked myostatin-induced Smad2/3-dependent signaling, thereby confirming that MSV antagonizes the
canonical myostatin pathway. Furthermore, MSV over expression increased the abundance of MyoD, Myogenin and MRF4 proteins (P,0.05), which indicates that MSV stimulates myogenesis through the induction of myogenic regulatory factors. To help elucidate a possible role in vivo, we observed that MSV protein was more abundant during early post-natal muscle development, while myostatin remained unchanged, which suggests that MSV may promote the growth of skeletal muscles. We conclude that MSV represents a unique example of intra-genic regulation in which a splice variant directly antagonizes the biological activity of the canonical gene product
The Primordial Inflation Polarization Explorer (PIPER)
The Primordial Inflation Polarization Explorer (PIPER) is a balloon-borne
cosmic microwave background (CMB) polarimeter designed to search for evidence
of inflation by measuring the large-angular scale CMB polarization signal.
BICEP2 recently reported a detection of B-mode power corresponding to the
tensor-to-scalar ratio r = 0.2 on ~2 degree scales. If the BICEP2 signal is
caused by inflationary gravitational waves (IGWs), then there should be a
corresponding increase in B-mode power on angular scales larger than 18
degrees. PIPER is currently the only suborbital instrument capable of fully
testing and extending the BICEP2 results by measuring the B-mode power spectrum
on angular scales = ~0.6 deg to 90 deg, covering both the reionization
bump and recombination peak, with sensitivity to measure the tensor-to-scalar
ratio down to r = 0.007, and four frequency bands to distinguish foregrounds.
PIPER will accomplish this by mapping 85% of the sky in four frequency bands
(200, 270, 350, 600 GHz) over a series of 8 conventional balloon flights from
the northern and southern hemispheres. The instrument has background-limited
sensitivity provided by fully cryogenic (1.5 K) optics focusing the sky signal
onto four 32x40-pixel arrays of time-domain multiplexed Transition-Edge Sensor
(TES) bolometers held at 140 mK. Polarization sensitivity and systematic
control are provided by front-end Variable-delay Polarization Modulators
(VPMs), which rapidly modulate only the polarized sky signal at 3 Hz and allow
PIPER to instantaneously measure the full Stokes vector (I, Q, U, V) for each
pointing. We describe the PIPER instrument and progress towards its first
flight.Comment: 11 pages, 7 figures. To be published in Proceedings of SPIE Volume
9153. Presented at SPIE Astronomical Telescopes + Instrumentation 2014,
conference 915
Elevated Baseline C-Reactive Protein as a Predictor of Outcome After Aneurysmal Subarachnoid Hemorrhage: Data From the Simvastatin in Aneurysmal Subarachnoid Hemorrhage (STASH) Trial.
BACKGROUND: There remains a proportion of patients with unfavorable outcomes after aneurysmal subarachnoid hemorrhage, of particular relevance in those who present with a good clinical grade. A forewarning of those at risk provides an opportunity towards more intensive monitoring, investigation, and prophylactic treatment prior to the clinical manifestation of advancing cerebral injury. OBJECTIVE: To assess whether biochemical markers sampled in the first days after the initial hemorrhage can predict poor outcome. METHODS: All patients recruited to the multicenter Simvastatin in Aneurysmal Hemorrhage Trial (STASH) were included. Baseline biochemical profiles were taken between time of ictus and day 4 post ictus. The t-test compared outcomes, and a backwards stepwise binary logistic regression was used to determine the factors providing independent prediction of an unfavorable outcome. RESULTS: Baseline biochemical data were obtained in approximately 91% of cases from 803 patients. On admission, 73% of patients were good grade (World Federation of Neurological Surgeons grades 1 or 2); however, 84% had a Fisher grade 3 or 4 on computed tomographic scan. For patients presenting with good grade on admission, higher levels of C-reactive protein, glucose, and white blood cells and lower levels of hematocrit, albumin, and hemoglobin were associated with poor outcome at discharge. C-reactive protein was found to be an independent predictor of outcome for patients presenting in good grade. CONCLUSION: Early recording of C-reactive protein may prove useful in detecting those good grade patients who are at greater risk of clinical deterioration and poor outcome.Financial support: British Heart Foundation. None of the authors have any personal or institutional financial interest in drugs or materials in the manuscript. PJK and PJH are supported by the Cambridge NIHR BRC and PJH is supported by a NIHR Research Professorship. We also acknowledge the support of the Cambridge Clinical Trials Unit, UK Clinical Research Network and all 35 participating sites.This is the final version of the article. It first appeared from Wolters Kluwer via http://dx.doi.org/10.1227/NEU.000000000000096
Feedhorn-coupled TES polarimeter camera modules at 150 GHz for CMB polarization measurements with SPTpol
The SPTpol camera is a dichroic polarimetric receiver at 90 and 150 GHz.
