84 research outputs found
Effectiveness and safety of first-generation protease inhibitors in clinical practice: Hepatitis C virus patients with advanced fibrosis
- Author
- Aguilar V.M.
- Almanzor E.
- Alonso S.
- Amoros A.
- Andrade R.
- Arenas J.
- Baeyens E.
- Berenguer M.
- Berenguer R.
- Bernal V.
- Carmona I.
- Casado M.
- Conde P.
- Cortés L.
- Cuaresma M.
- De Rueda P.M.
- Diago M.
- Escolano E.
- Espinosa D.
- Estévez M.
- Fernández C.
- Fernández M.
- Ferrer M.T.
- Fuentes J.
- García M.
- Gila A.
- González A.
- González M.
- González O.
- Granados R.
- Gutiérrez M.L.
- Hallal H.
- Jiménez F.
- Jordan T.
- Jorquera F.
- Jurado A.
- Llamoza C.
- López M.A.
- Macías M.A.
- Martín A.B.
- Martín E.
- Martín J.M.
- Martín M.I.
- Millán R.
- Molina E.
- Montero J.
- Montero J.L.
- Navarro J.M.
- Nogueras F.
- Ortega A.
- Pascasio J.M.
- Peláez G.
- Pons J.A.
- Prieto M.
- Pérez F.
- Pérez R.
- Quiles R.
- Rodriguez F.J.
- Rodríguez S.
- Romero-Gómez M.
- Ruano J.J.S.
- Salmerón J.
- Serra M.Á.
- Simón M.A.
- Sousa F.L.
- Sousa J.M.
- Sánchez G.
- Testillano M.
- Vinaixa C.
- Vázquez J.M.
- Publication venue
- 'Baishideng Publishing Group Inc.'
- Publication date
- 01/01/2015
- Field of study
AIM: To evaluates the effectiveness and safety of the first generation, NS3/4A protease inhibitors (PIs) in clinical practice against chronic C virus, especially in patients with advanced fibrosis.
METHODS: Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1, treatment-nai¨ve (TN) or treatment-experienced (TE),
who underwent triple therapy with the first generation NS3/4A protease inhibitors, boceprevir (BOC) and telaprevir (TVR), in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow up.
RESULTS: One thousand and fifty seven patients were included, 405 (38%) were treated with BOC and 652 (62%) with TVR. Of this total, 30% (n = 319) were TN and the remaining were TE: 28% (n = 298) relapsers, 12% (n = 123) partial responders (PR), 25% (n = 260) null-responders (NR) and for 5% (n = 57) with prior response unknown. The rate of sustained virologic response (SVR) by intention-to-treatment (ITT) was greater in those treated with TVR (65%) than in those treated with BOC (52%) (P < 0.0001), whereas by modified intention-to-treatment (mITT) no were found significant differences. By degree of fibrosis, 56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients, both TN and TE. In the analysis by groups, the TN patients treated with TVR by ITT showed a higher SVR (P = 0.005). However, by mITT there were no significant differences between BOC and TVR. In the multivariate analysis by mITT, the significant SVR factors were relapsers, IL28B CC and non-F4; the type of treatment (BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients, treated with BOC (46%) or with TVR (45%). 28% of the patients interrupted the treatment, mainly by non-viral response (51%): this outcome was more frequent in the TE than in the TN patients (57% vs 40%, P = 0.01). With respect to severe haematological disorders, neutropaenia was more likely to affect the patients treated with BOC (33% vs 20%, P = 0.0001), and thrombocytopaenia and anaemia, the F4 patients (P = 0.000, P = 0.025, respectively).
CONCLUSION: In a real clinical practice setting with a high proportion of patients with advanced fibrosis, effectiveness of first-generation PIs was high except for NR patients, with similar SVR rates being achieved by BOC and TVR
International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality
- Author
- Aaron JR
- Agapito G
- Albayrak A
- Albi G
- Alessiani M
- Alloni A
- Amendola DF
- Angoulvant F
- Anthony LLLJ
- Aronow BJ
- Ashraf F
- Atz A
- Avillach P
- Avillach P
- Azevedo PS
- Balazote PS
- Balshi J
- Barrio NG
- Beaulieu-Jones BK
- Beaulieu-Jones BK
- Bell DS
- Bellasi A
- Bellazzi R
- Benoit V
- Benoit V
- Beraghi M
- Bernal-Sobrino JL
- Bernaux M
- Bey R
- Bhatnagar S
- Blanco-Martínez A
- Boeker M
- Bonzel CL
- Booth J
- Bosari S
- Bourgeois FT
- Bradford RL
- Brat GA
- Brown NW
- Bruno R
- Bryant WA
- Bréant S
- Bucalo M
- Bucholz E
- Burgun A
- Cai T
- Cannataro M
- Carmona A
- Caucheteux C
- Champ J
- Chen J
- Chen KY
- Chiovato L
- Cho K
- Dagliati A
- DuVall SL
- Gutiérrez-Sacristán A
- Hanauer DA
- Ho YL
- Holmes JH
- Hong C
- Issitt RW
- Keller MS
- Klann JG
- Liu M
- Loh NHW
- Luo Y
- Lynch KE
- L’Yi S
- Maidlow SE
- Malovini A
- Mandl KD
- Mao C
- Matheny ME
- Moore JH
- Morris JS
- Morris M
- Mowery DL
- Murphy SN
- Neuraz A
- Ngiam KY
- Omenn GS
- Palmer NP
- Patel LP
- Pedrera-Jimenez M
- Ramoni RB
- Schriver ER
- Schubert P
- Serret-Larmande A
- South AM
- Spiridou A
- Tan ALM
- Tan BWL
- Tibollo V
- Torti C
- Trecarichi EM
- Visweswaran S
- Wang X
- Weber GM
- Xia Z
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/06/2022
- Field of study
