Positive and negative regulation of angiogenesis by soluble vascular endothelial growth factor receptor-1

Vascular endothelial growth factor receptor (VEGFR)-1 exists in different forms, derived from alternative splicing of the same gene. In addition to the transmembrane form, endothelial cells produce a soluble VEGFR-1 (sVEGFR-1) isoform, whereas non-endothelial cells produce both sVEGFR-1 and a different soluble molecule, known as soluble fms-like tyrosine kinase (sFlt)1-14. By binding members of the vascular endothelial growth factor (VEGF) family, the soluble forms reduce the amounts of VEGFs available for the interaction with their transmembrane receptors, thereby negatively regulating VEGFR-mediated signaling. In agreement with this activity, high levels of circulating sVEGFR-1 or sFlt1-14 are associated with different pathological conditions involving vascular dysfunction. Moreover, sVEGFR-1 and sFlt1-14 have an additional role in angiogenesis: they are deposited in the endothelial cell and pericyte extracellular matrix, and interact with cell membrane components. Interaction of sVEGFR-1 with α5β1 integrin on endothelial cell membranes regulates vessel growth, triggering a dynamic, pro-angiogenic phenotype. Interaction of sVEGFR-1/sFlt1-14 with cell membrane glycosphingolipids in lipid rafts controls kidney cell morphology and glomerular barrier functions. These cell-matrix contacts represent attractive novel targets for pharmacological intervention in addition to those addressing interactions between VEGFs and their receptors

Trust model of privacy-concerned, emotionally-aware agents in a cooperative logistics problem

In this paper we propose a trust model to be used into a hypothetical mixed environment where humans and unmanned vehicles cooperate. We address the inclusion of emotions inside a trust model in a coherent way to the practical approaches to the current psychology theories. The most innovative contribution is how privacy issues play a role in the cooperation decisions of the emotional trust model. Both, emotions and trust have been cognitively modeled and managed with the Beliefs, Desires and Intentions (BDI) paradigm into autonomous agents implemented in GAML (the programming language of GAMA agent platform) that communicates using the IEEE FIPA standard. The trusting behaviour of these emotional agents is tested in a cooperative logistics problem where: agents have to move objects to destinations and some of the objects and places have privacy issues. The execution of simulations of this logistic problem shows how emotions and trust contribute to improve the performance of agents in terms of both, time savings and privacy protectio

Merging plans with incomplete knowledge about actions and goals through an agent-based reputation system

Managing transition plans is one of the major problems of people with cognitive disabilities. Therefore, finding an automated way to generate such plans would be a helpful tool for this community. In this paper we have specifically proposed and compared different alternative ways to merge plans formed by sequences of actions of unknown similarities between goals and actions executed by several operator agents which cooperate between them applying such actions over some passive elements (node agents) that require additional executions of another plan after some time of use. Such ignorance of the similarities between plan actions and goals would justify the use of a distributed recommendation system that would provide an useful plan to be applied for a certain goal to a given operator agent, generated from the known results of previous executions of different plans by other operator agents. Here we provide the general framework of execution (agent system), and the different merging algorithms applied to this problem. The proposed agent system would act as an useful cognitive assistant for people with intelectual disabilities such as autism

The teaching of ethics in occupational risks prevention through the debate on ethical dilemmas

[EN] It seems reasonable to think that ethics and occupational risk prevention always go hand in hand. However, very little is known about the International Code of Ethics for Occupational Health Professionals, whose third edition was published in 2014 by the International Commission on Occupational Health (ICOH). Moreover, some circumstances in occupational risk prevention can lead to controversial issues and ethical dilemmas. Despite this, most occupational risk prevention master¿s studies do not include ethics in professional practice matters. This paper presents the teaching experiences in professional practice ethics workshops in the Master¿s Degree in Occupational Risks Prevention of the Universitat Politècnica de València. In these workshops, ethical issues are included in their curricula, and ethical dilemmas are discussed through academic debates. The results of the experience were positive and encouraging. The students learn to open their minds to a different point of view and understand the problems they will have to face in their professional careers.Pellicer, TM.; López-Mateu, V.; Gimenez-Carbo, E. (2022). The teaching of ethics in occupational risks prevention through the debate on ethical dilemmas. IATED. 10039-10045. https://doi.org/10.21125/edulearn.2022.2426100391004

