Two-soliton collisions in a near-integrable lattice system

We examine collisions between identical solitons in a weakly perturbed Ablowitz-Ladik (AL) model, augmented by either onsite cubic nonlinearity (which corresponds to the Salerno model, and may be realized as an array of strongly overlapping nonlinear optical waveguides), or a quintic perturbation, or both. Complex dependences of the outcomes of the collisions on the initial phase difference between the solitons and location of the collision point are observed. Large changes of amplitudes and velocities of the colliding solitons are generated by weak perturbations, showing that the elasticity of soliton collisions in the AL model is fragile (for instance, the Salerno's perturbation with the relative strength of 0.08 can give rise to a change of the solitons' amplitudes by a factor exceeding 2). Exact and approximate conservation laws in the perturbed system are examined, with a conclusion that the small perturbations very weakly affect the norm and energy conservation, but completely destroy the conservation of the lattice momentum, which is explained by the absence of the translational symmetry in generic nonintegrable lattice models. Data collected for a very large number of collisions correlate with this conclusion. Asymmetry of the collisions (which is explained by the dependence on the location of the central point of the collision relative to the lattice, and on the phase difference between the solitons) is investigated too, showing that the nonintegrability-induced effects grow almost linearly with the perturbation strength. Different perturbations (cubic and quintic ones) produce virtually identical collision-induced effects, which makes it possible to compensate them, thus finding a special perturbed system with almost elastic soliton collisions.Comment: Phys. Rev. E, in pres

A polymerase III-like reinitiation mechanism is operating in regulation of histone expression in archaea

An archaeal histone gene from the hyperthermophile Pyrococcus furiosus containing four consecutive putative oligo-dT terminator sequences was used as a model system to investigate termination signals and the mechanism of termination in vitro. The archaeal RNA polymerase terminated with high efficiency at the first terminator at 90°C when it contained five to six T residues, at 80°C readthrough was significantly increased. A putative hairpin structure upstream of the first terminator had no effect on termination efficiency. Template competition experiments starting with RNA polymerase molecules engaged in ternary complexes revealed recycling of RNA polymerase from the terminator to the promoter of the same template. This facilitated reinitiation was dependent upon the presence of a terminator sequence suggest-ing that pausing at the terminator is required for recycling as in the RNA polymerase III system. Replacement of the sequences immediately down-stream of the oligo-dT terminator by an AT-rich segment improved termination efficiency. Both AT-rich and GC-rich downstream sequences seemed to impair the facilitated reinitiation pathway. Our data suggest that recycling is dependent on a subtle interplay of pausing of RNA polymerase at the ter-minator and RNA polymerase translocation beyond the oligo-dT termination signal that is dramatically affected by downstream sequences

Quantifying the healthcare costs of treating severely bleeding major trauma patients: a national study for England.

INTRODUCTION: Severely bleeding trauma patients are a small proportion of the major trauma population but account for 40% of all trauma deaths. Healthcare resource use and costs are likely to be substantial but have not been fully quantified. Knowledge of costs is essential for developing targeted cost reduction strategies, informing health policy, and ensuring the cost-effectiveness of interventions. METHODS: In collaboration with the Trauma Audit Research Network (TARN) detailed patient-level data on in-hospital resource use, extended care at hospital discharge, and readmissions up to 12 months post-injury were collected on 441 consecutive adult major trauma patients with severe bleeding presenting at 22 hospitals (21 in England and one in Wales). Resource use data were costed using national unit costs and mean costs estimated for the cohort and for clinically relevant subgroups. Using nationally available data on trauma presentations in England, patient-level cost estimates were up-scaled to a national level. RESULTS: The mean (95% confidence interval) total cost of initial hospital inpatient care was £19,770 (£18,177 to £21,364) per patient, of which 62% was attributable to ventilation, intensive care, and ward stays, 16% to surgery, and 12% to blood component transfusion. Nursing home and rehabilitation unit care and re-admissions to hospital increased the cost to £20,591 (£18,924 to £22,257). Costs were significantly higher for more severely injured trauma patients (Injury Severity Score ≥15) and those with blunt injuries. Cost estimates for England were £148,300,000, with over a third of this cost attributable to patients aged 65 years and over. CONCLUSIONS: Severely bleeding major trauma patients are a high cost subgroup of all major trauma patients, and the cost burden is projected to rise further as a consequence of an aging population and as evidence continues to emerge on the benefits of early and simultaneous administration of blood products in pre-specified ratios. The findings from this study provide a previously unreported baseline from which the potential impact of changes to service provision and/or treatment practice can begin to be evaluated. Further studies are still required to determine the full costs of post-discharge care requirements, which are also likely to be substantial

