Talent management practices for the future of work: leading a successful remote onboarding program

Talent Management Practices for the Future of Work: Leading a Successful Remote Onboarding Program Over the years, the academic field has been coming up with new studies, frameworks, and definitions of what work is and, consecutively, what its future is, taking into account all the technological evolution and disruptors, such as the case of Covid-19. In this way, it is necessary to follow what are the new trends in the market and be able to adapt. This project is then based on an in-depth analysis of the Company XYZ to understand its readiness for the Future of Work within Talent Management, focusing more concretely on how to lead a successful remote onboarding program

Catheter ablation in atrial fibrillation: a state-of-the-art review

n/

Long-Term Results of Cryoballoon Ablation for Atrial Fibrillation

n/

Congenital complete atrioventricular block in the early pediatric population

Congenital complete atrioventricular block (CCAVB) is a rare potentially lethal disease with an estimated incidence of 1 every 15.000 to 20.000 live born infants

Effects of Rivaroxaban on Biomarkers of Coagulation and Inflammation: A Post Hoc Analysis of the X-VeRT Trial.

Introduction  This X-VeRT (eXplore the efficacy and safety of once-daily oral riVaroxaban for the prevention of caRdiovascular events in patients with nonvalvular aTrial fibrillation scheduled for cardioversion) substudy evaluated the effects of treatment with rivaroxaban or a vitamin-K antagonist (VKA) on levels of biomarkers of coagulation (D-dimer, thrombin-antithrombin III complex [TAT] and prothrombin fragment [F1.2]) and inflammation (high sensitivity C-reactive protein [hs-CRP] and high-sensitivity interleukin-6 [hs-IL-6]) in patients with atrial fibrillation (AF) who were scheduled for cardioversion and had not received adequate anticoagulation at baseline (defined as, in the 21 days before randomization: no oral anticoagulant; international normalized ratio <2.0 with VKA treatment; or <80% compliance with non-VKA oral anticoagulant treatment). Methods  Samples for biomarker analysis were taken at baseline ( n  = 958) and treatment completion (42 days after cardioversion; n  = 918). The influence of clinical characteristics on baseline biomarker levels and the effect of treatment on changes in biomarker levels were evaluated using linear and logistic models. Results  Baseline levels of some biomarkers were significantly associated with type of AF (D-dimer and hs-IL-6) and with history of congestive heart failure (hs-CRP, D-dimer, and hs-IL-6). Rivaroxaban and VKA treatments were associated with reductions from baseline in levels of D-dimer (-32.3 and -37.6%, respectively), TAT (-28.0 and -23.1%, respectively), hs-CRP (-12.5 and -17.9%, respectively), and hs-IL-6 (-9.2 and -9.8%, respectively). F1.2 levels were reduced from baseline in patients receiving a VKA (-53.0%) but not in those receiving rivaroxaban (2.7%). Conclusion  Anticoagulation with rivaroxaban reduced levels of key inflammation and coagulation biomarkers to a similar extent as VKAs, with the exception of F1.2. Further investigation to confirm the value of these biomarkers in patients with AF is merited

Simulation numérique des instabilités rotor stator dans une turbine hydraulique avec Foam-Extend

RÉSUMÉ Le projet de recherche présenté ici, est réalisé en partenariat entre la société Andritz Hydro et le groupe de recherche, dirigé par François Guibault. Cette coopération a pour but de développer des outils informatiques de conception, simulation et validation de produits relatifs aux turbines hydrauliques. Pour les turbines destinées à des hautes chutes, le mouvement des pales de la roue passant devant les aubes du distributeur, crée des vibrations. Ce phénomène instationnaire, appelé interaction rotor-stator (RSI) peut être à l’origine de rupture en fatigue des composants de la roue de turbine. Étudiées depuis près de vingt ans, les interactions rotor-stator doivent être prises en compte lors de la phase de design préliminaire et constituent un véritable critère de décision pour la conception des turbines. Dans ce mémoire nous nous focaliserons sur l’étude des différents paramètres numériques du logiciel Foam-extend, dans le but de réaliser avec celui-ci une simulation robuste et précise du phénomène des interactions rotor-stator. Foam-extend (anciennement OpenFoam), est un logiciel libre de simulation numérique basé sur la méthode des volumes finis. Cette étude présentera les différents solveurs disponibles sous Foam-extend, ainsi que leurs algorithmes de résolution. Ces solveurs seront utilisés avec un maillage tournant et seront couplés à un modèle de turbulence k-". La géométrie étudiée est un modèle d’une turbine Francis, qui comprends une roue (constituée de 15 pales) et un distributeur (constitué de 20 aubes directrices et de 20 avant-directrices). La méthode de connexion General Grid Interface (GGI) sera utilisée pour connecter les différentes parties du maillage. Enfin, dans le but d’accélérer le calcul, une partie de l’étude se focalisera sur la simulation d’un cinquième de la géométrie. Tous les résultats obtenus seront comparés à des résultats numériques provenant de logiciels commerciaux ainsi qu’à des données expérimentales.----------ABSTRACT This master research is realised in partnership with the company Andritz Hydro and the research group, directed by François Guibault. This purpose of this collaboration is to develop software tools to design and simulate some phenomenon in hydraulic turbines. In the development of high head hydraulic turbines, dynamic stresses induced by vibrations have to be taken into account. This paper focuses on the study of the rotor-stator interactions (RSI). In hydraulic turbines, the movement of the blades passing in front of the guide vanes creates vibrations. This unsteady phenomenon can be responsible for fatigue failures on turbine runners. Studied for about twenty years, RSI must now be taken into account during preliminary hydraulic design phase through CFD analysis, as it constitutes a decisive criterion for designing turbines. This work investigates various aspects of the numerical setup required to perform accurate and robust URANS simulations of an RSI case using the open source CFD software Foamextend 3.2. Foam-extend (formerly named OpenFoam) is a software which includes solvers based on the finite volumes method. The solver chosen for this study is a transient solver for incompressible flow on a moving mesh coupled with a k-" turbulence model. The geometry studied is a model of a Francis turbine, which consist of a runner (15 blades) and a distributor (20 guide vanes and 20 stay vanes). To enable the connection between all mesh patches the General grid Interface (GGI) method is used. To speed up calculations, some simulations are realised on a part (a fifth) of the model. All numerical results obtained are compared to data from commercial softwares and experimental results

Identification of reference genes for quantitative PCR during C3H10T1/2 chondrogenic differentiation

C3H10T1/2, a mouse mesenchymal stem cell line, is a well-known in vitro model of chondrogenesis that can be easily employed to recapitulate some of the mechanisms intervening in this process. Moreover, these cells can be used to validate the effect of candidate molecules identified by high throughput screening approaches applied to the development of targeted therapy for human disorders in which chondrogenic differentiation may be involved, as in conditions characterized by heterotopic endochondral bone formation. Chondrogenic differentiation of C3H10T1/2 cells can be monitored by applying quantitative polymerase chain reaction (qPCR), one of the most sensitive methods that allows detection of small dynamic changes in gene expression between samples obtained under different experimental conditions. In this work, we have used qPCR to monitor the expression of specific markers during chondrogenic differentiation of C3H10T1/2 cells in micromass cultures. Then we have applied the geNorm approach to identify the most stable reference genes suitable to get a robust normalization of the obtained expression data. Among 12 candidate reference genes (Ap3d1, Csnk2a2, Cdc40, Fbxw2, Fbxo38, Htatsf1, Mon2, Pak1ip1, Zfp91, 18S, ActB, GAPDH) we identified Mon2 and Ap3d1 as the most stable ones during chondrogenesis. ActB, GAPDH and 18S, the most commonly used in the literature, resulted to have an expression level too high compared to the differentiation markers (Sox9, Collagen type 2a1, Collagen type 10a1 and Collagen type 1a1), therefore are actually less recommended for these experimental conditions. In conclusion, we identified nine reference genes that can be equally used to obtain a robust normalization of the gene expression variation during the C3H10T1/2 chondrogenic differentiation

Sexual behavior and practices of adolescent students in the city of Recife, Brazil