Characterization of the cardiac ganglion in the crab Neohelice granulata and immunohistochemical evidence of GABA-like extrinsic regulation

The aim of the present work is to provide an anatomical description of the cardiac system in the crab Neohelice granulata and evidence of the presence of GABA by means of immunohistochemistry. The ganglionic trunk was found lying on the inner surface of the heart's dorsal wall. After dissection, this structure appeared as a Y-shaped figure with its major axis perpendicular to the major axis of the heart. Inside the cardiac ganglion, we identified four large neurons of 63.7 μm ± 3.7 in maximum diameter, which were similar to the motor neurons described in other decapods. All the GABA-like immunoreactivity (GABAi) was observed as processes entering mainly the ganglionic trunk and branching in slender varicose fibers, forming a network around the large neurons suggesting that GABAi processes contact them. Our findings strengthen previous results suggesting that the GABAergic system mediates the cardio-inhibitory response upon sensory stimulation.Fil: Yang, Margarita.Fil: Carbo, Martin.Fil: Freudenthal, Ramiro A. M..Fil: Hermitte, Gabriela

Revisiting the student outcome "ethical, environmental and professional responsibility" within the Civil Engineering Bachelor Degree

[EN] In 2013, an institutional project was launched at Universitat Politècnica de València to ensure that all graduates, in addition to acquiring the specific technological skills of their degrees, would also acquire a series of essential soft skills for developing their profession in an excellent way. At present, there are already graduates who have completed the degree with the integration of generic outcomes; therefore, it is time to review the success that the project has achieved. One of these generic outcomes is "Ethical, environmental and professional responsibility". In this work, we develop a diagnosis of the current state of this competence in the civil engineering BSc degree programme, and we analyse the level of acquisition of the competence by students. For this purpose, the subjects in which this generic competence is worked on and evaluated will be analysed, studying how lecturers introduce it within different activities to collect evidences of the competence level of acquisition. We also studied whether the results obtained respond to the expected learning goals. The diagnosis will be completed by collecting opinions from last year students, as well as by interviewing lecturers responsible for these subjects. The final objective of the project will be to estimate at what extent the students have acquired this competence upon graduation and to propose improvement measures if necessary.Gimenez-Carbo, E.; Gómez-Martín, ME.; Andrés-Doménech, I. (2020). Revisiting the student outcome "ethical, environmental and professional responsibility" within the Civil Engineering Bachelor Degree. SEFI. 802-809. http://hdl.handle.net/10251/177483S80280

NMDA-like receptors in the nervous system of the crab Neohelice granulata: A neuroanatomical description

N-Methyl-D-aspartate receptors (NMDARs) are involved in learning and memory processes in vertebrates and invertebrates. In Neohelice granulata, NMDARs are involved in the storage of associative memories (see references in text). The aim of this work was to characterize this type of glutamate receptor in Neohelice and to describe its distribution in the central nervous system (CNS). As a first step, a detailed study of the CNS of N. granulata was performed at the neuropil level, with special focus on one of the main structures involved in this type of memory, the supraesophageal ganglion, called central brain. The characterization of the NMDAR was achieved by identifying the essential subunit of these receptors, the NR1-like subunit. The NR1-like signals were found via western blot and immunohistochemistry techniques in each of the major ganglia: the eyestalk ganglia, the central brain, and the thoracic ganglion. Western blots yielded two bands for the crab NR1-like subunit, at ∼88 and ∼84 kDa. This subunit is present in all the major ganglia, and shows a strong localization in synaptosomal membranes. NMDARs are distributed throughout the majority of each ganglion but show prominent signal intensity in some distinguishable neuropils and neurons. This is the first general description of the N. granulata nervous system as a whole and the first study of NMDARs in the CNS of decapods. The preferential localization of the receptor in some neuropils and neurons indicates the presence of possible new targets for memory processing and storage.Fil: Hepp, Yanil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; ArgentinaFil: Carbo, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; ArgentinaFil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; ArgentinaFil: Freudenthal, Ramiro A. M.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentin

Boosting the sustainable development goals in a civil engineering bachelor degree program