Given the growing number of prediction algorithms developed to predict COVID-19 mortality, we evaluated the transportability of a mortality prediction algorithm using a multi-national network of healthcare systems. We predicted COVID-19 mortality using baseline commonly measured laboratory values and standard demographic and clinical covariates across healthcare systems, countries, and continents. Specifically, we trained a Cox regression model with nine measured laboratory test values, standard demographics at admission, and comorbidity burden pre-admission. These models were compared at site, country, and continent level. Of the 39,969 hospitalized patients with COVID-19 (68.6% male), 5717 (14.3%) died. In the Cox model, age, albumin, AST, creatine, CRP, and white blood cell count are most predictive of mortality. The baseline covariates are more predictive of mortality during the early days of COVID-19 hospitalization. Models trained at healthcare systems with larger cohort size largely retain good transportability performance when porting to different sites. The combination of routine laboratory test values at admission along with basic demographic features can predict mortality in patients hospitalized with COVID-19. Importantly, this potentially deployable model differs from prior work by demonstrating not only consistent performance but also reliable transportability across healthcare systems in the US and Europe, highlighting the generalizability of this model and the overall approach
Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study
- Author
- Aaron JR
- Abu-el-rub N
- Agapito G
- Albayrak A
- Albi G
- Alessiani M
- Alloni A
- Amendola DF
- Angoulvant F
- Anthony LLLJ
- Aronow BJ
- Ashraf F
- Atz A
- Avillach P
- Azevedo PS
- Balshi J
- Batugo A
- Beaulieu-Jones BK
- Beaulieu-Jones BR
- Bell DS
- Bellasi A
- Bellazzi R
- Benoit V
- Beraghi M
- Bernal-Sobrino JL
- Bernaux M
- Bey R
- Bhatnagar S
- Blanco-Martínez A
- Boeker M
- Bonzel CL
- Booth J
- Bosari S
- Bourgeois FT
- Bradford RL
- Brat GA
- Brown NW
- Bruno R
- Bryant WA
- Bréant S
- Bucalo M
- Bucholz E
- Burgun A
- Cai T
- Cannataro M
- Carmona A
- Cattelan AM
- Caucheteux C
- Champ J
- Chen J
- Chen KY
- Chiovato L
- Chiudinelli L
- Cho K
- Cimino JJ
- Colicchio TK
- Cormont S
- Cossin S
- Dagliati A
- Das P
- García Barrio N
- Gutiérrez-Sacristán A
- Hanauer DA
- Ho YL
- Holmes JH
- Hong C
- Hutch MR
- Klann JG
- Kohane IS
- Liu M
- Loh NHW
- Luo Y
- Maidlow SE
- Makoudjou A
- Malovini A
- Moal B
- Morris M
- Mowery DL
- Neuraz A
- Ngiam KY
- Omenn GS
- Panickan VA
- Patel LP
- Pedrera Jimenez M
- Samayamuthu MJ
- Schriver ER
- Serrano Balazote P
- South AM
- Tan ALM
- Tan BWL
- Tan BWQ
- Tibollo V
- Tippmann P
- Verdy G
- Visweswaran S
- Weber GM
- Xia Z
- Yuan W
- Zhang HG
- Zöller D
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2023
- Field of study
Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1–365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021. Findings: Advanced age (HR 2.77, 95%CI 2.53–3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03–4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55–5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14–1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37–0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17–1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20–1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45–1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80–13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10–1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32–1.67) and 365 days (RR 1.54, 95%CI 1.21–1.96) compared to COVID-19 patients with no AKI. Interpretation: COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. Funding: Authors are supported by various funders, with full details stated in the acknowledgement section
Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019
- Author
- Alcaráz A.
- Aldámiz-Echevarría T
- Alonso G.
- Arazo P.
- Armiñanzas Carlos
- Armiñanzas Carlos
- Arnalich F.
- Arponen S.
- Arranz A.
- Arribas J. R.
- Artero Arturo
- Artero Arturo
- Azkune H.
- Baraia J.
- Barrufet P.
- Berenguer J.
- Berenguer Juan
- Bernal E.
- Bernardino J.I.
- Bisbal O.
- Bisbe J.
- Blanes M.
- Boix Vicente
- Brieva T.
- Busca Carmen
- Busca Carmen
- Calabuig Eva
- Camacho A.
- Campoamor M.
- Cano A.
- Carmena J.
- Carmona M.P.
- Carretero S.
- Casado J.L.
- Casas E.
- Castellano A.
- Chamarro E.
- Chocarro A.
- Cifuentes C.
- Cifuentes Carmen
- Crespo M.
- Cuellar S.
- de la Fuente Belén
- de la Fuente Belén
- de la Peña M.
- De Lagarde M.
- de Miguel J.
- De Miguel Marta
- Del Romero J.
- Delgado A.
- Domingo Pere
- Domínguez L.
- Domínguez Lourdes
- Díez C.
- Díez M.
- Echevarría S.
- Egea I.
- Escrig C.
- Esteban M.C.
- Estrada V.
- Fanciulli C.
- Fanciulli Chiara
- Fariñas C.
- Fernández I.
- Fernández J.
- Ferrer A.
- Ferrero O.L.
- Ferrero Oscar L.
- Force L.
- Force Luis
- Galindo María José
- Galindo María José
- García C.
- García Coral
- García L.
- Gaspar G.
- Gaspar Gabriel
- Geijo P.
- Gimeno A.
- Giner L.
- Giner Livia
- Goenaga M.A.
- González Garcia Juan
- González-García J.
- Guardiola J.M.
- Gutiérrez I.
- Gutiérrez M.
- Gutiérrez-Cuadra M.
- Hernando A.
- Hernández-Quero J.
- Hervás R.
- Hontañón V.
- Ibarguren M.
- Ibarra S.
- Iribarren J.A.
- Iribarren José A.
- Jarrín I.
- Jarrín Inmaculada
- Lara G.
- Losa J.E.
- Losa Juan E.
- López I.
- López J.C.
- López-Aldeguer J.
- Machuca I.
- Manzardo Christian
- Martín-Carbonero M.L.
- Martínez-Alfaro Elisa
- Matarranz M.
- Mateo G.
- Merino E.
- Micán R.
- Miralles C.
- Montejano R.
- Montero M.
- Montero Marta
- Montero-Martínez Carmen Cecilia Ordoñez
- Montes M.L.
- Morano L.
- Morano Luis
- Moreno A.
- Moreno J.
- Moreno Javier
- Moreno L.
- Moreno S.
- Moreno V.
- Muñoz A.
- Muñoz J.
- Muñoz J.
- Muñoz L.
- Márquez M.
- Navarro C.
- Navarro J.
- Navarro Jordi
- Nuño E.
- Núñez M.J.
- Ocampo A.
- Orti A.J.
- Oteo J.A.
- Padilla B.
- Palacios R.
- Pampliega M.
- Peláez A.I.
- Peraire J.
- Piera-Rojo G.
- Planas B.
- Portilla I.
- Portilla J.
- Prado-González E.
- Puerta T.
- Pulido F.
- Pérez L.
- Pérez Laura
- Pérez-Elías M.J.
- Pérez-Latorre L.
