Attention modulates psychophysical and electrophysiological response to visual texture segmentation in humans

none5noTo investigate whether processing underlying texture segmentation is limited when texture is not attended, we measured orientation discrimination accuracy and visual evoked potentials (VEPs) while a texture bar was cyclically alternated with a uniform texture, either attended or not. Orientation discrimination was maximum when the bar was explicitly attended, above threshold when implicitly attended, and fell to just chance when unattended, suggesting that orientation discrimination based on grouping of elements along texture boundary requires explicit attention. We analyzed tsVEPs (variations in VEP amplitude obtained by algebraic of uniform-texture from segmented-texture VEPs) elicited by the texture boundary orientation discrimination task. When texture was unattended, tsVEPs still reflected local texture segregation. We found larger amplitudes of early tsVEP components (N75, P100, N150, N200) when texture boundary was parallel to texture elements, indicating a saliency effect, perhaps at V1 level. This effect was modulated by attention, disappearing when the texture was not attended, a result indicating that attention facilitates grouping by collinearity in the direction of the texture boundary.openCasco, C; Grieco, A; Campana, G; CORVINO M., P; Caputo, GIOVANNI BATTISTACasco, C; Grieco, A; Campana, G; CORVINO M., P; Caputo, GIOVANNI BATTIST

Modelling of a Hybrid-Electric Light Aircraft

Abstract The European Research and Innovation Agenda as well as the NASA long-term programs have set ambitious targets in terms of emission reduction for the aviation industry. Continuous improvements of conventional technologies will not be enough to fulfil these ambitious requirements; there is a need for revolutionary aircraft concepts and/or radical innovative systems. One such concept is to use a hybrid-electric propulsion system. The CIRA and the Department of Industrial Engineering of the University of Naples "Federico II" have started a joint program in order to develop models and technologies related to the electrification of propulsive system in aviation. The aim of this work is, then, the exploration of possible benefits of hybrid-electric propulsion with a focus on general aviation and selecting appropriate missions. The hybrid-electric system has been designed assembling elements/systems all commercially available, realizing a very simple parallel layout, classifiable as "minimal hybrid". Furthermore, such hybrid-electric system, -inclusive of energy storage system, transmission system, power management system, etc.- has been conceived to fit the original ICE requirements in term of weight, volume and max power at take-off. In this study, a simple model to evaluate the performances of a light aircraft equipped with a hybrid-electric propulsive system has been developed. The approach adopted combine the so-called 0D/1D simulation to evaluate the "single" ICE performances with a simple engineering modeling which allows the performances evaluation of the integrated power plant. The application of model for a simple transfer mission leads to fuel saving up to 20% while for classical training mission, where pilots make numerous run(lap) "touch –and-go", the fuel saving can reach a significative 30%

Managing Rhizoctonia Damping-Off of Rocket (Eruca sativa) Seedlings by Drench Application of Bioactive Potato Leaf Phytochemical Extracts

Plants produce a huge array of secondary metabolites that play a key role in defense mechanisms against detrimental microorganisms and herbivores, and represent a suitable alternative to synthetic fungicides in sustainable agriculture. In this work, twelve crude hydroethanolic extracts derived from leaves of different potato cultivars were chemically characterized by LC/MS and their antioxidant properties were investigated in vitro. Furthermore, the biological activity against the fungal pathogen Rhizoctonia solani was evaluated both in vitro and in vivo. Extracts showed the ability to inhibit R. solani growth in vitro and significantly reduced damping-off incidence in in vivo experiments. Furthermore, R. solani mycelia exposed to the extracts showed an altered morphology (low translucency, irregular silhouette, and cytoplasmatic content coagulation) compared to the untreated control in light microscopy examination. Principal component analysis conducted on identified chemical compounds highlighted significant metabolic variations across the different extracts. In particular, those that inhibited most of the growth of the pathogen were found to be enriched in α-chaconine or α-solanine content, indicating that their biological activity is affected by the abundance of these metabolites. These results clearly indicated that plant-derived compounds represent a suitable alternative to chemicals and could lead to the development of new formulates for sustainable control of plant diseases

Diffusion in multiscale spacetimes

We study diffusion processes in anomalous spacetimes regarded as models of quantum geometry. Several types of diffusion equation and their solutions are presented and the associated stochastic processes are identified. These results are partly based on the literature in probability and percolation theory but their physical interpretation here is different since they apply to quantum spacetime itself. The case of multiscale (in particular, multifractal) spacetimes is then considered through a number of examples and the most general spectral-dimension profile of multifractional spaces is constructed.Comment: 23 pages, 5 figures. v2: discussion improved, typos corrected, references adde