This article is (c) Emerald Group Publishing and permission has been granted for this version to appear here (please insert the web address here). Emerald does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Emerald Group Publishing Limited.[EN] Purpose The purpose of this paper is to analyze the potential for implementing Sustainable Development Goals (SDGs) into the civil engineering bachelor degree in the School of Civil Engineering at Universitat Politecnica de Valencia (Spain). Design/methodology/approach All the 2019/2020 course syllabi were analyzed to diagnose at which extent each subject within the program curriculum contributes to achieving the different SDGs. Findings The results show a promising starting point as 75% of the courses address or have potential to address targets covering the 2030 Agenda. This paper also presents actions launched by the School of Civil Engineering to boost the SDGs into the civil engineering curriculum. Originality/value This paper presents a rigorous and systematic method that can be carried out in different bachelor degrees to find the subjects that have the potential to incorporate the SDGs into their program. This paper also presents actions launched by the Civil Engineering School to boost the SDGs into the civil engineering curriculum.This innovative educational project and the article processing charge of this paper were funded by Universitat Politecnica de Valencia, through the project PIME/19-20/159 "Incorporacion de los Objetivos de Desarrollo Sostenible en el plan de estudios del Grado en Ingenieria Civil". The authors thank the support and cooperation given by individuals, organizations, and companies that collaborated in the different transversal activities, as well as to the instructors who gave us feedback on the reviewing of their course syllabi.Gómez-Martín, ME.; Gimenez-Carbo, E.; Andrés-Doménech, I.; Pellicer, E. (2021). Boosting the sustainable development goals in a civil engineering bachelor degree program. International Journal of Sustainability in Higher Education. 22(8):125-145. https://doi.org/10.1108/IJSHE-02-2021-0065S12514522

The Effect Of Campus Praktikum On The Choice Of University Studies

In some Spanish universities in recent years, there has been a decrease in the number of students, mainly due to the drop in the birth rate and the increase in the number of universities throughout the country. In addition, the number of (unknown)bachelor\u27s degrees that can be studied at university has also increased. For these reasons, since 2010, an activity called Campus Praktikum has been carried out at the Universitat Politècnica de València to bring the university studies taught at this centre closer to secondary school students. The aim is to show the studies taught at the UPV (mainly engineering studies), to find out about the professions linked to these studies and to be able to have testimonials from university students who are currently studying. During one week, secondary school students take part in workshops related to university studies, which give them an in-depth understanding of the content of their studies and university life. The main objective is to increase the number of students in general and, above all, to increase the number of women who choose the UPV for their university studies. The paper describes what the activities of the Campus Praktikum consist of and compares the opinions obtained through surveys of students who enjoyed the activity right after finishing the campus and the information obtained from the student\u27s registration at the university. With all this information conclusion will be drawn, analysing the actual effect of this type of activity on the student\u27s choice of university studies

Electrochemical characterization of biodeterioration of paint films containing cadmium yellow pigment

