158 research outputs found
Morpho-radiological and brain endocast analysis in the study of Hyperostosis Frontalis Interna (HFI): A combined approach
The purpose of this study is to anatomically evaluate the impact on the patient intra vitam of an endocranial condition on a late 20th century skull housed in the Section of Legal Medicine of the University of Foggia (Foggia, Apulia, Italy). After performing a retrospective diagnosis, the condition is framed in the broader context of studies on this pathology. An anthropological and radiological analysis (X-ray and CT scan imaging) made it possible to confirm the preliminary information and to detail the osteological diagnosis of HFI. In order to assess the impact on the cerebral surface of the endocranial growth a 3D endocast was obtained using the Software OrtogOnBlender. The skull is demonstrated to have belonged to a female senile individual known, from limited documentary evidence, to have suffered from a psychiatric condition during her life. The final diagnosis is hyperostosis frontalis interna (HFI), Type D. Although a direct correlation between the demonstrated intracranial bony growth and the onset of the patientâs psychiatric condition is difficult to retrospectively ascertain, the pressure exerted on this female individualâs frontal lobe may have contributed to further degenerative behavioural changes in the last years of her life. This case adds to previous knowledge, especially from the palaeopathological literature, on this condition and, for the first time, presents a neuroanatomical approach to assess the global impact of the disease
Incompressible flow in porous media with fractional diffusion
In this paper we study the heat transfer with a general fractional diffusion
term of an incompressible fluid in a porous medium governed by Darcy's law. We
show formation of singularities with infinite energy and for finite energy we
obtain existence and uniqueness results of strong solutions for the
sub-critical and critical cases. We prove global existence of weak solutions
for different cases. Moreover, we obtain the decay of the solution in ,
for any , and the asymptotic behavior is shown. Finally, we prove the
existence of an attractor in a weak sense and, for the sub-critical dissipative
case with , we obtain the existence of the global attractor
for the solutions in the space for any
Framing automatic grading techniques for open-ended questionnaires responses. A short survey
The assessment of students' performances is one of the essential components of teaching activities, and it poses different challenges to teachers and instructors, especially when considering the grading of responses to open-ended questions (i.e., short-answers or essays). Open-ended tasks allow a more in-depth assessment of students' learning levels, but their evaluation and grading are time-consuming and prone to subjective bias. For these reasons, automatic grading techniques have been studied for a long time, focusing mainly on short-answers rather than long essays. Given the growing popularity of Massive Online Open Courses and the shifting from physical to virtual classrooms environments due to the Covid-19 pandemic, the adoption of questionnaires for evaluating learning performances has rapidly increased. Hence, it is of particular interest to analyze the recent effort of researchers in the development of techniques designed to grade students' responses to open-ended questions. In our work, we consider a systematic literature review focusing on automatic grading of open-ended written assignments. The study encompasses 488 articles published from 1984 to 2021 and aims at understanding the research trends and the techniques to tackle essay automatic grading. Lastly, inferences and recommendations are given for future works in the Learning Analytics field
Development and validation of low-intensity pulsed ultrasound systems for highly controlled in vitro cell stimulation
This work aims to describe the development and validation of two low-intensity pulsed ultrasound stimulation systems able to control the dose delivered to the biological target. Transducer characterization was performed in terms of pressure field shape and intensity, for a high-frequency range (500 kHz to 5 MHz) and for a low-frequency value (38 kHz). This allowed defining the distance, on the beam axis, at which biological samples should be placed during stimulation and to exactly know the intensity at the target. Carefully designed retaining systems were developed, for hosting biological samples. Sealing tests proved their impermeability to external contaminants. The assembly/de-assembly time of the systems resulted ~3 min. Time-domain acoustic simulations allowed to precisely estimate the ultrasound beam within the biological sample chamber, thus enabling the possibility to precisely control the pressure to be transmitted to the biological target, by modulating the transducer's input voltage. Biological in vitro tests were also carried out, demonstrating the sterility of the system and the absence of toxic and inflammatory effects on growing cells after multiple immersions in water, over seven days
Development and validation of low-intensity pulsed ultrasound systems for highly controlled in vitro cell stimulation
This work aims to describe the development and validation of two low-intensity pulsed ultrasound stimulation
systems able to control the dose delivered to the biological target. Transducer characterization was performed in