Translation to practice: a randomised controlled study of an evidenced based booklet targeted at breast care nurses in the United Kingdom

BACKGROUND: In the United Kingdom (UK), it was documented that a problem of knowledge transfer existed within the speciality of breast-cancer care, thus depriving patients of receiving optimal care. Despite increasingly robust research evidence indicating recommendation of whole body exercise for people affected by breast cancer, commensurate changes to practice were not noted amongst breast-care nurses (BCNs). AIM: To evaluate the effect of a targeted booklet, Exercise and Breast Cancer: A Booklet for Breast-Care Nurses, on changes in knowledge, reported practice, and attitudes of BCNs in the UK. METHOD: A prospective, experimental approach was used for designing a pre- and post-test randomised controlled study. Comparisons of knowledge, reported practice, and attitudes based on responses to a questionnaire were made at two time-points in two groups of BCNs (control and experimental). The unit of randomisation and analysis was hospital clusters of BCNs. The sample comprised 92 nurses from 62 hospitals. Analysis consisted of descriptive statistics and clustered regression techniques: clustered logistic regression for knowledge items, clustered linear regression for knowledge scores, ologit for attitude and reported practice items, and clustered multiple regression for paired and multiple variable analysis. RESULTS: A statistically significant increase in knowledge and changes in reported practice and attitudes were found. Robust variables affecting knowledge acquisition were: promotion of health, promotion of exercise, and understanding how exercise can reduce cancer-related fatigue. DISCUSSION: The study has shown that evidence-based printed material, such as an information booklet, can be used as an effective research dissemination method when developed for needs, values, and context of a target audience. CONCLUSIONS: This practical approach to research dissemination could be replicated and applied to other groups of nurses.</p

The Structure of Nanoscale Polaron Correlations in La1.2Sr1.8Mn2O7

A system of strongly-interacting electron-lattice polarons can exhibit charge and orbital order at sufficiently high polaron concentrations. In this study, the structure of short-range polaron correlations in the layered colossal magnetoresistive perovskite manganite, La1.2Sr1.8Mn2O7, has been determined by a crystallographic analysis of broad satellite maxima observed in diffuse X-ray and neutron scattering data. The resulting q=(0.3,0,1) modulation is a longitudinal octahedral-stretch mode, consistent with an incommensurate Jahn-Teller-coupled charge-density-wave fluctuations, that implies an unusual orbital-stripe pattern parallel to the directions.Comment: Reformatted with RevTe

Average Lattice Symmetry and Nanoscale Structural Correlations in Magnetoresistive Manganites

We report x-ray scattering studies of nanoscale structural correlations in the paramagnetic phases of the perovskite manganites La$_{0.75}$(Ca$_{0.45}$Sr$_{0.55}$)$_{0.25}$MnO$_3$, La$_{0.625}$Sr$_{0.375}$MnO$_3$, and Nd$_{0.45}$Sr$_{0.55}$MnO$_3$. We find that these correlations are present in the orthorhombic $O$ phase in La$_{0.75}$(Ca$_{0.45}$Sr$_{0.55}$)$_{0.25}$MnO$_3$, but they disappear abruptly at the orthorhombic-to-rhombohedral transition in this compound. The orthorhombic phase exhibits increased electrical resistivity and reduced ferromagnetic coupling, in agreement with the association of the nanoscale correlations with insulating regions. In contrast, the correlations were not detected in the two other compounds, which exhibit rhombohedral and tetragonal phases. Based on these results, as well as on previously published work, we propose that the local structure of the paramagnetic phase correlates strongly with the average lattice symmetry, and that the nanoscale correlations are an important factor distinguishing the insulating and the metallic phases in these compounds.Comment: a note on recent experimental work, and a new reference adde

