Essential and checkpoint functions of budding yeast ATM and ATR during meiotic prophase are facilitated by differential phosphorylation of a meiotic adaptor protein, Hop1

A hallmark of the conserved ATM/ATR signalling is its ability to mediate a wide range of functions utilizing only a limited number of adaptors and effector kinases. During meiosis, Tel1 and Mec1, the budding yeast ATM and ATR, respectively, rely on a meiotic adaptor protein Hop1, a 53BP1/Rad9 functional analog, and its associated kinase Mek1, a CHK2/Rad53-paralog, to mediate multiple functions: control of the formation and repair of programmed meiotic DNA double strand breaks, enforcement of inter-homolog bias, regulation of meiotic progression, and implementation of checkpoint responses. Here, we present evidence that the multi-functionality of the Tel1/Mec1-to-Hop1/Mek1 signalling depends on stepwise activation of Mek1 that is mediated by Tel1/Mec1 phosphorylation of two specific residues within Hop1: phosphorylation at the threonine 318 (T318) ensures the transient basal level Mek1 activation required for viable spore formation during unperturbed meiosis. Phosphorylation at the serine 298 (S298) promotes stable Hop1-Mek1 interaction on chromosomes following the initial phospho-T318 mediated Mek1 recruitment. In the absence of Dmc1, the phospho-S298 also promotes Mek1 hyper-activation necessary for implementing meiotic checkpoint arrest. Taking these observations together, we propose that the Hop1 phospho-T318 and phospho-S298 constitute key components of the Tel1/Mec1- based meiotic recombination surveillance (MRS) network and facilitate effective coupling of meiotic recombination and progression during both unperturbed and challenged meiosis

On the origin of the X-ray emission from a narrow-line radioquasar at z>1

We present new XMM-Newton X-ray observations of the z=1.246 narrow-line radioquasar RX J1011.2+5545 serendipitously discovered by ROSAT. The flat X-ray spectrum previously measured by ROSAT and ASCA is shown to be the result of a steep Gamma~1.8 power law spectrum seen through a moderate intrinsic absorbing column NH~4E21 cm^-2. The position of the X-ray source is entirely coincident with the nucleus of the radio source that we have resolved in new sensitive VLA observations at 3.6 and 6 cm, implying that scattering in the radio lobes is not responsible for the bulk of X-ray emission. In the EPIC pn image, a faint patch of X-ray emission is apparent 14'' to the NE of the main X-ray source. The former is positionally coincident with an apparently extended optical object with R~21.9, but there is no associated radio emission, thus ruling out the possibility that this represents a hotspot in a jet emanating from the primary X-ray source. No reflection features are detected in the X-ray spectrum of the narrow-line radioquasar, although an Fe line with equivalent width of up to 600 eV cannot be ruled out.Comment: 7 pages, 6 figures, MNRAS in the pres

Influencia de la inteligencia emocional en la autoeficacia para el liderazgo

Muchas investigaciones se han centrado en analizar y estudiar los beneficios que la inteligencia emocional podría aportar en temas de capacitación y desarrollo de personal. El objetivo de este estudio es comparar las relaciones que existen entre la inteligencia emocional rasgo de los líderes con algunos procesos emocionales; y cómo éstos procesos influyen en otras variables como la autoeficacia para el liderazgo y el desempeño. La muestra fue de 176 estudiantes de Psicología. Cada uno de ellos fue asignado aleatoriamente a los roles de líder y de seguidor, y fueron distribuidos para conformar equipos. El procedimiento de la investigación se desarrolló a lo largo de tres fases. Los resultados del estudio mostraron que la inteligencia emocional rasgo de los líderes influyó significativamente en la autoeficacia para el liderazgo y también predijo el desempeño final del equipo, aunque en este último caso su influencia es parcial. Esta investigación tiene importantes repercusiones para avanzar en la comprensión de las emociones en el lugar de trabajo.Many researches have focused on analyzing and studying the benefits of emotional intelligence could provide in training and staff development issues. The aim of this study is to compare the relationship between trait emotional intelligence of leaders with some emotional processes and how these processes affect other variables such as leadership self-efficacy, self-efficacy and collective effectiveness of a team. The sample comprised 176 students of Psychology. Each person was randomly assigned the roles of leader and follower and they were distributed to form teams. The research procedure was developed over three phases. The results showed that self-efficacy for leadership significantly influenced self-efficacy in the task of the leader and also predicted the team’s final performance; although in the latter case its influence is only partial. This research has important implications for advancing the understanding of emotions in the workplace

