Towards a Philosophical Anthropology of Culture

This book explores the question of what it means to be a human being through sustained and original analyses of three important philosophical topics: relativism, skepticism, and naturalism in the social sciences. Kevin Cahill’s approach involves an original employment of historical and ethnographic material that is both conceptual and empirical in order to address relevant philosophical issues. Specifically, while Cahill avoids interpretative debates, he develops an approach to philosophical critique based on Cora Diamond’s and James Conant’s work on the early Wittgenstein. This makes possible the use of a concept of culture that avoids the dogmatism that not only typifies traditional metaphysics but also frequently mars arguments from ordinary language or phenomenology. This is especially crucial for the third part of the book, which involves a cultural-historical critique of the ontology of the self in Stanley Cavell’s work on skepticism. In pursuing this strategy, the book also mounts a novel and timely defense of the interpretivist tradition in the philosophy of the social sciences. Towards a Philosophical Anthropology of Culture will be of interest to researchers working on the philosophy of the social sciences, Wittgenstein, and philosophical anthropology

Towards a Philosophical Anthropology of Culture

This book explores the question of what it means to be a human being through sustained and original analyses of three important philosophical topics: relativism, skepticism, and naturalism in the social sciences. Kevin Cahill’s approach involves an original employment of historical and ethnographic material that is both conceptual and empirical in order to address relevant philosophical issues. Specifically, while Cahill avoids interpretative debates, he develops an approach to philosophical critique based on Cora Diamond’s and James Conant’s work on the early Wittgenstein. This makes possible the use of a concept of culture that avoids the dogmatism that not only typifies traditional metaphysics but also frequently mars arguments from ordinary language or phenomenology. This is especially crucial for the third part of the book, which involves a cultural-historical critique of the ontology of the self in Stanley Cavell’s work on skepticism. In pursuing this strategy, the book also mounts a novel and timely defense of the interpretivist tradition in the philosophy of the social sciences. Towards a Philosophical Anthropology of Culture will be of interest to researchers working on the philosophy of the social sciences, Wittgenstein, and philosophical anthropology

2008 Commencement Address: Kevin M. Cahill, M.D.

Kevin M. Cahill, M.D., a driving force in humanitarian assistance and relief efforts across the globe for more than 45 years and a leading specialist in tropical medicine, will receive an honorary degree from the College of the Holy Cross and address this year’s graduates during the College’s Commencement ceremonies on Friday, May 23 at 10:30 a.m. on the campus. Physician, teacher, activist, diplomat, and advocate, Cahill is the director of the Institute of International Humanitarian Affairs, president of the Center for International Health and Cooperation and a University Professor at Fordham University. He serves as the director of the Tropical Disease Center at Lenox Hill Hospital, and has done extensive research and aid work in Africa, Latin America, and the Near and Far East. He is professor of International Humanitarian Affairs at the Royal College of Surgeons in Ireland, senior consultant to the United Nations Health Service, and president-general of the American-Irish Historical Society. Cahill received degrees from Fordham University, Cornell University School of Medicine, The Royal College of Surgeons in England and The London School of Hygiene and Tropical Medicine. Upon completing his medical degree in 1961, Cahill was awarded a grant to work in Calcutta where he worked with Mother Teresa. He served as director of Clinical Tropical Medicine in Egypt and Sudan while in the U.S. Navy, and continued active medical research for the next forty years in Africa, Latin America, the Near and Far East, with long-term programs in Somalia, Sudan, India and Nicaragua. He has written or edited 29 books and more than 200 articles on subjects including tropical disease, the global land mine crisis, and health and foreign policy.https://crossworks.holycross.edu/commence_address/1008/thumbnail.jp

Molecular Electroporation and the Transduction of Oligoarginines

Certain short polycations, such as TAT and polyarginine, rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction as well as by endocytosis and macropinocytosis. These cell-penetrating peptides (CPPs) promise to be medically useful when fused to biologically active peptides. I offer a simple model in which one or more CPPs and the phosphatidylserines of the inner leaflet form a kind of capacitor with a voltage in excess of 180 mV, high enough to create a molecular electropore. The model is consistent with an empirical upper limit on the cargo peptide of 40--60 amino acids and with experimental data on how the transduction of a polyarginine-fluorophore into mouse C2C12 myoblasts depends on the number of arginines in the CPP and on the CPP concentration. The model makes three testable predictions.Comment: 15 pages, 5 figure

Evaluating the Use of Daily Care Notes Software for Older People with Dementia

There has been little research to investigate the impact of software to support the care for older people with dementia care. This article reports the evaluation of software adapted to support one key person-centered task for the care of older residents with dementia – recording and sharing daily care notes. The evaluation on the dementia wing of 1 residential home for over 6 months revealed that use of the software on mobile devices carried by the carers increased the number and volume of daily care notes recorded, but only for the types of content that were already being recorded by carers. Carers reported more advantages that resulted from daily care notes once in digital form than from the documenting task, as well as barriers to the use of mobile digital software to record daily care notes