terms of pressure field shape and intensity, for a high-frequency range (500 kHz to 5 MHz) and for a low-
frequency value (38 kHz). This allowed defining the distance, on the beam axis, at which biological samples
should be placed during stimulation and to exactly know the intensity at the target. Carefully designed retaining
systems were developed, for hosting biological samples. Sealing tests proved their impermeability to external
contaminants. The assembly/de-assembly time of the systems resulted ~3 min. Time-domain acoustic simula-
tions allowed to precisely estimate the ultrasound beam within the biological sample chamber, thus enabling the
possibility to precisely control the pressure to be transmitted to the biological target, by modulating the trans-
ducerâs input voltage. Biological in vitro tests were also carried out, demonstrating the sterility of the system and
the absence of toxic and inflammatory effects on growing cells after multiple immersions in water, over seven
day
The effect of massage on localized lumbar muscle fatigue
BACKGROUND: There is not enough evidence to support the efficacy of massage for muscle fatigue despite wide utilization of the modality in various clinical settings. This study investigated the influence of massage application on localized back muscle fatigue. METHODS: Twenty-nine healthy subjects participated in two experimental sessions (massage and rest conditions). On each test day, subjects were asked to lie in the prone position on a treatment table and perform sustained back extension for 90 seconds. Subjects then either received massage on the lumbar region or rested for a 5 minute duration, then repeated the back extension movement. The median frequency (MDF), mean power frequency (MNF), and root mean square (RMS) amplitude of electromyographic signals during the 90 second sustained lumbar muscle contraction were analyzed. The subjective feeling of fatigue was then evaluated using the Visual Analogue Scale (VAS). RESULTS: MDF and MNF significantly declined with time under all conditions. There was no significant difference in MDF, MNF or RMS value change between before and after massage, or between rest and massage conditions. There was a significant increase in fatigue VAS at the end of the 2(nd) back extension with rest condition. There was a significant difference in fatigue VAS change between massage and rest condition. CONCLUSIONS: A significant difference was observed between massage and rest condition on VAS for muscle fatigue. On EMG analysis, there were no significant differences to conclude that massage stimulation influenced the myoelectrical muscle fatigue, which is associated with metabolic and electrical changes
Decay of weak solutions to the 2D dissipative quasi-geostrophic equation
We address the decay of the norm of weak solutions to the 2D dissipative
quasi-geostrophic equation. When the initial data is in only, we prove
that the norm tends to zero but with no uniform rate, that is, there are
solutions with arbitrarily slow decay. For the initial data in ,
with , we are able to obtain a uniform decay rate in . We
also prove that when the norm of the initial data
is small enough, the norms, for have uniform
decay rates. This result allows us to prove decay for the norms, for , when the initial data is in .Comment: A paragraph describing work by Carrillo and Ferreira proving results
directly related to the ones in this paper is added in the Introduction. Rest
of the article remains unchange
Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation in Vitro, in Both a Normal and Inflammatory Milieu
The use of piezoelectric nanomaterials combined with ultrasound stimulation is emerging as a promising approach for wirelessly triggering the regeneration of different tissue types. However, it has never been explored for boosting chondrogenesis. Furthermore, the ultrasound stimulation parameters used are often not adequately controlled. In this study, we show that adipose-tissue-derived mesenchymal stromal cells embedded in a nanocomposite hydrogel containing piezoelectric barium titanate nanoparticles and graphene oxide nanoflakes and stimulated with ultrasound waves with precisely controlled parameters (1 MHz and 250 mW/cm2, for 5 min once every 2 days for 10 days) dramatically boost chondrogenic cell commitment in vitro. Moreover, fibrotic and catabolic factors are strongly down-modulated: proteomic analyses reveal that such stimulation influences biological processes involved in cytoskeleton and extracellular matrix organization, collagen fibril organization, and metabolic processes. The optimal stimulation regimen also has a considerable anti-inflammatory effect and keeps its ability to boost chondrogenesis in vitro, even in an inflammatory milieu. An analytical model to predict the voltage generated by piezoelectric nanoparticles invested by ultrasound waves is proposed, together with a computational tool that takes into consideration nanoparticle clustering within the cell vacuoles and predicts the electric field streamline distribution in the cell cytoplasm. The proposed nanocomposite hydrogel shows good injectability and adhesion to the cartilage tissue ex vivo, as well as excellent biocompatibility in vivo, according to ISO 10993. Future perspectives will involve preclinical testing of this paradigm for cartilage regeneration
Impaired Growth and Force Production in Skeletal Muscles of Young Partially Pancreatectomized Rats: A Model of Adolescent Type 1 Diabetic Myopathy?
