Wills—Testamentary Capacity—Insane Delusions

In re Meagher\u27s Estate apparently establishes a new rule requiring that the contestant of a will on the ground of insane delusions must show that the delusion, exclusive of any rational motive, was the controlling cause in the disposition of the property

Creditor\u27s Rights—Bankruptcy—Section 70(c)—Actual Creditor Required

In Pacific Finance Corp. v. Edwards the United States Court of Appeals for the Ninth Circuit interpreted § 70(c) of the Bankruptcy Act to mean that the trustee acquires the status of a hypothetical lien creditor only if there is an actual creditor who could have acquired a lien on the date of the petition in bankruptcy

Studies of the dynamics of nuclear clustering in human syncytiotrophoblast

Syncytial nuclear aggregates (SNAs), clusters of nuclei in the syncytiotrophoblast of the human placenta, are increased as gestation advances and in pregnancy pathologies. The origins of increased SNAs are unclear; however, a better appreciation of the mechanism may give insight into placental ageing and factors underpinning dysfunction. We developed three models to investigate whether SNA formation results from a dynamic process of nuclear movement and to generate alternative hypotheses. SNA count and size were measured in placental explants cultured over 16 days and particles released into culture medium were quantified. Primary trophoblasts were cultured for 6 days. Explants and trophoblasts were cultured with and without cytoskeletal inhibitors. An in silico model was developed to examine the effects of modulating nuclear behaviour on clustering. In explants, neither median SNA number (108 SNA/mm(2) villous area) nor size (283 μm(2)) changed over time. Subcellular particles from conditioned culture medium showed a wide range of sizes that overlapped with those of SNAs. Nuclei in primary trophoblasts did not change position relative to other nuclei; apparent movement was associated with positional changes of the syncytial cell membrane. In both models, SNAs and nuclear clusters were stable despite pharmacological disruption of cytoskeletal activity. In silico, increased nuclear movement, adhesiveness and sites of cytotrophoblast fusion were related to nuclear clustering. The prominence of SNAs in pregnancy disorders may not result from an active process involving cytoskeleton-mediated rearrangement of syncytial nuclei. Further insights into the mechanism(s) of SNA formation will aid understanding of their increased presence in pregnancy pathologies

Export Production in the Subarctic North Pacific over the Last 800 kyrs: No Evidence for Iron Fertilization?

The subarctic North Pacific is a high nitrate-low chlorophyll (HNLC) region, where phytoplankton growth rates, especially those of diatoms, are enhanced when micronutrient Fe is added. Accordingly, it has been suggested that glacial Fe-laden dust might have increased primary production in this region. This paper reviews published palaeoceanographic records of export production over the last 800 kyrs from the open North Pacific (north of ∼35°N). We find different patterns of export production change over time in the various domains of the North Pacific (NW and NE subarctic gyres, the marginal seas and the transition zone). However, there is no compelling evidence for an overall increase in productivity during glacials in the subarctic region, challenging the paradigm that dust-born Fe fertilization of this region has contributed to the glacial draw down of atmospheric CO 2 . Potential reasons for the lack of increased glacial export production include the possibility that Fe-fertilization rapidly drives the ecosystem towards limitation by another nutrient. This effect would have been exacerbated by an even more stable mixed layer compared to today.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41539/1/10872_2004_Article_5383267.pd

New petrological, geochemical, and geochronological perspectives on andesite-dacite magma genesis at Ruapehu volcano, New Zealand

