Multicriteria Model for the Choice of Best Battery Provider

The choice of suppliers is a matter of great importance in organizations. The cost, quality and delivery time provided to customers may depend to a large extent on this decision. This paper, therefore, describes a model applicable to a real organization, using multicriteria decision techniques to choose the best supplier of batteries. In order to establish concordance and discordance thresholds the values provided by the decision-maker of the company will be compared with those obtained by the fuzzy Analytic Hierarchy Process. Both valuations of the thresholds will be applied in the ELECTRE II technique

Selección de Aplicación para Gamificación en una Asignatura de los Grados en Ingeniería Eléctrica y Electrónica Industrial y Automática

[ES] Debido al gran número de beneficios que reporta, el número de aplicaciones para gamificación se ha incrementado considerablemente desde 2002. Por ello, la selección de la aplicación idónea a emplear en una asignatura universitaria de grado se ha vuelto más compleja. Esta contribución pretende ayudar en esta toma de decisiones proponiendo un modelo objetivo elaborado mediante Measuring Attractiveness by a Categorical Based Evaluation Technique (MACBETH). Este modelo se ha aplicado a una asignatura de los grados en Ingeniería Eléctrica e Ingeniería Electrónica Industrial y Automática de la Escuela Técnica Superior de Ingenieros Industriales de Ciudad Real, empleándose como centro decisor uno de los profesores de la asignatura. El modelo emplea diez criterios de decisión dispuestos en una estructura jerárquica. Para cada criterio, a partir de una matriz de comparaciones por parejas construida a partir de los juicios emitidos por el centro decisor, se obtiene mediante programación lineal una función de valor. Mediante la aplicación de la metodología MACBETH, y con la ayuda del software M-MACBETH, que emplea un método simple aditivo, se obtiene una clasificación completa de las diferentes aplicaciones para gamificación evaluadas.Carnero, MC. (2020). Selección de Aplicación para Gamificación en una Asignatura de los Grados en Ingeniería Eléctrica y Electrónica Industrial y Automática. Editorial Universitat Politècnica de València. 821-829. https://doi.org/10.4995/INN2019.2019.10252OCS82182

Analysis for the Heritage Consideration of Historic Spanish Railway Stations (1848¿1929)

[EN] This article presents the study carried out on the main Spanish historic railway stations to obtain a joint and comparative view of the current state of its heritage conservation. The temporal scope is limited to the construction period of the Spanish historic stations. A motivated selection of a series of extrinsic and intrinsic variables is proposed, checking heritage variables to evaluate the degree of adequate heritage protection. The conclusions of the study show the antithesis between what is to be protected (the railway station) and what is really saved (the passenger building), making it necessary to change the legal protection status from monuments to landscapes. Thus, various interventions can be observed on the disaffected land with no heritage connection. The material and technological valorisation of unique components such as the large platform and track roofs is ignored. It is also observed that the maintenance of railway use is essential and that global interventions lead to a more significant loss of significance than those carried out for maintenance purposes. This leads to the conclusion that preventive conservation is more effective in protecting this heritage than global interventions.This work was carried out at the Universitat Politècnica de València in the framework of CONDEREFF project (Ref. PGI05560-CONDEREFF). This work has been carried out within the framework of the PREDILAB research group, as part of the research carried out at the University of Castilla La Mancha and entitled Methodology and systems for improving maintenance and energy efficiency in the rehabilitation and reuse of industrial heritage. Phase 2.Martínez-Corral, A.; Cárcel-Carrasco, J.; Carnero, MC.; Aparicio Fernandez, CS. (2022). Analysis for the Heritage Consideration of Historic Spanish Railway Stations (1848¿1929). Buildings. 12(2):1-17. https://doi.org/10.3390/buildings1202020611712

MAP17 (PDZK1IP1) and pH2AX are potential predictive biomarkers for rectal cancer treatment efficacy