- Pérez-Valero I.
- Quereda C.
- Ramírez M.
- Raposo M.
- Reus S.
- Rivero-Juárez A.
- Rivero-Román A.
- Rivero-Román Antonio
- Rodrigo M.
- Rodríguez C.
- Rodríguez Carmen
- Rodríguez-Arrondo F.
- Rubio R.
- Ruiz J.
- Salavert M.
- Santos I.
- Santos Ignacio
- Santos J.
- Santos Jesús
- Sanz J.
- Sanz J.
- Sanz José
- Silvariño R.
- Tasias M.
- Teira R.
- Tejerina F.
- Toledo C.
- Torrella A.
- Torrús D.
- Tuya M.J.
- Téllez M.J.
- Téllez María J.
- Valencia E.
- Vargas M.
- Vegas A.
- Velasco M.
- Veloso S.
- Veloso Sergio
- Vera M.
- Vergas J.
- Vidal F.
- Viladés C.
- Vilaró J.
- Vinuesa D.
- Vivancos M.J.
- Vivancos María J.
- Von Wichmann M.A.
- Zubero Z.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Spanish AIDS Research Network; European Funding for Regional Development (FEDER).Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population
CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative
- Author
- A Mori M.
- Aguado Carmen
- Aguilera Paula
- Albiñana Virginia
- Almoguera Berta
- Alonso Javier
- Alonso-Ferreira Verónica
- Alías Laura
- Andrés Jimenez-Estrada J.
- Antiñolo Gil Guillermo
- Antonio Tenorio-Castaño J.
- Antón Puig-Butille J.
- Arbones ML.
- Arenas Joaquín
- Arjona Emilia
- Armangue Thais
- Armstrong Judith
- Arnedo María
- Artuch Rafael
- Artuch Rafael
- Aulinas-Masó Anna
- Avila-Fernandez Almudena
- Ayuso Carmen
- Badell Isabel
- Badenas Celia
- Baeza Maria Luisa
- Baiget Montserrat
- Balcells Susanna
- Ballesta Martínez María Juliana
- Barahona María-José
- Barros Francisco
- Bartoccioni Paola Chiara
- Bayona-Bafaluy María Pilar
- Benito Sanz Sara
- Bernabéu Carmelo
- Bernal Sara
- Blanco-Kelly Fiona
- Blázquez Alberto
- Bodoy Susanna
- Bogliolo Massimo
- Borralleras Cristina
- Borrego Salud
- Botella Luisa-Maria
- Bou de Pieri Francesc
- Bovolenta Paola
- Bravo Gil Nereida
- Brea-Fernández Alejandro
- Bueno-Lozano Gloria
- Bueren Juan
- Bueren Juan
- Bustamante Ana
- Caballero Teresa
- Camacho-Macorra Carlos
- Camats Tarruella Núria
- Campos-Barros Angel
- Campuzano Victoria
- Cantarero Abad Lara
- Cantó Judith
- Caparros-Martin Jose A.
- Cardellach Francesc
- Carlos Rodriguez-Aguilera J.
- Carmen Martínez-Romero M.
- Carmona Rosario
- Carracedo Angel
- Carrera Cristina
- Carretero Marta
- Casado Jose A.
- Casado Mercedes
- Casasnovas Pons Carlos
- Cascón Alberto
- Casino Patricia
- Castaño Luís Antonio
- Castilla-Vallmanya Laura
- Catala Albert
- Cayuela Maria Luisa
- Cediel R.
- Cervera J.
- Codina-Solà M.
- Contreras J.
- Cormand B.
- Corominas R.
- Corral J.
- Corrochano V.
- Corrochano Virginia
- Corton M.
- Cortés-Rodríguez A.
- Costa-Roger M.
- Cozar M.
- Crespo I.
- Crispi F.
- Cristina Estañ M.
- Cruz R.
- Cuezva J.
- Cuscó I.
- Cámara Yolanda
- Dalmau J.
- de Cima S.
- de la Luna S.
- de Oyarzabal Sanz A.
- del Campo M.
- del Castillo I.
- Del Pino Molina L.
- Del Pozo Á.
- del Río M.
- Delmiro A.
- Desviat L.R.
- Dierssen M.
- Domínguez-González C.
- Domínguez-Ruiz M.
- Dopazo J.
- Errasti E.
- Escámez M.J.
- Esteban J.
- Estévez R.
- Ezquieta B.
- Fernàndez-Castillo N.
- Fernández A.
- Fernández L.
- Fernández-Cancio M.
- Fernández-San Jose P.
- Fillat Cristina
- Fons C.
- Fort J.
- Fourcade S.
- Fraga M. F.
- Gabriela Palacios-Verdú M.
- Gallano Pia
- Gallano Pia
- Gallardo E.
- Garcia-Garcia F.J.
- Garcia-Gimeno M.A.
- García Santiago F.
- García M.
- García-Arumí E.
- García-Bravo M.
- García-Cazorla A.
- García-Consuegra I.
- García-García G.
- García-Giménez J.
- García-Miñaur S.
- García-Redondo A.
- García-Villoria J.
- Garrabou G.
- Garrido G.
- Garrido-Pérez N.
- Gaztambide S.
- Gil-Campos M.
- Giroud-Gerbetant J.
- Glover G.
- Gonzalez-Cabo P.
- Gonzalez-Casacuberta I.
- González-del Pozo M.
- González-Quereda L.
- González-Quintana A.
- Gort L.
- Gougeard N.
- Gratacos E.
- Grinberg D.
- Guerrero R.
- Guillén-Navarro E.
- Guitart-Mampel M.
- Gutiérrez-Arumí A.
- Gómez B.
- Gómez Beatriz
- Gómez-Puertas P.
- Güenechea G.
- Heath K.
- Heredia M.
- Hernández-Chico C.
- Herreras E.
- Herreras Enrique
- Hoenicka J.
- Homs A.
- Jimenez-Mallebrera C.
- JoséRamírez de Haro M.
- JoséSánchez Soler M.
- JoséTrujillo-Tiebas M.
- Jou C.
- Lapunzina P.
- Lapunzina Pablo
- Larcher F.
- Lasa A.
- Lassaletta L.
- Latorre Pellicer Ana
- Linares D.
- Llacer J.
- Llames S.
- Lopez-Gallardo E.
- Lopez-Lopez D.
- Lorda-Sanchez I.
- Luis Ruiz-Perez V.
- Luisa Lozano M.
- Luna N.
- Luque J.
- Luque Juan A.
