9,353 research outputs found
Entropic Barriers, Frustration and Order: Basic Ingredients in Protein Folding
We solve a model that takes into account entropic barriers, frustration, and
the organization of a protein-like molecule. For a chain of size , there is
an effective folding transition to an ordered structure. Without frustration,
this state is reached in a time that scales as , with
. This scaling is limited by the amount of frustration which
leads to the dynamical selectivity of proteins: foldable proteins are limited
to monomers; and they are stable in {\it one} range of temperatures,
independent of size and structure. These predictions explain generic properties
of {\it in vivo} proteins.Comment: 4 pages, 4 Figures appended as postscript fil
История музейного дела в Крыму и один из ее современных старателей
Рецензия на монографию Андрея Анатольевича Непомнящего "Музейное дело в Крыму и его старатели (XlX-начало XX века). Библиографическое исследование
Critical points in a relativistic bosonic gas induced by the quantum structure of spacetime
It is well known that phase transitions arise if the interaction among
particles embodies an attractive as well as a repulsive contribution. In this
work it will be shown that the breakdown of Lorentz symmetry, characterized
through a deformation in the relation dispersion, plus the bosonic statistics
predict the emergence of critical points. In other words, in some quantum
gravity models the structure of spacetime implies the emergence of critical
points even when no interaction among the particle has been considered.Comment: 5 pages, no figure
Reply to Comment on "Criterion that Determines the Foldability of Proteins"
We point out that the correlation between folding times and in protein-like heteropolymer models where
and are the collapse and folding transition temperatures
was already established in 1993 before the other presumed equivalent criterion
(folding times correlating with alone) was suggested. We argue that the
folding times for these models show no useful correlation with the energy gap
even if restricted to the ensemble of compact structures as suggested by
Karplus and Shakhnovich (cond-mat/9606037).Comment: 6 pages, Latex, 2 Postscript figures. Plots explicitly showing the
lack of correlation between folding time and energy gap are adde
Influence of turbidity and clouds on satellite total ozone data over Madrid (Spain)
This article focuses on the comparison of the total ozone column data from three satellite instruments; Total Ozone Mapping Spectrometers (TOMS) on board the Earth Probe (EP), Ozone Monitoring Instrument (OMI) on board AURA and Global Ozone Monitoring Experiment (GOME) on board ERS/2, with ground-based measurement recorded by a well calibrated Brewer spectrophotometer located in Madrid during the period 1996–2008. A cluster classification based on solar radiation (global, direct and diffuse), cloudiness and aerosol index allow selecting hazy, cloudy, very cloudy and clear days. Thus, the differences between Brewer and satellite total ozone data for each cluster have been analyzed. The accuracy of EP-TOMS total ozone data is affected by moderate cloudiness, showing a mean absolute bias error (MABE) of 2.0%. In addition, the turbidity also has a significant influence on EP-TOMS total ozone data with a MABE ~1.6%. Those data are in contrast with clear days with MABE ~1.2%. The total ozone data derived from the OMI instrument show clear bias at clear and hazy days with small uncertainties (~0.8%). Finally, the total ozone observations obtained with the GOME instrument show a very smooth dependence with respect to clouds and turbidity, showing a robust retrieval algorithm over these conditions.Manuel Ant´on
thanks Ministerio de Ciencia e Innovaci´on and Fondo Social Europeo
for the award of a postdoctoral grant (Juan de la Cierva). This
work was partially supported by Ministerio de Ciencia e Innovacion
under project CGL2008-05939-C03-02/CLI
Scalable Focused Ion Beam Creation of Nearly Lifetime-Limited Single Quantum Emitters in Diamond Nanostructures
The controlled creation of defect center---nanocavity systems is one of the
outstanding challenges for efficiently interfacing spin quantum memories with
photons for photon-based entanglement operations in a quantum network. Here, we
demonstrate direct, maskless creation of atom-like single silicon-vacancy (SiV)
centers in diamond nanostructures via focused ion beam implantation with nm lateral precision and nm positioning accuracy relative to a
nanocavity. Moreover, we determine the Si+ ion to SiV center conversion yield
to and observe a 10-fold conversion yield increase by additional
electron irradiation. We extract inhomogeneously broadened ensemble emission
linewidths of GHz, and close to lifetime-limited single-emitter
transition linewidths down to MHz corresponding to -times
the natural linewidth. This demonstration of deterministic creation of
optically coherent solid-state single quantum systems is an important step
towards development of scalable quantum optical devices
Finite size effects on thermal denaturation of globular proteins
Finite size effects on the cooperative thermal denaturation of proteins are
considered. A dimensionless measure of cooperativity, Omega, scales as N^zeta,
where N is the number of amino acids. Surprisingly, we find that zeta is
universal with zeta = 1 + gamma, where the exponent gamma characterizes the
divergence of the susceptibility for a self-avoiding walk. Our lattice model
simulations and experimental data are consistent with the theory. Our finding
rationalizes the marginal stability of proteins and substantiates the earlier
predictions that the efficient folding of two-state proteins requires the
folding transition temperature to be close to the collapse temperature.Comment: 3 figures. Physical Review Letters (in press
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