991 research outputs found

    Avaliação do desempenho de um modelo de estimativa de saldo de radiação em algumas culturas.

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    Avaliou-se o desempenho do método de estimativa do saldo de radiação proposto por ALLEN, 1998, em experimentos de culturas de girassol, amendoim, café, limão e grama, através de regressões lineares com base nos indicadores estatísticos coeficiente de correlação r?, índice de Willmott ?d? e índice de desempenho ?c?. Segundo os critérios de avaliação do índice ?c?, o método proposto por ALLEN, 1998 representa de forma satisfatória os dados de saldo de radiação, sendo obtidos os desempenhos equivalentes a 0,79 (muito bom) para as culturas de girassol e grama e de 0,96; 0,86 e 0,88 (ótimo) para as culturas de amendoim, café e limão, respectivamente.CBA 2009

    Balanço de energia em amendoim irrigado.

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    O presente estudo utilizou o método do balanço de energia através da razão de Bowen para estimar os fluxos de calor latente (LE) e sensível (H) a partir de medidas do saldo de radiação (Rn), fluxo do calor do solo (G) e gradientes psicométricos (com termopares) em dois cultivares amendoim (Arachis hypogaea L.) irrigado. Os resultados indicam que a partição de Rn em fluxos de LE, H e G varia durante o ciclo, principalmente em função do desenvolvimento vegetativo da cultura. O método da razão de Bowen propiciou medidas de consumo hídrico coerentes com a cultura do amendoim (valores médios de 6 mm.dia-1 para ambos os cultivares).CBA 2009

    Na+/Ca(2+ )Exchanger a Druggable Target to Promote beta -Cell Proliferation and Function

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    An important feature of type 2 diabetes is a decrease in <i>β</i> -cell mass. Therefore, it is essential to find new approaches to stimulate <i>β</i> -cell proliferation. We have previously shown that heterozygous inactivation of the Na <sup>+</sup> /Ca <sup>2+</sup> exchanger (isoform 1; NCX1), a protein responsible for Ca <sup>2+</sup> extrusion from cells, increases <i>β</i> -cell proliferation, mass, and function in mice. Here, we show that <i>Ncx</i> 1 inactivation also increases <i>β</i> -cell proliferation in 2-year-old mice and that NCX1 inhibition in adult mice by four small molecules of the benzoxyphenyl family stimulates <i>β</i> -cell proliferation both <i>in vitro</i> and <i>in vivo</i> . NCX1 inhibition by small interfering RNA or small molecules activates the calcineurin/nuclear factor of activated T cells (NFAT) pathway and inhibits apoptosis induced by the immunosuppressors cyclosporine A (CsA) and tacrolimus in insulin-producing cell. Moreover, NCX1 inhibition increases the expression of <i>β</i> -cell-specific genes, such as <i>Ins1, Ins2,</i> and <i>Pdx</i> 1, and inactivates/downregulates the tumor suppressors retinoblastoma protein (pRb) and miR-193a and the cell cycle inhibitor p53. Our data show that Na <sup>+</sup> /Ca <sup>2+</sup> exchange is a druggable target to stimulate <i>β</i> -cell function and proliferation. Specific <i>β</i> -cell inhibition of Na <sup>+</sup> /Ca <sup>2+</sup> exchange by phenoxybenzamyl derivatives may represent an innovative approach to promote <i>β</i> -cell regeneration in diabetes and improve the efficiency of pancreatic islet transplantation for the treatment of the disease

    STUDY OF THE O-18+Ni-64 TWO-NEUTRON TRANSFER REACTION AT 84 MeV BY MAGNEX

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    A study of the two-neutron transfer reaction of the O-18 + Ni-64 system at 84 MeV incident energy to the ground and first 2(+) excited state of the residual Ni-66 nucleus is presented. The experiment was performed at the INFN-LNS (Italy) by using the large acceptance MAGNEX spectrometer. Theoretical models are used in order to disentangle the competition between long-range and short-range correlations

    Long-range versus short-range correlations in the two-neutron transfer reaction Ni 64 (O 18, O 16) Ni 66