Reach of the Fermilab Tevatron for minimal supergravity in the region of large scalar masses

The reach of the Fermilab Tevatron for supersymmetric matter has been calculated in the framework of the minimal supergravity model in the clean trilepton channel. Previous analyses of this channel were restricted to scalar masses m_0<= 1 TeV. We extend the analysis to large values of scalar masses m_0\sim 3.5 TeV. This includes the compelling hyperbolic branch/focus point (HB/FP) region, where the superpotential \mu parameter becomes small. In this region, assuming a 5\sigma (3\sigma) signal with 10 (25) fb^{-1} of integrated luminosity, the Tevatron reach in the trilepton channel extends up to m_{1/2}\sim 190 (270) GeV independent of \tan\beta . This corresponds to a reach in terms of the gluino mass of m_{\tg}\sim 575 (750) GeV.Comment: 11 page latex file including 6 EPS figures; several typos corrected and references adde

Protecting the primordial baryon asymmetry in the seesaw model compatible with WMAP and KamLAND

We require that the primordial baryon asymmetry is not washed out in the seesaw model compatible with the recent results of WMAP and the neutrino oscillation experiments including the first results of KamLAND. We find that only the case of the normal neutrino mass hierarchy with an approximate $L_{e}$-symmetry satisfies the requirement. We further derive, depending on the signs of neutrino mass eigenvalues, three types of neutrino mass matrixes, where the values of each element are rather precisely fixed.Comment: 21pages; added reference

Leptogenesis from a sneutrino condensate revisited

We re--examine leptogenesis from a right--handed sneutrino condensate, paying special attention to the $B-$term associated with the see--saw Majorana mass. This term generates a lepton asymmetry in the condensate whose time average vanishes. However, a net asymmetry will result if the sneutrino lifetime is not much longer than the period of oscillations. Supersymmetry breaking by thermal effects then yields a lepton asymmetry in the standard model sector after the condensate decays. We explore different possibilities by taking account of both the low--energy and Hubble $B-$terms. It will be shown that the desired baryon asymmetry of the Universe can be obtained for a wide range of Majorana mass.Comment: 17 revtex pages, 3 figures, 1 table. Slightly modified and references added. Final version accepted for publication in Phys. Rev.

Leptogenesis and rescattering in supersymmetric models

The observed baryon asymmetry of the Universe can be due to the $B-L$ violating decay of heavy right handed (s)neutrinos. The amount of the asymmetry depends crucially on their number density. If the (s)neutrinos are generated thermally, in supersymmetric models there is limited parameter space leading to enough baryons. For this reason, several alternative mechanisms have been proposed. We discuss the nonperturbative production of sneutrino quanta by a direct coupling to the inflaton. This production dominates over the corresponding creation of neutrinos, and it can easily (i.e. even for a rather small inflaton-sneutrino coupling) lead to a sufficient baryon asymmetry. We then study the amplification of MSSM degrees of freedom, via their coupling to the sneutrinos, during the rescattering phase which follows the nonperturbative production. This process, which mainly influences the (MSSM) $D-$flat directions, is very efficient as long as the sneutrinos quanta are in the relativistic regime. The rapid amplification of the light degrees of freedom may potentially lead to a gravitino problem. We estimate the gravitino production by means of a perturbative calculation, discussing the regime in which we expect it to be reliable.Comment: (20 pages, 6 figures), references added, typos corrected. Final version in revte