305 research outputs found
On the use of Hidden Markov Processes and auto-regressive filters to incorporate indoor bursty wireless channels into network simulation platforms
In this paper we thoroughly analyze two alternatives to replicate the bursty behavior that characterizes real indoor wireless channels within Network Simulation platforms. First, we study the performance of an improved Hidden Markov Process model, based on a time-wise configuration so as to decouple its operation from any particular traffic pattern. We compare it with the behavior of Bursty Error Model Based on an Auto-Regressive Filter, a previous proposal of ours that emulates the received Signal to Noise Ratio by means of an auto-regressive filter that captures the âmemoryâ assessed in real measurements. We also study the performance of one of the legacy approaches intrinsically offered by most network simulation frameworks. By means of a thorough simulation campaign, we demonstrate that our two models are able to offer a much more realistic behavior, yet maintaining an affordable response in terms of computational complexity.The authors would like to express their gratitude to the Spanish government for its funding in the project âConnectivity as a Service: Access for the Internet of the Futureâ, COSAIF (TEC2012-38574-C02-01
Ultrasonography of the distal limbs in Nellore and Girolando calves 8 to 12Â months of age
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Artigo - Pryscilla Vanessa Rodrigues Gonçalves - 2014.pdf: 738775 bytes, checksum: 17c42f29f233f408ef568a5c45b1b787 (MD5)
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Previous issue date: 2014Background: Ultrasonography can be used anywhere and allows rapid, noninvasive differentiation of soft tissue
structures of the musculoskeletal system. The objectives of this study were to describe the ultrasonographic
appearance of the structures of the metacarpo-/metatarsophalangeal and the interphalangeal joints, the appearance of
the growth plates of the distal metacarpus/metatarsus and of the proximal phalanx and to measure the
cross-sectional dimensions of the DDFT and SDFT in Nellore and Girolando calves eight to 12 months of age.
Results: In the longitudinal dorsal view the common digital extensor tendon and the digital extensor tendon were
depicted as echogenic parallel fiber bundles located directly under the skin. The joint spaces appeared as anechoic
interruptions of the hyperechogenic bone surfaces. The normal amount of synovial fluid could not be depicted.
The growth plates were seen as anechoic interruptions of the bone surface proximal and distal to the fetlock joint
space. In transverse sonograms of the distal palmar/plantar regions, the flexor tendons and branchs of the
suspensory ligament were imaged as echogenic structures. The lumen of the digital flexor tendon sheath could
not be imaged in these normal cattle. The thin digital distal annular ligament and the reversal of positions of the
DDFT and SDFT could be appreciated. No significant differences were found between the cross-sectional measurements
of the DDFT and the SDFT from Nellore and Girolando in any age, thoracic/pelvic limbs, right/left sides and
lateral/medial digits.
Conclusions: The results of this study establish important ultrasonographic reference data of the normal structures of
the distal limbs and the normal dimensions of the flexor tendons in Nellore and Girolando calves for use in clinical
practice
An angiopoietin 2, FGF23, and BMP10 biomarker signature differentiates atrial fibrillation from other concomitant cardiovascular conditions
Early detection of atrial fibrillation (AF) enables initiation of anticoagulation and early rhythm control therapy to reduce stroke, cardiovascular death, and heart failure. In a cross-sectional, observational study, we aimed to identify a combination of circulating biomolecules reflecting different biological processes to detect prevalent AF in patients with cardiovascular conditions presenting to hospital. Twelve biomarkers identified by reviewing literature and patents were quantified on a high-precision, high-throughput platform in 1485 consecutive patients with cardiovascular conditions (median age 69 years [Q1, Q3 60, 78]; 60% male). Patients had either known AF (45%) or AF ruled out by 7-day ECG-monitoring. Logistic regression with backward elimination and a neural network approach considering 7 key clinical characteristics and 12 biomarker concentrations were applied to a randomly sampled discovery cohort (n=933) and validated in the remaining patients (n=552). In addition to age, sex, and body mass index (BMI), BMP10, ANGPT2, and FGF23 identified patients with prevalent AF (AUC 0.743 [95% CI 0.712, 0.775]). These circulating biomolecules represent distinct pathways associated with atrial cardiomyopathy and AF. Neural networks identified the same variables as the regression-based approach. The validation using regression yielded an AUC of 0.719 (95% CI 0.677, 0.762), corroborated using deep neural networks (AUC 0.784 [95% CI 0.745, 0.822]). Age, sex, BMI and three circulating biomolecules (BMP10, ANGPT2, FGF23) are associated with prevalent AF in unselected patients presenting to hospital. Findings should be externally validated. Results suggest that age and different disease processes approximated by these three biomolecules contribute to AF in patients. Our findings have the potential to improve screening programs for AF after external validation
Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?
<p>Abstract</p> <p>Background</p> <p>Mitochondrial membrane complexes (MMCs) are key mediators of cellular oxidative phosphorylation, and inhibiting them could lead to cell death. No published data are available on the relative abundance of MMCs in different periampullary cancers. Therefore, we studied the expression profile of MMCs I, III, IV and V in periampullary cancers, reactive pancreatitis, normal pancreas and chronic pancreatitis.</p> <p>Methods</p> <p>This was a retrospective study on tissue microarrays constructed from formalin-fixed paraffin-embedded tissue from 126 consecutive patients (cancer = 104, chronic pancreatitis = 22) undergoing pancreatic resections between June 2001 and June 2006. 78 specimens of chronic pancreatitis tissue were obtained adjacent to areas of cancer. Normal pancreatic tissue was obtained from the resection specimens in a total of 30 patients. Metastatic tumours in 61 regional lymph nodes from 61 patients were also studied.</p> <p>Results</p> <p>MMCs I, III, IV and V were highly expressed (p < 0.05) in all primary periampullary cancers compared with metastatic lymph nodes and adjacent benign pancreas. MMCs III, IV and V were highly expressed in all cancers regardless of type compared with chronic pancreatitis (p < 0.05). Higher expression of MMCs I and V was associated with better survival and may, in part, relate to lower expression of these MMCs in poorly differentiated tumours compared with well and moderately differentiated tumours.</p> <p>Conclusions</p> <p>Differential expression of MMCs III, IV and V in primary periampullary cancers compared with adjacent benign periampullary tissue and chronic pancreatitis is a novel finding, which may render them attractive anticancer targets.</p
Search for CP violation in D+âÏÏ+ and D+sâK0SÏ+ decays
A search for CP violation in D + â ÏÏ + decays is performed using data collected in 2011 by the LHCb experiment corresponding to an integrated luminosity of 1.0 fbâ1 at a centre of mass energy of 7 TeV. The CP -violating asymmetry is measured to be (â0.04 ± 0.14 ± 0.14)% for candidates with K â K + mass within 20 MeV/c 2 of the Ï meson mass. A search for a CP -violating asymmetry that varies across the Ï mass region of the D + â K â K + Ï + Dalitz plot is also performed, and no evidence for CP violation is found. In addition, the CP asymmetry in the D+sâK0SÏ+ decay is measured to be (0.61 ± 0.83 ± 0.14)%
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