OB Stars & Stellar Bowshocks in Cygnus-X: A Novel Laboratory Estimating Stellar Mass Loss Rates

We use mid-IR images from the Spitzer Cygnus~X Legacy Survey to search for stellar bowshocks, a signature of early type "runaway" stars with high space velocities. We identify ten arc-shaped nebulae containing centrally located stars as candidate bowshocks. New spectroscopic observations of five stars show that all are late O to early B dwarfs. Our morphologically selected sample of bowshock candidates encompasses diverse physical phenomena. Three of the stars appear to be pre-main-sequence objects on the basis of rising SEDs in the mid-IR, and their nebulae may be photon-dominated regions (PDRs). Four objects have ambiguous classification. These may be partial dust shells or bubbles. We conclude that three of the objects are probable bowshocks, based on their morphological similarity to analytic prescriptions. Their nebular morphologies reveal no systematic pattern of orientations that might indicate either a population of stars ejected from or large-scale hydrodynamic outflows from Cyg OB2. The fraction of runaways among OB stars near Cyg OB2 identified either by radial velocity or bowshock techniques is ~0.5%, much smaller than the 8% estimated among field OB stars. We also obtained a heliocentric radial velocity for the previously known bowshock star, BD+43\degr3654, of -66.2+/-9.4 km/s, solidifying its runaway status and implying a space velocity of 77+/-10 km/s. We use the principles of momentum-driven bowshocks to arrive at a novel method for estimating stellar mass loss rates. Derived mass loss rates range between 10^-7 and few x10^-6 solar masses/yr for the three O5V -- ~B2V stars identified as generating bowshocks. These values are at the upper range of, but broadly consistent with, estimates from other methods. (Abridged)Comment: 49 pages, 19 figures; Accepted for publication in ApJ; full-resolution color figure version available at http://physics.uwyo.edu/~chip/Papers/CygXBowshocks; comments invite

Behavior During Tethered Kicking in Infants with Periventricular Brain Injury

Purpose: To describe behavior of children with periventricular brain injury (PBI) in a tethered-kicking intervention. Methods: Sixteen infants with PBI were randomly assigned to exercise or no-training in a longitudinal pilot study. Frequencies of leg movements and interlimb coordination were described from videos at 2 and 4 months\u27 corrected age (CA). Results: Eight of the 13 children (62%) with longitudinal data increased the frequency of leg movements while tethered to a mobile between 2 and 4 months\u27 CA. Movement frequency was correlated with scores on the Test of Infant Motor Performance, but no differences between experimental groups were found. Children with typical development at 12 months\u27 CA increased the proportion of leg movements that were synchronous between 2 and 4 months, as did a child with cerebral palsy in the experimental group. Conclusions: The tethered-kicking intervention facilitates movement in infants with PBI, but effects on development remain to be demonstrated

A High Mass Dusty Disk Candidate: The Case of IRAS 18151-1208

Many questions remain regarding the properties of disks around massive prototstars. Here we present the observations of a high mass protostellar object including an elongated dust continuum structure perpendicular to the outflow. Submillimeter Array 230 GHz line and continuum observations of the high mass protostellar object IRAS 18151-1208 along with single dish IRAM 30m observations afford us high spatial resolution (0.8") as well as recovery of the extended emission that gets filtered out by the interferometer. The observations of 12CO confirm the outflow direction to be in the southeast-northwest direction, and the 1.3 mm continuum exhibits an elongation in the direction perpendicular to the outflow. We model the physical parameters of the elongated structure by simultaneously fitting the observed spectral energy distribution (SED) and the brightness profile along the major axis using the 3D Radiative Transfer code MC3D. Assuming a density profile similar to that of a low mass disk, we can also reproduce the observations of this high mass protostellar object. This is achieved by using the same density distribution and flaring parameters as were used in the low mass case, and scaling up the size parameters that successfully modeled the circumstellar disk of several T Tauri stars. We also calculate that a region within the inner 30 AU of such a high mass disk is stable under the Toomre criterion. While we do not rule out other scenarios, we show here that the observations in the high mass regime are consistent with a scaled up version of a low mass disk. Implications on high mass star formation are discussed.Comment: 14 pages, 11 figures, accepted for publication in Ap

d-Methionine protects against cisplatin-induced neurotoxicity in cortical networks

Article discussing D-Methionine protecting against cisplatin-induced neurotoxicity in cortical networks

Rapid evolution in crop-weed hybrids under artificial selection for divergent life histories

When species hybridize, offspring typically exhibit reduced fitness and maladapted phenotypes. This situation has biosafety implications regarding the unintended spread of novel transgenes, and risk assessments of crop-wild hybrids often assume that poorly adapted hybrid progeny will not evolve adaptive phenotypes. We explored the evolutionary potential of early generation hybrids using nontransgenic wild and cultivated radish (Raphanus raphanistrum, Raphanus sativus) as a model system. We imposed four generations of selection for two weedy traits – early flowering or large size – and measured responses in a common garden in Michigan, USA. Under selection for early flowering, hybrids evolved to flower as early as wild lineages, which changed little. These early-flowering hybrids also recovered wild-type pollen fertility, suggesting a genetic correlation that could accelerate the loss of crop traits when a short life cycle is advantageous. Under selection for large size at reproduction, hybrids evolved longer leaves faster than wild lineages, a potentially advantageous phenotype under longer growing seasons. Although early generation hybrid offspring have reduced fitness, our findings provide novel support for rapid adaptation in crop-wild hybrid populations. Biosafety risk assessment programs should consider the possibility of rapid evolution of weedy traits from early generations of seemingly unfit crop-wild hybrids