- Luz Juarez-Flores D.
- López de Heredia M.
- López de Heredia Miguel
- López Granados E.
- López-Laso E.
- López-Lera A.
- López-Sánchez M.
- Madrigal I.
- Malvehy J.
- Manguán García C.
- Mansilla E.
- Marco-Marín C.
- Marfany G.
- Marina A.
- Martin Y.
- Martin-Merida I.
- Martinez-Delgado B.
- Martorell L.
- Martí R.
- Martí S.
- Martín M.A.
- Martín-Hernandez. E.
- Martínez Fernández P.
- Martínez Santamaría L.
- Martínez R.
- Martínez-Azorín F.
- Martínez-Gil N.
- Martínez-Glez V.M.
- Martínez-Momblán M.A.
- María Grau J.
- María Sánchez Cuesta A.
- Meade P.
- Meana Á.
- Medrano A.
- Mendes I.
- Mendes Ingrid
- Millán J.
- Millán José
- Minguez P.
- Minguillón J.
- Mirra S.
- Molla B.
- Moltó E.
- Montero R.
- Montoliu L.
- Montoliu Lluis
- Montoya J.
- Moren C.
- Moreno J.
- Moreno M.
- Moreno-Galdó A.
- Morin M.
- Morte B.
- Morte Beatriz
- Morán M.
- Mulero V.
- Murillas R.
- Murillo-Cuesta S.
- Muñoz-Pujol G.
- Méndez-Vidal C.
- Nascimento A.
- Navarro S.
- Navas P.
- Nevado J.
- Nicolas A.
- O'Callaghan M.
- Olavarrieta L.
- Ormazabal A.
- Ortiz-Romero P.
- Osorio A.
- Palacín M.
- Palau F.
- Palau Francesc
- Palencia-Campos A.
- Pallardó F.V.
- Palomares M.
- Perez-Florido J.
- Perez-Jimenez E.
- Perkins J.R.
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- Serratosa J.
- Sevilla T.
- Surrallés J.
- Tahsin-Swafiri S.
- Tell-Martí G.
- Teresa García-Silva M.
- Tizzano E.
- Tobias E.
- Tort F.
- Trujillano L.
- Ugalde C.
- Ugarteburu O.
- Universitat Autònoma de Barcelona
- Urreizti R.
- Urrutia I.
- Valencia M.
- Vallcorba P.
- Vallespín E.
- Varela-Nieto I.
- Vega A.
- Villa O.
- Villamar M.
- Vélez-Santamaria V.
- Vílchez J.J.
- Webb S.M.
- Webb Susan
- Zubeldia J.
- Zurita O.
- Álvarez-Mora María Isabel
- Ángel Medina M.
- Ángel Moreno-Pelayo M.
- Ángela Nieto M.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
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- Hualde JB
- Huang CH
- Huang WC
- Huang WC
- Huang WC
- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
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- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
- Irazabal JM
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- Ishimatsu S
- Itenov TS
- Iwamoto M
- Izawa M
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- Jaber S
- Jacky A
- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
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- Jeong IY
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- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
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- Jung K
- Jung KW
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- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
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- Kang PL
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- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
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- Katira BH
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- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
- Ke MW
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- Keep J
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- Keller E
- Kellner F
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- Kerhuel L
- Kerr C
- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
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- King HS
- Kinnear J
- Kirakli C
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- Kirca H
- Kirman M
- Kirwan CJ
- Kittnar O
- Klapsing P
- Klaus DA
- Kleinpell R
- Kluge S
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- Ko JI
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- Kobayashi A
- Koco E
- Kodate A
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- Kokkini S
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- Komuro T
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- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
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- Kou PS
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- Kovacikova L
- Kox M
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- Kristof J
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- Ku NS
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- Kubik M
- Kubota K
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- Kulaga EV
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- Kunze-Szikszay N
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- Kurth T
- Kurtz P
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- Kwon HM
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- Kye YC
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- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
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- Lagonidis D
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- Lebherz-Eichinger D
- Lebiedz P
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- Lipcsey M
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- Lissonde F
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- Litchfield K
- Liu CP
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- Maekawa K
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- Mistry M
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- Saito M
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- Sakieva FI
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- Savi C
- Savin I
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- Soussi S
- Souza VA
- Spadaro S
- Spadaro S
- Spahn DR
- Spatenkova V
- Spazzadeschi A
- Spijkstra JJ
- Spronk PE
- Spronk PE
- Sprung CL
- St George’s University of London
- Stamm J
- Stamouli M
- Stanić R
- Starczewska M
