Acerca del antirrepresentacionalismo de Richard Rorty

La presente comunicación, de carácter descriptivo, da cuenta de algunos de los aspectos principales que articulan el llamado antirrepresentacionalismo que fuera defendido por el filósofo pragmatista Richard Rorty. Además, contiene una explicación sucinta del modo en que la noción rortiana de etnocentrismo opera como enlace entre el antirrepresentacionalismo y el liberalismo para, finalmente, proponer a la filosofía como una forma de conversación y práctica social

ALEXY: LAS PROPIEDADES ESENCIALES Y CONTINGENTES DEL DERECHO

In this brief communication we describe the main approaches of Robert Alexy regarding the conditions of possibility of his argumentative model, in the light of the way in which, in his opinion, principles and values can be considered essential constitutive elements of the law.En esta breve comunicación se describen los principales planteamientos de Robert Alexy referidos a las condiciones de posibilidad de su modelo argumentativo, a la luz del modo en que, en su opinión, principios y valores pueden ser considerados elementos constitutivos esenciales del derecho

The impact of prescription pain reliever misuse and heroin use on morbidity and mortality by level of urbanicity: 2002-2014

Non-medical use of prescription pain relievers (PPRs), heroin, and more recently fentanyl, continue to have major public health consequences in the United States. This article analyzes trends in PPR and heroin use, emergency department and hospital stays, substance use treatment services, and mortality to assess the relative impact of the opioid crisis on rural versus more urbanized counties in the United States. Our findings suggest that while more urbanized counties have had greater increases in opioid use, rural and less urbanized counties tended to be more negatively impacted than larger and non-rural counties. Disparities in service availability highlight the need for a serious discussion on how resources are allocated in counties that have lower tax bases. Based on these results, we conclude that rural and less urbanized counties can benefit from real increases in resources for substance use prevention and treatment services, including the expansion of prescribers trained to screen and treat opioid use. Understanding the unique challenges of rural and less urbanized counties may help decrease the disparity in consequences found in this study

The seaweed industry of the Philippines

The paper presents the status of commercial useful seaweeds in the Philippines. Likewise, the common uses of seaweeds are also presented

Triquiñueles : diálogos, artículos y poesías en bable, inspiradas todas en diversos asuntos reales desarrollados en Oviedo, Gijón, Infiesto, Llanes, Luanco, Candás, etcétera etcétera

Copia digital : Biblioteca de Asturias "Ramón Pérez de Ayala" : Biblioteca Pública Estatal de Oviedo, 201

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry : a meta-analysis

Background Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve treatment options. We did a meta-analysis of genome-wide association studies (GWASs) to identify potential molecular targets. Methods In the discovery stage, we combined three GWAS datasets (EU-RLS GENE, INTERVAL, and 23andMe) with diagnosis data collected from 2003 to 2017, in face-to-face interviews or via questionnaires, and involving 15126 cases and 95 725 controls of European ancestry. We identified common variants by fixed-effect inverse-variance meta-analysis. Significant genome-wide signals (p Findings We identified and replicated 13 new risk loci for restless legs syndrome and confirmed the previously identified six risk loci. MEIS1 was confirmed as the strongest genetic risk factor for restless legs syndrome (odds ratio 1.92, 95% CI 1 85-1.99). Gene prioritisation, enrichment, and genetic correlation analyses showed that identified pathways were related to neurodevelopment and highlighted genes linked to axon guidance (associated with SEMA6D), synapse formation (NTNG1), and neuronal specification (HOXB cluster family and MYT1). Interpretation Identification of new candidate genes and associated pathways will inform future functional research. Advances in understanding of the molecular mechanisms that underlie restless legs syndrome could lead to new treatment options. We focused on common variants; thus, additional studies are needed to dissect the roles of rare and structural variations.Peer reviewe