Deployed in January 2012 on the South Pole Telescope (SPT), SPTpol is looking
for faint polarization signals in the Cosmic Microwave Background (CMB). The
camera consists of 180 individual Transition Edge Sensor (TES) polarimeters at
90 GHz and seven 84-polarimeter camera modules (a total of 588 polarimeters) at
150 GHz. We present the design, dark characterization, and in-lab optical
properties of the 150 GHz camera modules. The modules consist of
photolithographed arrays of TES polarimeters coupled to silicon platelet arrays
of corrugated feedhorns, both of which are fabricated at NIST-Boulder. In
addition to mounting hardware and RF shielding, each module also contains a set
of passive readout electronics for digital frequency-domain multiplexing. A
single module, therefore, is fully functional as a miniature focal plane and
can be tested independently. Across the modules tested before deployment, the
detectors average a critical temperature of 478 mK, normal resistance R_N of
1.2 Ohm, unloaded saturation power of 22.5 pW, (detector-only) optical
efficiency of ~ 90%, and have electrothermal time constants < 1 ms in
transition.Comment: 15 pages, 11 figure
The Atacama Cosmology Telescope: Two-Season ACTPol Spectra and Parameters
We present the temperature and polarization angular power spectra measured by
the Atacama Cosmology Telescope Polarimeter (ACTPol). We analyze night-time
data collected during 2013-14 using two detector arrays at 149 GHz, from 548
deg of sky on the celestial equator. We use these spectra, and the spectra
measured with the MBAC camera on ACT from 2008-10, in combination with Planck
and WMAP data to estimate cosmological parameters from the temperature,
polarization, and temperature-polarization cross-correlations. We find the new
ACTPol data to be consistent with the LCDM model. The ACTPol
temperature-polarization cross-spectrum now provides stronger constraints on
multiple parameters than the ACTPol temperature spectrum, including the baryon
density, the acoustic peak angular scale, and the derived Hubble constant.
Adding the new data to planck temperature data tightens the limits on damping
tail parameters, for example reducing the joint uncertainty on the number of
neutrino species and the primordial helium fraction by 20%.Comment: 23 pages, 25 figure
The Primordial Inflation Polarization Explorer (PIPER): Current Status and Performance of the First Flight
The Primordial Inflation Polarization ExploreR (PIPER) is a balloon-borne instrument optimized to measure the polarization of the CMB at large angular scales. It will map 85% of the sky over a series of conventional balloon flights from the Northern and Southern hemispheres, measuring the B-mode polarization power spectrumover a range of multipoles from 2-300 covering both the reionization bump and the recombination peak, with sensitivity to measure the tensor-to-scalar ratio down to r = 0.007. PIPER will observe in four frequency bands centered at 200, 270, 350, and 600 GHz to characterize dust foregrounds. The instrument has background-limited sensitivity provided by fully cryogenic (1.7 K) optics focusing the sky signal onto kilo-pixel arrays of time-domain multiplexed Transition-Edge Sensor (TES) bolometers held at 100 mK. Polarization sensitivity and systematiccontrol are provided by front-end Variable-delay Polarization Modulators (VPMs). PIPER had its engineering flight in October 2017 from Fort Sumner, New Mexico. This papers outlines the major components in the PIPER system discussing the conceptual design as well as specific choices made for PIPER. We also report on the results of the engineering flight, looking at the functionality of the payload systems, particularly VPM, as well as pointing out areas of improvement
Overview and status of EXCLAIM, the experiment for cryogenic large-aperture intensity mapping
The EXperiment for Cryogenic Large-Aperture Intensity Mapping (EXCLAIM) is a
balloon-borne far-infrared telescope that will survey star formation history
over cosmological time scales to improve our understanding of why the star
formation rate declined at redshift z < 2, despite continued clustering of dark
matter. Specifically,EXCLAIM will map the emission of redshifted carbon
monoxide and singly-ionized carbon lines in windows over a redshift range 0 < z
< 3.5, following an innovative approach known as intensity mapping. Intensity
mapping measures the statistics of brightness fluctuations of cumulative line
emissions instead of detecting individual galaxies, thus enabling a blind,
complete census of the emitting gas. To detect this emission unambiguously,
EXCLAIM will cross-correlate with a spectroscopic galaxy catalog. The EXCLAIM
mission uses a cryogenic design to cool the telescope optics to approximately
1.7 K. The telescope features a 90-cm primary mirror to probe spatial scales on
the sky from the linear regime up to shot noise-dominated scales. The telescope
optical elements couple to six {\mu}-Spec spectrometer modules, operating over
a 420-540 GHz frequency band with a spectral resolution of 512 and featuring
microwave kinetic inductance detectors. A Radio Frequency System-on-Chip
(RFSoC) reads out the detectors in the baseline design. The cryogenic telescope
and the sensitive detectors allow EXCLAIM to reach high sensitivity in spectral
windows of low emission in the upper atmosphere. Here, an overview of the
mission design and development status since the start of the EXCLAIM project in
early 2019 is presented.Comment: SPIE Astronomical Telescopes + Instrumentation. arXiv admin note:
substantial text overlap with arXiv:1912.0711
Development of multi-chroic MKIDs for next-generation CMB polarization studies
We report on the status of an ongoing effort to develop arrays of horn-coupled, polarization-sensitive microwave kinetic inductance detectors (MKIDs) that are each sensitive to two spectral bands between 125 and 280 GHz. These multi-chroic MKID arrays are tailored for next-generation, large-detector-count experiments that are being designed to simultaneously characterize the polarization properties of both the cosmic microwave background and Galactic dust emission. We present our device design and describe laboratory-based measurement results from two 23-element prototype arrays. From dark measurements of our first engineering array, we demonstrated a multiplexing factor of 92, showed the resonators respond to bath temperature changes as expected, and found that the fabrication yield was 100%. From our first optically loaded array, we found the MKIDs respond to millimeter-wave pulses; additional optical characterization measurements are ongoing. We end by discussing our plans for scaling up this technology to kilo-pixel arrays over the next 2 years
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