- Staszewsky L
- Stauffert N
- Stella A
- Stephens T
- Stiphout C
- Stocchetti N
- Stocchetti N
- Stougianni M
- Street H
- Stretti F
- Struijs A
- Stubbs C
- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
- Stümpfle R
- Stümpfle R
- Su F
- Su L
- Su PL
- Su PL
- Suchomel P
- Suh GJ
- Suh GJ
- Suh GJ
- Suh GY
- Suh JW
- Sullivan E
- Sun WZ
- Sun XM
- Sung D
- Suwanpasu S
- Suzuki S
- Suzuki T
- Swart M
- Sy O
- Sydow K
- Sylla P
- Sáez VC
- Sánchez B
- Sánchez B
- Sánchez EC
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez PC
- Sánchez PC
- Sánchez-Elvira LA
- Tabatabaei HR
- Tabei SH
- Taccone F
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taggu A
- Taggu A
- Takahashi H
- Takaki S
- Takaki S
- Takeda M
- Takeda M
- Takei T
- Takei T
- Talan L
- Tamura T
- Tanaka H
- Tanaka S
- Tanaka S
- Tane N
- Tang KB
- Tang LK
- Tapia A
- Tapponnier R
- Tapponnier R
- Tapponnier R
- Tarabrin O
- Tarabrin P
- Tavazzi G
- Tavazzi G
- Teboul JL
- Telli S
- Temprano-Gómez I
- Tena SA
- Tencé N
- Terzi N
- Terzi N
- Terzi N
- Terzi N
- Thabut G
- Thabut G
- Theodorakopoulou M
- Thies P
- Thilakasiri MC
- Thomas B
- Thompson E
- Thévenin D
- Tiainen M
- Timsit JF
- Tirkkonen J
- Tirumala S
- Tjepkema-Cloostermans MC
- Tobar M
- Tofiño AL
- Toh CH
- Tokyo Womens Medical University
- Tomas E
- Tomas E
- Tomic I
- Tominaga N
- Tomás MA
- Tonelotto BF
- Tonetti T
- Tonetti T
- Topcu L
- Tormos P
- Torner MM
- Torner MM
- Torrance HD
- Torrent RL
- Torrent RL
- Torres A
- Torres E
- Torres JC
- Torriglia F
- Torriglia F
- Torriglia F
- Torsvik M
- Tosi F
- Touratier S
- Touw HR
- Toval S
- Tran N
- Trapp O
- Travierso C
- Travieso PM
- Traynor T
- Trefler S
- Trenado J
- Trenado J
- Treso-Geira M
- Trifan B
- Triulzi F
- Troeltzsch M
- Troncoso I
- Trouiller P
- Tseng CJ
- Tsirigotis P
- Tsukahara K
- Tsunano Y
- Tsunoda M
- Tsunoda M
- Tsutui T
- Tucci MR
- Tudor BA
- Tuinman PR
- Tullo L
- Turel M
- Turon R
- Twisk JW
- Törnblom S
- Ugawa T
- Ujike Y
- Ulla DV
- Ullman A
- Unal M
- Urbanaviciute I
- Uriona S
- Urli T
- Usón MC
- Vaahersalo J
- Vaara S
- Vaid N
- Vakalos A
- Valbuena BL
- Valbuena BL
- Valeiras-Valero A
- Vallecoccia MS
- Vallejo-Báez J
- Vallverdu M
- Vallverdu M
- Vallverdú I
- Vallés J
- van den Boogaard M
- van der Heiden ES
- van der Hoeven JG
- van der Hoeven JG
- van der Voort PH
- van Galen T
- van Ieperen SN
- Van Logten T
- van Nes M
- van Putten MJ
- van Thiel RJ
- van Wijk A
- Vandijck D
- Vaneker I
- Vanhuyse F
- Vaporidi K
- Vaquerizo C
- Varas GM
- Varas JL
- Varea MM
- Vargiolu A
- Varma A
- Varpula T
- Vatsik MV
- Vazquez D
- Vedage D
- Vega LM
- Veigas P
- Vela JL
- Velasquez T
- Venkatesan K
- Venn R
- Venn R
- Venot M
- Venrdramin A
- Ventura-Rosado A
- Vergani G
- Verginella F
- Verhaeghe R
- Verhage R
- Vermeir P
- Veronesi M
- Vezzani A
- Vezzani A
- Vianna G
- Viciana R
- Vidal A
- Vidal MV
- Vidal MV
- Viegas E
- Vieillard-Baron A
- Vieira JE
- Viera MA
- Viera MA
- Vigne C
- Villa G
- Villa P
- Villalba D
- Villamizar PR
- Villamizar PR
- Villanova M
- Villard I
- Villarreal E
- Villarreal E
- Vincent B
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vinje LJ
- Vinsonneau C
- Vitaller S
- Vittone F
- Vogelaers D
- Voiriot G
- Volker T
- Volta CA
- Volta CA
- Vondrakova D
- Vondrakova D
- Vondrakova D
- Vong LV
- Vourli S
- Vrettou C
- Vucic M
- Vázquez CF
- Vázquez CF
- Wada T
- Wada T
- Wada T
- Wada T
- Waldauf P
- Wand S
- Wang CH
- Wang H
- Wann SR
- Wann SR
- Wann SR
- Wann SR
- Wathanawatthu T
- Wee S
- Welte T
- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
- Yager T
- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU
- Author
- A. A. Tanaka Montoya
- A. Abougabal
- A. Akcan-Arikan
- A. Akcan-Arikan
- A. Alkan
- A. Alklit
- A. Alvarez
- A. Amatu
- A. Amirian
- A. Andreotti
- A. Arali
- A. Arcadipane
- A. Armaganidis
- A. Armaganidis
- A. Arthur
- A. Artigas
- A. Artigas
- A. Ballin
- A. Ballin
- A. Barrero-Almodóvar
- A. Bartkowska-Sniatkowska
- A. Bauer
- A. Ben Cheikh
- A. Benard
- A. Berry
- A. Bertomeu-Artecero
- A. Betbese-Roig
- A. Bienert
- A. Bienert
- A. Bjärtå
- A. Blandino Ortiz
- A. Blet
- A. Borsuk
- A. Borsuk
- A. Braschi
- A. Bruhn
- A. C. Falk
- A. C. Jorge
- A. C. Jorge
- A. C. P. Antonio
- A. C. Santos
- A. C. Waldenström
- A. Calini
- A. Campanario Garcia
- A. Canabal
- A. Cariou
- A. Carranza Pinel
- A. Ceccato
- A. Chaari
- A. Chaari
- A. Chaari
- A. Chan
- A. Chao
- A. Chao
- A. Colombo
- A. Colombo
- A. Cortina-Gutiérrez
- A. Costa
- A. Costa
- A. D. Waldmann
- A. D. Wright
- A. De Cassai
- A. Demoule
- A. DeWan
- A. Diamantakis
- A. Diamantakis
- A. Doronzio
- A. Dubin
- A. Dubrawski
- A. Dyson
- A. Dyson
- A. Dyson
- A. E. Andersson
- A. E. K. Jensen
- A. El Sakka
- A. El-adawy
- A. El-Sherif
- A. Eladawy
- A. Eladawy
- A. Eladawy
- A. Escoresca-Ortega
- A. Escoval
- A. Escoval
- A. Evdokimov
- A. F. Garcia Marin
- A. F. Leivas
- A. Fernandez-Blanco
- A. Fernández-Porcel
- A. Fernández-Porcel
- A. Fernández-Porcel
- A. Fernández-Porcel
- A. G. Wojnicka
- A. Gabarrus
- A. Garcia de Lorenzo y Mateos
- A. García-Alcántara
- A. García-Alcántara
- A. García-Alcántara
- A. García-Alcántara
- A. García-de la Torre
- A. Gazenkampf
- A. Giangregorio
- A. Gibson
- A. Glossop
- A. Goffi
- A. Gordillo-Brenes
- A. Gritsan
- A. Guiga
- A. Gunther
- A. Gutiérrez-Pizarraya
- A. H. Elsaka
- A. H. Guirgis
- A. H. V. Andrade
- A. Hartley
- A. Hasanin
- A. Hasanin
- A. Herpain
- A. Hollinger
- A. Hoogendijk
- A. Horton
- A. J. Ferguson
- A. Jones
- A. Jorda
- A. K. Reyners
- A. K. Reyners
- A. Kadioglu
- A. Kara
- A. Khedher
- A. Khedher
- A. Khedher
- A. Kilembe
- A. Kleyman
- A. Koch
- A. Komaromi
- A. Kortgen
- A. Krajčová
- A. Kuriyama
- A. Kuzovlev
