Influencia de la dureza de las penas en la disminución de la comisión del delito de violencia familiar en la sociedad piurana año - 2010

La presente tesis está dirigido a todos los estudiantes que forman parte de la Facultad de Derecho, así como a los abogados, juristas y jurisconsultos, así mismo también va dirigido por su contenido a toda la colectividad piurana, que en muchas ocasiones están inmersos dentro de esta problemática y que buscan soluciones y muy pocos la encuentran o cuando la encuentran desisten de su pretensión, ello en el sentido que se debe a la falta de concientización que tienen mucho de los pobladores que se resisten a saber que la comisión del delito de violencia familiar tiene solución y que el único remedio a esto es que ellos mismo ponga de su total disposición, disponga de su voluntad para que denuncien este ilícito penal. Así mismo, tiene como objetivo establecer que si se puede erradicar la comisión del ¡lícito penal de violencia familiar, en razón al endurecimiento de las penas, y determinar cual es su influencia dentro de la sociedad piurana para el año 2010

A dusty filament and turbulent CO spirals in HD135344B - SAO206462

peer reviewedPlanet-disc interactions build up local pressure maxima that may halt the radial drift of protoplanetary dust, and pile it up in rings and crescents. ALMA observations of the HD135344B disc revealed two rings in the thermal continuum stemming from ~mm-sized dust. At higher frequencies the inner ring is brighter relative to the outer ring, which is also shaped as a crescent rather than a full ring. In near-IR scattered light images, the disc is modulated by a 2-armed grand-design spiral originating inside the ALMA inner ring. Such structures may be induced by a massive companion evacuating the central cavity, and by a giant planet in the gap separating both rings, that channels the accretion of small dust and gas through its filamentary wakes while stopping the larger dust from crossing the gap. Here we present ALMA observations in the J=(2-1)CO isotopologue lines and in the adjacent continuum, with up to 12km baselines. Angular resolutions of 0.03'' reveal the tentative detection of a filament connecting both rings, and which coincides with a local discontinuity in the pitch angle of the IR spiral, proposed previously as the location of the protoplanet driving this spiral. Line diagnostics suggest that turbulence, or superposed velocity components, is particularly strong in the spirals. The 12CO(2-1) 3-D rotation curve points at stellocentric accretion at radii within the inner dust ring, with a radial velocity of up to ~6%+-0.5% Keplerian, which corresponds to an excessively large accretion rate of ~2E-6M_sun/yr if all of the CO layer follows the 12CO(2-1) kinematics. This suggests that only the surface layers of the disc are undergoing accretion, and that the line broadening is due to superposed laminar flows

Global Retinoblastoma Presentation and Analysis by National Income Level.

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs

Variable structure in the PDS70 disc and uncertainties in radio-interferometric image restoration

The compact mm-wavelength signal in the central cavity of the PDS70 disc, revealed by deep ALMA observations, is aligned with unresolved Halpha emission, and is thought to stem from a circum-planetary disc (CPD) around PDS70c. We revisit the available ALMA data on PDS70c with alternative imaging strategies, and with special attention to uncertainties and to the impact of the so-called "JvM correction", which is thought to improve the dynamic range of restored images. We also propose a procedure for the alignment and joint imaging of multi-epoch visibility data. We find that the JvM correction exaggerates the peak signal-to-noise of the data, by up to a factor of 10. In the case of PDS70, we recover the detection of PDS70c from the July 2019 data, but only at 8sigma. However, its non-detection in Dec. 2017 suggests that PDS70c is variable by at least 42%+-13% over a 1.75yr time-span, so similar to models of the Halpha variability. We also pick up fine structure in the inner disc, such that its peak is offset by ~ 0.04" from the disc centre. The inner disc is variable too, which we tentatively ascribe to Keplerian rotation as well as intrinsic morphological changes.Comment: accepted MNRA

