Initiation of ovarian stimulation independent of the menstrual cycle (random-start) in an oocyte donation programme a large, single-center experience

Research Question Do live birth rates differ between recipients matched with donors using conventional ovarian stimulation versus those using random-start protocols? Design Retrospective analysis of 891 ovarian stimulations in egg donors (January-December 2018) and clinical outcomes in matched recipients (n=935). Donors commenced ovarian stimulation on day 1/3 of the menstrual cycle (n=223) or in the mid/late-follicular (n=388) or luteal phase (n=280) under a conventional antagonist protocol. Live birth rate of matched recipients was the main outcome. Results Duration of stimulation and total gonadotropins dose were comparable between conventional versus random-start groups. The number of collected eggs were also similar: 17.6±8.8 vs 17.2±8.5, p=0.6, respectively. Sub-group analysis showed an increased stimulation length (10.2±1.8 vs 9.8±1.7 vs 10.4±1.7, p<0.001) and gonadotropin consumption (2041.5±645.3 vs 2003.2±647.3 vs 2158.2±685.7 IU, p=0.01) in the luteal phase group vs the mid/late follicular and conventional groups; respectively. In matched recipients receiving fresh oocytes and undergoing fresh embryo transfer, the biochemical pregnancy (63.8% and 63.3%; p=0.9), clinical pregnancy (54.6% and 56.1%; p=0.8) and live birth rates (47.7% and 46.6%; p=0.7) per embryo-transfer were similar between conventional versus random groups. Similar results were obtained in recipients receiving vitrified eggs. Euploidy rate was also comparable. Conclusions There were no notable variations in clinical outcomes using oocytes obtained from random-start protocols and those proceeding from conventional ovarian stimulation in oocyte donation treatments. However, luteal-phase stimulation seems to require longer stimulation and higher FSH consumption. Our results indicate that random-start stimulation strategy does not impair the potential of the oocyte yield or clinical outcomes in oocyte donation cycles

XVI International Congress of Control Electronics and Telecommunications: "Techno-scientific considerations for a post-pandemic world intensive in knowledge, innovation and sustainable local development"

Este título, sugestivo por los impactos durante la situación de la Covid 19 en el mundo, y que en Colombia lastimosamente han sido muy críticos, permiten asumir la obligada superación de tensiones sociales, políticas, y económicas; pero sobre todo científicas y tecnológicas. Inicialmente, esto supone la existencia de una capacidad de la sociedad colombiana por recuperar su estado inicial después de que haya cesado la perturbación a la que fue sometida por la catastrófica pandemia, y superar ese anterior estado de cosas ya que se encontraban -y aún se encuentran- muchos problemas locales mal resueltos, medianamente resueltos, y muchos sin resolver: es decir, habrá que rediseñar y fortalecer una probada resiliencia social existente - producto del prolongado conflicto social colombiano superado parcialmente por un proceso de paz exitoso - desde la tecnociencia local; como lo indicaba Markus Brunnermeier - economista alemán y catedrático de economía de la Universidad de Princeton- en su libro The Resilient Society…La cuestión no es preveerlo todo sino poder reaccionar…aprender a recuperarse rápido.This title, suggestive of the impacts during the Covid 19 situation in the world, and which have unfortunately been very critical in Colombia, allows us to assume the obligatory overcoming of social, political, and economic tensions; but above all scientific and technological. Initially, this supposes the existence of a capacity of Colombian society to recover its initial state after the disturbance to which it was subjected by the catastrophic pandemic has ceased, and to overcome that previous state of affairs since it was found -and still is find - many local problems poorly resolved, moderately resolved, and many unresolved: that is, an existing social resilience test will have to be redesigned and strengthened - product of the prolonged Colombian social conflict partially overcome by a successful peace process - from local technoscience; As Markus Brunnermeier - German economist and professor of economics at Princeton University - indicates in his book The Resilient Society...The question is not to foresee everything but to be able to react...learn to recover quickly.Bogot

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p &lt; 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics

INSTITUTIONALISING FARMER PARTICIPATION IN ADAPTIVE TECHNOLOGY TESTING WITH THE `CIAL'