[EN] The voltammetry of microparticles (VMP) methodology was used to characterize the biological attack of different bacteria and fungi to reconstructed egg tempera and egg linseed oil emulsion paint films containing cadmium yellow (CdS), which mimic historical painting techniques. When these paint films are in contact with aqueous acetate buffer, different cathodic signals are observed. As a result of the crossing of VMP data with attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), scanning electrochemical microscopy (SECM), field emission scanning electron microscopy (FESEM), and atomic force microscopy (AFM), these voltammetric signals can be associated with the reduction of CdS and different complexes associated to the proteinaceous and fatty acid fractions of the binders. After biological attack with different fungi (Acremonium chrysogenum, Aspergillus niger, Mucor rouxii, Penicillium chrysogenum, and Trichoderma pseudokoningii) and bacteria (Arthrobacter oxydans, Bacillus amyloliquefaciens, and Streptomyces cellulofans), the observed electrochemical signals experience specific modifications depending on the binder and the biological agent, allowing for an electrochemical monitoring of biological attack.Financial support from the MINECO Projects CTQ2014-53736-C3-1-P and CTQ2014-53736-C3-2-P which are supported with ERDF funds is gratefully acknowledged. The authors also wish to thank Dr. José Luis Moya López, Mr. Manuel Planes Insausti, and Mrs. Alicia Nuez Inbernón (Microscopy Service of the Universitat Politècnica de València) for technical support.Ortiz-Miranda, A.; Domenech Carbo, A.; Domenech Carbo, MT.; Osete Cortina, L.; Valle-Algarra, FM.; Bolivar Galiano, F.; Martin Sanchez, I.... (2016). Electrochemical characterization of biodeterioration of paint films containing cadmium yellow pigment. Journal of Solid State Electrochemistry. 20(12):3287-3302. https://doi.org/10.1007/s10008-016-3349-6S328733022012Ratledge C (1994) Biochemistry of microbial degradation. Springer, BerlinCaneva G, Nugari MP, Salvadori O (2008) Plant biology for cultural heritage, the Getty Conservation Institute, Los AngelesSterflinger K (2010) Fungi: their role in deterioration of cultural heritage. Fungal Biol Rev 47–55 and references thereinGargani G (1968) Fungus contamination of Florence art masterpieces before and after the 1966 disaster. In: Walters AH, Elphick JJ (eds) Biodeterioration of materials. Elsevier, Amsterdam, pp. 252–257Seves AM, Sora S, Ciferr O (1996) The microbial colonization of oil paintings—a laboratory investigation. Int Biodeter Biodegr. 37:215–224Tiano P (2002) Biodegradation of cultural heritage: decay mechanisms and control methods. University of LisbonStrzelczyk AB (2004) Observations on aesthetic and structural changes induced in polish historic objects by microorganisms. Int Biodeter Biodegr. 53:151–156López-Miras M, Piñar G, Romero-Noguera J, Bolivar-Galiano FC, Ettenauer J, Sterflinger K, Martín-Sánchez I (2013) Microbial communities adhering to the obverse and reverse sides of an oil painting on canvas: identification and evaluation of their biodegradative potential. Aerobiologia 29:301–314Koszewski A, Rymuza Z, Reuther F (2008) Evaluation of nanomechanical, nanotribological and adhesive properties of ultrathin polymer resist film by AFM. Micro Engn 85:1189–1192Schabereiter-Gurtner C, Piñar G, Lubitz W, Rölleke S (2001) An advanced molecular strategy to identify bacterial communities on art objects. J Microbiol Meth 45:77–87Florian MLE (1996) The role of the conidia of fungi in fox spots. Stud Conserv 41:65–75Arai H, Matsui N, Matsumura N, Murakita H (1988) Biochemical investigations on the formation mechanisms of foxing. Stud Conserv 33:11–12Arai H, Matsumura N, Murakita H (1990) Microbiological studies on the conservation of paper and related cultural properties: part 9, induction of artificial foxing. Science for Conservation 29:25–34Hayashi T, Namili M (1986) Role of sugar fragmentation in early stage browning of amino-carbonyl reaction of sugars with amino acids. Agr Biol Chem Tokyo 50:1965–1970Allsopp D, Seal KJ, Gaylarde CC (2004) Introduction to biodeterioration, 2 edn. Cambridge University Press, CambridgeBock E, Sand W (1993) The microbiology of masonry biodeterioration. J Appl Bacteriol 74:503–514Ciferri O (2002) The role of microorganisms in the degradation of cultural heritage. Rev Conserv 3:35–45Van der Snickt G, Dik J, Cotte M, Janssens