Rectal cancer represents approximately 10% of cancers worldwide. Preoperative chemoradiotherapy increases complete pathologic response and local control, although it offers a poor advantage in survivorship and sphincter saving compared with that of radiotherapy alone. After preoperative chemoradiotherapy, approximately 20% of patients with rectal cancer achieve a pathologic complete response to the removed surgical specimen; this response may be related to a better prognosis and an improvement in disease-free survival. However, better biomarkers to predict response and new targets are needed to stratify patients and obtain better response rates. MAP17 (PDZK1IP1) is a small, 17 kDa non-glycosylated membrane protein located in the plasma membrane and Golgi apparatus and is overexpressed in a wide variety of human carcinomas. MAP17 has been proposed as a predictive biomarker for reactive oxygen species, ROS, inducing treatments in cervical tumors or laryngeal carcinoma. Due to the increase in ROS, MAP17 is also associated with the marker of DNA damage, phosphoH2AX (pH2AX). In the present manuscript, we examined the values of MAP17 and pH2AX as surrogate biomarkers of the response in rectal tumors. MAP17 expression after preoperative chemoradiotherapy is able to predict the response to chemoradiotherapy, similar to the increase in pH2AX. Furthermore, we explored whether we can identify molecular targeted therapies that could help improve the response of these tumors to radiotherapy. In this sense, we found that the inhibition of DNA damage with olaparib increased the response to radio- and chemotherapy, specifically in tumors with high levels of pH2AX and MAP17.Spanish Ministry of Economy and Competitivity, Plan Estatal de I+D+I 2013–2016, ISCIII (Fis: PI15/00045) and CIBER de Cáncer (CB16/12/00275)co-funded by FEDER from Regional Development European Funds (European Union), Consejería de Ciencia e Innovación (CTS-1848)Consejería de Salud of the Junta de Andalucía (PI-0096–2014)

A vision on air pollution in cities and the human effect

[EN] The human effect on air quality in cities and the evolution of air pollution is obvious, due to economic activity, vehicle traffic, etc. The situation created indirectly by COVID-19, has caused many countries to impose during certain periods restriction of movement and stoppage of economic activities, which has allowed us to observe the instant effect that occurs on the air quality in cities. This article discusses what the observed effect has been, focusing on the early moments of the pandemic (January 2020 to March 2020), with an analysis of the situation from its origin in China to its arrival in Europe and more specifically the situation created in Spain. After the analysis of the situation, it can be seen the large reduction of pollutants in the air of different cities, and in particular in Spain, which came to reduce about 80%. All this leads us to the observation of how human activity can greatly influence air pollution.Cárcel Carrasco, FJ.; Peñalvo López, E.; Carnero, MC.; Langa Sanchis, J. (2020). A vision on air pollution in cities and the human effect. VITRUVIO - International Journal of Architectural Technology and Sustainability. 5(2):57-70. https://doi.org/10.4995/vitruvio-ijats.2020.14607OJS57705

Microfluidic devices manufacturing with a stereolithographic printer for biological applications

Stereolithographic printers have revolutionized many manufacturing processes with their capacity to easily produce highly detailed structures. In the field of microfluidics, this technique avoids the use of complex steps and equipment of the conventional technologies. The potential of low force stereolithography technology is analysed for the first time using a Form 3B printer and seven printing resins through the fabrication of microchannels and pillars. Manufacturing performance of internal and superficial channels and pillars is studied for the seven printing resins in different configurations. A complete characterization of printed structures is carried out by optical, confocal and SEM microscopy, and EDX analysis. Internal channels with unobstructed lumen are obtained for diameters and angles greater than 500 μm and 60°, respectively. Outward and inward superficial channels in the range of hundreds of microns can be fabricated with an accurate profile, printing them with a perpendicular orientation respect to the base, allowing a proper uncured resin evacuation. Outward channels are replicated by soft lithography using polydimethylsiloxane. Clear, Model and Tough resins show a good behaviour to be used as master, but Amber and Dental resins present a poor topology transference from the master to the replica. According to the needs of devices used for biological and biomedical research, transparency as well as superficial biocompatibility of some resins is evaluated. Human umbilical vein endothelial cells (HUVEC) adhesion is confirmed on Amber, Dental and Clear resins, but these cells were only able to grow and progress as a cell culture over the Amber resin. Therefore, Amber showed an adequate biocompatibility, in terms of cell adhesion and growth for HUVECAuthors gratefully thank contracts AEI RTI2018-097063-B-100, AEI/FEDER, UE; ED431B 2020/29; ED431E 2018/08 and ED481D-2021-019, Consellería de Educación Xunta de Galicia/FEDER e Estructuración Xunta de Galicia, IN607A2019-02 and Sociedad española de cardiología y Fundación español del corazón, SEC/FEC-INV-BAS 20/013S

CA15.3 Serum Concentrations in Older Women with Infiltrating Ductal Carcinomas of the Breast

