8 research outputs found
Spatial attention modulates auditory dominance in audiovisual order judgment
Auditory dominance in audiovisual temporal order judgment is shown here to be modulated by exogenous orienting of attention to a spatial cue independent of the cue modality. The visual stimulus has to lead the auditory one further in advance for cued relative to uncued locations in order for the two to be perceived simultaneously, possibly suggesting an inhibitory function of spatial attention on temporal processing
The two‐ to three‐second time window of shot durations in movies
Movie shots of singular scenes have a preferential duration of 2 to 3 s regardless of producers, movie types, and cultural environments. This observation suggests that the temporal structure of movies matches a neural mechanism of information processing in the time domain
Prevalence and genetic characterization of Cryptosporidium in yaks in Qinghai Province of China.
The objective of this study was to determine the prevalence, species and subtypes of Cryptosporidium infecting yaks in the Qinghai Province of Northwestern China. The prevalence of Cryptosporidium spp. was detected by microscopy and nested-PCR. A total of 586 fecal samples were collected from yaks in 6 counties, of which 142 (24.2%) samples tested positive for Cryptosporidium. The small subunit (SSU) rRNA gene of fifty-five samples were amplified and sequenced successfully and demonstrated that Cryptosporidium bovis (31/55, 56.4%) was the most common species, followed by C. parvum (16/55, 29.1%) and C. ryanae (5/55, 9.0%). Mixed infections of C. parvum and C. bovis (n = 2), C. ryanae and C. bovis (n = 1) were also detected. All three species were found in yaks ranging in age from 2 years. Cryptosporidium was most commonly detected in spring (28.4%), followed by summer (20.9%), then winter (17.5%). Cryptosporidium parvum positive samples were subtyped using the 60 kDa glycoprotein (gp60) gene. Subtypes IIaA15G2R1 (n = 8), IIaA16G2R1 (n = 2), IIaA14G1R1 (n = 1), IIaA14G2R1 (n = 1) and IIaA16G3R1 (n = 1) were detected. All of these subtypes are zoonotic, and may pose a potential threat to human health
Prevalence and molecular characterization of Cryptosporidium spp. in different seasons.
<p>ND, not determined species.</p
Mesenchymal Stem Cell Derived Exosomes Repair Uterine Injury by Targeting Transforming Growth Factor‑β Signaling
Intrauterine
adhesions (IUA) refer to adhesions within the uterine
cavity and cervix caused by injuries from uterine surgery. They are
a significant cause of female infertility. Exosomes derived from mesenchymal
stem cells (MSCs) play an active role in the treatment of IUA. However,
the mechanism by which they reduce fibrosis in the damaged endometrium
remains unclear. In this paper, we demonstrate that exosomes derived
from placental mesenchymal stem cells (PMSCs) can restore uterine
functions and improve the fertility rate of injured animals. This
is achieved by promoting cell proliferation, increasing endometrial
thickness, and reversing fibrosis. Regarding the molecular mechanism
behind these therapeutic effects, we identify three specific miRNAs,
namely, miR-125b-5p, miR-30c-5p, and miR-23a-3p, enriched in PMSC-exosomes,
as the key players in the treatment of IUA. Specifically, miR-125b-5p/miR-30c-5p
and miR-23a-3p inhibit the expression of smad2 and smad3 by targeting
their 3′-untranslated regions, resulting in the downregulation
of the transforming growth factor-β (TGF-β)/smad signaling
pathway and the reversal of fibrosis. Notably, the safety of PMSC-exosomes
in intrauterine treatment was also been confirmed. In conclusion,
we illustrate that exosomes derived from PMSCs possess the capability
to repair endometrial damage and enhance fertility in injured animals
by regulating the TGF-β/smad pathway via miR-125b-5p, miR-30c-5p,
and miR-23a-3p. This provides insights into the precision treatment
of IUA through exosome-based cell-free therapy
Prevalence and molecular characterization of Cryptosporidium spp. in different host age groups.
<p>ND, not determined species.</p
Prevalence and molecular characterization of Cryptosporidium spp. in different counties.
<p>ND, not determined species.</p