Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide

© 2018 Antimicrobial peptide loaded poly(2-hydroxyethyl methacrylate) particles were synthesized in supercritical carbon dioxide via one-pot free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate and a cross-linker. Discrete particles with a well-defined spherical morphology and a diameter as low as 450 nm have been obtained in mild conditions. The encapsulation and release of the peptide were confirmed by antimicrobial tests that demonstrated for the first time a sustained release of the peptide from poly(2-hydroxyethyl methacrylate) microgels prepared by one-pot dispersion polymerization in supercritical carbon dioxide and then dispersed in water

Adiabatic invariants and Mixmaster catastrophes

We present a rigorous analysis of the role and uses of the adiabatic invariant in the Mixmaster dynamical system. We propose a new invariant for the global dynamics which in some respects has an improved behaviour over the commonly used one. We illustrate its behaviour in a number of numerical results. We also present a new formulation of the dynamics via Catastrophe Theory. We find that the change from one era to the next corresponds to a fold catastrophe, during the Kasner shifts the potential is an Implicit Function Form whereas, as the anisotropy dissipates, the Mixmaster potential must become a Morse 0--saddle. We compare and contrast our results to many known works on the Mixmaster problem and indicate how extensions could be achieved. Further exploitation of this formulation may lead to a clearer understanding of the global Mixmaster dynamics.Comment: 24 pages, LaTeX, 5 figures (which can be obtained by sending a message to the first author), submitted to Phys.Rev.

Comparative law and unification of laws

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Expect the Unexpected: Avoiding Possible Pitfalls in National Arbitration Laws

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L'organisation du pouvoir dans les groupes de sociétés

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About Major Alkaloids of Strychnos Scheffleri from Zaire.

Leaves and stem barks of S. SCHEFFLERI G ILG afforded eight dihydroindole alkaloids. Four tertiary monomers (O-methyl Na-acetylstrychnosplendine, Na-acetylstrychnosplendine, strychnobrasiline and strychnofendlerine) have been isolated from leaf material while stem barks yielded one tertiary monomer (desacetylisoretuline), one tertiary symmetrical dimer (bis-nordihydrotoxiferine) and two quaternary monomers (mavacurine and fluorocurine)

Limitation du nombre de sociétés: Qu'en est-il des sociétés de capitaux (SA, SPRL, SCRL)?

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The Isolation and Structure Elucidation of Afrocurarine

The structure and the stereochemistry of afrocurarine (a new unsymmetrical bisindole alkaloid) previously isolated from S. USAMBARENSIS Gilg. are established especially from (1)H-NMR spectroscopic data. The separation of quaternary alkaloids has always been very tedious. Ion-pair reversed-phase column chromatography applied to the purification of afrocurarine is proved very useful and seems to be a suitable technique in quaternary alkaloid research