Riemannian Gauge Theory and Charge Quantization

In a traditional gauge theory, the matter fields \phi^a and the gauge fields A^c_\mu are fundamental objects of the theory. The traditional gauge field is similar to the connection coefficient in the Riemannian geometry covariant derivative, and the field-strength tensor is similar to the curvature tensor. In contrast, the connection in Riemannian geometry is derived from the metric or an embedding space. Guided by the physical principal of increasing symmetry among the four forces, we propose a different construction. Instead of defining the transformation properties of a fundamental gauge field, we derive the gauge theory from an embedding of a gauge fiber F=R^n or F=C^n into a trivial, embedding vector bundle F=R^N or F=C^N where N>n. Our new action is symmetric between the gauge theory and the Riemannian geometry. By expressing gauge-covariant fields in terms of the orthonormal gauge basis vectors, we recover a traditional, SO(n) or U(n) gauge theory. In contrast, the new theory has all matter fields on a particular fiber couple with the same coupling constant. Even the matter fields on a C^1 fiber, which have a U(1) symmetry group, couple with the same charge of +/- q. The physical origin of this unique coupling constant is a generalization of the general relativity equivalence principle. Because our action is independent of the choice of basis, its natural invariance group is GL(n,R) or GL(n,C). Last, the new action also requires a small correction to the general-relativity action proportional to the square of the curvature tensor.Comment: Improved the explanations, added references, added 3 figures and an appendix, corrected a sign error in the old figure 4 (now figure 5). Now 33 pages, 7 figures and 2 tables. E-mail Serna for annimation

The EGS Grading Scale For Skin And Soft Tissue Infections Is Predictive Of Poor Outcomes : A Multicenter Validation Study

Introduction: Over the last five years, the American Association for the Surgery of Trauma (AAST) has developed grading scales for Emergency General Surgery (EGS) diseases. In a prior validation study using diverticulitis, the grading scales were predictive of complications and length of stay. As EGS encompasses diverse diseases, the purpose of this study was to validate the grading scale concept against a different disease process with a higher associated mortality. We hypothesized that the grading scale would be predictive of complications, length of stay and mortality in skin and soft tissue infections (STI). Methods: This multi-institutional trial encompassed 12 centers. Data collected included demographic variables, disease characteristics and outcomes such as mortality, overall complications, hospital and ICU length of stay. The EGS scale for STI was used to grade each infection and two surgeons graded each case to evaluate inter-rater reliability. Results: 1170 patients were included in this study. Inter-rater reliability was moderate (kappa coefficient 0.472-0.642, with 64-76% agreement). Higher grades (IV and V) corresponded to significantly higher LRINEC scores when compared with lower EGS grades. Patients with grade IV and V STI had significantly increased odds of all complications, as well as ICU and overall length of stay. These associations remained significant in logistic regression controlling for age, gender, comorbidities, mental status and hospital-level volume. Grade V disease was significantly associated with mortality as well. Conclusion: This validation effort demonstrates that Grade IV and V STI are significantly predictive of complications, hospital length of stay and mortality. Though predictive ability does not improve linearly with STI grade, this is consistent with the clinical disease process, in which lower grades represent cellulitis and abscess and higher grades are invasive infections. This second validation study confirms the EGS grading scale as predictive, and easily used, in disparate disease processes

Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition

Synthesis and biological evaluation of a series of novel indole derivatives as anticancer agents is described. A bisindolylmaleimide template has been derived as a versatile pharmacophore with which to pursue chemical diversification. Starting from maleimide, the introduction of an oxygen to the headgroup (hydroxymaleimide) was initially investigated and the bioactivity assessed by screening of kinase inhibitory activity, identifying substituent derived selectivity. Extension of the hydroxymaleimide template to incorporate substitution of the indole nitrogens was next completed and assessed again by kinase inhibition identifying unique selectivity patterns with respect to GSK-3 and CDK kinases. Subsequently, the anticancer activity of bisindolylmaleimides were assessed using the NCI-60 cell screen, disclosing the discovery of growth inhibitory profiles towards a number of cell lines, such as SNB-75 CNS cancer, A498 and UO-31 renal, MDA MB435 melanoma and a panel of leukemia cell lines. The potential for selective kinase inhibition by modulation of this template is evident and will inform future selective clinical candidates

Salt marsh ecosystem restructuring enhances elevation resilience and carbon storage during accelerating relative sea-level rise

Salt marshes respond to sea-level rise through a series of complex and dynamic bio-physical feedbacks. In this study, we found that sea-level rise triggered salt marsh habitat restructuring, with the associated vegetation changes enhancing salt marsh elevation resilience. A continuous record of marsh elevation relative to sea level that includes reconstruction of high-resolution, sub-decadal, marsh elevation over the past century, coupled with a lower-resolution 1500-year record, revealed that relative sea-level rose 1.5 ± 0.4 m, following local glacial isostatic adjustment (1.2 mm/yr). As sea-level rise has rapidly accelerated, the high marsh zone dropped 11 cm within the tidal frame since 1932, leading to greater inundation and a shift to flood- and salt-tolerant low marsh species. Once the marsh platform fell to the elevation favored by low-marsh Spartina alterniflora, the elevation stabilized relative to sea level. Currently low marsh accretion keeps pace with sea-level rise, while present day high marsh zones that have not transitioned to low marsh have a vertical accretion deficit. Greater biomass productivity, and an expanding subsurface accommodation space favorable for salt marsh organic matter preservation, provide a positive feed-back between sea-level rise and marsh platform elevation. Carbon storage was 46 ± 28 g C/m2/yr from 550 to 1800 CE, increasing to 129 ± 50 g C/m2/yr in the last decade. Enhanced carbon storage is controlled by vertical accretion rates, rather than soil carbon density, and is a direct response to anthropogenic eustatic sea-level rise, ultimately providing a negative feedback on climate warming