- A. L. Beam
- A. L. Ruíz Aguilar
- A. L. Ruíz Aguilar
- A. Lenoire
- A. Lesmes Serrano
- A. Lobo-Civico
- A. Lomas
- A. Lotfy
- A. Loza Vazquez
- A. Luciani
- A. Luzi
- A. M. A. Liberatore
- A. M. A. Liberatore
- A. M. A. Liberatore
- A. M. A. Liberatore
- A. M. C. R. P. F. Martins
- A. M. C. R. P. F. Martins
- A. M. Cavalheiro
- A. M. Dell’Anna
- A. M. Dondorp
- A. M. Doyle
- A. M. E. Spoelstra-de Man
- A. M. E. Spoelstra-de Man
- A. M. Elmenshawy
- A. M. Fagerdahl
- A. M. Fayed
- A. M. López Lago
- A. M. Moktar
- A. M. Mukhtar
- A. M. Pronina
- A. M. Pérez Bailón
- A. M. Spoelstra-de Man
- A. MacKay
- A. Mackay
- A. Mackay
- A. MacKay
- A. MacKay
- A. Marino
- A. Martinez de la Gandara
- A. Martins
- A. Marulanda
- A. Mebazaa
- A. Mebazaa
- A. Mehl
- A. Mehl
- A. Mekontso Dessap
- A. Mercat
- A. Messina
- A. Michalsen
- A. Michalsen
- A. Modler
- A. Mohamed Fehmi
- A. Mukhtar
- A. Mukhtar
- A. Mukhtar
- A. Mula Gómez
- A. Murza
- A. Nierhaus
- A. Ntantana
- A. Ojados Muñoz
- A. Oldner
- A. Ortín Freire
- A. Ozcan
- A. P. Meert
- A. P. Meert
- A. Palmaccio
- A. Pedraza Montenegro
- A. Pereira
- A. Perner
- A. Perner
- A. Perner
- A. Pesenti
- A. Pesenti
- A. Pesenti
- A. Petosic
- A. Pironet
- A. Pivkina
- A. Pizza
- A. Piñol-Tena
- A. Puppo-Moreno
- A. R. De Gaudio
- A. Raafat
- A. Reintam Blaser
- A. Rhodes
- A. Rhodes
- A. Richardson
- A. Rimmer
- A. Rizk
- A. Rodriguez
- A. Rodriguez
- A. Roman
- A. Rugerio Cabrera
- A. Ruiz-Perea
- A. S. Arunkumar
- A. Sanaei Dashti
- A. Sandgren
- A. Sandiumenge
- A. Saraste
- A. Sari
- A. Scaramuzza
- A. Schafer
- A. Schettler
- A. Serpa Neto
- A. Shah
- A. Shakotko
- A. Sigurta
- A. Sinclair
- A. Stacke
- A. Sugiura
- A. Sustic
- A. T. Dewan
- A. T. Mazzeo
- A. Taggu
- A. Tonilo
- A. Topeli
- A. Torres
- A. Torres
- A. Ukere
- A. Urbano
- A. Valeiras-Valero
- A. Vallejo-Baez
- A. Vallejo-Báez
- A. Vargiolu
- A. Vazin
- A. Vazin
- A. Vazir
- A. Vezzani
- A. Vishnu
- A. Vàzquez
- A. Wallin
- A. Wilson
- A. Wong
- A. Yousefipour
- A. Z. Fouad
- A. Zaghlol
- A. Zanella
- A. Zapatero
- A. Zerman
- B. A. McGrath
- B. Aisling
- B. Ana
- B. Balicco
- B. Balsera Garrido
- B. Balsera Garrido
- B. Barbrel
- B. Basarık Aydoğan
- B. Bein
- B. Blackwood
- B. Blackwood
- B. Bovento
- B. Bovento
- B. C. Connolly
- B. C. L. Lim
- B. Cambiaghi
- B. Champigneulle
- B. Coloma-Gomez
- B. Creagh-Brown
- B. Erdogdu
- B. Ergin
- B. Ergin
- B. G. Hassen
- B. Gelee
- B. Huschens
- B. Koeneman
- B. Lambermont
- B. Lara
- B. Lesimple
- B. Llorente Ruiz
- B. Lévy
- B. Maertens
- B. Maghsudi
- B. Maghsudi
- B. Maghsudi
- B. Maitre
- B. Marsh
- B. Matt
- B. McGrath
- B. Morton
- B. Morton
- B. Nashan
- B. O. Åsvold
- B. O. Åsvold
- B. Oomen
- B. Opitz
- B. Paldusová
- B. Pereira
- B. Pezza
- B. Philippon-Jouve
- B. Pifferi
- B. Plaud
- B. S. Rasmussen
- B. Saugel
- B. Scicluna
- B. Suberbiola
- B. Sánchez
- B. Tudor
- B. Tudor
- B. Van den Bulcke
- B. Van den Bulcke
- B. Voisin
- B. West
- B. Ziaian
- B. Ziaian
- C. A. Arango-Dávila
- C. A. C. Abreu Filho
- C. Aldasoro
- C. Bader
- C. Balan
- C. Balci
- C. Balci
- C. Biboulet
- C. Boer
- C. Brun-Buisson
- C. C. Chao
- C. C. Cheng
- C. C. Cheng
- C. C. Chiang
- C. C. Hung
- C. Cai
- C. Cai
- C. Campbell
- C. Candeias
- C. Canullán
- C. Chiurazzi
- C. Chiurazzi
- C. Cilloniz
- C. Climent
- C. Colón-Pallarés
- C. Corbett
- C. de Tymowski
- C. Diakaki
- C. Doree
- C. E. Baldwin
- C. E. Kennedy
- C. E. Kennedy
- C. Ebm
- C. F. Lordani
- C. Filippini
- C. Fleischmann
- C. Fortes
- C. Fuchs
- C. Galban Rodriguez
- C. Galban Rodriguez
- C. Galbán Rodríguez
- C. García-Fuentes
- C. Gecele
- C. Giolitti
- C. Gomez-Gonzalez
- C. Gonen
- C. Gonen
- C. Granja
- C. Groves
- C. Gutierrez Melón
- C. H. Chang
- C. H. Chang
- C. H. Chang
- C. H. Chiang
- C. H. Lai
- C. H. Wang
- C. Hernandez Caballero
- C. Hilasque
- C. Hällsjö Sander
- C. Hällsjö Sander
- C. I. Bernal Matilla
- C. I. Bernal Matilla
- C. I. Olvera Guzman
- C. Iaquaniello
- C. Ince
- C. Ince
- C. Ince
- C. Ince
- C. J. C. Trepte
- C. J. Chen
- C. J. Hinds
- C. J. Hinds
- C. J. Trepte
- C. J. Wickerts
- C. K. Ho
- C. Kaymak
- C. Kerr
- C. Kirakli
- C. Knox
- C. Kripper
- C. König
- C. L. Granger
- C. Lai
- C. Lange
- C. Lee
- C. Lee
- C. M. Chau
- C. M. Park
- C. M. Radu
- C. Maldonado
- C. Maldonado Toral
- C. Marenghi
- C. Martin Lopez
- C. Martin Lopez
- C. Marzorati
- C. Massant
- C. Mazo
- C. Mudarra-Reche
- C. Orford
- C. Ori
- C. Ori
- C. Ori
- C. O’Loughlin
- C. P. Liu
- C. P. Liu
- C. Padilla
- C. Palazzi
- C. Paños-Espinosa
- C. Pena Gil
- C. Pena Gil
- C. Pintado Delgado
- C. Qiu
- C. R. Behem
- C. R. Chung
- C. R. L. M. Costa
- C. R. L. M. Costa
- C. Richard
- C. Ritter
- C. Rodríguez-Mejías
- C. Roger
- C. Rueda-Molina
- C. Rueda-Molina
- C. Rueda-Molina
- C. Rueda-Molina
- C. Ryan
- C. S. Gerrard
- C. S. Hartog
- C. S. Socolovsky
- C. S. Vallone
- C. Scheer
- C. Svensen
- C. Sánchez Ramirez
- C. T. Anthon
- C. T. Chong
- C. T. Chong
- C. T. Lee
- C. T. Lee
- C. Trepte
- C. Turrini
- C. Villavicencio Lujan
- C. Vilà
- C. Vilà
- C. W. Hong
- C. Waldmann
- C. Whiteley
- C. Wright
- C. Wright
- C. Wright
- C. Wright
- C. Y. Hung
- C. Y. Hung
- C. Y. Hung
- C. Y. Liu
- C. Zahrte
- C. Zöllner
- D. A. Dongelmans
- D. A. Dongelmans
- D. A. M. P. J. Gommers
- D. A. M. P. J. Gommers
- D. A. Mckim
- D. A. Reuter
- D. A. Reuter
- D. A. Reuter
- D. A. Reuter
- D. Andreas
- D. Antonakaki
- D. Arias-Verdú
- D. Atkinson
- D. Bastoni
- D. Benoit
- D. Benoit
- D. Benten
- D. Bourdeaux
- D. Buche
- D. C. Marshall
- D. Cabestrero Alonso
- D. Chiumello
- D. Chiumello
- D. Colombo
- D. Consonni
- D. Coquerel
- D. Dawson
- D. De Backer
- D. De Caria
- D. Díaz Diaz
- D. E. Tullis
- D. F. Christensen
- D. F. Christensen