K, Jaroszewicz J, De Wolf W, Groenewegen J, Van der Loeff L (2009) Characterization of a degraded cadmium yellow (CdS) pigment in an oil painting by means of synchrotron radiation based X-ray techniques. Anal Chem 81:2600–2610Child AM (1995) Microbial taphonomy of archaeological bone. Stud Conserv 40:19–30Soliman NA, Knoll M, Abdel-Fattah YR, Schmid RD, Lange S (2007) Molecular cloning and characterization of thermostable esterase and lipase from Geobacillus thermoleovorans YN isolated from desert soil in Egypt. Process Biochem 42(2007):1090–1100Kinderlerer JL (1994) Degradation of the lauric acid oils. Int Biodeter Biodegr 33(1994):345–354van den Berg JDJ, van den Berg KJ, Boon JJ (2002) Identification of non-cross-linked compounds in methanolic extracts of cured and aged linseed oil-based paint films using gas chromatography-mass spectrometry. J Chromatogr A 950:195–211 and references thereinLefèvre M (1974) La ‘maladie verte’ de Lascaux. Stud Conserv 19:126–156Petushkova JP, Lyalikova NN (1986) Microbiological degradation of lead-containing pigments in mural paintings. Stud Conserv 31:65–69Breitbach AM, Rocha JC, Gaylarde CC (2011) Influence of pigment on biodeterioration of acrylic paint films in southern Brazil. J Coat Technol Res 8:619–628Keune K, van Loon A, Boon JJ (2011) SEM backscattered-electron images of paint cross sections as information source for the presence of the lead white pigment and lead-related degradation and migration phenomena in oil paintings. Microsc Microanal 17:696–701Meilunas RJ, Bentsen JG, Steinberg A (1990) Analysis of aged paint binders by FTIR spectroscopy. Stud Conserv 35:33–51Mazzeo R, Prati S, Quaranta M, Joseph E, Kendix E, Galeotti M (2008) Attenuated total reflection micro FTIR characterization of pigment–binder interaction in reconstructed paint films. Anal Bioanal Chem 392:65–76Salvadó N, Butí S, Nicholson J, Emerich H, Labrador A, Pradell T (2009) Identification of reaction compounds in micrometric layers from gothic paintings using combined SR-XRD and SR-FTIR. Talanta 79:419–428Scholz F, Meyer B (1998) Voltammetry of solid microparticles immobilized on electrode surfaces. Electroanal Chem 20:1–86Scholz F, Schröder U, Gulabowski R, Doménech-Carbó A (2014) Electrochemistry of immobilized particles and Dropletst, 2 edn. Springer, Berlin-HeidelbergDoménech-Carbó A, Labuda J, Scholz F (2013) Electroanalytical chemistry for the analysis of solids: characterization and classification (IUPAC technical report). Pure Appl Chem 85:609–631Doménech-Carbó A, Doménech-Carbó MT, Costa V (2009) Electrochemical methods for Archaeometry, conservation and restoration (monographs in electrochemistry series Scholz F edit). Springer, Berlin-HeidelbergDoménech-Carbó A (2010) Electrochemistry for conservation science. J Solid State Electr 14:349–351Matteini M, Moles A (1989) La Chimica nel Restauro. Nardini, FirenzeGettens RJ, Stout GL (1966) Painting materials. A short encyclopedia. Dover Publications, New YorkCennini C (1982) Il libro dell’ arte. Akal, MadridCepriá G, García-Gareta E, Pérez-Arantegui J (2005) Cadmium yellow detection and quantification by voltammetry of immobilized microparticles. Electroanalysis 17:1078–1084Domínguez I, Doménech-Carbó A, Cerisuelo JP, López-Carballo G, Henández-Muñoz P, Gavara R (2014) Contact probe electrochemical characterization and metal speciation of silver LLDPE nanocomposite films. J Solid State Electrochem 18:2099–2110Byler DM, Susi H (1986) Examination of the secondary structure of proteins by deconvolved FTIR spectra. Biopolymers 25:469–487Chang CM, Powrie WD, Fennema O (1977) Microstructure of egg yolk. J Food Sci 42:1193–1200Prestrelski SJ, Tedeschi N, Arakawa T, Carpenter JF (1993) Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers. Biophys J 65:661–671Boehm S, Abaturov LV (1977) Structural changes of met-haemoglobin by dehydration. FEBS Lett 77:21–24Karpowicz A (1981) Ageing and deterioration of proteinaceous media. Stud Conserv 26:153–160Koper A, Grabarczyk M (2012) Simultaneous voltammetric determination of trace bismuth(III) and cadmium(II) in water samples by adsorptive stripping voltammetry in the presence of cupferron. J Electroanal Chem 681:1–5Zakharchuk N, Meyer S, Lange B, Scholz F (2000) A comparative study of lead oxide modified graphite paste electrodes and solid graphite electrodes with mechanically immobilized lead oxides. Croat Chem Acta 73:667–704Komorsky-Lovric S, Lovric M, Bond AM (1992) Comparison of the square-wave stripping voltammetry of lead and mercury following their electrochemical or abrasive deposition onto a paraffin impregnated graphite electrode. Anal Chim Acta 258:299–305Arjmand F, Adriaens A (2012) Electrochemical quantification of copper-based alloys using voltammetry of microparticles: optimization of the experimental conditions. J Solid State Electrochem 16:535–543Meyer B, Ziemer B, Scholz F (1995) In situ X-ray diffraction study of the electrochemical reduction of tetragonal lead oxide and orthorhombic Pb(OH)Cl mechanically immobilized on a graphite electrode. J Electroanal Chem 392:79–83Hasse U, Scholz F (2001) In situ atomic force microscopy of the reduction of lead oxide nanocrystals immobilised on an electrode surface. Electrochem Commun 3:429–434Doménech-Carbó A, Doménech-Carbó MT, Mas-Barberá X (2007) Identification of lead pigments in nanosamples from ancient paintings and polychromed sculptures using voltammetry of nanoparticles/atomic force microscopy. Talanta 71:1569–1579Eissler RL, Princen RH (1972) The interface between reactive pigment and binder matrix. J Electroanal Chem 37:327–336Kuznetsov AM, Ulstrup J (1989) Protein dynamics and electronic fluctuation effects in electron transfer reactions of membrane-bound proteins and metalloprotein complexes. J Electroanal Chem 275:289–305Colletti LP, Teklay D, Stickney JL (1994) Thin-layer electrochemical studies of the oxidative underpotential deposition of sulfur and its application to the electrochemical atomic layer epitaxy deposition of CdS. J Electroanal Chem 369:145–152Gulaboski R, Mirceski V, Bogeski I, Hoth M (2012) Protein film voltammetry: electrochemical enzymatic spectroscopy. A review on recent progress. J Solid State Electrochem 16:2315–2328Guidelli R, Becucci L (2011) Ion transport across biomembranes and model membranes. J Solid State Electrochem 15:1459–1470Sutherland K (2003) Solvent-extractable components of linseed oil paint films. Stud Conserv 48:111–135Rossi M, Alamprese C, Ratti S (2007) Tocopherols and tocotrienols as free radical-scavengers in refined vegetable oils and their stability during deep-fat frying. Food Chem 102:812–817Ziyatdinova G, Morozov M, Budnikov H (2012) MWNT-modified electrodes for voltammetric determination of lipophilic vitamins. J Solid State Electrochem 16:2441–2447Madani A, Nessark B, Boukherroub R, Chehimi MM (2011) Preparation and electrochemical behaviour of PPy–CdS composite films. J Electroanal Chem 650:176–181Derrick MR, Stulik DC, Landry MJ (1999) Infrared spectroscopy in conservation science. Getty Conservation Institute, Los Angelesvan der Weerd J, van Loon A, Boon JJ (2005) FTIR studies of the effects of pigments on the aging of oil. Stud Conserv 50:3–22Kong J, Yu S (2007) Fourier transform infrared spectroscopic analysis of protein secondary structures. Acta Bioch Bioph Sin 39:549–559Haris PI, Severcan F (1999) FTIR spectroscopic characterization of protein structure in aqueous and non-aqueous media. J Mol Catal B-Enzym 7:207–221Furlan PY, Scott SA, Peaslee MH (2007) FTIR-ATR study of pH effects on egg albumin secondary structure. Spectrosc Lett 40:475–482Dong A, Huang P, Caughey WS (1990) Protein secondary structures in water from second-derivative amide I infrared spectra. Biochemistry-US 29:3303–3308Rajkhowa R, Hu X, Tsuzuki T, Kaplan DL, Wang X (2012) Structure and biodegradation mechanism of milled B. mori silk particles. Biomacromolecules 13:2503–2512Anton M (2013) Egg yolk: structures, functionalities and processes. J Sci Food Agr 93:2871–2880Hevonoja T, Pentikäinen MO, Hyvönen MT, Kovanen PT, Ala-Korpela M (2000) Structure of low density lipoprotein (LDL) particles: basis for understanding molecular changes in modified LDL. Biochim Biophys Acta 1488:189–210Kumpula LS, Kumpula JM, Taskinen MR, Jauhiainen M, Kaski K, Ala-Korpela M (2008) Reconsideration of hydrophobic lipid distributions in lipoprotein particles. Chem Phys Lipids 155:57–62 and references thereinSchneider H, Morrod RS, Colvin JR, Tattrie NH (1973) The lipid core model of lipoproteins. Chem Phys Lipids 10:328–353Doménech-Carbó MT, Osete-Cortina L, de la Cruz-Cañizares J, Bolívar-Galiano F, Romero-Noguera J, Martín-Sánchez I, Fernández-Vivas MA (2006) Study of the microbiodegradation of terpenoid resin-based varnishes from easel painting using pirolisis-gas chromatography-mass spectrometry and gas chromatography-mass spectrometry. Anal Bioanal Chem 385:1265–128