Screening magnetic fields by superconductors: A simple model

We introduce a simple approach to evaluate the magnetic field distribution around superconducting samples, based on the London equations; the elementary variable is the vector potential. This procedure has no adjustable parameters, only the sample geometry and the London length determine the solution. This approach was validated by comparing the induction field calculated to the one measured above MgB2 disks of different diameters, at 20K and for applied fields lower than 0.4T. The model can be applied if the flux line penetration inside the sample can be neglected when calculating the induction field distribution outside the superconductor. We conclude by showing on a cup-shape geometry how one can design a magnetic shield satisfying a specific constraint

Liquid biopsy in the assessment of microRNAs in oral squamous cell carcinoma : a systematic review

The identification of non-invasive biomarkers from biological fluids collected by liquid biopsy provides new horizons for individualized therapeutic strategies and improves clinical decision-making in OSCC patients. Circulating microRNAs have emerged as

Discordant biochemical parameters of acromegaly remission do not influence the prevalence or aggressiveness of metabolic comorbidities: a single-center study

Purpose: The discrepancy between the biomarkers of disease's activity in acromegalic patients (GH and IGF-1) is almost frequent representing a challenge for the development of comorbidities in the long term. The aim of this study was to evaluate the prevalence and severity of metabolic comorbidities (diabetes, hypertension, and dyslipidemia) in surgically treated acromegalic patients with disease control and discordant GH and/or IGF-1 levels compared with those with concordant values.Patients and methods: Retrospective monocentric observational study on acromegalic surgically treated patients with biochemical remission (group A) or mild discordant GH or IGF-1 levels (group B). Metabolic complications and medical therapy were assessed at diagnosis and at the last follow-up visit. Severity of the disease was set for drug titration or shift to another molecule or more than before.Results: There were 18 patients that met the inclusion criteria [group A: nine patients; group B: nine patients, follow-up 7 years (IQR 5.0;11.25)]. The prevalence of female patients was significantly higher in the remission group compared with the discordant group (p < 0.02). Considering metabolic complications, at the last follow-up, 61.1% was affected by hypertension, 33.3% by diabetes, and 61.1% by dyslipidemia, without differences between groups. Drug characteristics (dose, shift, number) during the follow-up did not differ significantly between groups.Conclusion: Metabolic complications, mainly dyslipidemia, are frequent in cured acromegalic patients, but GH/IGF-1 discrepancy does not seem to represent a risk factor for their presence or persistence. More extended studies are needed to confirm our results in a long-term period

Transsphenoidal surgery for pituitary adenomas: early results from a single center

To evaluate early results of transsphenoidal surgery for pituitary adenomas

Case Report: Liraglutide for Weight Management in Beckwith-Wiedemann Syndromic Obesity

Genetic obesity, including syndromic and non-syndromic forms, represents a minority of cases compared to essential obesity but gene dysregulations lead to complex clinical conditions that make their management particularly difficult. Among them, Beckwith-Wiedemann syndrome (BWS) is a multisystem human genomic imprinting disorder characterized by overgrowth. We describe the first case of liraglutide treatment in an 18-year-old boy patient affected by BWS complicated by macroglossia, cryptorchidism, nephroblastoma, organomegaly, microscopic lymphocytic colitis, pharmacologically treated arterial hypertension, obesity, and obstructive sleep apnea syndrome. He presented a normal cognitive development. Body mass index at the time of first transition visit in the adult endocrinology department at the age of 18-years-old was 40.6 kg/m2 without glucose metabolism impairment. Lifestyle interventions failed because of poor compliance. During 20 months of 3.0 mg liraglutide treatment, a weight loss of 19 kg (−13.3%) and BMI reduction of 6.8 points were registered without side effects. To date, liraglutide treatment was effective on obesity in 7 subjects with Prader Willy Syndrome and 14 with melanocortin-4 receptor mutations. The efficacy of liraglutide in BWS could be related to a crosstalk among glucagon-like peptide (GLP)-1 system, mechanisms related to the cyclin-dependent kinase inhibitor 1C (CDKN1C), and dopamine mesolimbic circuit. Clinical trials aiming at a tailored medicine in genetic obesity are needed