Public sector research and extension agencies are frequently unable (because of cost constraints) or unwilling to serve the needs of small farmers living in complex, diverse and risk-prone environments. This paper describes one attempt to increase these farmers' demand-pull on public sector and non-governmental technology-providing agencies by harnessing their capacity for local experimentation and combining it with some of the techniques of more formal agricultural research. The CIAT IPRA programme has provided resources, technical support and management training to locally elected committees (CIALs), composed of 'experimenting' farmers, which manage and conduct research on behalf of the community as a whole. The community is responsible not only for the election of the committee, but also for setting the agenda for research and helping to evaluate the results. The risks of conducting research are reduced by the existence of a fund — which is 'owned' by the community as a whole — on which the committees can draw should the experimentation result in financial losses. So far 55 of these committees have been established in Colombia since the programme began in 1990. A number of these have evolved into significant local seed production enterprises. The committees as a group have now formed their own corporation. This enhances the scope for information exchange and puts them on an independent financial footing. Other committees have been established in Bolivia, Ecuador, Honduras and Peru. The CIAT programme has monitored the progress of the Colombian CIALs and developed a range of training materials which can be used by others interested in establishing committees. This paper looks at the results of the programme, focusing in particular on the support needs of CIALs and the relative costs and quality of CIAL research. It also notes some of the distributional and institutional issues which are expected to be important to the future adoption of the CIAL approach to adaptive agricultural research

Swing- attenuation for a quadrotor transporting a cable suspended payload

International audienc

Passivity-Based Control for a Micro Air Vehicle Using Unit Quaternions

In this paper the development and practical implementation of a Passivity-Based Control (PBC) algorithm to stabilize an Unmanned Aerial Vehicle (UAV) described with unit quaternions are presented. First, a mathematical model based on Euler-Lagrange formulation using a logarithmic mapping in the quaternion space is introduced. Then, a new methodology: a quaternion-passivity-based control is derived, which does not compute excessive and complex Partial Differential Equations (PDEs) for synthesizing the control law, making a significant advantage in comparison with other methodologies. Therefore, the control design to a system as the quad-rotor is easily solved by the proposed methodology. Another advantage is the possibility to stabilize quad-rotor full dynamics which may not be possible with classical PBC techniques. Experimental results and numerical simulations to validate our proposed scheme are presented

Nonlinear Control Strategies for a UAV Carrying a Load with Swing Attenuation

International audienceTwo novel nonlinear control schemes for Unmanned Aerial Vehicles (UAV) carrying a load and their comparative results are presented in this paper. The goal is to carry the load to a desired position, with oscillation attenuation along the trajectory. The proposed control structures are hierarchical schemes consisting of nonlinear controllers to stabilize the vehicle translational movements and the payload swing together with a well-known state-dependent differential Riccati equation controller to stabilize the rotational dynamics. We present new methodologies where two nonlinear controllers are proposed to obtain precise aerial vehicle positioning and efficient load oscillation reduction by exploiting the natural coupling between the horizontal quadcopter movement and the payload oscillation. It is shown that asymptotic stability can be guaranteed by the use of the Lyapunov approach and La Salle’s invariance principle. Numerical experiments were carried out to validate the nonlinear control behaviors where the results show improvements with respect to a strategy from the literature

El Caudillo del Sur: forjador de la nación mexicana

CONFORME A LAS EVIDENCIAS ofrecidas por varios historiadores el 30 de septiembre y el 22 de diciembre de 2015 se conmemoro el 250 aniversario del natalicio y el bicentenario de la muerte, respectivamente, de quien fuera la persona más extraordinario y de mayor trascendencia durante la Guerra de Independencia de México: don José María Morelos y Pavón. Estas fechas nos son propicias no sólo para conmemorar o los próceres que nos dieron patrio y libertad sino también para reflexionar qué hemos hecho los y los ciudadanos actuales con el legado y herencia que recibimos de quienes consideramos nuestros padres de lo noción mexicano. Lo Universidad Autónomo del Estado de México se suma con este libro y otros acciones o lo serie de conmemoraciones que diversas personas, instituciones y entidades del país están realizando este año al líder supremo de la insurgencia del Sur

Physical-productive characterization and typologies of diversified dairy systems in the highlands of Ecuador

The objective of this work was to characterize and establish a typology of Cotopaxi cattle systems in the northern Sierra region of Ecuador. The data were collected through direct surveys of 212 farmers and reflect the main technical, economic and productive aspects of the farms. The typology was established using multivariate analytical techniques. Cluster analysis revealed four groupings. Group I, defined as Small Family Farms (GPF), Group II, as Family Farms Farms (GMF), Group III, as Technified Family Farms Farms (GMFT) and Group IV, as Very Small Family Farms (GMPF). An ANAVA was applied. The evaluation indicated important differences in the group farms, despite the fact that they are developed in the same agroclimatic environment, operate in the same markets and also have similar information. The result is a varied universe of situations with significant variations between medium and small systems. By scale and by reason of their areas dedicated to livestock and crops and their productive and efficiency results measured as income for each activity and level of expenditure