The effect of Haemophilus influenzae type b and pneumococcal conjugate vaccines on childhood pneumonia incidence, severe morbidity and mortality

Background With the aim of populating the Lives Saved Tool (LiST) with parameters of effectiveness of existing interventions, we conducted a systematic review of the literature assessing the effect of Haemophilus influenzae type b (Hib) and pneumococcal (PC) conjugate vaccines on incidence, severe morbidity and mortality from childhood pneumonia

Resolved 24.5 micron emission from massive young stellar objects

Massive young stellar objects (MYSO) are surrounded by massive dusty envelopes. Our aim is to establish their density structure on scales of ~1000 AU, i.e. a factor 10 increase in angular resolution compared to similar studies performed in the (sub)mm. We have obtained diffraction-limited (0.6") 24.5 micron images of 14 well-known massive star formation regions with Subaru/COMICS. The images reveal the presence of discrete MYSO sources which are resolved on arcsecond scales. For many sources, radiative transfer models are capable of satisfactorily reproducing the observations. They are described by density powerlaw distributions (n(r) ~ r^(-p)) with p = 1.0 +/-0.25. Such distributions are shallower than those found on larger scales probed with single-dish (sub)mm studies. Other sources have density laws that are shallower/steeper than p = 1.0 and there is evidence that these MYSOs are viewed near edge-on or near face-on, respectively. The images also reveal a diffuse component tracing somewhat larger scale structures, particularly visible in the regions S140, AFGL 2136, IRAS 20126+4104, Mon R2, and Cep A. We thus find a flattening of the MYSO envelope density law going from ~10 000 AU down to scales of ~1000 AU. We propose that this may be evidence of rotational support of the envelope (abridged).Comment: 21 pages, accepted for A&

Development and initial testing of a computer-based patient decision aid to promote colorectal cancer screening for primary care practice

BACKGROUND: Although colorectal cancer screening is recommended by major policy-making organizations, rates of screening remain low. Our aim was to develop a patient-directed, computer-based decision aid about colorectal cancer screening and investigate whether it could increase patient interest in screening. METHODS: We used content from evidence-based literature reviews and our previous decision aid research to develop a prototype. We performed two rounds of usability testing with representative patients to revise the content and format. The final decision aid consisted of an introductory segment, four test-specific segments, and information to allow comparison of the tests across several key parameters. We then conducted a before-after uncontrolled trial of 80 patients 50–75 years old recruited from an academic internal medicine practice. RESULTS: Mean viewing time was 19 minutes. The decision aid improved patients' intent to ask providers for screening from a mean score of 2.8 (1 = not at all likely to ask, 4 = very likely to ask) before viewing the decision aid to 3.2 afterwards (difference, 0.4; p < 0.0001, paired t-test). Most found the aid useful and reported that it improved their knowledge about screening. Sixty percent said they were ready to be tested, 18% needed more information, and 22% were not ready to be screened. Within 6 months of viewing, 43% of patients had completed screening tests. CONCLUSION: We conclude that a computer-based decision aid can increase patient intent to be screened and increase interest in screening. Practice Implications: This decision aid can be viewed by patients prior to provider appointments to increase motivation to be screened and to help them decide about which modality to use for screening. Further work is required to integrate the decision aid with other practice change strategies to raise screening rates to target levels

Organic electrode coatings for next-generation neural interfaces

Traditional neuronal interfaces utilize metallic electrodes which in recent years have reached a plateau in terms of the ability to provide safe stimulation at high resolution or rather with high densities of microelectrodes with improved spatial selectivity. To achieve higher resolution it has become clear that reducing the size of electrodes is required to enable higher electrode counts from the implant device. The limitations of interfacing electrodes including low charge injection limits, mechanical mismatch and foreign body response can be addressed through the use of organic electrode coatings which typically provide a softer, more roughened surface to enable both improved charge transfer and lower mechanical mismatch with neural tissue. Coating electrodes with conductive polymers or carbon nanotubes offers a substantial increase in charge transfer area compared to conventional platinum electrodes. These organic conductors provide safe electrical stimulation of tissue while avoiding undesirable chemical reactions and cell damage. However, the mechanical properties of conductive polymers are not ideal, as they are quite brittle. Hydrogel polymers present a versatile coating option for electrodes as they can be chemically modified to provide a soft and conductive scaffold. However, the in vivo chronic inflammatory response of these conductive hydrogels remains unknown. A more recent approach proposes tissue engineering the electrode interface through the use of encapsulated neurons within hydrogel coatings. This approach may provide a method for activating tissue at the cellular scale, however, several technological challenges must be addressed to demonstrate feasibility of this innovative idea. The review focuses on the various organic coatings which have been investigated to improve neural interface electrodes