Interpersonal functioning in obsessive-compulsive personality disorder

The core symptoms of obsessive-compulsive personality disorder (OCPD) often lead to interpersonal difficulties. However, little research has explored interpersonal functioning in OCPD. This study examined interpersonal problems, interpersonal sensitivities, empathy, and systemizing, the drive to analyze and derive underlying rules for systems, in a sample of 25 OCPD individuals, 25 individuals with comorbid OCPD and obsessive-compulsive disorder (OCD), and 25 healthy controls. We found that OCPD individuals reported hostile-dominant interpersonal problems and sensitivities with warm-dominant behavior by others, whereas OCPD+OCD individuals reported submissive interpersonal problems and sensitivities with warm-submissive behavior by others. Individuals with OCPD, with and without OCD, reported less empathic perspective taking relative to healthy controls. Finally, we found that OCPD males reported a higher drive to analyze and derive rules for systems than OCPD females. Overall, results suggest that there are interpersonal deficits associated with OCPD and the clinical implications of these deficits are discussed

Using a bespoke situated digital kiosk to encourage user participation in healthcare environment design

Involving users through participation in healthcare service and environment design is growing. Existing approaches and toolkits for practitioners and researchers are often paper based involving workshops and other more traditional design approaches such as paper prototyping. The advent of digital technology provides the opportunity to explore new platforms for user participation. This paper presents results from three studies that used a bespoke situated user participation digital kiosk, engaging 33 users in investigating healthcare environment design. The studies, from primary and secondary care settings, allowed participant feedback on each environment and proved a novel, engaging “21st century” way to participate in the appraisal of the design process. The results point toward this as an exciting and growing area of research in developing not just a new method of user participation but also the technology that supports it. Limitations were noted in terms of data validity and engagement with the device. To guide the development of user participation using similar situated digital devices, key lessons and reflections are presented

Fluctuating Hall resistance defeats the quantized Hall insulator

Using the Chalker-Coddington network model as a drastically simplified, but universal model of integer quantum Hall physics, we investigate the plateau-to-insulator transition at strong magnetic field by means of a real-space renormalization approach. Our results suggest that for a fully quantum coherent situation, the quantized Hall insulator with R_H approx. h/e^2 is observed up to R_L ~25 h/e^2 when studying the most probable value of the distribution function P(R_H). Upon further increasing R_L ->\infty the Hall insulator with diverging Hall resistance R_H \propto R_L^kappa is seen. The crossover between these two regimes depends on the precise nature of the averaging procedure.Comment: major revision, discussion of averaging improved; 8 pages, 7 figures; accepted for publication in EP

Quantitative Nanofriction Characterization of Corrugated Surfaces by Atomic Force Microscopy

Atomic Force Microscopy (AFM) is a suitable tool to perform tribological characterization of materials down to the nanometer scale. An important aspect in nanofriction measurements of corrugated samples is the local tilt of the surface, which affects the lateral force maps acquired with the AFM. This is one of the most important problems of state-of-the-art nanotribology, making difficult a reliable and quantitative characterization of real corrugated surfaces. A correction of topographic spurious contributions to lateral force maps is thus needed for corrugated samples. In this paper we present a general approach to the topographic correction of AFM lateral force maps and we apply it in the case of multi-asperity adhesive contact. We describe a complete protocol for the quantitative characterization of the frictional properties of corrugated systems in the presence of surface adhesion using the AFM.Comment: 33 pages, 9 figures, RevTex 4, submitted to Journal of Applied Physic

Measuring the Stellar Masses of z~7 Galaxies with Spitzer Ultrafaint Survey Program (SURFS UP)