COMPETENCIA MOTRIZ EN ESCOLARES DE PRIMER Y SEGUNDO AÑO DE PRIMARIA EN LA REGIÓN LA ARAUCANÍA, CHILE

Martinez-Lopez, N., Espinoza-Silva, M. y Carcamo-Oyarzun,J. (2021). Competencia motriz en escolares de primer y segundo año de primaria en la región La Araucanía, Chile. PENSAR EN MOVIMIENTO: Revista de Ciencias del Ejercicio y la Salud, 19(2), 1-16. La competencia motriz es un componente importante para la participación en la cultura del juego, deportes y actividad física, por lo que su desarrollo es fundamental en el inicio de la trayectoria escolar. Este estudio tuvo como propósitos:describir el desempeño en la competencia motriz de Control de Objetos y Control del Cuerpo de estudiantes de primer y segundo grado de primaria de Chile; determinar la relación entre la competencia motriz y la edad; y establecer la existencia de posibles diferencias según el sexo de los estudiantes. Se utilizó un enfoque cuantitativo, siendo un estudio no experimental de corte transversal y de tipo descriptivo-correlacional. Participaron 289 escolares (51.2% niñas, 48.8% niños) de entre seis y ocho años de cinco establecimientos educacionales de la región de La Araucanía, Chile. Se utilizóel test MOBAK 1-2 para la evaluación de la competencia motriz en dos dimensiones (Control de Objetos y Control del Cuerpo). Para establecer la relación entre competencia motriz y edad se utilizó el coeficiente rho de Spearman, y para determinar la existencia de diferencias según sexo se utilizó la prueba U de Mann-Whitney, determinando el tamaño del efecto a través del cálculo de probabilidad de superioridad(PS). Los resultados indican que la edad se relaciona de forma positiva con el Control de Objetos (p<.001, r=.315) y el Control del Cuerpo (p<.001, r=.261). Al comparar los desempeños motrices según sexo, los niños presentan mejores resultados que las niñas en tareas motrices asociadas al Control de Objetos (U=13533.000, Z=4.439, p<.001, PSest=.61), mientras que en Control del Cuerpo no se encontraron diferencias estadísticamente significativas.Tanto la edad como el sexo de los estudiantes son variables asociadas al desarrollo de la competencia motriz.Estos resultados aportan información relevante para diseñar estrategias pedagógicas que busquen fomentar la competencia motriz de manera óptima y equitativa

Effect of bovine lactoferrin on prevention of late-onset sepsis in infants <1500 g: a pooled analysis of individual patient data from two randomized controlled trials

We previously conducted two randomized controlled trials with bovine lactoferrin (bLF) for the prevention of late-onset sepsis (LOS) in infants with a birth weight <2500 g (Study 1) and <2000 g (Study 2). The aim of this study was to determine the preventative effects of bLF on culture-proven or probable LOS in infants with a birth weight <1500 g from both studies, and to determine the effect of bLF in relation to intake of human milk. Both trial designs had similar inclusion and exclusion criteria, the same dose of bLF [200 mg·(kg body mass)–1·day–1], and used the same control (maltodextrin). We fitted multivariate Cox regression models to estimate the effect of bLF on the risk of development of the composite outcome, adjusting for covariates. We included 335 neonates with a mean birth weight of 1162 ± 244 g; 27.5% were <1000 g. There were 33 first episodes of LOS in the bLF treatment group and 48 in the control group (19.5% vs. 28.9%). bLF had a protective effect on the risk of development of LOS [hazard ratio (HR) = 0.64; %95 CI = 0.41–0.99; p = 0.048]; particularly among infants weighing <1000 g [HR = 0.46; %95 CI = 0.22–0.96; p = 0.039] and infants with a low intake of human milk [HR = 0.40; %95 CI = 0.19–0.84; p = 0.015]. Therefore, bLF supplementation protects infants <1500 g from LOS, particularly those infants not receiving human milk.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author