- D. F. McAuley
- D. F. Mcauley
- D. Fergusson
- D. García Huertas
- D. Genc
- D. Gibson
- D. Goodall
- D. H. Kim
- D. Hall
- D. Hansell
- D. J. Gebhard
- D. J. Levine
- D. J. Pennington
- D. K. Song
- D. Kiers
- D. L. Grieco
- D. L. J. Moolenaar
- D. Le Bars
- D. Leasa
- D. Lockey
- D. Loghmari
- D. M. Ferreira
- D. Markopoulou
- D. Martínez Baño
- D. Massari
- D. Matamis
- D. McWilliams
- D. Miglioranza
- D. Milliken
- D. Mojgan
- D. Morely
- D. Naumann
- D. O. Thomas-Rueddel
- D. Ong
- D. Orbegozo Cortes
- D. Overgaard
- D. Overgaard
- D. Oztuna
- D. P. Gund
- D. P. Park
- D. Padilla
- D. Phelan
- D. Pogson
- D. Pogson
- D. R. Thickett
- D. Rageb
- D. Ringaitiene
- D. S. Y. Ong
- D. Salvail
- D. Savo
- D. Schwarzkopf
- D. Shilkin
- D. Siluk
- D. Silva
- D. Swigon
- D. T. Malheiro
- D. Talmor
- D. Talmor
- D. ten Kate
- D. Titeca
- D. Tonon
- D. Trásy
- D. Trásy
- D. Verboom
- D. Vikulova
- D. W. de Lange
- D. Wang
- D. Wendt
- D. Williams
- D. Z. Roushdy
- D. Érces
- D. Érces
- D. Šímová
- E. Aguilar-Alonso
- E. Akerman
- E. Alonso Peces
- E. Antok
- E. Asadpour
- E. Ayman
- E. Azoulay
- E. Azoulay
- E. Barsam
- E. Black
- E. Black
- E. Bonicolini
- E. Bulent
- E. Campello
- E. Campello
- E. Carlesso
- E. Carlesso
- E. Carton
- E. Chrysanthopoulou
- E. Chrysanthopoulou
- E. Colombo
- E. Curiel-Balsera
- E. Cámara-Sola
- E. Cámara-Sola
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- Y. Inagaki
- Y. Ince
- Y. Ince
- Y. Ince
- Y. J. Chang
- Y. J. Cheng
- Y. J. Cho
- Y. J. Lim
- Y. J. Liou
- Y. K. Jee
- Y. Kang
- Y. Kashiwagi
- Y. Koh
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- Y. Onodera
- Y. Palmeiro
- Y. R. Kang
- Y. R. Kang
- Y. S. Kim
- Y. S. Lin
- Y. Sutherasan
- Z. A. Puthucheary
- Z. Costa e Silva
- Z. Costa Silva
- Z. Güllü
- Z. Jian
- Z. Kokot
- Z. Marutyan
- Z. Molnár
- Z. Molnár
- Z. Tang
- Z. Tang
- Z. Trogrlic
- Z. Trogrlic
- Z. Uz
- Z. Xie
- Z. Yan
- Z. Yu xiang
- Z. Ülger
- Á. Fernández Martínez
- Á. J. Roldán Reina
- Å. Askim
- Å. Askim
- Å. Norberg
- Å. Norberg
- Å. Valsø
- Ø. Sundin
- Ü. Gaygısız
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Contains fulltext :
172380.pdf (publisher's version ) (Open Access
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- Abellán Am
- Abellán Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
- Ahad A
- Ahel J
- Ahern Dp
- Ahmad A
- Ahmed B
- Ahmed G
- Ahmed Os
- Ahmed Os
- Ahmed S
- Ainsworth P
- Ais G
- Ais G
- Aisoni F
- Akbari K
- Akhtar K
- Akinsola O
- Akram F
- Al-Faham Z
- Al-Khafaji N
- Al-Khyatt W
- Al-Musawi S
- Al-Sarireh B
- Al-Sheikh M
- Alagna V
- Alani M
- Alberca-Paramo A
- Aldrey I
- Alexander R
- Alhammali T
- Alhammali T
- Ali M
- Aljorfi A
- Allen M
- Allington J
- Alonzo A
- Alshafei A
- Altomare Ma
- Alvarez Cm
- Alvarez E
- Alvarez-Gallego M
- Amaducci E
- Amarasinghe R
- Amayo A
- Ambrona-Zafra D
- Amin V
- Ammendola M
- Amtul N
- Amtul N
- Amuthalingam T
- Anandan L
- Anania G
- Anania M
- Anderson Dj
- Anderson O
- Andolfi E
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- Angelieri D
- Angelini M
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- Ball A
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- Ballabio M
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- Banks A
- Bansal H
- Baraghini M
- Barbosa L
- Barker T
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- Barnieh W
- Baronio G
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- Barrie A
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- Baseggio M
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- Berry B
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- Beverstock A
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- Bhangu A. Nepogodiev D
- Bhangu A
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- Bhargava A
- Biancafarina A
- Biancafarina A
- Bianchi Cl
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- Bilku D
- Birindelli A
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- Birindelli A
- Blackford Od
- Blackwell J
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- Bolton W
- Bolzon S
- Bond S
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- Bondurri A
- Bonfante P
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- Borges Fc
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- Boshier Pr
- Botelho P
- Bowen J
- Bowerman H
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- Bowman Cr
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- Boyd-Carson H
- Boza K
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- Branagan G
- Bravo-Gutiérrez Af
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- Brennan S
- Brett M
- Brewer H
- Brewer Hk
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- Brews R
- Brien Jo
- Bronder C
- Brown A
- Brown Ag
- Brown Ce
- Brown Ce
- Brown Ce
- Brown M
- Brown M
- Brown Od
- Brown R
- Bruce Js
- Brunelli Db
- Bryan Es
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- Bukhari W
- Bull C
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- Busuttil A
- Byrne Be
- Byrnes Ck
- Caballero A
- Caldeira Ab
- Caldwell M
- Callan R
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- Calvo H
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- Cameron Fc
- Campagnaro T
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- Campbell U
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- Cannata G
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- Cantafio S
- Capelli P
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- Carden Ca
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- Caro A
- Carral-Freire M
- Carrano Fm
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- Cartwright H
- Carvalho Lc
- Carvalho N