This present study investigated the temporal effects of type 1 diabetes mellitus (T1DM) on adolescent skeletal muscle growth, morphology and contractile properties using a 90% partial pancreatecomy (Px) model of the disease. Four week-old male Sprague-Dawley rats were randomly assigned to Px (nâ=â25) or Sham (nâ=â24) surgery groups and euthanized at 4 or 8 weeks following an in situ assessment of muscle force production. Compared to Shams, Px were hyperglycemic (>15 mM) and displayed attenuated body mass gains by days 2 and 4, respectively (both P<0.05). Absolute maximal force production of the gastrocnemius plantaris soleus complex (GPS) was 30% and 50% lower in Px vs. Shams at 4 and 8 weeks, respectively (P<0.01). GP mass was 35% lower in Px vs Shams at 4 weeks (1.24±0.06 g vs. 1.93±0.03 g, P<0.05) and 45% lower at 8 weeks (1.57±0.12 vs. 2.80±0.06, P<0.05). GP fiber area was 15â20% lower in Px vs. Shams at 4 weeks in all fiber types. At 8 weeks, GP type I and II fiber areas were âŒ25% and 40% less, respectively, in Px vs. Shams (group by fiber type interactions, P<0.05). Phosphorylation states of 4E-BP1 and S6K1 following leucine gavage increased 2.0- and 3.5-fold, respectively, in Shams but not in Px. Px rats also had impaired rates of muscle protein synthesis in the basal state and in response to gavage. Taken together, these data indicate that exposure of growing skeletal muscle to uncontrolled T1DM significantly impairs muscle growth and function largely as a result of impaired protein synthesis in type II fibers
The dramatic COVID-19 outbreak in italy is responsible of a huge drop in urological surgical activity: A multicenter observational study
OBJECTIVE: Italy is facing the COVID-19 outbreak with an abrupt reorganization of its national health-system, in order to augment care provision to symptomatic patients. The sudden shift of personnel and resources towards COVID-19 care has led to the reduction of surgery, with possible severe drawbacks. The aim of the study is to describe the trend in surgical volume in urology, in Italy. MATERIALS AND METHODS: Thirty-three urological units with physicians affiliated to the AGILE consortium were involved in a survey. Urologists were asked to report the amount of surgical elective procedures week-by-week, from the beginning of the emergency to the following month. RESULTS: The 33 hospitals involved in the study account, globally, for 22,945 beds and are distributed in 13/20 Italian regions. Before the outbreak, the involved urology units performed an overall amount of 1,213 procedures per week, half of which were oncological. One month later, the amount of surgery declined by 78%. Lombardy, the first region with positive-cases, experienced a 94% reduction. The decrease in oncological and non-oncological surgical activity was 35,9% and 89%, respectively. The trend of the decline showed a delay of roughly 2 weeks for the other regions. CONCLUSION: Italy, the country with the highest fatality rate from COVID-19, is experiencing a sudden decline in surgical activity. It is inversely related to the increase in COVID-19 care, with potential harm particularly in the oncological field. The Italian experience can be helpful for future surgical pre-planning in other countries not so hardly hit by the disease yet
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