El emprendedor desde el enfoque de la psicología positiva

En el presente trabajo se pretende analizar la conexión entre la psicología positiva y el comportamiento emprendedor. Desde sus orígenes y hasta hace no tanto tiempo atrás, la psicología sólo se centraba en la patología, en la debilidad y en el sufrimiento. Actualmente, el acento se pone sobre el bienestar mental o la calidad de vida para que el ser humano pueda, además de vivir saludablemente, salir fortalecido ante las adversidades o crisis que puedan presentársele. Conceptos propios de la psicología positiva como son resiliencia, motivación o felicidad, son cualidades propias del emprendedor, el cual tiene una sensibilidad especial para detectar oportunidades, movilizar recursos, interconectar información o tener ideas innovadoras. En definitiva, para hallar oportunidades donde otros no las ven o convertir en hechos lo pensado. Tener espíritu emprendedor es hacer las cosas, levantarse con más fuerza cada vez que se cae y ser capaz de convivir con la incertidumbre manteniéndose optimista. Por consiguiente, el estudio del comportamiento y el éxito emprendedor no puede ser correctamente entendido si no se aborda desde la óptica de la psicología positiva.In this paper, we expect to analyse the relationship between Positive Psychology and entrepreneur behaviour. Originally and since no some much time ago, psychology only concentrated in the pathology, weakness and suffering. Nowadays the emphasis is on the mental welfare or quality of life, so that the human being could, in addition of living healthy, get stronger in adversity or crisis that could experience. Typical concepts of Positive Psychology as resilience, motivation and happiness, are qualities of the entrepreneur. The entrepreneur has an special feeling to detect opportunities, mobilize resources, link information or has innovative ideas. In short, to find opportunities where other people don´t see it or make thoughts real. Having entrepreneur´s nature is to do things, to get up with more strength when you have fallen and to be optimist living with uncertainty. Therefore, the study of entrepreneur´s behaviour and sucess can´t be understood if we don´t take the point of view of Positive Psychology

Low-cost carriers and airports: a complex relationship

In the last decades, low-cost carriers have generated several changes in the air market for both passengers and airports. Mainly for regional airports, low-cost carriers have represented an important opportunity to improve their connectivity levels and passenger traffic. Furthermore, many regional airports have become key factors to regenerate the local economy by improving accessibility and stimulating several markets, such as tourism. However, the relationship between low-cost carriers and airports is rather complex and the outcomes not always predictable. In order to analyse and understand better such relationship and its outcomes, this chapter discusses the main underlying factors identified in: relation with the regional air market (secondary/primary airports), balance of power (dominated/non-dominated airports) and industrial organisation (bases/non-bases). Starting from the proposed Relative Closeness Index, which combines yearly airport passengers and distance between airport pairs, a large sample of European airports is analysed. Then, a smaller sub-sample – which includes selected, significant case studies referring to mid-sized airports – is discussed in detail. Among the main findings, airports sharing their catchment area with others are in a very risky position, due to the potential mobility of LCCs, while geographically isolated airports in good catchment areas can better counterbalance the power of carriers

Heart rate variability in association with frequent use of household sprays and scented products in SAPALDIA

Background: Household cleaning products are associated with adverse respiratory health outcomes, but the cardiovascular health effects are largely unknown.Objective: We determined if long-term use of household sprays and scented products at home was associated with reduced heart rate variability (HRV), a marker of autonomic cardiac dysfunction.Methods: We recorded 24-hr electrocardiograms in a cross-sectional survey of 581 Swiss adults, 1, 1-3, or 4-7 days/week, unexposed (reference)] of using cleaning sprays, air freshening sprays, and scented products.Results: Decreases in 24-hr SDNN and TP were observed with frequent use of all product types, but the strongest reductions were associated with air freshening sprays. Compared with unexposed participants, we found that using air freshening sprays 4-7 days/week was associated with 11% [95% confidence interval (CI): -20%, -2%] and 29% (95% CI: -46%, -8%) decreases in 24-hr SDNN and TP, respectively. Inverse associations of 24-SDNN and TP with increased use of cleaning sprays, air freshening sprays, and scented products were observed mainly in participants with obstructive lung disease (p > 0.05 for interactions).Conclusions: In predominantly older adult women, long-term frequent use of household spray and scented products was associated with reduced HRV, which suggests an increased risk of cardiovascular health hazards. People with preexisting pulmonary conditions may be more susceptibl