We present Spitzer/IRAC observations of nine $z'$-band dropouts highly magnified (2<mu<12) by the Bullet Cluster. We combine archival imaging with our Exploratory program (SURFS UP), which results in a total integration time of ~30 hr per IRAC band. We detect (>3sigma) in both IRAC bands the brightest of these high-redshift galaxies, with [3.6]=23.80+-0.28 mag, [4.5]=23.78+-0.25 mag, and (H-[3.6])=1.17+-0.32 mag. The remaining eight galaxies are undetected to [3.6]~26.4 mag and [4.5]~26.0 mag with stellar masses of ~5x10^7 M_sol. The detected galaxy has an estimated magnification of mu=12+-4, which implies this galaxy has an ultraviolet luminosity of L_1500~0.3 L*_{z=7} --- the lowest luminosity individual source detected in IRAC at z>7. By modeling the broadband photometry, we estimate the galaxy has an intrinsic star-formation rate of SFR~1.3 M_sol/yr and stellar mass of M~2x10^9 M_sol, which gives a specific star-formation rate of sSFR~0.7 Gyr^-1. If this galaxy had sustained this star-formation rate since z~20, it could have formed the observed stellar mass (to within a factor of ~2), we also discuss alternate star-formation histories and argue the exponentially-increasing model is unlikely. Finally, based on the intrinsic star-formation rate, we estimate this galaxy has a likely [C II] flux of = 10^{-17} erg/s/cm2.Comment: Accepted to ApJL. 6 pages, 3 figures, 2 table

“That Cross-Curricular Business”: The Engineering Design Process in Mathematics and Science Classrooms

The engineering design process (EDP) is one tool teachers can use to facilitate STEM integration. As part of a larger three-year longitudinal research project regarding engineering identity development among middle school youth in a summer robotics outreach program, this study aims to understand teachers’ willingness to incorporate engineering design in their classrooms through an exploration of their perceptions of the EDP, its applications to their subject matter and classroom context, methods of enacting the EDP, and perceived challenges to and supports for doing so. We conducted a qualitative case study and drew our results from focus groups and semi-structured interviews with eight teacher participants. Participants were successful in describing the EDP and its cyclical nature. However, classroom enactment of the EDP was predominantly indirect and often used to solve non-subject-specific classroom problems. Direct enactment was limited to projects already part of the existing curriculum. Issues with instructional resources, lesson planning, time, and student background were the EDP enactment barriers most frequently noted, while supports described were all responses to the identified barriers. The EDP offers a promising way to integrate engineering with math and science. However, additional support is needed for more meaningful classroom enactment of the EDP

Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific

Heterotetrameric glutamate receptors are essential for the development, function, and plasticity of spine synapses but how they are organized to achieve this is not known. Here we show that the nanoscale organization of glutamate receptors containing specific subunits define distinct subsynaptic features. Glutamate receptors containing GluA2 or GluN1 subunits establish nanomodular elements precisely positioned relative to Synaptotagmin-1 positive presynaptic release sites that scale with spine size. Glutamate receptors containing GluA1 or GluN2B specify features that exhibit flexibility: GluA1-subunit containing AMPARs are found in larger spines, while GluN2B-subunit containing NMDARs are enriched in the smallest spines with neither following a strict modular organization. Given that the precise positioning of distinct classes of glutamate receptors is linked to diverse events including cell death and synaptic plasticity, this unexpectedly robust synaptic nanoarchitecture provides a resilient system, where nanopositioned glutamate receptor heterotetramers define specific subsynaptic regions of individual spine synapses

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand

We have constructed an artificial ligand for the hepatocyte-specific asialoglycoprotein receptor for the purpose of generating a synthetic delivery system for DNA. This ligand has a tetra-antennary structure, containing four terminal galactose residues on a branched carrier peptide. The carbohydrate residues of this glycopeptide were introduced by reductive coupling of lactose to the alpha- and epsilon-amino groups of the two N-terminal lysines on the carrier peptide. The C-terminus of the peptide, containing a cysteine separated from the branched N-terminus by a 10 amino acid spacer sequence, was used for conjugation to 3-(2-pyridyldithio)propionate-modified polylysine via disulfide bond formation. Complexes containing plasmid DNA bound to these galactose-polylysine conjugates have been used for asialoglycoprotein receptor-mediated transfer of a luciferase gene into human (HepG2) and murine (BNL CL.2) hepatocyte cell lines. Gene transfer was strongly promoted when amphipathic peptides with pH-controlled membrane-disruption activity, derived from the N-terminal sequence of influenza virus hemagglutinin HA-2, were also present in these DNA complexes. Thus, we have essentially borrowed the small functional domains of two large proteins, asialoglycoprotein and hemagglutinin, and assembled them into a supramolecular complex to generate an efficient gene-transfer system