Introduction: The adolescent sexuality should not be understood only from the biological point of view; it is necessary to consider the whole social context.Objective: To characterize the adolescents’ behavior and sexual practices , according to sex.Methods: Cross-sectional study with adolescents aged 14 to 19 years registered in the  Recife-PE state. A questionnaire with sociodemographic data and sexual behavior was used. The data were analyzed using SPSS, being employed a descriptive analysis and the tests chi-square and Mann-Whitney.Results: The data from 674 adolescents with an average age of 16.07 ± 1.46 years were analyzed. It was verified sexual initiation in 52.9% of boys and 38.7% girls. There was a significant difference between the number of partners (p = 0.001) with the boys showing greater quantitative. The barrier method was the most used in the first (68.8%) and last intercourse (52.2%). There was a significant difference in the first and last intercourse, in use (p = 0.006; p = 0.010) and type of contraceptive method (p= 0.001; p 0.001). Regarding the social network, riends were the most popular. However, it was observed a significant difference (p = 0.026), being the maternal figure more prevalent in girls. There was a significant difference in the absence of sexual initiation (p= 0.001). The lack of opportunity was the most reported condition by boys (52.2%) and marry virgin by the girls (33.9%).Conclusion: Most had already had sexual life, with higher prevalence in males. Regarding the sexual practices and behaviors in most conditions analyzed different values between the sexes were observed, with greater freedom and permissiveness in males.

Combining the Morris Method and Multiple Error Metrics to Assess Aquifer Characteristics and Recharge in the Lower Ticino Basin, in Italy

Groundwater flow model accuracy is often limited by the uncertainty in model parameters that characterize aquifer properties and aquifer recharge. Aquifer properties such as hydraulic conductivity can have an uncertainty spanning orders of magnitude. Meanwhile, parameters used to configure model boundary conditions can introduce additional uncertainty. In this study, the Morris Method sensitivity analysis is performed on multiple quantities of interest to assess the sensitivity of a steady-state groundwater flow model to uncertain input parameters. The Morris Method determines which of these parameters are less influential on model outputs. Uninfluential parameters can be set constant during subsequent parameter optimization to reduce computational expense. Combining multiple quantities of interest (e.g., RMSE, groundwater fluxes) when performing both the Morris Method and parameter optimization offers a more complete assessment of groundwater models, providing a more reliable and physically consistent estimate of uncertain parameters. The parameter optimization procedure also provides us an estimate of the residual uncertainty in the parameter values, resulting in a more complete estimate of the remaining uncertainty. By employing such techniques, the current study was able to estimate the aquifer hydraulic conductivity and recharge rate due to rice field irrigation in a groundwater basin in Northern Italy, revealing that a significant proportion of surficial aquifer recharge (approximately 81-94%) during the later summer is due to the flood irrigation practices applied to these fields.Comment: second submission after minor revision

Shoulder Muscular Activity During Isometric Three-Point Kneeling Exercise on Stable and Unstable Surfaces

The purpose of this study was to determine if performing isometric 3-point kneeling exercises on a Swiss ball influenced the isometric force output and EMG activities of the shoulder muscles when compared with performing the same exercises on a stable base of support. Twenty healthy adults performed the isometric 3-point kneeling exercises with the hand placed either on a stable surface or on a Swiss ball. Surface EMG was recorded from the posterior deltoid, pectoralis major, biceps brachii, triceps brachii, upper trapezius, and serratus anterior muscles using surface differential electrodes. All EMG data were reported as percentages of the average root mean square (RMS) values obtained in maximum voluntary contractions for each muscle studied. The highest load value was obtained during exercise on a stable surface. A significant increase was observed in the activation of glenohumeral muscles during exercises on a Swiss ball. However, there were no differences in EMG activities of the scapulothoracic muscles. These results suggest that exercises performed on unstable surfaces may provide muscular activity levels similar to those performed on stable surfaces, without the need to apply greater external loads to the musculoskeletal system. Therefore, exercises on unstable surfaces may be useful during the process of tissue regeneration.State of Sao Paulo Research Foundation (FAPESP)National Council for Scientific and Technological Development (CNPq