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    Recently, various two-neutron transfer studies using the (18O,16O) reaction were performed with a large success. This was achieved because of a combined use of the microscopic quantum description of the reaction mechanism and of the nuclear structure. In the present work we use this methodology to study the two-neutron transfer reaction of the 18O+64Ni system at 84 MeV incident energy, to the ground and first 2+ excited state of the residual 66Ni nucleus. All the experimental data were measured by the large acceptance MAGNEX spectrometer at the Instituto Nazionale di Fisica Nucleare \u2013Laboratori Nazionali del Sud (Italy). We have performed exact finite range cross section calculations using the coupled channel Born approximation (CCBA) and coupled reaction channel (CRC) method for the sequential and direct two-neutron transfers, respectively. Moreover, this is the first time that the formalism of the microscopic interaction boson model (IBM-2) was applied to a two-neutron transfer reaction. From our results we conclude that for two-neutron transfer to the ground state of 66Ni, the direct transfer is the dominant reaction mechanism, whereas for the transfer to the first excited state of 66Ni, the sequential process dominates. A competition between long-range and short-range correlations is discussed, in particular, how the use of two different models (Shell model and IBM's) help to disentangle long- and short-range correlations

    Outbreak Of NDM-1-producing Klebsiella Pneumoniae In A Neonatal Unit In Colombia

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    Six multiresistant, NDM-1-producing Klebsiella pneumoniae strains were recovered from an outbreak that affected six neonatal patients in a Colombian hospital. Molecular analysis showed that all of the isolates harbored the blaNDM-1, qnrA, and intI1 genes and were clonally related. Multilocus sequence typing showed that the isolates belonged to a new sequence type (ST1043) that was different from the sequence types that had previously been reported. This is the first report of NDM-1-producing isolates in South America

    Elastic scattering measurements for the 10C + 208Pb system at Elab = 66 MeV

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    Background: The influence of halo structure of 6 He, 8 B, 11Be, and 11Li nuclei in several mechanisms such as direct reactions and fusion is already established, although not completely understood. The influence of the 10C Brunnian structure is less known. Purpose: To investigate the influence of the cluster configuration of 10C on the elastic scattering at an energy close to the Coulomb barrier. Methods: We present experimental data for the elastic scattering of the 10C + 208Pb system at Elab = 66 MeV. The data are compared to the three- and the four-body continuum-discretized coupled-channels calculations assuming 9 B +p, 6 Be +α, and 8 Be +p + p configurations. Results: The experimental angular distribution of the cross sections shows the suppression of the Fresnel peak that is reasonably well reproduced by the continuum-discretized coupled-channels calculations. However, the calculations underestimate the cross sections at backward angles. Couplings to continuum states represent a small effect. Conclusions: The cluster configurations of 10C assumed in the present work are able to describe some of the features of the data. To explain the data at backward angles, experimental data for the breakup and an extension of theoretical formalism towards a four-body cluster seem to be in need to reproduce the measured angular distribution.Ministerio de España de Economía y Competitividad, el Foro Regional Europeo Fondo de Desarrollo (FEDER) FIS2017- 88410-PPrograma Horizonte 2020 de la Unión Europea Subvención No. 654002Fondos SID 2019 (Università degli Studi di Padova, Italia) CASA_SID19_01

    Modeling dose-response relationships of the effects of fesoterodine in patients with overactive bladder

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    <p>Abstract</p> <p>Background</p> <p>Fesoterodine is an antimuscarinic for the treatment of overactive bladder, a syndrome of urgency, with or without urgency urinary incontinence (UUI), usually with increased daytime frequency and nocturia. Our objective was to develop predictive models to describe the dose response of fesoterodine.</p> <p>Methods</p> <p>Data from subjects enrolled in double-blind, placebo-controlled phase II and III trials were used for developing longitudinal dose-response models.</p> <p>Results</p> <p>The models predicted that clinically significant and near-maximum treatment effects would be seen within 3 to 4 weeks after treatment initiation. For a typical patient with 11 micturitions per 24 hours at baseline, predicted change was -1.2, -1.7, and -2.2 micturitions for placebo and fesoterodine 4 mg and 8 mg, respectively. For a typical patient with 2 UUI episodes per 24 hours at baseline, predicted change was -1.05, -1.26, and -1.43 UUI episodes for placebo and fesoterodine 4 mg and 8 mg, respectively. Increase in mean voided volume was estimated at 9.7 mL for placebo, with an additional 14.2 mL and 28.4 mL for fesoterodine 4 mg and 8 mg, respectively.</p> <p>Conclusions</p> <p>A consistent dose response for fesoterodine was demonstrated for bladder diary endpoints in subjects with overactive bladder, a result that supports the greater efficacy seen with fesoterodine 8 mg in post hoc analyses of clinical trial data. The dose-response models can be used to predict outcomes for doses not studied or for patient subgroups underrepresented in clinical trials.</p> <p>Trial Registration</p> <p>The phase III trials used in this analysis have been registered at ClinicalTrials.gov (NCT00220363 and NCT00138723).</p
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