Time–composition relationships in eruptive sequences at composite volcanoes can show how the ongoing intrusion of magmas progressively affects the lithosphere at continental convergent margins. Here, new whole-rock and microanalytical major and trace element data from andesite-dacite lava flows are integrated with previous studies and existing isotopic data, and placed within the framework of a high-resolution chronostratigraphy for Ruapehu volcano (southern Taupo Volcanic Zone, New Zealand). The geochemical evolution of lavas erupted over the ∼200 kyr lifetime of the exposed edifice reflects variable degrees of fractionation and systematic changes in the type of crustal assimilation in the Ruapehu magma system. Lavas erupted from ∼200–150 ka have previously been distinguished from those erupted <150 ka based on Sr-Nd isotopic characteristics, which indicate that the oldest lavas were sourced from magmas that assimilated oceanic crust. Such source rocks underlie the regionally widespread Mesozoic meta-sedimentary greywacke-argillite basement, which was conversely assimilated by <150 ka magmas. New results from this work reveal that since 150 ka, an upper limit of magma differentiation occurred from ∼50–35 ka. High K2O (∼6 wt%) and Rb contents (∼270 ppm) in melt inclusions, interstitial glass, and glass from in situ quenched melts of partially fused crustal xenoliths are reported for andesite-dacite lavas erupted during this period. In addition to crystal fractionation, selective partial melting and assimilation of K- and Rb-rich mineral phases (e.g., biotite, K-feldspar) that are significant components of the meta-sedimentary basement rocks is inferred to explain these geochemical characteristics. These processes coincided also with the effusion of high-MgO andesitedacite lavas that display petrological evidence for mixing between andesite-dacite and more mafic magmas. An influx of hotter mafic magma into the system explains why the extent of crustal assimilation recorded by Ruapehu lavas peaked during the ∼50–35 ka eruptive period. From 26 ka to the present, andesite lavas have reverted to more mafic compositions with less potassic melt inclusion and whole-rock compositions when compared to the ∼50–35 ka lavas. We suggest that the younger lavas assimilated less-enriched melts because fertile phases had been preferentially extracted from the crustal column during earlier magmatism. This scenario of bottom-up heating of the lithosphere and exhaustion of fertile phases due to the progressive intrusion of magma explains the geochemical evolution of Ruapehu lavas. This model may be applicable to other long-lived composite volcanoes of the circum-Pacific continental arcs

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

Nitrite (NO2−) is an intrinsic signaling molecule that is reduced to NO during ischemia and limits apoptosis and cytotoxicity at reperfusion in the mammalian heart, liver, and brain. Although the mechanism of nitrite-mediated cytoprotection is unknown, NO is a mediator of the ischemic preconditioning cell-survival program. Analogous to the temporally distinct acute and delayed ischemic preconditioning cytoprotective phenotypes, we report that both acute and delayed (24 h before ischemia) exposure to physiological concentrations of nitrite, given both systemically or orally, potently limits cardiac and hepatic reperfusion injury. This cytoprotection is associated with increases in mitochondrial oxidative phosphorylation. Remarkably, isolated mitochondria subjected to 30 min of anoxia followed by reoxygenation were directly protected by nitrite administered both in vitro during anoxia or in vivo 24 h before mitochondrial isolation. Mechanistically, nitrite dose-dependently modifies and inhibits complex I by posttranslational S-nitrosation; this dampens electron transfer and effectively reduces reperfusion reactive oxygen species generation and ameliorates oxidative inactivation of complexes II–IV and aconitase, thus preventing mitochondrial permeability transition pore opening and cytochrome c release. These data suggest that nitrite dynamically modulates mitochondrial resilience to reperfusion injury and may represent an effector of the cell-survival program of ischemic preconditioning and the Mediterranean diet

The spread of marine anoxia on the northern Tethys margin during the Paleocene-Eocene Thermal Maximum

Records of the paleoenvironmental changes that occurred during the Paleocene-Eocene Thermal Maximum (PETM) are preserved in sedimentary rocks along the margins of the former Tethys Ocean and Peri-Tethys. This paper presents new geochemical data that constrain paleoproductivity, sediment delivery, and seawater redox conditions, from three sites that were located in the Peri-Tethys region. Trace and major element, iron speciation, and biomarker data indicate that water column anoxia was established during episodes when inputs of land-derived higher plant organic carbon and highly weathered detrital clays and silts became relatively higher. Anoxic conditions are likely to have been initially caused by two primary processes: (i) oxygen consumption by high rates of marine productivity, initially stimulated by the rapid delivery of terrestrially derived organic matter and nutrients, and (ii) phosphorus regeneration from seafloor sediments. The role of the latter process requires further investigation before its influence on the spread of deoxygenated seawater during the PETM can be properly discerned. Other oxygen-forcing processes, such as temperature/salinity-driven water column stratification and/or methane oxidation, are considered to have been relatively less important in the study region. Organic carbon enrichments occur only during the initial stages of the PETM as defined by the negative carbon isotope excursions at each site. The lack of observed terminal stage organic carbon enrichment does not support a link between PETM climate recovery and the sequestration of excess atmospheric CO2 as organic carbon in this region; such a feedback may, however, have been important in the early stages of the PETM

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE