58 research outputs found
Histoire et anthropologie du monde hispanique
Wolfgang Kaiser, Jean-FrĂ©dĂ©ric Schaub, Bernard Vincent, directeurs dâĂ©tudesJordi Canal, Enric Porqueres i GenĂ©, Jean-Paul Zuñiga, maĂźtres de confĂ©rences Le sĂ©minaire dâhistoire et anthropologie du monde hispanique est un espace tant de recherche que de rencontre et dâinformation. Les activitĂ©s ont Ă©tĂ© mĂ©thodologiques et thĂ©matiques. Des interventions de type mĂ©thodologique ont constituĂ© le fil rouge de cette annĂ©e. Nation, naturel, Ă©tranger, originaires sont autant de catĂ©gories passĂ©es en re..
Histoire et anthropologie du monde hispanique
Wolfgang Kaiser, Jean-FrĂ©dĂ©ric Schaub, Bernard Vincent, directeurs dâĂ©tudesJordi Canal, Enric Porqueres i GenĂ©, Jean-Paul Zuñiga, maĂźtres de confĂ©rences Le sĂ©minaire dâhistoire et anthropologie du monde hispanique est un espace tant de recherche que de rencontre et dâinformation. Les activitĂ©s ont Ă©tĂ© mĂ©thodologiques et thĂ©matiques. Des interventions de type mĂ©thodologique ont constituĂ© le fil rouge de cette annĂ©e. Nation, naturel, Ă©tranger, originaires sont autant de catĂ©gories passĂ©es en re..
Séminaire collectif du Groupe de recherches sur les missions religieuses dans le monde ibérique moderne
Bernard Vincent et Pierre-Antoine Fabre, directeurs dâĂ©tudesJean-Paul Zuñiga, maĂźtre de confĂ©rences Compte rendu non communiquĂ©. Bernard Vincent, Jean-FrĂ©dĂ©ric Schaub, Wolfgang Kaiser, directeurs dâĂ©tudesJordi Canal, Enric Porqueres i GenĂ©, Jean-Paul Zuñiga, maĂźtres de confĂ©rences Histoire et anthropologie du monde hispanique Compte rendu non communiquĂ©
CRH-GEI â Groupe dâĂ©tudes ibĂ©riques
Wolfgang Kaiser, Jean-FrĂ©dĂ©ric Schaub, Bernard Vincent (*),Enric Porqueres i GenĂ©, directeurs dâĂ©tudesJordi Canal, Jean-Paul Zuñiga, Catarina Madeira Santos, Natalia Muchnik, maĂźtres de confĂ©rencesFrĂ©dĂ©rique Langue, directrice de recherche au CNRSGrĂ©goire Salinero, maĂźtre de confĂ©rences Ă lâUniversitĂ© Paris 1-PanthĂ©on-Sorbonne Histoire et anthropologie du monde ibĂ©rique La formule inaugurĂ©e pour notre sĂ©minaire lâannĂ©e derniĂšre sâest mieux installĂ©e cette annĂ©e. Ă cĂŽtĂ© de la mission de lieu d..
Histoire et anthropologie du monde ibérique
Wolfgang Kaiser, Bernard Vincent, Jean-FrĂ©dĂ©ric Schaub, directeurs dâĂ©tudesJordi Canal, Catarina Madeira Santos, Natalia Muchnik, Enric Porqueres i GenĂ©, Jean-Paul Zuñiga, maĂźtres de confĂ©rences Ă lâEHESSFrĂ©dĂ©rique Langue, chargĂ©e de recherche au CNRSGrĂ©goire Salinero, maĂźtre de confĂ©rences Ă lâUniversitĂ© Paris-I/PanthĂ©on-Sorbonne Histoire et anthropologie du monde ibĂ©rique Cette annĂ©e, particuliĂšrement intense avec vingt-six interventions encadrĂ©es par des discutants, nous nous sommes intĂ©re..
CRH â Groupe dâĂ©tudes ibĂ©riques (GEI)
Wolfgang Kaiser, Enric Porqueres i GenĂ©, Bernard Vincent, Jean-FrĂ©dĂ©ric Schaub, directeurs dâĂ©tudesJordi Canal, Natalia Muchnik, Catarina Madeira Santos, Jean-Paul Zuhiga, maĂźtres de confĂ©rencesFrĂ©dĂ©rique Langue, directrice de recherche au CNRSGrĂ©goire Sallnero, maĂźtre de confĂ©rences Ă lâUniversitĂ© Paris-I/PanthĂ©on-Sorbonne Histoire et anthropologie du monde ibĂ©rique Sur un rythme bimensuel, notre sĂ©minaire collectif est organisĂ© selon une double dĂ©marche. Il cherche tout dâabord Ă se constit..
Histoire et anthropologie du monde ibérique
Bernard Vincent, Wolfgang Kaiser, Jean-FrĂ©dĂ©ric Schaub, directeurs dâĂ©tudesJordi Canal, Enric Porqueres i GenĂ©, Jean-Paul Zuñiga, Catarina Madeira Santos, Natalia Muchnik, maĂźtres de confĂ©rencesMarie-Lucie Copete, maĂźtre de confĂ©rences Ă lâUniversitĂ© de NancyFrĂ©dĂ©rique Langue, chargĂ©e de recherche au CNRSStĂ©phane Michonneau, maĂźtre de confĂ©rences Ă lâUniversitĂ© de PoitiersGrĂ©goire SalinĂ©ro, maĂźtre de confĂ©rences Ă lâUniversitĂ© Paris-I Histoire et anthropologie du monde ibĂ©rique Cette annĂ©e, l..
Histoire et anthropologie du monde ibérique
Bernard Vincent, Wolfgang Kaiser, Jean-FrĂ©dĂ©ric Schaub, directeurs dâĂ©tudesJordi Canal, Enric Porqueres i GenĂ©, Jean-Paul Zuñiga, Catarina Madeira Santos, Natalia Muchnik, maĂźtres de confĂ©rencesMarie-Lucie Copete, maĂźtre de confĂ©rences Ă lâUniversitĂ© de NancyFrĂ©dĂ©rique Langue, chargĂ©e de recherche au CNRSStĂ©phane Michonneau, maĂźtre de confĂ©rences Ă lâUniversitĂ© de PoitiersGrĂ©goire SalinĂ©ro, maĂźtre de confĂ©rences Ă lâUniversitĂ© Paris-I Histoire et anthropologie du monde ibĂ©rique Cette annĂ©e, l..
High dose genistein in Sanfilippo syndrome: A randomised controlled trial
From Wiley via Jisc Publications RouterHistory: received 2021-02-09, rev-recd 2021-05-25, accepted 2021-05-27, pub-electronic 2021-06-13Article version: VoRPublication status: PublishedFunder: UK MPS SocietyFunder: National MPS society; Id: http://dx.doi.org/10.13039/100013927Funder: GEM AppealAbstract: The aim of this study was to evaluate the efficacy of high dose genistein aglycone in Sanfilippo syndrome (mucopolysaccharidosis type III). High doses of genistein aglycone have been shown to correct neuropathology and hyperactive behaviour in mice, but efficacy in humans is uncertain. This was a single centre, doubleâblinded, randomised, placeboâcontrolled study with openâlabel extension phase. Randomised participants received either 160 mg/kg/day genistein aglycone or placebo for 12 months; subsequently all participants received genistein for 12 months. The primary outcome measure was the change in heparan sulfate concentration in cerebrospinal fluid (CSF), with secondary outcome measures including heparan sulfate in plasma and urine, total glycosaminoglycans in urine, cognitive and adaptive behaviour scores, quality of life measures and actigraphy. Twentyâone participants were randomised and 20 completed the placeboâcontrolled phase. After 12 months of treatment, the CSF heparan sulfate concentration was 5.5% lower in the genistein group (adjusted for baseline values), but this was not statistically significant (P = .26), and CSF heparan sulfate increased in both groups during the openâlabel extension phase. Reduction of urinary glycosaminoglycans was significantly greater in the genistein group (32.1% lower than placebo after 12 months, P = .0495). Other biochemical and clinical parameters showed no significant differences between groups. High dose genistein aglycone (160 mg/kg/day) was not associated with clinically meaningful reductions in CSF heparan sulfate and no evidence of clinical efficacy was detected. However, there was a statistically significant reduction in urine glycosaminoglycans. These data do not support the use of genistein aglycone therapy in mucopolysaccharidosis type III. High dose genistein aglycone does not lead to clinically meaningful reductions in biomarkers or improvement in neuropsychological outcomes in mucopolysaccharidosis type III
A Roadmap for HEP Software and Computing R&D for the 2020s
Particle physics has an ambitious and broad experimental programme for the coming decades. This programme requires large investments in detector hardware, either to build new facilities and experiments, or to upgrade existing ones. Similarly, it requires commensurate investment in the R&D of software to acquire, manage, process, and analyse the shear amounts of data to be recorded. In planning for the HL-LHC in particular, it is critical that all of the collaborating stakeholders agree on the software goals and priorities, and that the efforts complement each other. In this spirit, this white paper describes the R&D activities required to prepare for this software upgrade.Peer reviewe
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