Suicidal Behavior and Alcohol Abuse

Suicide is an escalating public health problem, and alcohol use has consistently been implicated in the precipitation of suicidal behavior. Alcohol abuse may lead to suicidality through disinhibition, impulsiveness and impaired judgment, but it may also be used as a means to ease the distress associated with committing an act of suicide. We reviewed evidence of the relationship between alcohol use and suicide through a search of MedLine and PsychInfo electronic databases. Multiple genetically-related intermediate phenotypes might influence the relationship between alcohol and suicide. Psychiatric disorders, including psychosis, mood disorders and anxiety disorders, as well as susceptibility to stress, might increase the risk of suicidal behavior, but may also have reciprocal influences with alcohol drinking patterns. Increased suicide risk may be heralded by social withdrawal, breakdown of social bonds, and social marginalization, which are common outcomes of untreated alcohol abuse and dependence. People with alcohol dependence or depression should be screened for other psychiatric symptoms and for suicidality. Programs for suicide prevention must take into account drinking habits and should reinforce healthy behavioral patterns

Propuesta metodológica para control de producto no conforme: aplicación a la depuración de aguas servidas en planta La Farfana

Tesis (Ingeniero Industrial)En la presente memoria se desarrolla una propuesta metodológica para el control de producto no conforme en el tratamiento de aguas servidas en planta La Farfana. Para la obtención de estos resultados, primero se recopilaron los datos diarios de las mediciones ejecutadas a los diferentes parámetros a controlar durante el año 2012 en planta. Luego, se efectuaron análisis estadísticos de estos datos a través de gráficos de control para determinar el comportamiento normal del proceso. A continuación, se realiza un diagrama de Pareto para determinar la prioridad de los problemas a eliminar y también se investigaron las causas que generan los diferentes PNC. Finalmente, se elaboraron diagramas de flujo para señalar los procedimientos a seguir en la resolución de problemas

Interstrain competition and host control of nodulation in the Phaseolus vulgaris-Rhizobium leguminosarum bv. phaseoli symbiosis

Typescript.Thesis (Ph. D.)--University of Hawaii at Manoa, 1990.Includes bibliographical references (leaves 156-169).Microfiche.ix, 169 leaves, bound ill. 29 cmThe legume-Rhizobium symbiosis is a plant-microbe interaction that results in the formation of nitrogen-fixing root nodules. Competition for nodulation among rhizobial strains is a significant, but poorly understood, ecological and agronomic problem. This study addressed the role of the host as a variable that may influence the outcome of interstrain competition. The Phaseolus vulgaris-Rhizobium leguminosarum bv. phaseoli symbiosis was studied to characterize the competitiveness of rhizobial strains and to correlate competitiveness with the ability to induce suppression, a host-mediated regulatory response that restricts the extent of nodulation. The results of this study showed that Rhizobium leguminosarum bv. phaseoli strains have differential intrinsic competitive abilities. There was a correspondence between competitiveness and effectiveness, but there was no correlation between competitiveness and nodulation characteristics. Two highly competitive and highly effective strains, TAL 1472 and TAL 182, were identified as good model strains for genetic manipulation. Nodulation in common bean was subject to nodulation suppression. When a primary inoculation was done on one side of a split-root, followed by a secondary inoculation on the opposite side with increasing delay, secondary nodulation was suppressed in a time-dependent manner, becoming more pronounced as the delay period was increased. strains with varying competitive abilities induced a suppression response that partially corresponded with their competitive abilities. suppressiveness was not related to the speed of nodule formation or to the nodulating potential of a strain. suppression was correlated with rhizobial presence inside the nodules, but was not related to the ability to induce visible nodule primordia, or to the ability to fix nitrogen. Homologous complementation restored the nodulation abilities of the nonnodulating Class I and the nodule primordia-forming Class II mutants. However, the complemented Class I mutants were ineffective and did not regain full ability to induce nodulation suppression. In contrast, the complemented Class II mutants regained the wild-type nodulation, fixation, and suppression characteristics. Restriction analysis of the cosmids complementing Class I mutants showed a 7.2-kb region in common. Two complementation groups corrected the Class II mutants (MLC35 and MLC640), showing an 8.0-kb and a 13.4-kb region in common, respectively