Breast cancer is currently becoming a disease of the elderly. We have studied the relation between CA 15.3 serum concentrations and clinical-pathological parameters in 69 women with IDC aged over 70 years (76.3 ± 4.2; range: 71–88; median 76). A group of 205 women with the same tumor but aged <70 years (62.8 ± 4.0; range: 55–70; median 63) was also considered for comparison. Tumor size, axillary lymph node involvement, distant metastasis and histological grade were taken account. Serum CA 15.3 was determined by luminescence assay. CA 15.3 serum concentrations ranged between 6 and 85 U/mL (median 22.9 U/mL), and were higher only in patients with greater (qualitative and quantitative; p: 0.041) tumor size. Our results show that in women with IDCs, and aged over 70 years, serum CA 15.3 serum concentrations are associated exclusively with a greater tumor size, being these findings different to those described in women with the same subtype of tumor considered as a whole or with lower age.This work was supported by grant PI11/01806 from ISCIII (Spain)S

Clinicopathological characteristics of infiltrating lobular breast carcinoma in elderly women: Preliminary results

This study was conducted to investigate the clinicopathological parameters in elderly women (aged >70 years) with infiltrating lobular carcinoma (ILC) of the breast and compare the results with those obtained from younger patients (aged 55-70 years). The study sample included a total of 46 women with ILCs, 10 aged >70 and 36 aged 55-70 years. The parameters analysed were tumor size, histological grade (HG), axillary lymph node involvement, distant metastasis and immunohistochemical expression of estrogen, progesterone and androgen receptors, Ki67, p53 and B cell lymphoma 2. Compared to women aged 55-70 years, ILCs in women aged >70 years were commonly of larger size (P=0.068) and were more frequently HG3 (P=0.024). There were no statistically significant differences in the other parameters analysed. Furthermore, we were unable to determine differences in cancer recurrence and mortality in the two patient subgroups during our follow-up. In conclusion, our preliminary results, based on the limited number of cases included in this study, indicate that i) ILCs in women aged >70 years tended to be larger compared to those in women aged 55-70 years and were more frequently of grade 3; and ii) there were no significant differences in terms of recurrence and mortality between the two patient subgroups during our follow-up

PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208

Colorectal cancer (CRC) is the third most common cancer worldwide. The standard treatment in locally advanced rectal cancer is preoperative radiation alone or in combination with chemotherapy, followed by adjuvant chemotherapy. Rectal cancer is highly lethal, with only 20% of patients showing a complete remission (by RECIST) after standard treatment, although they commonly show local or systemic relapse likely due to its late detection and high chemotherapy resistance, among other reasons. Here, we explored the role of PAI1 (Serpin E1) in rectal cancer through the analyses of public patient databases, our own cohort of locally advanced rectal cancer patients and a panel of CRC cell lines. We showed that PAI1 expression is upregulated in rectal tumors, which is associated with decreased overall survival and increased metastasis and invasion in advanced rectal tumors. Accordingly, PAI1 expression is correlated with the expression of (Epithelial-to-Mesenchymal Transition) EMT-associated genes and genes encoding drug targets, including the tyrosine kinases PDGFRb, PDGFRa and FYN, the serine/threonine kinase PIM1 and BRAF. In addition, we demonstrate that cells expressing PAI1 protein are more sensitive to the PIM inhibitor AZD1208, suggesting that PAI1 could be used to predict response to treatment with PIM inhibitors and to complement radiotherapy in rectal tumors.España Consejería de Salud of the Junta de Andalucía (PI-0397-2017)España , Consejeria of Economía, Conocimiento, Empresas y Universidad of the Junta de Andalucia (P18-RT-2501

Internal Microchannel Manufacturing Using Stereolithographic 3D Printing

Internal channels are one of the most interesting structures to implement in microfluidics devices. Unfortunately, the optical technologies typically used in microfluidics, such as photolithography or reactive ion etching, are unable to generate these structures by only allowing surface structuring. Stereolithographic 3D printing has emerged as a very promising technology in internal microchannel manufacturing, by allowing a layer-by-layer structuring in volume performed by a laser that photopolymerises a liquid resin. Recent advances in laser technologies have reached resolutions of tens of micrometres. The high resolution of this type of printer, which a priori would allow the fabrication of channels of the same dimensions, may pose a problem by impeding the evacuation of uncured resin. In this chapter, the compromise between size and resin evacuation will be evaluated to find the optimal diameter range in which unobstructed and accurate microchannels can be obtained