- Casimiro C
- Castagnoli G
- Castagnoli G
- Caula C
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- Cavallo D
- Cavero A
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- Cerdán-Santacruz C
- Cerdán-Santacruz C
- Cerdán-Santacruz C
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- Cervellera M
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- Chan D
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- Chandratreya N
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- Chapman J
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- Charalabopoulos A
- Charalambous Mp
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- Chatzikonstantinou M
- Chatzikonstantinou M
- Chauhan P
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- Cheng Sa
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- Chetta G
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- Chillitupa Cz
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- Chitsabesan P
- Chng S
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- Chong B
- Choolani-Bhojwani E
- Choong Jh
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- Chowdhury F
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- Coletti M
- Collado-Roura F
- Collier-Wakefield O
- Colombo F
- Colombo F
- Colvin Da
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- Compagnoni B
- Conci S
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- Contine Ac
- Contreras Rg
- Contreras-Saiz E
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- Cormenzana Ob
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- Cortés Gv
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- Cynthia G
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- D'Auria M
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- Danquah-Boateng D
- Dar Fa
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- Davidson S
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- De Chaves-Rodríguez Pg
- De Freitas S
- De Luca E
- De Marchi F
- De Marco P
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- De Padua C
- De Prizio M
- De-La-Herranz-Guerrero P
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- De-Manzoni-Garberini A
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- De-Marchi Ja
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- Dean Ea
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- Del Pozo E
- Del-Valle-Ruiz Sr
- Delgado-Plasencia Lj
- Delimpalta C
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- Delogu D
- Denley S
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- Depalma N
- Deserra A
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- Dhari Aa
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- García V
- García-Carrero M
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- García-Granero A
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- García-Novoa A
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- Pata F
- Pata F.
- Pata G
- Pata G
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- Patel By
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- Patel C
- Patel H
- Patel Mm
- Patel N
- Patel Pk
- Patel Rt
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- Peiris Gb
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- Photiou D
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- Pietrabissa A
- Pigem A
- Pila U
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- Pinillos-Somalo A
- Pinkney Td
- Pinkney Td
- Pinkney Td
- Pinna E
- Pino-Perez O
- Pirari Pf
- Pisanu A
- Piu F
- Planellas P
- Plua-Muniz Kt
- Poacher A
- Podda F
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- Pollard H
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- Ranathunga S
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- Rodriguez-Lopez M
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- Romoli L
- Roncero Ls
- Ronda Rn
- Roomi S
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- Roscio F
- Rossi C
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- Rossi Gm
- Roth N
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- Rubbini M
- Rudland I
- Ruffolo C
- Rufo E
- Ruggiu Gv
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- Rutherford Dg
- Ruzvidzo F
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- Saba A
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- Sarmah P
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- Sasia D
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- Saunders S
- Savill A
- Savino G
- Savino G
- Savioli F
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- Scabini S
- Scabini S
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- Scanlon K
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- Segalini E
- Segura-Sampedro Jj
- Sena G
- Sena-Ruiz F
- Seneviratne N
- Sepe C
- Serventi F
- Serventi F
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- Sooriyamoorthy T
- Soria-Aledo V
- Soria-Aledo V
- Soriano Jt
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- Sparta C
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- Speake D
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- Stevenson R
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- Strange Ja
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- Stupalkowska W
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- Zhang Ay
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- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
Apneas del sueño e insuficiencia cardíaca, ¿está ya todo claro?
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2003
- Field of study
Apneas del sueño e insuficiencia cardíaca, ¿está ya todo claro?
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
- …